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1. 脂肪組織代謝穩(wěn)態(tài)的免疫調(diào)控

2. 天然淋巴細(xì)胞發(fā)育及功能的調(diào)控機(jī)制及其與炎癥性疾病的關(guān)系

1. 1.Sun J, Zhang Y, Zhang Q, Hu L, Zhao L, Wang H, Yuan Y, Niu H, Wang D, Zhang H, Liu J, Feng X, Su X, Qiu J, Sun J, Xu H, Zhang C, Wang K, Bi Y, Engleman EG, Shen L*. Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance. Immunity. 2024 May 14:S1074-7613(24)00229-2. doi:10.1016/j.immuni.2024.04.024. Online ahead of print. PMID: 38772366

2. 2.Wang H, Du Y, Huang S, Sun X, Ye Y, Sun H, Chu X, Shan X, Yuan Y, Shen L*, Bi Y*. Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis. Nat Commun. 2024 Jun 6;15(1):4827. doi: 10.1038/s41467-024-48914-w. PMID: 38844451

3. 3.Qi J, Yan L, Sun J, Huang C, Su B, Cheng J, Shen L*. SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5. Proc Natl Acad Sci U S A. 2024 May 28; 121(22):e2314619121
   

4. 4.Niu H, Zhang H, Wang D, Zhao L, Zhang Y, Zhou W, Zhang J, Su X, Sun J, Su B, Qiu J, Shen L*. LKB1 prevents ILC2 exhaustion to enhance antitumor immunity. Cell Rep. 2024 May 28;43(5):113579. doi: 10.1016/j.celrep.2023.113579

5. 5.Xu Y, Zhang H, Wu S, Liu J, Liu H, Wang D, Zhang Y, Niu H, Su X, Sun J, Shen L*. PLZF restricts intestinal ILC3 function in gut defense. Cell Mol Immunol. 2023 Apr;20(4):379-388.

6. 6.Zhou J, Zhang J, Tao L,Peng K, Zhang Q, Yan K, Luan J, Pan J, Su X, Sun J, Zhang Z, Shen L*. Up-regulation of BTN3A1 on CD14+ cells promotes Vγ9Vδ2 T cell activation in psoriasis. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2117523119.

7. 7.Zhang J,，Qiu J, Zhou W, Cao J, Hu X, Mi W, Su B, He B, Qiu J, Shen L*. Neuropilin-1 mediates lung tissue-specific control of ILC2s function in type 2 immunity. Nature Immunology. 2022 Feb;23(2):237-250.

8. 8.Chen Z,，Xie X，Jiang N, Li J, Shen L*, Zhang Y*. CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest. Cell Death Dis. 2021 Feb 15;12(2):184.

9. 9.Shen L,Ye Y, Sun H, Su B. ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy. Cancer Cell. 2021 Oct 11;39(10):1308-1310.

10. 10.Gao L, Yu Q, Zhang H, Wang Z, Zhang T, Xiang J, Yu S, Zhang S, Wu H, Xu Y, Wang Z, Shen L, Shu G, Chen YG, Liu H, Shen L*, Li1 BJ*. A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice. Sci Transl Med.2021 Jul 21;13(603): eabb5071.

11. 11.Qi J, Crinier A, Escalière B, Ye Y, Wang Z, Zhang T, Batista L, Liu H, Hong L, Wu N, Zhang M, Chen L, Liu Y, Shen L*, Narni-Mancinelli E, Vivier E, Su B. Single cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression. Cell Rep Med. 2021 Jul 27;2(8):100353.

12. 12.Qiu J, Zhang J, Ji Y, Sun H, Gu Z, Sun Q, Bai M, Gong J, Tang J, Zhang Y, Li S, Shao Z, Li J, Sheng H, Shen L*, Qiu J*. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. Mucosal Immunol. 2021 Nov;14(6):1306-1322.

13. 13.Li C, Liu J, Pan J, Wang Y, Shen L*, Xu Y*. ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients. Front Immunol. 2021 Jul 26;12:708678.

14. 14.Ji Z, Wu S, Xu Y, Qi J, Su X, Shen L*. Obesity promotes EAE through IL-6 and CCL-2-mediated T cells infiltration. Front Immunol. 2019 Aug 27;10:1881.

15. 15.Cai T, Qiu J, Ji Y, Li W, Ding Z, Suo C, Chang J, Wang J, He R, Qian Y, Guo X, Zhou L, Sheng H, Shen L*, Qiu J. IL-17-producing ST2+ group 2 Innate Lymphoid Cells play a pathogenic role in lung inflammation. J Allergy Clin Immunol. 2019 143(1):229-244.
    

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