1983-1993年就讀于北京大學(xué)化學(xué)系（現(xiàn)北京大學(xué)化學(xué)與分子工程學(xué)院）,，依次獲學(xué)士學(xué)位（1987年）,、碩士學(xué)位（1990年,，有機(jī)化學(xué)）和博士學(xué)位（1993年,，有機(jī)化學(xué)）,。1993-1996年在中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所蔣錫夔院士課題組進(jìn)行博士后研究,，1996-1998年在以色列魏茨曼科學(xué)研究所（Weizmann Institute of Science）有機(jī)化學(xué)系從事視紫紅質(zhì)（rhodopsin）研究,，1999-2006年先后在美國(guó)威斯康星大學(xué)（University of Wisconsin-Madison）生物化學(xué)系和比較生物科學(xué)系從事固氮酶（nitrogenase）研究和1,3-丁二烯毒理研究,，2006-2008年在美國(guó)阿姆斯特學(xué)院（Amherst College）化學(xué)系從事蛋白質(zhì)酪氨酸磷酸酶（protein tyrosine phosphatases）研究,，2008-2017年在上海大學(xué)環(huán)境與化學(xué)工程學(xué)院環(huán)境污染與健康研究所任研究員，2017年至今任上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院研究員,。主要從事化合物代謝,、遺傳毒性、DNA加合物和致癌機(jī)理的研究,，研究領(lǐng)域涉及化學(xué),、毒理學(xué),、生物化學(xué)、細(xì)胞生物學(xué)以及環(huán)境科學(xué),。主持國(guó)家自然科學(xué)基金項(xiàng)目3項(xiàng),，在毒理學(xué)、分析化學(xué)和環(huán)境科學(xué)等學(xué)科國(guó)際知名期刊如Chemical Research in Toxicology,、Analytical Chemistry和Environment International等發(fā)表論文20余篇,，受邀撰寫《Advances in Molecular Toxicology》（Vol. 12，Elsevier出版集團(tuán)）中的一章,。2017年獲上海市自然科學(xué)獎(jiǎng)三等獎(jiǎng),，是多個(gè)專業(yè)協(xié)會(huì)會(huì)員，包括美國(guó)化學(xué)會(huì),、中國(guó)毒理學(xué)會(huì),、中國(guó)環(huán)境科學(xué)學(xué)會(huì)（高級(jí)會(huì)員）和中國(guó)藥理學(xué)會(huì)（藥物代謝專業(yè)委員會(huì)委員），并任Toxicology and Applied Pharmacology雜志編委,。
主要研究方向
外源性和內(nèi)源性化合物的代謝,、遺傳毒性、DNA加合物,、生物標(biāo)志以及毒性和致癌性的分子機(jī)理,。外源性化合物包括環(huán)境污染物（尤其是以1,3-丁二烯為代表的烯烴類污染物）和天然化合物（如中藥有效成分馬兜鈴酸），內(nèi)源性化合物包括血紅素和膽紅素等,。目前進(jìn)行的具體研究方向如下：
1. 髓過氧化酶（myeloperoxidase）和中性粒細(xì)胞參與的代謝,、代謝產(chǎn)物和生物標(biāo)志，以及這種代謝與炎癥和慢性疾病的關(guān)系,；
2. 膽紅素降解產(chǎn)物與蛛網(wǎng)膜下腔出血并發(fā)癥的關(guān)聯(lián),。
近年代表性論文
1.Wen-Jing Wu, Wei-Feng Tang, Ming-Hui Xiang*, Jianshe Yan, Xiumei Cao, Chang-Hui Zhou, Yan Chang, Jing Xi, Yi-Yi Cao, Yang Luan,Xin-Yu Zhang*, Isotope dilution LC/ESI--MS-MS quantitation of urinary 1,4-bis(N-acetyl-S-cysteinyl)-2-butanone in mice and rats as the biomarker of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene.Chemico-Biological Interactions2019,311, 108760.
2.Hao Xu, Chao Feng, Yiyi Cao, Ying Lu, Jing Xi, Jieyun Ji, Dasheng Lu*,Xin-Yu Zhang*, Yang Luan, Distribution of the parent compound and its metabolites in serum, urine, and feces of mice administered 2,2￠,4,4￠-tetrabromodiphenyl ether.Chemosphere2019,225, 217-225.
3.Xin-Yu Zhang*, Adnan A Elfarra*,Myeloperoxidase-mediated bioactivation of olefins.InAdvances in Molecular Toxicology,Vol. 12(J. C. Fishbein and J. M. Heilman Eds.) Chapter 4, Academic Press, Cambridge, USA,2018.
4.Xin-Yu Zhang, Adnan A Elfarra*,Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design.Expert Opinion on Drug Discovery2018,13, 815-824.https://www.tandfonline.com/eprint/vpsPKjTX8GDRNSBsvgch/full.
5.Ye Wang, Ying-Xin Yu, Yang Luan, Jing An, Dong-Guang Yin,Xin-Yu Zhang*, Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes.Chemico-Biological Interactions2018,282, 36-44.http://authors.elsevier.com/sd/article/S0009279717310918.
6.Xin-Yu Zhang*, Adnan A. Elfarra*, Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties.Expert Opinion on Drug Metabolism & Toxicology2017,13, 513-524.http://www.tandfonline.com/eprint/xIZWGQjBGdWgGKMVCkG2/full.
7.Ling-Yan Liu, Jin Zheng, Cong Kong, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Characterization of the major purine and pyrimidine adducts formed after incubations of 1-chloro-3-buten-2-one with single-/double-stranded DNA and human cells.Chemical Research in Toxicology2017,30, 552-563.
8.Fang-Mao Zeng, Ling-Yan Liu, Jin Zheng, Cong Kong, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Identification of a fused-ring 2￠-deoxyadenosine adduct formed in human cells incubated with 1-chloro-3-buten-2-one, a potential reactive metabolite of 1,3-butadiene.Chemical Research in Toxicology2016,29, 1041-1050.
9.Jin Zheng, Yan Li, Ying-Xin Yu, Jing An,Xin-Yu Zhang*, Adnan A. Elfarra*, Novel adducts from the reaction of 1-chloro-3-buten-2-one with 2￠-deoxyguanosine. Structural characterization and potential as tools to investigate 1,3-butadiene carcinogenicity.Chemico-Biological Interactions2015,226, 40-48.
10.Ying Wen, Keyin Liu, Huiran Yang, Yi Li, Haichuang Lan,Xinyu Zhang*, Tao Yi*, A highly sensitive ratiometric fluorescent probe for the detection of cytoplasmic and nuclear hydrogen peroxide.Analytical Chemistry2014,86, 9970-9976.
11.Liang Sun, Avishay Pelah, Dong-Ping Zhang, Yu-Fang Zhong, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Formation of fused-ring 2￠-deoxycytidine adducts from 1-chloro-3-buten-2-one, an in vitro 1,3-butadiene metabolite, under in vitro physiological conditions.Chemical Research in Toxicology2013,26, 1545-1553.
12.Xin-Jie Liu, Fang-Mao Zeng, Jing An, Ying-Xin Yu,Xin-Yu Zhang*, Adnan A. Elfarra*, Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene.Toxicology and Applied Pharmacology2013,271, 13-19.
13.Pan-Pan Zhang, Ying Wen, Jing An, Ying-Xin Yu*, Ming-Hong Wu,Xin-Yu Zhang*, DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells.Mutation Research2012,747, 240-245.
14.Ying-Xin Yu, Yu-Ping Pang, Chen Li, Jun-Ling Li,Xin-Yu Zhang*, Zhi-Qiang Yu, Jia-Liang Feng, Ming-Hong Wu, Guo-Ying Sheng, Jia-Mo Fu, Concentrations and seasonal variations of polybrominated diphenyl ethers (PBDEs) in in- and out-house dust and human daily intake via dust ingestion corrected with bioaccessibility of PBDEs.Environment International2012,42, 124-131.
15.Ying Wen, Pan-Pan Zhang, Jing An, Ying-Xin Yu, Ming-Hong Wu, Guo-Ying Sheng, Jia-Mo Fu,Xin-Yu Zhang*, Diepoxybutane induces the formation of DNA-DNA rather than DNA-protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells.Mutation Research2011,716, 84-91.
