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B淋巴細胞是免疫系統(tǒng)的重要組成部分,，發(fā)育過程中經(jīng)歷多個前體細胞階段,，成熟后進入淋巴結(jié)等外周淋巴器官,，在接觸外源性病原體后,，在濾泡T輔助細胞的幫助下,，逐步分化并在B淋巴濾泡內(nèi)形成生發(fā)中心B細胞,，并最終分化成能產(chǎn)生大量保護性抗體的漿細胞,，來消滅病原菌,。生發(fā)中心B細胞分化異常和許多人類疾病相關(guān)，其中包括自身免疫性疾病以及B細胞淋巴瘤,。我們實驗室深入研究：生發(fā)中心B細胞發(fā)育,、分化以及惡變的轉(zhuǎn)錄和表觀遺傳學機制；B細胞淋巴瘤的免疫治療,。目前,，我們的主要研究手段包括小鼠遺傳學模型，經(jīng)典免疫學,，分子生物學和二代測序等,。

1.  Zhang H, Dai D, Hu Q, Yang F, Xue Y, Li F, Shen N, Zhang M, Huang C(通訊作者）.Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development.Cell Reports,2021,35(6):109096.  [Link]

2.  Zhou XR, Li X, Liao LP, Han J, Huang J, Li JC, Tao HR, Fan SJ, Chen ZF, Li Q, Chen SJ, Ding H, Yang YX, Zhou B, Jiang HL, Chen KX, Zhang YY, Huang CX(共同通訊）, Luo C.P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib.Acta Pharmacol Sin . ,2021,s41401-021-00643-2.  [Link]

3.  Peng C, Hu Q, Yang F, Zhang H, Li F, Huang C (通訊).BCL6-Mediated Silencing of PD-1 Ligands in Germinal Center B Cells Maintains Follicular T Cell Population..J Immunol,2019,202(3):704-713.  [Link]

4.  Deng S,, Hu Q, Zhang H, Yang F, Peng C, Huang C (通訊).HDAC3 inhibition up-regulates PD-L1 expression in B-cell lymphomas and augments the efficacy of anti-PD-L1 therapy..Molecular Cancer Therapeutic ,2019,18(5):900-908.  [Link]

5.  Peng H, Yang F, Hu Q, Sun J, Peng C, Zhao Y, Huang C（通訊）.The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity..Autophagy,2019,Jul 1:1-11.  [Link]

6.  Zhang H, Hu Q, Zhang M, Yang Fang, Peng C, Zhang Z, Huang C(通訊）.Bach2 deficiency leads to spontaneous expansion of IL-4-producing T follicular helper cells and autoimmunity.Frontier In Immunology,2019,.  [Link]

7.  Sun J, Hu Q, Peng H , Peng C, Zhou L, Lu J, Huang C (通訊作者）.ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43. Journal of Biology Chemistry.Journal of Biology Chemistry,2018,293(21):8275-8284 .  [Link]

8.  Chen J, Jian X, Deng S, Ma Z, Shou X, Shen Y, Zhao Y, Huang C (共同通訊) & Shi Y.Identification of recurrent USP48 and BRAF mutations in Cushing’s disease.Nature Communication,2018,9(1):3171.  [Link]

9.  Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C (共同通訊), Yi J, Zou Q.SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation..Nature Communication,2018,9(1):3157.  [Link]

10.  Zhang Q, Peng C, Song J, Zhang Y, Chen J, Song Z, Shou X, Ma Z, Peng H, Jian X, He W, Ye Z, Li Z, Wang Y, Ye H, Zhang Z, Shen M, Tang F, Chen H, Shi Z, Chen C, Chen Z, Shen Y, Wang Y, Lu S, Zhang J, Li Y, Li S, Mao Y, Zhou L, Yan H, Shi Y, Huang C (共同通訊), Zhao Y.Germline Mutations in CDH23, Encoding Cadherin-Related 23, Are Associated with Both Familial and Sporadic Pituitary Adenomas.Am J Hum Genet,2017,100(5):817-823.  [Link]

11.  Ma ZY, Chen JH, Song ZJ, Huang C (共同通訊), Shi YY# and Zhao Y#.Recurrent gain-of-function USP8 mutations in Cushing’s disease.Cell Res,2015 ,25(3):306-17.  [Link]

12.  Huang C (共同通訊), Melnick A#.Mechanisms of action of BCL6 during germinal center B cell development.Science China Life sciences,2015,58(12): 1226-1232.  [Link]

13.  Huang C, Geng H, Boss I, Wang L, Melnick AM.Cooperative transcriptional repression by BCL6 and BACH2 in germinal centre B-cell differentiation.Blood,2014,123(7):1012-20.  [Link]

14.  Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A.The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers.Cell Reports,2014,8(5):1497-508.  [Link]

15.  Huang C, Hatzi K, Melnick AM.Lineage-specific functions of Bcl6 in immunity and inflammation are mediated through distinct biochemical mechanisms.Nature Immunology ,2013,14(4): 380-8.  [Link]

16.  Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Carina Ng, Titz B, Hurtz C, Sadiyah F, Melnick AM, Müschen M.BACH2 mediates negative ion and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.Nature Medicine ,2013,19(8):1014-22.  [Link]

17.  Cubedo E, Gentles AJ, Huang C, Natkunam, Y, Melnick A; Lossos IS.Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.Blood,2012,119(23): 5478-5491.  [Link]

18.  Sun Z, Huang C, He J, Lamb, Kristy L Kang X Shen WH Yin, Y.PTEN C-terminal deletion causes genomic instability and tumor development.Cell Reports,2014,13;6(5):844-54.  [Link]

19.  Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, GElemento O, Melnick A.A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.Cell Reports,2013,15;4(3):578-88.  [Link]