李辰 博士,、研究員
上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院,，
單細(xì)胞組學(xué)與疾病研究中心，
蛋白質(zhì)組學(xué)與代謝組學(xué)平臺主任,，
通訊地址：上海市黃浦區(qū)重慶南路227號
電子郵件：[email protected]; [email protected]
李辰博士畢業(yè)于中國科學(xué)院上海生命科學(xué)研究院生物化學(xué)與細(xì)胞生物學(xué)研究所,，獲生物化學(xué)與分子生物學(xué)博士學(xué)位；2006-2020,，中國科學(xué)院上海生命科學(xué)研究院,，生物化學(xué)與細(xì)胞生物學(xué)研究所，期間聘任為副研究員,。2020年3月加入上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院單細(xì)胞組學(xué)與疾病研究中心,，任蛋白質(zhì)組學(xué)與代謝組學(xué)平臺主任。
主要從事單細(xì)胞與空間分辨蛋白質(zhì)組技術(shù)的開發(fā)與應(yīng)用,；質(zhì)譜技術(shù)的開發(fā)及其在癌癥,、疾病動物模型,、心血管疾病和信號轉(zhuǎn)導(dǎo)途徑研究的應(yīng)用,；結(jié)直腸癌、胰腺癌,、肺癌的蛋白質(zhì)基因組學(xué)等多組學(xué)研究,。發(fā)表SCI研究論文24篇（Cancer Cell, Genom. Proteom. Bioinf., Cell Discov., J Mol Cell Biol., Cell Res., Nat Chem Biol.等），參與編撰國際系列叢書1部,，參與編撰科學(xué)書籍1部,。參與申請中國發(fā)明專利27項，其中12項獲得授權(quán),。主持國家及省部級項目3項,，參與科技部973計劃、國自然重大研究計劃,、國家重點研發(fā)計劃重點專項,、中科院戰(zhàn)略性先導(dǎo)科技專項等10項。獲賽諾菲—中科院上海生科院優(yōu)秀青年人才獎勵基金,，入選上海市科技專家?guī)?、浦東新區(qū)科技專家?guī)臁?dān)任GPB,、WJG等期刊審稿人,。
Publications:(#第一作者, *通訊作者)
1. Li H#, Fu X#, Zhao J#, Li C#, Li L, Xia P, Guo J, Wei W, Zeng R, Wu J*, Sun Y*, Huang L*, Wang X*. EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal. Mol Cancer Res. 2022 Jul 6;20(7):1021-1034.
2. Wu Y, Cao Y, Xu K, Zhu Y, Qiao Y, Wu Y, Chen J, Li C*, Zeng R*, Ge G*. Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis. Cell Death Dis. 2021 Feb 8;12(2):163.
3. Feng L#, Sun YD#, Li C, Li YX, Chen LN, Zeng R*. Pan-cancer Network Disorders Revealed by Overall and Local Signaling Entropy. J Mol Cell Biol. 2021 Dec 6;13(9):622-635.
4. Sun Y#, Li C#, Pang S, Yao Q, Chen L*, Li Y*, Zeng R*. Kinase-substrate edge biomarkers provide a more accurate prognostic prediction in ER-negative breast cancer. Genomics, Proteomics & Bioinformatics. 2020 Oct;18(5):525-538.
5. Li C#, Sun Y#, Yu G#, Cui J#, Lou Z#, Zhang H, Huang Y, Bai C, Deng L, Liu P, Zheng K, Wang Y, Wang Q, Li Q, Wu Q, Liu Q, Shyr Y, Li Y, Chen L, Wu J*, Zhang W*, Zeng R*. Integrated Omics of Metastatic Colorectal Cancer. Cancer Cell. 2020 Nov 9;38(5):734-747.
6. Han J#, Yu M#, Bai Y#, Yu J#, Jin F, Li C, Zeng R, Peng J, Li A, Song X, Li H*, Wu D*, Li L*. Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. Cancer Cell. 2020 Dec 14;38(6):844-856.
7. Tang Y#, He Y#, Li C# Mu W, Zou Y, Liu C, Qian S, Zhang F, Pan J, Wang Y, Huang H, Pan D, Yang P, Mei J*, Zeng R*, Tang QQ*. RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases. Cell Discovery. 2018 Aug 21;4:52.
8. Zhu X, Yuan C, Tian C, Li C, Nie F, Song X, Zeng R, Wu D, Hao X, Li L*. The plant sesquiterpene lactone parthenoide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1. J Biol Chem. 2018 Apr 6;293(14):5335-5344.
9. Li M#, Li C#, Liu W, Liu C, Cui J, Li Q, Ni H, Yang Y, Wu C, Chen C, Xing Z, Liu X, Zeng T, Zhao M, Chen L, Wu J*, Zeng R*, Chen L*. Dysfunction of PLA2G6 and CYP2C44 associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma. J Mol Cell Biol. 2017 Dec 1;9(6):489-503.
10. He X#, Zhang W#, Yan C#, Nie F, Li C, Liu X, Fei C, Li S, Song X, Jia Y, Zeng R, Wu D, Pan W*, Hao X*, Li L*. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discovery. 2017, 3, 17003.
11. Liang J#, Cao R#, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W, Yang W*. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res. 2017 Mar;27(3):329-351.
12. Li F#, Fang Z#, Zhang J#, Li C, Liu H, Xia J, Zhu H, Guo C, Qin Z, Li F, Han X, Wang Y, Feng Y, Wang Y, Zhang W, Wang Z, Jin Y, Sun Y, Wei W, Zeng R, Chen H, Ji H*.Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma. Cell Res. 2016 Oct;26(10):1149-1164.
13. Sheng Q#, Li R#, Dai J#, Li Q, Su Z, Guo Y, Li C, Shyr Y*, Zeng R*. Preprocessing significantly improves the peptide/protein identification sensitivity of high-resolution isobarically labeled tandem mass spectrometry data. Mol Cell Proteomics. 2015 Feb;14(2):405-17.
14. Fei C, Li Z, Li C, Chen Y, Chen Z, He X, Mao L, Wang X, Zeng R, Li L*.Smurf1-mediated Lys29-linked non-proteolytic poly-ubiquitination of Axin negatively regulates Wnt/β-catenin signaling. Mol Cell Biol. 2013, 33(20):4095-105.
15. Wang S#, Yin J#, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X*, Li L*. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.
16. Li C#, Ruan HQ#, Liu YS#, Xu MJ, Dai J, Sheng QH, Tan YX, Yao ZZ, Wang HY, Wu JR, Zeng R*. Quantitative proteomics reveal up-regulated protein expression of the SET complex associated with hepatocellular carcinoma. J Proteome Res. 2012 Feb 3;11(2):871-85.
17. Wu C#, Wei W#, Li C, Li Q, Sheng Q, Zeng R*. J Proteome Res. Delicate analysis of post-translational modifications on Dishevelled 3. J Proteome Res. 2012 Jul 6;11(7):3829-37.
18. Liu YS#, Luo XY#, Li QR, Li H, Li C, Ni H, Li RX, Wang R, Hu HC, Pan YJ, Chen HQ*, Zeng R*. Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer. J Mol Cell Biol. 2012 Oct;4(5):344-7.
19. Micutkova L, Diener T, Li C, Rogowska-Wrzesinska A, Mueck C, Huetter E, Weinberger B, Grubeck-Loebenstein B, Roepstorff P, Zeng R, Jansen-Duerr P*. Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts. Mech Ageing Dev. 2011 Oct;132(10):468-79.
20. Sun B, Guo S, Tang Q, Li C, Zeng R, Xiong Z, Zhong C, Ding J*. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274. Cell Res. 2011 Aug;21(8):1262-6.
21. Liu Y#, Li C#, Xing Z, Yuan X, Wu Y, Xu M, Tu K, Li Q, Wu C, Zhao M*, Zeng R*. Proteomic mining in the dysplastic liver of WHV/c-myc mice--insights and indicators for early hepatocarcinogenesis. FEBS J. 2010 Oct;277(19):4039-53.
22. Li C, Hong Y, Tan YX, Ai JH, Zhou H, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*, Zeng R*. Analysis of microdissected cells by two-dimensional LC-MS approaches. Methods Mol Biol. 2008;428:193-208.
23. Ding Y#, Xi Y#, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L*. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol. 2008 Sep 8;182(5):865-72.
24. Li C#, Tan YX#, Zhou H, Ding SJ, Li SJ, Ma DJ, Man XB, Hong Y, Zhang L, Li L, Xia QC, Wu JR, Wang HY*, Zeng R*. Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers. Proteomics. 2005 Mar;5(4):1125-39.
25. Li C, Hong Y, Tan YX, Zhou H, Ai JH, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*, Zeng R*, Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry. Mol Cell Proteomics. 2004 Apr;3(4):399-409.
26. 屠成劍, 李辰, 第十三章, 樣品的全息制備; 丁士健, 唐柳婭, 李辰, 第二十三章, 蛋白質(zhì)組學(xué)在各領(lǐng)域中的應(yīng)用; 曾嶸,、夏其昌主編, 《蛋白質(zhì)化學(xué)與蛋白質(zhì)組學(xué)》, 1 ed. 北京: 科學(xué)出版社, 2004
