WANG Xianli
Associate Professor
Department of Food Safety and Toxicology
Address: Room 709, Teaching and Research Building
E-mail：[email protected]
Bio
WANG Xianli graduated from Ocean University of China in 2009 and majored in cell Biology. For many years, she has been engaged in the regulation of genomic stability of adult neural stem cells on aging and the regulation of neural diversity by the genomic stability of neural stem cells during neural development. In recent years, Wang Xianli has focused on the research of the epigentics regulatory mechanisms of aging neural stem cells.
Professional Experience
2019.08-now, Associate Professor, School of Public Health
2017.12-2019.07, Associate Professor, Institute of Neuroscience, Chinese Academy of Sciences
2016.03-2017.11, Assistant Researcher, Institute of Neuroscience, Chinese Academy of Sciences
2011.08-2015.02, Post Doctor, School of Medicine, Tongji University
2009.08-2011.08, Post Doctor, Chinese Academy of Fishery Sciences
Research Interests
Role of Stem cells Response to Obesity in Regulating Chronic Diseases
Stem Cell Responses to DNA Damage during Aging
Role of Stem Cells in Tumorigenesis and Development
Research Projects
National Natural Science Foundation of China (2023.01-2026.12)
National Natural Science Foundation of China (2016.01-2018.12)
The 51st China Postdoctoral Science Foundation (2012.06-2013.09)
Postdoctoral Research Funding Program of Shanghai (2012.09-2013.09)
Excellent Young Talents Training Program of Shanghai Health System (2014.01- 2016.12)
Excellent Talent Training Program of Tongji University (2011.12-2013.09)
Postdoctoral Innovation Project of Shandong Province, The first prize (2011.03- 2013.03)
Scientific Research Award Fund for Outstanding Young and Middle-aged Scientists of Shandong Province (2011.02-2013.12)
The 48th China Postdoctoral Science Foundation (2010.03-2011.08)
Publications
1.XL Wang#, SZh Yang#, CD Zheng#, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Multi-omics profiles on small intestine organoids of comparisons between nutrition effects of breast milk and different infant formulae. Nutrients,2024 Aug22. doi:org/12.11 6/j.nutrients. 2024.
2.XL Wang#, YM Zhong#, CD Zheng#, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Transcriptome and metabolome analyses reveal the effects of formula and breast milk on the growth and development of human small intestinal organoids. Food Res int,2024 Aug23. doi:org/10.1016/j.foodres.2024.114999.
3.XL Wang#, YX Jing#, CD Zheng#, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids. Food Funct,2024 Aug19. doi: 10.1039 /d4fo01723d.
4.GM Wang, Ren, XH Zeng, X Chen, AB Liang, XL Wang*, Jun Xu*. Serine and arginine-rich splicing factor 3 promotes the activation of quiescent mouse neural stem cells. Stem Cells Dev, 2024 Jan 18. doi: 10.1089/scd.2023.0172.
5.YM Zhong, GM Wang, SZH Yang, Y Zhang, XL Wang. The role of DNA damage in neural stem cell. J Cell Physiol,2024 Jan 14. doi: 10.1002/ jcp. 31187.
6.HY Yao, YL Wu, YM Zhong, CX Huang, ZM Guo, YP Jin, XLWang. Role of c-Fos in DNA damage repair. J Cell Physiol,2024 Feb 7. doi: 10.1002/jcp. 31216.
7.HX Cheng, LY Hua, HL Tang, ZY Bao, XP Xu, HG Zhu, SY Wang, ZD Jiapaer, R Bhatia , Ian F. Dunn, JJ Deng, DJ Wang, XL Wang*, Y Gong*. CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44 /c-MY C/LDHA axis. J Mol Cell Biol,2023 Oct 3:mjad057. doi: 10.1093/jmcb/mjad057.
8.HY Liu, XL Wang. Esophageal organoids: applications and future prospects. J Mol Med, 2023,101:931-945.4.
9.YM Yan, Io Hong Cheong , PZ Chen, XG Li, XL Wang, H Wang. Patient-derived rectal cancer organoids-applications in basic and translational cancer research. Front Onco,2022 Jul 26:12:922430. doi: 10.3389/fonc.2022.922430. eCollection 2022.
10.J Ren#, XL Wang#, CM Dong#, GM Wang#, WJ Zhang, CH Cai, MQ Qian, DJ Yang, B Ling, K Ning, ZY Mao, BH Liu, TH Wang, LL Xiong, WY Wang, AB Liang, ZL Gao, J Xu. Sirt1 protects subventricular zone-derived neural stem cells from DNA double-strand breaks and contributes to olfactory function maintenance in aging mice. Stem Cells,2022,
11.CM Dong#, XL Wang#, GM Wang#, LX Sun#, L Zhu, DJ Yang, S Gao, WJ hang, B Ling, AB Liang, ZL Gao, J Xu. ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway. Stem Cell Res,58 (2022)102618, https://doi.org /10. 1016/j.scr.2021.102618.
12.YP Jin, JY Wang, HC Li, SE Gao, RF Shi, DJ Yang, XL Wang, L Zhu, XJ Wang, CW Chen, K Ning, QC Fu, J Xu, ZL Gao. Extracellular vesicles secreted by human adipose-derived stem cells hASCs improve survival rate of rats with acute liver failure by releasing lncRNA H19. EBioMedicine,34:231-242,2018.
13.XL Wang, CX Sun, L Zhu, LX Sun, RJ Ma, ZG Wang, B Lu, X Chen, J Xu. Quantitative
proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells. Neuro Lett,2017, 653: 355-361.
14.XL Wang, CM Dong, lX sun, L Zhu, CX Sun, RJ Ma, k Ning, JF Zhang, B Lu, J Xu. Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. Sci Rep,2016,6,37443;doi:10.1038/ srep37443.
15.SE Gao, P Zhao, C Lin, YX Sun, YL Wang, ZC Zhou, DJ Yang, XL Wang, HZ Xu, F Zhou, LM Cao, W Zhou, K Ning, X Chen, J Xu. Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three- dimensional scaffolds. Tissue Eng:Part A,2014,DOI: 10.1089/ten.tea.2012.0773.
16.CM Dong#, XL Wang#, GM Wang, WJ Zhang, L Zhu, S Gao, DJ Yang, Y Qin, QJ Liang, YL Chen, HT Deng, K Ning, AB Liang, ZL Gao, J Xu. A stress induced cellular aging model with postnatal neural stem cells. Cell Death Dis,2014 Mar13;5: e1116. doi: 10.1038/cddis. 2014.82.12.
17.DJ Yang#, XL Wang#, A Ismail, CJ Ashman, CF Valori, GM Wang, SE Gao, A Higginbottom, PG Ince, M Azzouz, J Xu, PJ Shaw, K Ning. PTEN regulates AMPA receptor- mediated cell viability in iPS-derived motor neurons. Cell Death Dis,2014 Feb 27;5:e1096. doi:10.1038/cddis.2014.55.
18.N Wang#, XL Wang#, CG Yang, XJ Zhao, YX Zhang, TZ Wang, SL Chen. Molecular cloning and multifunctional characterization of GRIM-19 homologue from turbot. Dev Comp Immunol,43(1):96-105,2014.
19.CG Yang#, XL Wang#, J Tian, W Liu, F Wu, M Jiang, H Wen. Evaluation of reference genes for quantitative real-time RT-PCR analysis of gene expression in Nile tilapia. Gene,527:183- 192,2013.
20.N Wang#, XL Wang#, CG Yang, SL Chen. Molecular cloning, subcelluar location and expression profile of signal transducer and activator of transcription 2 (STAT2) from turbot. Fish Shellfish Immun,35:1200-1208,2013.
21.XL Wang, YX Zhang, CG Yang, SL Chen. Cloning, characterization and expression analysis of Y-Box family members YB-1 in turbot. Fish Shellfish Immun,33(5):1215- 1221, 2012.
22.B Zhang#, XL Wang#, SL Chen. Establishment and characterization of a testicular cell line from half smooth tongue sole. Int J Bio Sci,7(4):452 -459,2011.
23.XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization of a new cell line from heart of half smooth tongue sole. Fish Physiol Biochem,36: 1181-1189,2010.
24.N Wang#, XL Wang#, ZX Sha, YS Tian, SL Chen. Development and characterization of a new marine fish cell line from turbot. Fish Physiol Biochem,36(4):1227-1234,2010.
25.XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization, and virus susceptibility of a new marine cell line from spotted halibut. J Ocean U China,9(2):162-168, 2010.
26.ZX Sha#, GC Ren#, XL Wang#, N Wang, SL Chen. Development and characterization of a cell line from the embryos of half smooth tongue sole. Acta Oceanol Sin,29(2):81-87,2010.