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腫瘤免疫治療已經(jīng)被臨床應(yīng)用治療惡性腫瘤,，在一些患者中具有顯著療效,，但是依然存在臨床響應(yīng)率低的難題,。免疫細(xì)胞活性受到細(xì)胞代謝調(diào)控,，研究腫瘤免疫的代謝調(diào)控機(jī)制將為進(jìn)一步提高腫瘤免疫治療療效提供新的思路和策略,。課題組主要圍繞腫瘤免疫應(yīng)答與耐受的代謝調(diào)控機(jī)制，采用分子,、細(xì)胞,、生化、動(dòng)物模型,、臨床樣本等,，研究參與調(diào)控腫瘤免疫代謝的關(guān)鍵因子及其作用機(jī)制，探索干預(yù)腫瘤免疫代謝提高腫瘤免疫應(yīng)答的免疫治療策略,。

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