本實(shí)驗(yàn)室的主要研究興趣集中在腫瘤免疫機(jī)理的探索及免疫治療的開(kāi)發(fā)上,，專注于免疫細(xì)胞在腫瘤發(fā)生發(fā)展及腫瘤殺傷中的作用及調(diào)控,，從淋巴細(xì)胞和髓系細(xì)胞同時(shí)入手,，結(jié)合臨床抗體研究和人源化動(dòng)物模型開(kāi)發(fā)，通過(guò)研究腫瘤免疫（Tumor immunity）和自身免疫（Autoimmunity）的分子機(jī)理,，開(kāi)發(fā)安全有效的腫瘤免疫治療新抗體,，新藥物靶點(diǎn)，新化合物及聯(lián)合療法,。
(1)Yan Zhang; Michael Morgan; Ken Chen; Swati Choksi; Zhenggang Liu*; Indu ction of Autophagy is Essential for Monocyte-Macrophage Differentiation, Blood, 2012, 119(12): 2895-2905.
(2)Yan Zhang; Swati Chokis; Kun Chen; Yelena Pobezinskaya; Ilona Linnoila; Zhenggang Liu*; ROS plays a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor associated macrophages, Cell Research, 2013, 23: 898-914.
(3)Yan Zhang; Swati Choksi; Zhenggang Liu*; Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis, Cancers, 2013, 5(4): 1643-1654.
(4)Yan Zhang#*; Xuexiang Du#; Mingyue Liu#; Fei Tang; Peng Zhang; Chunxia Ai; James K. Fields; Eric J. Sundberg; Olga S. Latinovic; Martin Devenport; Pan Zheng*; Yang Liu*; Hijacking Antibody-induced CTLA-4 Lysosomal Degradation for Safer and More Effective Cancer Immunotherapy, Cell Research, 2019, 29: 609-627.
(5) Wei Zheng#;Yan Zhang#; Jingjing Chen#; Yu Hu#; Pan Jia; Xuelei Wang; Qifang Zhao; Yicong Deng; Ni Li; Yi Zhang; Jun Qin; Xiaoming Wang*; Wei Lu*; Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway, Science Immunology, 2019, 4(41).
(6) Pan Jia, Xiang Li, Xuelei Wang, Liangjiao Yao, Yingying Xu, Yu Hu, Wenwen Xu, Zhe He, Qifan Zhao, Yicong Deng, Yi Zang, Meiyu Zhang,Yan Zhang*,Jun Qin*& Wei Lu*.ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization. Nature Communications, 2021 Nov 11;12(1).
(7) Zhenyi Niu, Ruisen Jin,YanZhang*, Hecheng Li*. Signaling pathways and targeted therapies in lung squamous cell car cinoma: mechanisms and clinical trials. Signal Transduct Target Ther. 2022 Oct 5;7(1):353.
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