實驗室主頁：https://hua-binglilab.com/
1. Wang X#, Liu S#, Lu Y#, Chen H, Li H, Cai X, Li B, Liu R, Hu W*, Zhu X*, Ye Y*, Li HB*. (2023) tRNA m1A modification in macrophages promotes translation of interferon pathway genes to enhance CD8+ T cell-mediated anti-tumor immunity. Nature Immunology, under review
2. Zhang X#, Li H#, Wang G#, Hao Y, Li S, Li B, Xiao H, Su B, Wu Y*, Ye Y*, Li HB*. (2023) m6A RNA modification guides alternative polyadenylation to maintain T cell quiescence. Immunity, under revision
3. Wang X., Ding C*., and Li H.B.* (2023). The crosstalk between enteric nervous system and immune system in intestinal development, homeostasis and diseases. Sci China Life Sci 66, https://doi.org/10.1007/s11427-023-2376-0
4. Zhang Y, Hu W*, Li HB*. (2023) RNA Modification-mediated Translational Control in Immune Cells. RNA Biology, 2023 Jan; 20(1): 603-613. doi: 10.1080/15476286.2023.2246256. PMID: 37584554
5. Zhang Z, Chen N, Yin N, Liu R, He Y, Li D, Tong M, Gao A, Lu P, Zhao Y, Li H, Zhang J, Zhang D, Gu W, Hong J, Wang W, Qi L, Ning G, Wang J. The rs1421085 variant within FTO promotes brown fat thermogenesis. Nat Metab. 2023 Jul 17. doi: 10.1038/s42255-023-00847-2. Online ahead of print. PMID: 37460841
6. Wang X, Chen C, Sun H, Mao K, Yao J, Zhang W, Zhan M, Li HB, Zhang Z, Zhu S, Lu L. (2023) m6A mRNA modification potentiates Th17 functions to inflame autoimmunity. Sci China Life Sci. 2023 Jun 29. doi: 10.1007/s11427-022-2323-4. PMID: 37405565
7. Ding C#, Yu Z#, Sefik E#, Zhou J#, Kaffe E, Li B, Wang L, Flavell RA, Hu W, Ye Y, Li HB*. (2023) A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver. Nature Aging, 2023 Jul; 3(7):813-828. doi: 10.1038/s43587-023-00428-8. Epub 2023 Jun 5. PMID: 37277640.
(Highlighted by: News & Views: Ma Y. & Cao H. Nature Aging, 3, 760–761 (2023); Research Highlight: Hguyen H.T. & Batista P.J. Sci China Life Sci. 66)
8. Ma H, Hu T, Tao W, Tong J, Han Z, Herndler-Brandstetter D, Wei Z, Liu R, Zhou T, Liu Q, Xu X, Zhang K, Zhou R, Cho JH, Li HB*, Huang H*, Flavell RA*, Zhu S*. (2023) A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis. Cell Res. 2023 Apr 13. doi: 10.1038/s41422-023-00790-7. PMID: 37055591 (* co-corresponding)
9. Zhao J, Ding C*, Li HB*. (2023) N6-Methyladenosine defines a new checkpoint in γδ T cell development. Bioessays. 2023 Mar 21:e2300002. doi: 10.1002/bies.202300002. PMID: 36942692 (review)
10. Chen Y, Oh MH, Flavell R*, Li HB*. (2022) RNA methylation in immune cells. Advances in Immunology, 2022;155:39-94. doi: 10.1016/bs.ai.2022.08.002. Epub 2022 Sep 13. PMID: 36357012 (Book Chapter)
11. Liu Y#, Zhou J#, Li X#, Zhang X#, Shi J#, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zhen J, Liu RJ, Su B, Ye Y, Flavell RA*, Yi C*, Wu Y*, Li HB*. (2022) tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis. Nature Immunology, 2022 Oct; 23(10):1433-1444. doi: 10.1038/s41590-022-01301-3. Epub 2022 Sep 22. PMID: 36138184.
(Cover Article. Highlighted by: News & Views: Marchingo, J.M. Nat Immunol 23, 1401–1402 (2022). Research Briefing: Nat Immunol 23, 1408–1409 (2022). Research Highlight: Pei W. & Kuchroo V.K. Cell Res. 33(4):271-272. Research Highlight: Chen C. & Ye L. Cell Mol Immunol., 19(12):1328-1329. Research Highlight: Lin P., Li G. & Wu M. Signal Transduct Target Ther. 8(1):78.)
12. Ding C#, Xu H#, Yu Z#, Roulis M, Qu R, Zhou J, Oh J, Craford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W*, Flavell RA*, Li HB*. (2022) RNA m6A demethylase ALKBH5 regulates the development of γδ T cells. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203318119. doi: 10.1073/pnas.2203318119. Epub 2022 Aug 8. PMID: 35939687 (* co-corresponding)
13. Hu Q, Xu T, Zhang M, Zhang H, Liu Y, Li HB, Chen C, Zheng J, Zhang Z, Li F, Shen N, Zhang W, Melnick A, Huang C. (2022) Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response. Cell Rep. 2022 Jul 5;40(1):111035. doi: 10.1016/j.celrep.2022.111035. PMID: 35793628
14. Chen B#, Hu J#, Hu X#, Chen H, Bao R, Zhou Y, Ye Y, Zhan M*, Cai W*, Li H*, Li HB*. (2022) DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature Communications, 2022 Apr 19; 13(1):2059. doi: 10.1038/s41467-022-29754-y. PMID: 35440133 (* co-corresponding)
15. Zhang T#, Ding C#*, Chen H# Zhao J, Chen J, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M*, Flavell RA*, Li HB*. (2022) m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κb-mediated anti-apoptotic pathway. Science Advances, 2022 Mar 25; 8(12):eabl5723. doi: 10.1126/sciadv.abl5723. PMID: 35333576 (* co-corresponding)
16. Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, Qian C, Zhang G, Li R, Wang D, Ren X, Zhang K, Ding S, Flavell RA, Li H, Pan W, Zhu S. (2022) m6A modifications regulate intestinal immunity and rotavirus infection. Elife. 2022 Jan 31;11:e73628. doi: 10.7554/eLife.73628. PMID: 35098923
17. Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA*, Li HB*, Ouyang X*. (2021) m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity. Cell Rep., 2021 Nov 9;37(6):109968. doi: 10.1016/j.celrep.2021.109968. PMID: 34758326 (* co-corresponding) IF: 9.423
18. Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. (2021) METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells. Nat Commun., 2021 Sep 17;12(1):5522. doi: 10.1038/s41467-021-25803-0. PMID: 34535671 IF: 14.919
19. Zhou J#, Zhang X#, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA*, Li HB*. (2021) m6A Demethylase ALKBH5 Controls CD4+ T cell Pathogenicity and Promotes Autoimmunity. Science Advances, 2021 Jun 16;7(25):eabg0470. doi: 10.1126/sciadv.abg0470. PMID: 34134995 (*co-corresponding) IF: 14.136
20. Chao Y, Li HB*, Zhou J*. Multiple Functions of RNA Methylation in T Cells: A Review. Front Immunol., 2021 Apr 12;12:627455. doi: 10.3389/fimmu.2021.627455. eCollection 2021. PMID: 33912158 (* co-corresponding) IF: 7.561 (review)
21. Tong J#, Wang X#, Liu Y#, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Zhou Y, Xia Q*, Flavell RA*, Zhu S*, Li HB*. (2021) Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation. Science Advances, 2021 Apr 28; 7(18):eabd4742. doi: 10.1126/sciadv.abd4742. PMID: 33910903 (* co-corresponding) IF: 14.136
22. Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 2021 Apr;592(7855):606-610. doi: 10.1038/s41586-021-03283-y. Epub 2021 Mar 3. PMID: 33658717 IF: 49.962
23. Chen H#, Yao J#, Bao R, Dong Y, Zhang T, Du Y, Wang G, Ni D, Xun Z, Niu X, Ye Y*, Li HB*. (2021) Cross-talk of Four Types of RNA Modification Writers Defines Tumor Microenvironment and Pharmacogenomic Landscape in Colorectal Cancer. Molecular Cancer, 20(1):29. doi: 10.1186/s12943-021-01322-w. PMID: 33557837 (* co-corresponding, most cited) （ESI highly cited paper）IF: 27.401
24. Wang Y#, He K#, Sheng B#, Lei X, Tao WE, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H*, Li HB*, Flavell RA*, Zhu S*. (2021) The RNA helicase Dhx15 mediates Wnt-induced anti-microbial protein expression in Paneth cells. Proc. Natl. Acad. Sci. U.S.A., 118 (4) e2017432118 (* co-corresponding) IF: 11.205
25. Xu C*, Li HB*, Flavell RA*. A special collection of reviews on frontiers in immunology. Cell Research, Oct;30(10):827-828. doi: 10.1038/s41422-020-00403-7. (* co-corresponding, Editorial) IF: 25.617
26. Gao Y*#, Vasic R#, Song Y#, Teng R, Gbyli R, Biancon G, Nelakanti R, Liu C, Kudo E, Lobben K, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA*, Li HB*, Tebaldi T*, Halene S*. (2020) Activation of Double-Stranded RNA Innate Immune Response and Hematopoietic Failure upon Loss of METTL3-Mediated m6A RNA Modification. Immunity, 2020 Jun 16;52(6):1007-1021.e8. doi: 10.1016/j.immuni.2020.05.003. Epub 2020 Jun 3. PMID: 32497523 (* co-corresponding) IF: 31.745
27. Hwang SS, Lim J, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee GR, Li HB, Flavell RA. (2020) mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence. Science. 2020 Mar 13;367(6483):1255-1260. doi: 10.1126/science.aax0194. PMID: 32165587 IF: 47.728
28. Zhang X, Flavell RA*, Li HB*. (2019) hnRNPA2B1: a nuclear DNA sensor in antiviral immunity. Cell Research, 2019 Nov;29(11):879-880. doi: 10.1038/s41422-019-0226-8. IF: 25.617 (preview)
29. Wang J, Flavell RA*, Li HB*. (2019) Antiviral immunity: a link to bile acids. Cell Research, 2019 Mar;29(3):177-178. doi: 10.1038/s41422-019-0148-5. PMID: 30778178 (* co-corresponding) IF: 25.617 (preview)
30. Liu Y, Li HB*, Flavell RA*. (2018) cGAS activation in phased droplets. Cell Research, 2018 Oct;28(10):967-968. doi: 10.1038/s41422-018-0087-6. PMID: 30218060 (* co-corresponding) IF: 25.617 (preview)
31. Yu X, Teng XL, Wang F, Zheng Y, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li HB, Su B, Lu L, Liu Z, Sun SC, Zou Q. (2018) Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J Exp Med. 2018 Sep 3;215(9):2463-2476. doi: 10.1084/jem.20180397. PMID: 30115741 IF: 14.307
32. Tong J, Flavell RA*, Li HB*. (2018) RNA m6A modification and its functions in diseases. Frontiers of Medicine, 2018 Aug;12(4):481-489. doi: 10.1007/s11684-018-0654-8. PMID: 30097961 (* co-corresponding, most cited) （ESI highly cited paper） IF: 4.592 (review)
33. Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB*, Huang C*, Yi J* , Zou Q*. (2018) SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications, 2018 Aug 8;9(1):3157. doi: 10.1038/s41467-018-05676-6. PMID: 30089837 (* co-corresponding) IF: 14.919
34. Tong J#, Cao G#, Zhang T#, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA*, Li HB*. (2018) m6A mRNA methylation sustains Treg suppressive functions. Cell Research, 28(2): 253-256. doi:10.1038/cr.2018.7. PMID: 29303144 (*co-corresponding) IF: 25.617
35. Li HB#*, Tong J#, Zhu S#, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z*, Flavell RA*. (2017) m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway. Nature, 2017 Aug 17;548(7667):338-342. doi: 10.1038/nature23450. Epub 2017 Aug 9. PMID: 28792938 (# equal contribution, * co-corresponding) （ESI highly cited paper） IF: 49.962
36. Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. (2017) Nlrp9b inflammasome recognizes and restricts rotavirus infection in intestinal epithelial cells. Nature, 546(7660): 667-670. doi: 10.1038/nature22967. PMID: 28636595 IF: 49.962
37. Hu B#, Jin C#, Li HB#, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. (2016) The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science, 354 (6313): 765-768. DOI: 10.1126/science.aaf7532. PMID: 27846608 (# equal contribution) IF: 47.728
38. Li HB. (2016) Chromosome Conformation Capture in Drosophila. Methods Mol. Biol., 1480:207-12. doi: 10.1007/978-1-4939-6380-5_18. PMID: 27659987 IF:1.167
39. Cao G#, Li HB#, Yin Z, Flavell RA. (2016) Recent advances in dynamic m6A RNA modification. Open Biology, 6(4): 160003. doi: 10.1098/rsob.160003. PMID: 27249342 (# equal contribution, rank #8 of the most cited paper since 2011 of the journal) IF: 6.411 (review)
40. Zhu S#, Li HB#, Flavell RA. (2014) Resemble and Inhibit: When RLR Meets TGF-β. Mol Cell, 56(6):719-20. doi: 10.1016/j.molcel.2014.12.010. PMID: 25526529 (# equal contribution) IF: 17.97 (preview)
41. Li HB#, Jin C#, Chen Y#, Flavell RA. (2014) Inflammasome activation and metabolic disease progression. Cytokine Growth Factor Rev., 25(6):699-706. doi: 10.1016/j.cytogfr.2014.07.020. PMID: 25156419 (# equal contribution) IF: 7.638 (preview)
42. Li HB, Ohno K, Gui H, and Pirrotta V. (2013) Insulators target active genes to transcription factories and Polycomb-repressed genes to PcG bodies. PLoS Genet., 9(4):e1003436. doi: 10.1371/journal.pgen.1003436. PMID: 23637616 (Highlighted by Cell: 153(5), p935) IF: 5.917
43. Schwartz YB, Linder-Basso D, Kharchenko PV, Tolstorukov MY, Kim M, Li HB, Gorchakov AA, Minoda A, Shanower G, Alekseyenko AA, Riddle NC, Jung YL, Gu T, Plachetka A, Elgin SC, Kuroda MI, Park PJ, Savitsky M, Karpen GH, Pirrotta V. (2012) Nature and function of insulator protein binding sites in the Drosophila genome. Genome Res. 22(11): 2188-98. doi: 10.1101/gr.138156.112. PMID: 22767387 IF: 9.043
44. Pirrotta V., and Li HB (2012). A view of nuclear Polycomb bodies. Curr. Opin. Genet. Dev., 22(2):101-9. doi: 10.1016/j.gde.2011.11.004. PMID: 22178420 IF: 5.578 (review)
45. Li HB, Muller M, Bahechar I, Kyrchanova O, Ohno K, Georgiev P, and Pirrotta V. (2011) Insulators, not Polycomb Response Elements, are required for long-range interactions between Polycomb targets in Drosophila. Mol. Cell. Biol., 31(4):616-25. doi: 10.1128/MCB.00849-10. PMID: 21135119 IF:4.272
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