国产成人嫩模一区二区|超级黄色网页|兔子先生tz|麻豆文化传媒网站官网污|在线播放欧美日韩精品|爱豆影视传媒免费下载|蜜桃影像传媒av剧情|麻豆文化传媒APP最新iOS|陈可心倩女幽魂爱豆传媒|91国视频产,国产传媒播放,想看三级片,网红吃瓜黑料爆料网反差

2003年畢業(yè)于沈陽藥科大學(xué),，獲藥理學(xué)博士學(xué)位（2000-2001年于日本大冢制藥株式會社研究所進(jìn)行博士課題研究）,。2003-2006年于日本國立醫(yī)藥品食品衛(wèi)生研究所（NIHS）從事博士后研究（遺傳毒理學(xué)）,。2006-2013年受聘于中科院上海藥物研究所藥物安全性評價(jià)與研究中心毒理研究部門并入選上海市浦江人才計(jì)劃,。受聘期間，于2012年1月至4月作為作為訪問學(xué)者在美國FDA國家毒理研究院進(jìn)行學(xué)術(shù)交流,；于2012年5月至11月作為新藥審評員在國家藥品監(jiān)督管理局藥品審評中心進(jìn)行新藥審評工作,。2013年起任上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院研究員、毒理學(xué)課題研究組組長和公共衛(wèi)生學(xué)院實(shí)驗(yàn)平臺主任,。作為課題負(fù)責(zé)人主持國家自然科學(xué)基金面上項(xiàng)目4項(xiàng),、青年基金項(xiàng)目1項(xiàng)；作為主要參與人參與國家自然科學(xué)基金重大項(xiàng)目1項(xiàng)；指導(dǎo)課題組博士后獲得國家自然科學(xué)基金青年基金項(xiàng)目1項(xiàng),。

學(xué)術(shù)任職：任Mutation Research-Genetic Toxicology and Environmental Mutagenesis雜志區(qū)域編輯,、Mutagenesis雜志編委、Genes & Environment雜志編委,、《癌變畸變突變》雜志編委,、中國毒理學(xué)會遺傳毒理專業(yè)委員會副主任、中國環(huán)境誘變劑學(xué)會常務(wù)理事,、上海市毒理學(xué)會常務(wù)理事,、上海環(huán)境誘變劑學(xué)會理事、OECD遺傳毒性測試指南專家工作組成員等,。

研究方向?yàn)檫z傳毒理,，主要為新技術(shù)開發(fā)和外源化合物毒性機(jī)理研究.構(gòu)建了本研究領(lǐng)域較為前沿的體內(nèi)、體外試驗(yàn)?zāi)Ｐ图胺椒?；探索的新技術(shù)包括基于一致性測序的低頻突變檢測方法,，新遺傳學(xué)損傷效應(yīng)標(biāo)志人外周血PIG-A基因突變試驗(yàn)，基于微流控和微孔板體系的單線蟲高通量毒性測試方法等,；此外,，通過DNA加合物檢測、體外培養(yǎng)細(xì)胞DNA損傷,、染色體畸變和基因突變檢測、轉(zhuǎn)基因動物基因突變檢測等體系,，結(jié)合分子生物學(xué)手段,，對環(huán)境污染物及中藥有毒成分進(jìn)行毒性評價(jià)和機(jī)制研究。

1. You X, Cao Y, Suzuki T, Shao J, Zhu B, Masumura K, Xi J, Liu W, Zhang X, Luan Y*. Genome-wide direct quantification of in vivo mutagenesis using high-accuracy paired-end and complementary consensus sequencing.Nucleic Acids Res. 2023. gkad909, https://doi.org/10.1093/nar/gkad909.

2. Liu W, Shao F, You X, Cao Y, Xi J, Wu J, Wan J, ZhangX, Fei J, Luan Y*. Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-infammatory activities in mice.J Nat Med. 2023. 77(2):251-261.

3. Cao Y, Wang T, Xi J, Tian W, Liu W, Sun Y, Liu W, You X, Li A, Zhang G, Zhang X, Xia Z, Luan Y*. Benchmark dose estimation for benzene-exposed workers in China: Based on quantitative and multi-endpoint genotoxicity assessments.Environ Pollut. 2023. 330:121765.

4. Liu W, Yasui M, Sassa A, You X, Wan J, Cao Y, Xi J, Zhang X, Honma M, Luan Y*. FTO regulates the DNA damage response via effects on cell-cycle progression.Mutat Res Genet Toxicol Environ Mutagen. 2023. 887:503608.

5. Zhang X, Zhao T, Liu W, Xi J, Yao D, CaoY, You X, Wu J, Gao Z, Lei Y, Zhou C, Zhang X, Zheng J*, Luan Y*. Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver.Mutat Res Genet Toxicol Environ Mutagen. 2023.886:503582.

6. Xi J, Cao Y, Wang Y, You X, Liu W, Wang T, Yin J, Ma J, Wang Z, Wu N, Zhang X, Duan H, Luan Y*. PIG-A gene mutation as a mutagenicity biomarker among coke oven workers.Food Chem Toxicol. 2023. 178:113872.

7. Wu J, Gao Y, Xi J, You X, Zhang X, Zhang X, Cao Y, Liu P, Chen X, Luan Y*. A high-throughput microplate toxicity screening platform based onCaenorhabditis elegans.Ecotoxicol Environ Saf. 2022. 245:114089.

8. Luan Y*, Honma M*. Genotoxicity testing and recent advances.GenomeInstab. Dis. 2022. 3, 1-21.

9. Takeda S*, Luan Y*. Nature of spontaneously arising single base substitutions in normal cells.GenomeInstab. Dis. 2022. 3, 1-21.

10. Wan J, Chen R, Yang Z, Xi J, Cao Y, Chen Y, Zhang X, Luan Y*. Aristolochic acid IVa forms DNA adducts in vitro but is non-genotoxic in vivo.Arch Toxicol. 2021. 95(8):2839-2850.

11. Xu L, Gao S, Zhao H, Wang L, Cao Y, Xi J, Zhang X, Dong X, Luan Y*. Integrated Proteomic and Metabolomic Analysis of the Testes Characterizes BDE-47-Induced Reproductive Toxicity in Mice.Biomolecules. 2021 May 31;11(6):821.

12. Chen R, You X, Cao Y, Masumura K, Ando T, Hamada S, Horibata K, Wan J, Xi J, Zhang X, Honma M, Luan Y*.Benchmark dose analysis of multiple genotoxicity endpoints in gpt delta mice exposed to aristolochic acid I.Mutagenesis. 2021 Apr 28;36(1):87-94.

13. Takeda, S., Luan Y*. Nature of spontaneously arising single base substitutions in normal cells.GenomeInstab. Dis. 2021. 2, 339-357.

14. You X, Thiruppathi S, Liu W, Cao Y, Naito M, Furihata C, Honma M, Luan Y*, Suzuki T. Detection of genome-wide low-frequency mutations with Paired-End and Complementary Consensus Sequencing (PECC-Seq) revealed end-repair-derived artifacts as residual errors.Arch Toxicol. 2020 Oct;94(10):3475-3485.

15. Cao Y, Wang T, Xi J, Zhang G, Wang T, Liu W, You X, Zhang X, Xia Z, Luan Y*. PIG-A gene mutation as a genotoxicity biomarker in human population studies: An investigation in lead-exposed workers.Environ Mol Mutagen. 2020 Jul;61(6):611-621.

16. Cao Y, Wang X, Liu W, Feng N, Xi J, You X, Chen R, Zhang X, Liu Z, Luan Y*. The potential application of human PIG-A assay on azathioprine-treated inflammatory bowel disease patients.Environ Mol Mutagen. 2020 Apr;61(4):456-464.

17. Chen R, Zhou C, Cao Y, Xi J, Ohira T, He L, Huang P, You X, Liu W, Zhang X, Ma S, Xie T, Chang Y, Luan Y*.Assessment of Pig-a, Micronucleus, and Comet Assay Endpoints in Tg.RasH2 Mice Carcinogenicity Study of Aristolochic Acid I.Environ Mol Mutagen. 2020 Feb;61(2):266-275.