研究方向包括：
感染與自身免疫病
實(shí)驗(yàn)室主要關(guān)注一種特殊的左手螺旋核酸—Z型核酸,，已知病毒感染可以導(dǎo)致Z型核酸的產(chǎn)生,，在腸炎,、皮炎等自身免疫疾病中發(fā)現(xiàn)內(nèi)源的Z型核酸可以誘導(dǎo)炎癥反應(yīng),。
我們想要探索的科學(xué)問題包括：
1.1 Z型核酸在抗感染免疫中的功能
1.2 Z型核酸在疾病中的功能及調(diào)控
1.3 其他特殊構(gòu)象核酸的生理學(xué)功能
抗腫瘤免疫
探索干細(xì)胞技術(shù)在腫瘤免疫治療中的應(yīng)用,。
科研項(xiàng)目：
1. 國家自然科學(xué)基金 面上項(xiàng)目 (2023) 32370918
2. 上海市公衛(wèi)優(yōu)青項(xiàng)目 (2023) GWVI-11.2-YQ45
3. 上海交通大學(xué)醫(yī)學(xué)院/上海市免疫所PI啟動(dòng)經(jīng)費(fèi) (2023)
1. Qiannan Tang; Rachel E. Rigby; George R. Young; Astrid Korning Hvidt; Tanja Davis; Tiong Kit Tan; Anne Bridgeman; Alain R. Townsend; George Kassiotis; Jan Rehwinkel; Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS- dependent type I interferon responses, Immunity, 2021, 54(9): 1961-1975.e5
2. Qiannan Tang; Xinlu Wang; Guangxia Gao; The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1, Journal of Virology, 2017, 2(91): e01909-16
3. Qiannan Tang; Z-nucleic acids: Uncovering the functions from past to present, European Journal of Immunology, 2022, 52(11): 1700-1711
4. Le Qin; Yuanbin Cui; Tingjie Yuan; Dongmei Chen; Ruocong Zhao; Shanglin Li; Zhiwu Jiang; Qiting Wu; Youguo Long; Suna Wang; Zhaoyang Tang; Huixia Pan; Xiaoping Li; Wei Wei; Jie Yang; Xuequn Luo; Zhenfeng Zhang; Qiannan Tang; Pentao Liu; Robert Weinkove; Yao Yao; Dajiang Qin; Jean Paul Thiery; Peng Li; Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis, Nature Communications, 2022, 13(1): 6051
5. Shanglin Li; Ruocong Zhao; Diwei Zheng; Le Qin; Yuanbin Cui; Yao Li; Zhiwu Jiang; Mengjun Zhong; Jingxuan Shi; Ming Li; Xindong Wang; Zhaoyang Tang; Qiting Wu; Youguo Long; Duo Hu; Suna Wang; Yao Yao; Shuang Liu; Li-Hua Yang; Zhenfeng Zhang; Qiannan Tang; Pentao Liu; Yangqiu Li; Peng Li; DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D, Molecular Therapy - Oncolytics, 2022, 26: 15-26
6. Yuanbin Cui, Tingjie Yuan,Ying Wang, Di Diwei Zheng, Le Qin, Shanglin Li, Zhiwu Jiang, Shouheng Lin, Wenjing Guo, Zhaoduan Liang, Yi Li, Yao Yao, Xingguo Liu, Qiannan Tang, Hai-Yan Tu, Xu-Chao Zhang, Zhaoyang Tang, Yan-Lai Tang, Libin Huang, Xuequn Luo, Nathalie Wong, Zhenfeng Zhang, Dajiang Qin, Jean Paul Thiery, Kailin Xu, Peng Li. T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity. Cell Reports, 2023, Jul25; 42(7):112797.
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