馬文姬,，博士，研究員
上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院
通訊地址：上海市黃浦區(qū)重慶南路227號(hào)
郵箱: [email protected]
個(gè)人簡(jiǎn)介:
2009年于山東大學(xué)獲軟件工程學(xué)士學(xué)位,，2013年于香港城市大學(xué)計(jì)算機(jī)系獲得生物信息學(xué)博士學(xué)位,。2014-2019年于美國(guó)哥倫比亞大學(xué)醫(yī)學(xué)中心系統(tǒng)生物學(xué)系從事博士后研究并晉升為副研究員。2019-2023年在中國(guó)科學(xué)院生物物理所任研究員,。于2023年加入上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院,。長(zhǎng)期從事生物信息學(xué)研究，致力于用計(jì)算手段解決重要的生物醫(yī)學(xué)問題,，文章發(fā)表在Cell, Nature Immunology, Cell Reports等期刊上,，其中三篇入選ESI高被引用論文。入選2020年度“中國(guó)科協(xié)青年人才托舉工程”計(jì)劃,，獲得2021年度生物信息學(xué)十大進(jìn)展獎(jiǎng)項(xiàng),。目前主持國(guó)家自然科學(xué)基金青年項(xiàng)目一項(xiàng)，作為子課題組長(zhǎng)負(fù)責(zé)國(guó)家科技部科技創(chuàng)新2030重大項(xiàng)目一項(xiàng),，作為項(xiàng)目骨干參與科技部國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃一項(xiàng),。
研究方向:
1. 運(yùn)用單細(xì)胞多組學(xué)大數(shù)據(jù)分析建模細(xì)胞在健康/疾病狀態(tài)下的細(xì)胞亞群發(fā)育分化路徑及關(guān)鍵調(diào)控轉(zhuǎn)錄因子。
2. 開發(fā)新型單細(xì)胞多組學(xué)數(shù)據(jù)分析工具和數(shù)據(jù)庫(kù),。
代表性論文 (#: 共同第一, *: 共同通訊) :
1. G. Jia*, W. Ma*, Z. Wu, S. Li, X. Zhang, Z. He, S.Wu, H. Tao, Y. Fang, X. Wang#, and Q. Yang# . Molecular landscape at the embryo-maternal interface for conceptus elongation and implantation. Cell Reports, Accepted.2023.
2. M. Wang*, L. Zhuo*, W. Ma*, Q. Wu#, Y. Zhuo#, X. Wang#. AllenDigger, a Tool for Spatial Expression Data Visualization, Spatial Heterogeneity Delineation, and Single-Cell Registration Based on the Allen Brain Atlas. The Journal of Physical Chemistry A. 2023.
3. Q. Ma*, W. Ma*, T.Z. Song*, Z. Wu*, Z. Liu, Z. Hu, J.B. Han, L. Xu, B. Zeng, B. Wang, Y. Sun, D.D. Yu, Q. Wu, Y.G. Yao#, Y.T. Zheng#, X. Wang#. Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection. Zoological Research. 2022;43(6):1041-62.
4. X. Ren*, W. Wen*, X. Fan*, W. Hou*, B. Su*, P. Cai*, J. Li*, Y. Liu*, F. Tang*, F. Zhang*, Y. Yang*, J. He*, W. Ma*, J. He*, P. Wang*, …., P. Zhou#, Q. Jiang#, Z. Huang#, J.X. Bei#, L. Wei#, X.W. Bian#, X. Liu#, T. Cheng#, X. Li#, P. Zhao#, F.S. Wang#, H. Wang#, B. Su#, Z. Zhang#, K. Qu#, X. Wang#, J. Chen#, R. Jin#, Z. Zhang#. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 2021;184(7):1895-913 e19.
5. P. Dogra, C. Rancan, W. Ma, M. Toth, T. Senda, D.J. Carpenter, M. Kubota, R. Matsumoto, P. Thapa, P.A. Szabo, M.M. Li Poon, J. Li, J. Arakawa-Hoyt, Y. Shen, L. Fong, L.L. Lanier, D.L. Farber. Tissue Determinants of Human NK Cell Development, Function, and Residence. Cell. 2020;180(4):749-63 e13.
6. W. Ma, J. Lee, D. Backenroth, Y.J. Zhou, E. Bush, P. Sims, K. Liu#, Y. Shen#. Single cell RNA-Seq reveals pre-cDCs fate determined by transcription factor combinatorial dose. BMC molecular and cell biology. 2019;20(1):20.
7. J. Lee*, Y.J. Zhou*, W. Ma*, W. Zhang, A. Aljoufi, T. Luh, K. Lucero, D. Liang, M. Thomsen, G. Bhagat, Y. Shen#, K. Liu#. Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors. Nature Immunology. 2017;18(8):877-88.
8. B.V. Kumar*, W. Ma*, M. Miron, T. Granot, R.S. Guyer, D.J. Carpenter, T. Senda, X. Sun, S.H. Ho, H. Lerner, A.L. Friedman, Y. Shen#, D.L. Farber#. Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites. Cell Reports. 2017;20(12):2921-34.
9. W. Ma, C. McAnulla, L. Wang. Protein complex prediction based on maximum matching with domain-domain interaction. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 2012;1824(12):1418-24.
10. W. Ma, Y. Yang, Z.-Z. Chen, L. Wang. Mutation region detection for closely related individuals without a known pedigree. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2011;9(2):499-510.
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