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環(huán)境與健康系

謝和輝/ 職稱(chēng)：研究員/博士生導(dǎo)師

學(xué)歷學(xué)位：博士 研究生

Email: [email protected]

謝和輝,，男,，研究員，博士生導(dǎo)師,。1995年上海醫(yī)科大學(xué)（復(fù)旦大學(xué)上海醫(yī)學(xué)院）畢業(yè),，獲學(xué)士學(xué)位,。2003年第二軍醫(yī)大學(xué)博士研究生畢業(yè)，獲博士學(xué)位,。2006-2008年在美國(guó)密歇根州立大學(xué)藥理學(xué)與毒理學(xué)系做訪問(wèn)學(xué)者,。2008年至今相繼擔(dān)任第二軍醫(yī)大學(xué)藥理學(xué)教研室副教授、上海交通大學(xué)公共衛(wèi)生學(xué)院研究員,。2013年至今,，兼任中南大學(xué)血管與轉(zhuǎn)化醫(yī)學(xué)中心“升華學(xué)者”特聘教授、博士生導(dǎo)師,。曾主持國(guó)家自然科學(xué)基金項(xiàng)目4項(xiàng),，是973計(jì)劃子課題、教育部創(chuàng)新團(tuán)隊(duì)骨干,。在《Stroke》,、《Hypertension》《EBionedicine》等雜志發(fā)表SCI收錄文章40余篇。曾獲國(guó)家自然科學(xué)二等獎(jiǎng),、上海市自然科學(xué)二等獎(jiǎng),、第十屆中國(guó)藥理學(xué)會(huì)Servier獎(jiǎng)等,。是國(guó)際雜志《Front Pharmacol》的Review Editor，《Arterioscler Thromb Vasc Biol》等國(guó)際雜志審稿人,，國(guó)家自然科學(xué)基金面上項(xiàng)目通訊評(píng)議專(zhuān)家,。從事心腦血管藥理學(xué)和毒理學(xué)研究。

主要研究方向

  1. 環(huán)境因素對(duì)心腦血管疾病的影響及其機(jī)制

  2. 腦卒中與內(nèi)皮祖細(xì)胞

主要研究課題

  1. 國(guó)家自然科學(xué)基金（81370253）：二氯乙酸鈉改善糖尿病小鼠內(nèi)皮祖細(xì)胞功能及其在腦缺血損傷治療中的應(yīng)用,。80萬(wàn),。2014.01-2017.12。課題負(fù)責(zé)人,。

  2. 973計(jì)劃子課題（2014CB542403）：線粒體應(yīng)激在糖尿病繼發(fā)血管內(nèi)皮細(xì)胞損傷和修復(fù)中的作用及干預(yù)措施,。500萬(wàn)。2014.01-2018.12,。骨干,。

  3. 國(guó)家自然科學(xué)基金（81170115）：MnSOD缺陷引起的內(nèi)皮祖細(xì)胞功能障礙加重小鼠腦缺血損傷。60萬(wàn),。2012.01-2015.12,。課題負(fù)責(zé)人。

  4. 國(guó)家自然科學(xué)基金（30971158）：低腎素性高血壓小鼠內(nèi)皮祖細(xì)胞功能失常的TSP-1機(jī)制,。35萬(wàn),。2010.01-2012.12。課題負(fù)責(zé)人,。

  5. 國(guó)家自然科學(xué)基金（30700307）：氧化應(yīng)激與去氧皮質(zhì)酮/鹽高血壓小鼠內(nèi)皮祖細(xì)胞數(shù)量減少,。22萬(wàn)。2008.01-2010.12,。課題負(fù)責(zé)人,。

  6. 教育部創(chuàng)新團(tuán)隊(duì)：腦卒中發(fā)生和防治的基礎(chǔ)研究。300萬(wàn),。2010.01-2012.12,。骨干。

主要研究成果

  1. Xie HH, Miao CY, and Su DF. Importance of blood pressure variability in the organ protection in spontaneously hypertensive rats treated with combination of nitredipine and atenolol. Acta Pharmacol Sin 2002; 23: 1199-204.

  2. Miao CY, Xie HH, Wang JJ, Su DF. Candesartan inhibits sinoaortic denervation -induced cardiovascular hypertrophy in rats. Acta Pharmacol Sin 2002; 23: 713-20.

  3. Lu ZA, Xie HH, Xu LP, Yin AF, Miao CY, and Su DF. Restoration of arterial baroreflex function contributes to organ protection in spontaneously hypertensive rats treated with long-term hydrochlothiazide mixture. Clin Exp Pharmacol physiol 2003; 30: 49-54.

  4. Xie HH, Miao CY, Liu JG, and Su DF. Effects of Long-Term Treatment with Candesartan on Organ Damages in Sinoaortic Denervated Rats. J Cardiovasc Pharmacol 2003; 41: 325-31.

  5. Miao CY, Xie HH, Yu H, Chu ZX, Su DF. Ketanserin stabilizes blood pressure in conscious spontaneously hypertensive rats. Clin Exp Pharmacol physiol 2003; 30: 189-93.

  6. Zhang C, Chen H, Xie HH, Shu H, Yuan WJ, Su DF. Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. J Hypertens. 2003; 21: 2141-8.

  7. Cai GJ, Li L, Xie HH, Xu JJ, Miao CY, Su DF. Morphological evidence of reinnervation of the baroreceptive regions in sinoaortic-denervated rats. Clin Exp Pharmacol Physiol. 2003; 30: 925-9.

  8. Su DF, Xu LP, Miao CY, Xie HH, Shen FM, Jiang YY. Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats. Acta Pharmacol Sin. 2004; 25: 148-51.

  9. Zhang C, Xie HH, Lu ZA, Zhu MJ, Su DF. Inhibition of inflammation contributes to organ protection of atenolol in sinoaortic-denervated rats. J Cardiovasc Pharmacol. 2004; 43: 663-8.

  10. Miao CY, Xu LP, Liu JG, Xie HH, Yuan WJ, Su DF. Frequent ventricular premature beats increase blood pressure variability in rats. Acta Pharmacol Sin. 2004; 25: 545-53.

  11. Shen FM, Guan YF, Xie HH, Su DF. Arterial baroreflex function determines the survival time in lipopolysaccharide-induced shock in rats. Shock. 2004; 21: 556-60.

  12. Miao CY, Cai GJ, Tao X, Xie HH, Su DF. Greater hypertrophy in right than left ventricles is associated with pulmonary vasculopathy in sinoaortic-denervated wistar-kyoto rats. Clin Exp Pharmacol Physiol. 2004; 31: 450-5.

  13. Xie HH, Miao CY, Jiang YY, Su DF. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. J Hypertens 2005; 23: 193-201.

  14. Xie HH, Shen FM, Cao YB, Li HL, Su DF. Effects of low-dose ketanserin on blood pressure variability, baroreflex sensitivity and end-organ damage in spontaneously hypertensive rats. Clin Sci (Lond). 2005; 108: 547-52.

  15. Cai GJ, Miao CY, Xie HH, Lu LH, Su DF. Arterial baroreflex dysfunction promotes atherosclerosis in rats. Atherosclerosis. 2005; 183(1): 41-7.

  16. Wang DS, Xie HH, Shen FM, Cai GJ, Su DF. Blood pressure variability, cardiac baroreflex sensitivity, and end organ damage in experimentally hypertensive rats. Clin Exp Pharmacol Physiol 2005; 32: 545-52.

  17. Xie HH, Shen FM, Miao CY, Su DF. Blood pressure, baroreflex sensitivity and end organ damage in hybrid offspring of SHR and SD rats. Acta Pharmacol Sin 2005; 26: 1049-56.

  18. Shen FM, Xie HH (co-first author), Ling G, Xu LP, SU DF. Synergism of atenolol and amlodipine on lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin 2005; 26: 1303-8.

  19. Lu LH, Xie HH, Cai GJ, Shen FM, Su DF. Diminished responses to nifedipine imply severe end-organ damage in spontaneously hypertensive rats. J Cardiovasc Parmacolol 2005; 46: 836-41.

  20. Xie HH, Chen YY, Miao CY, Shen FM, Su DF. Effects of long-term treatment with candesartan on hemodynamics and organ damage in spontaneously hypertensive rats. Cardiovasc Drugs Ther 2005; 19: 391-7.

  21. Shen FM, Zhang SH, Xie HH, Su DF. Early structural changes of aortic wall in sinoaortic denervated rats. Clin Exp Pharmacol Physiol 2006; 33: 358-63.

  22. Miao CY, Xie HH, Zhan LS, Su DF. Blood pressure variability is more important than blood pressure level in determination of end-organ damage in rats. J Hypertens 2006; 24: 1137-46.

  23. Gu XW, Xie HH, Wang J, Shen FM, Su DF. Arterial baroreflex is not involved in salt preference in rats. Clin Exp Pharmacol Physiol 2006; 33: 607-11.

  24. Xie HH, Shen FM, Zhang XF, Jiang YY, Su DF. Blood pressure variability, baroreflex sensitivity and organ damage in spontaneously hypertensive rats treated with various antihypertensive drugs. Eur J Pharmacol 2006; 543: 77-82.

  25. Han P, Chu ZX, Shen FM, Xie HH, Su DF. Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats. Acta Pharmacol Sin. 2006; 27: 1575-9.

  26. Li M, Wang J, Xie HH, Shen FM, Su DF. The susceptibility of ventricular arrhythmia to aconitine in conscious Lyon hypertensive rats. Acta Pharmacol Sin. 2007; 28: 211-5.

  27. Xie HH, Shen FM, Xu LP, Han P, Miao CY, Su DF. Reduction of blood pressure variability by combination therapy in spontaneously hypertensive rats. J Hypertens 2007; 25: 2334–44.

  28. Xie HH, Zhang XF, Chen YY, Shen FM, Su DF. Synergism of Hydrochlorothiazide and Nifedipine on Blood Pressure Variability Reduction and Organ Protection in Spontaneously Hypertensive Rats. Hypertens Res 2008; 31: 685–691.

  29. Han P, Shen FM, Xie HH, Chen YY, Miao cy, Mehta JL, Sassard J, Su DF. The combination of atenolol and amlodipine is better than their monotherapy for preventing end-organ damage in different types of hypertension in rats. J Cell Mol Med 2009; 13: 726-734.

  30. Xie HH, Zhou S, Chen D, Channon KM, Su DF, Chen AF. GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. Hypertension 2010;56:1137-1144

  31. Yu YS, Xie HH, Li L, Song SW, Han P, Cai GJ, Su DF. Effects of low-dose ketanserin on atherosclerosis in rats and rabbits. Can J Physiol Pharmacol. 2010; 88: 1054-1060

  32. Ni M, Yang ZW, Li DJ, Li Q, Zhang SH, Su DF, Xie HH (Co-corresponding author), Shen FM. A potential role of alpha-7 nicotinic acetylcholine receptor in cardiac angiogenesis in a pressure overload rat model. J Pharmacol Sci 2010; 114: 311-319

  33. Shang W, Han P, Yang CB, Gu XW, Xu LP, Fu ST, Su DF, Xie HH (Corresponding author). Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats. Acta Pharmacol Sin. 2011; 32: 1109-1115.

  34. Ma J, Peng C, Guo W, Dong YF, Dong XH, Sun X, Xie HH (Corresponding author). A modified model of middle cerebral artery electrocoagulation in mice. CNS Neurosci Ther 2012; 18: 796-798.

  35. Liu F, Chen DD, Sun X, Xie HH, Yuan H, Jia W, Chen AF. Hydrogen Sulfide Improves Wound Healing via Restoration of Endothelial Progenitor Cell Functions and Activation of Angiopoietin-1 in Type 2 Diabetes. Diabetes. 2014; 63: 1763-78.

  36. Tie L, Chen LY, Chen DD, Xie HH, Channon KM, Chen AF. GTP Cyclohydrolase I Prevents Diabetic Impaired Endothelial Progenitor Cells and Wound Healing by Suppressing Oxidative Stress/Thrombospondin-1. Am J Physiol Endocrinol Metab 2014; 306: E1120-31.

  37. Dong XH, Sun X, Jiang GJ, Chen AF, Xie HH (Corresponding author). Dietary intake of sugar substitutes aggravates cerebral ischemic injury and impairs endothelial progenitor cells in mice. Stroke 2015; 46: 1714-18.

  38. Jiang Y, Wang LP, Dong XH, Cai J, Jiang GJ, Zhang C, Xie HH. Trace amounts of copper in drinking water aggravate cerebral ischemic injury via impairing endothelial progenitor cells in mice. CNS Neurosci Ther 2015; 21: 677-80.

  39. Wang LP, Jiang Y, Yang H, Peng C, Zhang C, Tao X,Xie HH (Corresponding author).Combination therapy of nifedipine and sulphonylureas exerts a mutual antagonistic effect on the endothelial cell dysfunction induced by hyperglycaemia linked to vascular disease. Cell Physiol Biochem 2016; 38: 2337-2347.

  40. Xin B, Liu CL, Yang H, Peng C, Dong XH, Zhang C, Chen AF,Xie HH (Corresponding author).Prolonged fasting improves endothelial progenitor cell-mediated ischemic angiogenesis in mice. Cell Physiol Biochem 2016; 40: 693-706.

  41. Dong XH, Peng C, Zhang YY, Tao YL, Tao X, Zhang C, Chen AF,Xie HH (Corresponding author). Chronic exposure to subtherapeutic antibiotics aggravates ischemic stroke outcome in mice. EBiomedicine 2017; 24: 116-126.

  42. Peng C, Wang LP, Tao X, Dong XH, Xu CF, Jiang Y, Liu CL, Ma HF, Zhang C, Chen AF,Xie HH (Corresponding author). Preventive cold acclimation augments the reparative function of endothelial progenitor cells in mice. Cell Physiol Biochem 2018; 45: 175-191.

科技獎(jiǎng)勵(lì)

  1. 血壓波動(dòng)性與器官損傷的研究,，國(guó)家自然科學(xué)二等獎(jiǎng),，中華人民共和國(guó)國(guó)務(wù)院，2009年12月,。獲得者：蘇定馮,，繆朝玉，沈甫明,，謝和輝,，劉建國(guó)。

  2. 動(dòng)脈壓力感受性反射與心血管疾病,，上海市自然科學(xué)二等獎(jiǎng),，上海市人民政府,，2006年11月。獲得者：蘇定馮,，繆朝玉,，沈甫明，謝和輝,，劉建國(guó),。

  3. 第十屆中國(guó)藥理學(xué)會(huì)Servier獎(jiǎng)，中國(guó)藥理學(xué)會(huì),，2006年11月,。獲得者：謝和輝。