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2016-至今，研究員,，課題組組長（PI）,，上海市免疫學研究所，上海交通大學醫(yī)學院

2010-2016,，博士后,，斯坦福大學醫(yī)學院，合作導師: Mark M. Davis

2005-2010,，博士研究生,，北京生命科學研究所，合作導師: 鄧興旺

2001-2005,，生物學,，學士，北京師范大學

本實驗室主要研究T淋巴細胞的免疫識別,，信號轉導和代謝調節(jié)機制,，以及其在腫瘤和自身免疫疾病中的作用。我們將應用免疫學,、分子細胞生物學,、生物物理和生物化學等多種技術手段對以下三個方向進行探索：（1）天然代謝產物調控免疫系統(tǒng)的分子機理和生理功能；（2）T細胞信號和免疫受體組庫在腫瘤免疫中的作用,；（3）免疫檢驗點抑制劑引起的抗腫瘤和自身免疫反應機制,。

項目編號	項目類型	項目名稱	起止年月	備注
82230055	國家自然科學基金重點項目	T細胞抗原識別調節(jié)腸道免疫耐受和炎癥機制	2023/01-2027/12	項目負責人
SQ2022YFA090022-1	科技部國家重點研發(fā)計劃	實體瘤響應工程免疫細胞的設計合成與應用	2023/01-2027/12	子課題負責人
82101879	國家自然科學基金青年項目	天然小分子化合物Lawsone在多發(fā)性硬化癥中的作用及機制探究	2022/01-2024/12	項目負責人（楊翠霞）
2021YFC2502300	科技部國家重點研發(fā)計劃青年科學家項目（青年973計劃）	TCR-T治療急性髓系白血病新方法的研發(fā)	2021/12-2024/11	項目骨干（羅凌杰）
NA	國家萬人計劃青年拔尖人才	免疫細胞識別和信號的代謝調節(jié)機制	2021/12-2023/12	項目負責人
82003013	國家自然科學基金青年項目	致癌病毒和驅動突變腫瘤新抗原及靶向TCR的篩選和驗證研究	2021/01-2023/12	項目負責人（羅凌杰）
82003011	國家自然科學基金青年項目	天然代謝產物伊維菌素對T細胞抗腫瘤效應的影響及作用機制研究	2021/01-2023/12	項目負責人（王秦蘭）
82071852	國家自然科學基金面上項目	免疫檢查點阻斷條件下共生菌對Treg細胞功能和腸道炎癥反應的調節(jié)機制	2021/01-2024/12	項目負責人
20410713800	上海市科學技術委員會國際合作項目	新型冠狀病毒抗原T細胞免疫識別及受體組庫動態(tài)研究	2020/10-2023/09	項目負責人
SQ2018YFA090045-01	科技部國家重點基礎研究發(fā)展計劃(973計劃)	重要病原體疫苗的人工合成	2019/07-2024/06	骨干參與
18JC1414100	上海市科學技術委員會基礎研究重點項目	基于T細胞受體和免疫檢查點基因編輯的抗腫瘤免疫策略	2018/07-2021/06	項目負責人
81701553	國家自然科學基金青年項目	硫酸膽固醇對T細胞受體信號的調控機制	2018/01-2020/12	項目負責人（蟻瑞榮）
1710000163	上海市教委高校特聘教授	基于代謝產物的免疫調節(jié)機制	2017/09-2020/08	項目負責人
KJ3-0214-16-0133	上海交通大學醫(yī)學院院基金	基于代謝產物的免疫調節(jié)機制研究	2016/11-2022/10	項目負責人
17PJ1408400	上海市科學技術委員會浦江人才計劃	膽固醇代謝的免疫調節(jié)	2017/07-2019/06	項目負責人
81771739	國家自然科學基金面上項目	硫酸膽固醇在實驗性自身免疫性腦脊髓炎中的作用機制	2018/01-2021/12	項目負責人

1. Liang W, Yi R, Wang W, Shi Y, Zhang J, Xu X, Wang Q, Liu M, Wang F#. Enhancing the antitumor immunity of T cells by engineering the lipid-regulatory site of the TCR/CD3 complex. Cancer Immunology Research, 2023; 11(1):93-108. doi: 10.1158/2326-6066. CIR-21-1118.

2. Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F#. Disulfiram bolsters T cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling. EMBO Journal, 2022; e110636. doi: 10.15252/embj.2022110636.

3. Zhao X, Liang W, Wang Y, Yi R, Luo L, Wang W, Sun N, Yu M, Xu W, Sheng Q, Lu L, Pang J, Lv Z#, Wang F#. Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis. Cell & Bioscience, 2022.

4. Wang Y, Jin H, Wang Y, Yao Y, Yang C, Meng J, Tan X, Nie Y, Xue L, Xu B, Zhao H, Wang F#. Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice. Theranostics, 2021; 11(20):10074-10090. doi:10.7150/thno.61646.

5. Luo L, Liang W, Pang J, Xu G, Chen Y, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H, Zhang Z, Wang F#. Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discovery, 2021,，28;7(1):89. doi: 10.1038/s41421-021-00321-x.

6. Qian Y, Yu W, Grzeskowiak C, Li J, Huang H, Guo J, Chen L, Wang F, Zhao F, Boehmer L, Metzner T, Leppert J, Chien Y, Kuo C, Davis MM. Nanoparticle-enabled innate immune stimulation activates endogenous tumor infiltrating T cells with broad antigen specificities. PNAS, 2021, doi.org/10.1073/pnas.2016168118.

7. Zhao X, Luo X, Sun R, Wang F#, and Sun X#. The interaction between microglia and macroglia in glaucoma, Frontiers in Neuroscience, 2021, doi: 10.3389/fnins.2021.610788.

8. Wang Y, Zhao X, Gao M, Wan X, Guo Y, Qu Y, Chen Y, Li T, Liu H, Jiang M, Wang F#, and Sun X#. Myosin 1f-mediated Activation of Microglia Contributes to the Photoreceptor Degeneration in a Mouse Model of Retinal Detachment. Cell Death & Disease, 2021, DOI:10.21203/rs.3.rs-80015/v1.

9. Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F#, and Sun X#. SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Frontiers in Cell and Developmental Biology, 2021, Doi: 10.3389/fcell.2021.639851.

10. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Chen J, Liang J, Li Y, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu S, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zou Z, Bai F, Huang X, Zhou P#, Jiang Q#, Huang Z#, Bei J#, Wei L#, Bian X#, Liu X#, Cheng T#, Li X#, Zhao P#, Wang F#, Wang H#, Su B#, Zhang Z#, Qu K#, Wang X#, Chen J#, Jin R#, Zhang Z#. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell, 2021, DOI: 10.1016/j.cell.2021.01.053.

11. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM#, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, DOI:https://doi.org/10.1073/pnas.1921223117.

12. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

13. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

14. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18:29. doi.org/10.1186/s12915-020-00765-9.

15. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.

16. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

17. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.

18. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

19. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

20. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

21. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

22. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

23. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

24. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

25. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.