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1、自身免疫病發(fā)病機(jī)制與免疫干預(yù)

2、新型腫瘤免疫治療策略研究

1.  Zheng Y, Sun L, Jiang T, Zhang D, He D, Nie H. .TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid arthritis. .J Immunol Res.,2014,385352.  [Link]

2.  Nie H, Zheng Y, Li R, Guo TB, He D, Fang L, Liu X, Xiao L, Chen X, Wan B, Chin YE, Zhang JZ. .Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-a?in rheumatoid arthritis. .Nat Med. ,2013,19(3): 322-8.  [Link]

3.  Sun Q, Zheng Y, Zhang X, Hu X, Wang Y, Zhang S, Zhang D, Nie H..Novel immunoregulatory properties of EGCG on reducing inflammation in EAE..Front Biosci (Landmark Ed). ,2013,18: 332-42.  [Link]

4.  Dang S, Peng Y, Ye L, Wang Y, Qian Z, Chen Y, Wang X, Lin Y, Zhang X, Sun X, Wu Q, Cheng Y, Nie H, Jin M, Xu H..Stimulation of TLR4 by LMW-HA induces metastasis in human papillary thyroid carcinoma through CXCR7..Clin Dev Immunol. ,2013,712561.  [Link]

5.  Yin Q, Liu C, Wu Y, Wu S, Wang Y, Zhang X, Hu X, Pu J, Lu Y, Zhou H, Wang H, Nie H, Sun H, Chen G..Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-kB signaling..J Immunol. ,2013,191(5): 2115-25.  [Link]

6.  Chen M, Chen, Nie H, Zhang X, Niu X, Zhang Y C.Q., Skinner SM, Zhang JW, Killian JM, Hong J..Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS..Eur J Immunol.,2009,39(9): 2525-36.  [Link]

7.  Nie H, Wu J, Zhang M, Xu J, Zou M..Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo. .Diabetes,2006,55 (11): 3133-41..  [Link]

8.  Wan B, Nie H, Liu A, Feng G, He D, Xu R, Zhang Q, Dong C, Zhang JW..Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis..J Immunol.,2006,177 (12): 8844-50.  [Link]

9.  Hong J, Zang Y, Nie H, Zhang JW. .CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis..Proc Natl Acad Sci U S A.,2006,103(13): 5024-29.  [Link]

10.  11. Xu G, Nie H, Li N, Zheng W, Zhang D, Feng G, Ni L, Xu R, Hong J, Zhang JZ..Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. .J Clin Invest. ,2005,115(4): 1060-7.  [Link]

11.  Sun W, Nie H, Li N, Zang Y C.Q., Zhang D, Feng G, Ni L, Xu R, S Prasad, RR Robinson, W Ho, E Sercarz, Zhang JZ..Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis..Genes Immun.,2005,6(3): 248-61.  [Link]