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環(huán)境與健康系

汪一心/ 職稱:研究員/博士生導師

學歷學位:醫(yī)學博士 研究生

Email: [email protected]

個人簡歷

汪一心,,研究員,,博士生導師?,F(xiàn)任上海交通大學公共衛(wèi)生學院副院長,、環(huán)境與健康系主任,、哈佛大學陳曾熙公共衛(wèi)生學院營養(yǎng)系和流行病學系Department Associate,。2017年獲華中科技大學同濟醫(yī)學院博士學位,,哈佛大學陳曾熙公共衛(wèi)生學院博士后/Lead Scientist(2019-2023),。獲國家高層次人才項目(青年),,聚焦全生命周期生殖流行病學,創(chuàng)建華中消毒副產(chǎn)物出生隊列(2014年至今)和精子庫男性隊列(2017年至今),,發(fā)表學術論文100余篇,,其中第一/通訊作者(含共同)70余篇,如BMJ(4篇),、JAMA Intern Med,、Eur Respir J(2)、Eur Heart J,、J Am Coll Cardiol,、JAMA Netw Open(2篇)、eClinicalMedicine(2篇),、Lancet Reg Health Am(3)、EHP(2),、ES&T(8篇),、Environ Int(11篇)等。擔任The Innovation,、Sustainable Horizons等雜志青年編委,,國家級圖書、研究生教材編委,。成果獲湖北省科技進步一等獎和三等獎,。安徽省運動會高校部田徑男子800和1500米冠軍,國家二級運動員,。

研究方向

從全生命周期視角出發(fā),,結合環(huán)境科學、流行病學,、人工智能,、多組學、生殖醫(yī)學和生命科學等交叉學科,探索人類生殖健康的環(huán)境危險因素及生殖健康狀況(如不孕癥,、妊娠期高血壓,、妊娠期糖尿病、月經(jīng)周期紊亂等)對母嬰長期健康的影響,,并揭示作用機制及潛在靶點,,為全生命周期健康管理提供科學依據(jù)和創(chuàng)新證據(jù)。

代表性研究成果

發(fā)表論著(#共同一作,;*通訊作者)

1.Wang YX*, Farland LV, Gaskins AJ, Wang S, Terry KL, Rexrode KM, Rich-Edwards JW, Tamimi R, Chavarro JE, Missmer SA. Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study. BMJ, 2024, 387:e078797.

2.Li G, Xu S, Pan SS, Shao HL, Gaskins AJ, Zhang Y, Sun Y, Mustieles V, Pan A, Liu C*, Jing LM*, Wang YX*. Hypertension and semen quality among 1381 young men: A cohort study with repeated measurements. Innovation Med, 2024, 2(4): 100099.

3.Tian M*, Li H, Wu S, Xi H, Wang YX*, Lu YY, Wei L, Huang Q*. Exposure to haloacetic acid disinfection by-products and male steroid hormones: An epidemiological and in vitro study. J Hazard Mater, 2024, 468:133796.

4.Li G, Xu S, Messerlian C, Zhang Y, Chen YJ, Sun Y, Mustieles V, Wang Y, Pan A, Liu C*, Wang YX*. Blood trihalomethane and urinary haloacetic acid concentrations in relation to hypertension: An observational study among 1162 healthy men. J Hazard Mater, 2024, 477:135411.

5.Li Y, Zheng Z, Luo D, Liu C, Yang S, Chen Y, Hu Q, Lu W, Wang YX*, Mei S*. Reproductive hormones, organophosphate esters and semen quality: Exploring associations and mediation effects among men from an infertility clinic. Environ Res, 2024, 240(Pt 1):117458.

6.Lu ZH, Liu C, Chen YJ, Chen YJ, Lei XN, Cai LJ, Zhou HX, Chang H, Zhu M, Wang YX*, Zhang J*. Gestational Exposure to PM2.5 and Specific Constituents, Meconium Metabolites, and Neonatal Neurobehavioral Development: A Cohort Study. Environ Sci Technol, 2024, 58(23):9980-9990.

7.Chen YJ, Messerlian C, Lu Q, Mustieles V, Zhang Y, Sun Y, Wang L, Lu WQ, Liu C*, Wang YX*. Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men. Environ Int, 2024, 189:108785.

8.Wang YX*, Yang Sun, Missmer SA, Rexrode KM, Wang L, Roberts Al, Chavarro JE, Rich-Edwards JW. Association of Childhood Physical and Sexual Abuse with Risk of Premature Mortality in Women: a Prospective Cohort Study. BMJ, 2023, 381:e073613.

9.Wang YX*, Mitsunami M, Manson JE, Gaskins AJ, Rich-Edwards JW, Wang L, Zhang C, Chavarro JE. Association of Gestational Diabetes Mellitus with Subsequent Long-term Risk of Mortality: A Large Prospective Cohort Study. JAMA Intern Med, 2023,183(11):1204-1213.

10.Sun Y, Wang YX*, Mustieles V, Shan Z, Zhang Y, Messerlian C. Blood trihalomethane concentrations and allergic sensitization: A nationwide cross-sectional study. Sci Total Environ, 2023, 871:162100.

11.Wang YX*, Raphalle Varraso, Orianne Dumas, Jennifer J. Stuart, Andrea Florio, Liang Wang, Janet W. Rich-Edwards, Carlos A. Camargo, Jr, Jorge Chavarro. Hypertensive disorders of pregnancy and risk of asthma and chronic obstructive pulmonary disease: a prospective cohort study. Lancet Reg Health Am, 2023, 23:100540.

12.Chen HG, Sun B, Lin F, Chen YJ, Xiong CL, Meng TQ, Duan P, Messerlian C, Hu Z, Pan A, Ye W*, Wang YX*. Sperm mitochondrial DNA copy number mediates the association between seminal plasma selenium concentrations and semen quality among healthy men. Ecotoxicol Environ Saf, 2023, 251:114532.

13.Sun Y, Wang YX*, Qian D, Mustieles V, Zhang Y, Messerlian C. Blood Trihalomethane Concentrations and Osteoarthritis among U.S. Population Aged over 50 Years. Environ Sci Technol, 2023, 57(43):16166-16175.

14.Liu C, Chen YJ, Sun B, Chen HG, Mustieles V, Messerlian C, Sun Y, Meng TQ, Lu WQ, Pan XF, Xiong CL*, Hou J*, Wang YX*. Blood trihalomethane concentrations in relation to sperm mitochondrial DNA copy number and telomere length among 958 healthy men. Environ Res, 2023, 216(Pt 4):114737.

15.Wang YX*, Stuart JJ, Rich-Edwards JW, Missmer SA, Rexrode KM, Farland5 LV, Mukamal KJ, Nelson SM, Solomon CG, Fraser A, Chavarro JE. Menstrual cycle regularity and length across the reproductive lifespan and risk of cardiovascular disease: a prospective cohort study. JAMA Netw Open, 2023, 5(10):e2238513.

16.Li Y, Luo D, Zhao X, Wang H, Zheng Z, Liu J, Liu C, Wang H, Chen Y, Shang Y, Lu W, Mei S*, Wang YX*. Urinary concentrations of organophosphate esters in relation to semen quality: A cross-sectional study, Sci Total Environ, 2023, 865:161202.

17.Liu N, Chen hg, Yu Lia Y, Zhang G, Zhang J, Qu G, He B, Meng TQ, Xiong CL, Pan A, Yin Y, Liang Y, Shi J, Wang YX*, Hu L*, Jianga GB. Exogenous Metals Atlas in Spermatozoa at Single-Cell Resolution in Relation to Human Semen Quality. Environ Sci Technol, 2023, 57(19):7358-7369.

18.Sun Y, Wang YX*, Liu C, Mustieles V, Pan XF, Zhang Y, Messerlian C. Exposure to Trihalomethanes and Bone Mineral Density in US Adolescents: A Cross-Sectional Study (NHANES). Environ Sci Technol, 2023, 57(51):21616-21626.

19.Lu ZH, Sun B, Wang YX*, Wu YR, Chen YJ, Sun SZ, Liang SJ, Xu S, Chang H, Chen HG, Zhang J*. Ozone exposure associates with sperm quality indicators: Sperm telomere length as a potential mediating factor, J Hazard Mater, 2023, 459:132292.

20.Sun B, Chen HG, Duan P, Tu ZZ, Chen YJ, Meng TQ, Xiong CL, Wang YX*, Pan A*. Association of handgrip strength with semen characteristics: a study with repeated measurements among healthy Chinese men. Asian J Androl, 2022, 24(6):594-600.

21.Tian M*, Wu S, Wang YX*, Liu L, Zhang J, Shen H, Lu Y, Bao H, Huang Q*. Associations of environmental phthalate exposure with male steroid hormone synthesis and metabolism: An integrated epidemiology and toxicology study. J Hazard Mater, 2022, 436:129213.

22.Xu S, Wu Y, Chen Y, Lu W, Wang YX*, Gao B, Zhang J*. Environmental metal exposure, seminal plasma metabolome and semen quality: Evidence from Chinese reproductive-aged men. Sci Total Environ, 2022, 838(Pt 2):155860.

23.Wang YX*, Arvizu M, Rich-Edwards JW, Manson JM, Wang L, Missmer SA, Chavarro JE. Breastfeeding duration and subsequent risk of mortality among US women: results from two prospective cohort studies. eClinicalMedicine, 2022, 54:101693.

24.Wang YX*, Li Y, Rich-Edwards JW, Florio AA, Shan Z, Wang S, Manson JE, Mukamal KJ, Rimm EB, Chavarro JE. Associations of birth weight and later life lifestyle factors with risk of cardiovascular disease in the USA: A prospective cohort study. eClinicalMedicine, 2022, 51: 101570.

25.Sun B, Hou J*, Ye YX, Chen HG, Duan P, Chen YJ, Xiong CL, Wang YX*, Pan A*. Sperm mitochondrial DNA copy number in relation to semen quality: A cross-sectional study of 1164 potential sperm donors. BJOG, 2022, 129(13):2098-2106.

26.Wang YX*, Ding M, Li Y, Wang L, Rich-Edwards JW, Florio A, Manson JE, Chavarro JE. Birth weight and risk of total and cause-specific mortality among US men and women: results from three prospective cohort studies. Lancet Reg Health Am, 2022,15: 100344.

27.Ye YX, Chen HG, Sun B, Chen YJ, Duan P, Meng TQ, Xiong CL, Wang YX*, Pan A*. Associations between depression, oxidative stress, and semen quality among 1,000 healthy men screened as potential sperm donors. Fertil Steril, 2022,117(1):86-94.

28.Sun Y, Wang YX*, Mustieles V, Zhang Y, Pan XF, Messerlian C. Association of blood trihalomethane concentrations with lung function in U.S. adolescents: a nationally representative cross-sectional study. Eur Respir J, 2022, 60(1):2200753.

29.Chen YJ, Liu C, Tu ZZ, Lu Q, Messerlian C, Mustieles V, Sun Y, Lu WQ, Pan XF, Mao C*, Wang YX*. Associations of Urinary Trichloroacetic Acid Concentrations with Spermatozoa Apoptosis and DNA Damage in a Chinese Population. Environ Sci Technol, 2022, 56(10):6491-6499.

30.Sun Y, Xia PF, Korevaar T, Mustieles V, Zhang Y, Pan XF, Wang YX*, Messerlian C. Relationship between Blood Trihalomethane Concentrations and Serum Thyroid Function Measures in U.S. Adults. Environ Sci Technol, 2021, 55(20):14087-14094.

31.Sun Y, Chen C, Mustieles V, Wang L, Zhang Y, Wang YX*, Messerlian C. Association of Blood Trihalomethane Concentrations with Risk of All-cause and Cause-specific Mortality in U.S. Adults: A Prospective Cohort Study. Environ Sci Technol, 2021, 55(13):9043-9051.

32.Sun Y, Xia PF, Xie J, Mustieles V, Zhang Y, Wang YX*, Messerlian C. Association of blood trihalomethane concentrations with asthma in U.S. adolescents: nationally representative cross-sectional study. Sci Total Environ, 2021, 2101440.

33.Chen HG, Lu Q, Tu ZZ, Chen YJ, Sun B, Hou J, Xiong CL, Wang YX*, Meng TQ*, Pan A*. Identifying windows of susceptibility to essential elements for semen quality among 1428 healthy men screened as potential sperm donors. Environ Int, 2021155:106586.

34.Wang YX, Wang SW, Mitsunam M, Pan A, Manson JE, Rich-Edwards JW, Wang L, Zhang CL, Chavarro JE. Pre-pregnancy menstrual cycle regularity and length and the risk of gestational diabetes mellitus: prospective cohort study. Diabetologia, 2021, 64(11):2415-2424.

35.Wang YX, Mínguez-Alarcón L, Gaskins A, Arvizu M, Missmer S, Rich-Edwards JW, Manson J, Pan A, Chavarro JE. Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study. BMJ, 2021, 372:n530.

36.Wang YX*, Farland l, Wang S, Gaskins A, Wang L, Rich-Edwards J, Tamimi R, Missmer S, Chavarro J. Association of infertility with premature mortality among US women: Prospective cohort study. Lancet Reg Health Am, 2021,100122.

37.Liu C, Messerlian C, Chen YJ, Mustieles V, Huang LL, Sun Y, Deng YL, Cheng YH, Liu J, Liu AM, Lu WQ*, Wang YX*. Trimester-specific associations of maternal exposure to disinfection by-products, oxidative stress, and neonatal neurobehavioral development. Environ Int, 2021,157:106838.

38.Wang YX, Arvizu M, Rich-Edwards JW, Wang L, Rosner B, Stuart JJ, Rexrode KM, Chavarro JE. Hypertensive disorders of pregnancy and subsequent risk of premature mortality: a prospective cohort study. 2021, JACC, 2021, 77 (10) 1302–1312.

39.Liu C, Sun Y, Mustieles V, Chen YJ, Huang LL, Deng YL, Wang YX*, Lu WQ*, Messerlian C. Relationship between Blood Trihalomethane Concentrations and Serum Thyroid Function Measures in U.S. Adults. Environ Sci Technol, 2021, 55(20):14087-14094.

40.Wang YX, Mínguez-Alarcón L, Wang L, Ding M, Missmer S, Rich-Edwards JW, Manson J, Chavarro JE. Spontaneous abortion and risk of cardiovascular disease: the Nurses’ Health Study II. Eur Heart J, 2021,43(3):190-199.

41.Wang LM, Luo D, Li X, Hu LQ, Chen JX, Tu ZZ, Sun B, Chen HG, Liu L, Yu M, Li YP, Pan A, Messerlian C, Mei SR*, Wang YX*. Temporal variability of organophosphate flame retardant metabolites in spot, first morning, and 24-hour urine samples among healthy adults. Environ Res, 2020,110373.

42.Chen YJ, Duan P, Meng TQ, Chen HG, Chavarro JE, Xiong CL, Pan A*, Wang YX*, Lu WQ*, Messerlian C. Associations of Blood Trihalomethanes with Semen Quality among 1199 Healthy Chinese Men Screened as Potential Sperm Donors. Environ Int, 2020,134:105335.

43.Liu C, Wang YX*, Chen YJ, Sun Y, Huang LL, Cheng YH, Liu EN, Lu WQ*, Messerlian C. Blood and urinary biomarkers of prenatal exposure to disinfection byproducts and oxidative stress: A repeated measurement analysis. Environ Int, 2020, 137:105518.

44.Tian M*, Wang YX*, Wang X, Wang H, Liu L, Zhang J, Nan B, Shen H, Huang Q*. Environmental doses of arsenic exposure are associated with increased reproductive-age male urinary hormone excretion and in vitro Leydig cell steroidogenesis. J Hazard Mater, 2020, 408:124904.

45.Wang YX, Arvizu M, Rich-Edwards JW, Stuart JJ, Manson JE, Missmer SA, Pan A, Chavarro JE. Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study. BMJ, 2020, 371:m3464.

46.Chen HG, Sun B, Chen YJ, Chavarro JE, Hu SH, Xiong CL, Pan A*, Meng TQ*, Wang YX*, Messerlian C. Associations of Blood Trihalomethanes with Semen Quality among 1199 Healthy Chinese Men Screened as Potential Sperm Donors. Environ Int, 2020, 135:105368.

47.Sun Y, Wang YX*, Wang Q, Liu C, Chen YJ, Lu WQ*, and Messerlian C. Trimester-Specific Blood Trihalomethane and Urinary Haloacetic Acid Concentrations and Adverse Birth Outcomes: Identifying Windows of Vulnerability during Pregnancy. Environ Health Perspect, 2020,128(10):107001.

48.Wang YX, Shan ZL, Arvizu M, Pan A, Manson JE, Missmer SA, Sun Q, Chavarro JE. Associations of menstrual cycle characteristics across the reproductive life span and lifestyle factors with risk of type 2 diabetes: a cohort study. JAMA Netw Open, 2020, 3(12):e2027928.

49.Wang YX#, Wu Y#, Chen HG, Duan P, Wang L, Shen HQ, Lu WQ, Sun B, Wang Q, Zhang B, Chavarro JE, Zhang J, Pan A. Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men. Environ Int, 2019, 129:354-363.  

50.Chen HG, Lu WQ, Wang YX*, Pan A*. Reproducibility of essential elements chromium, manganese, iron, zinc and selenium in spot samples, first-morning voids and 24-h collections among healthy adult men. Br J Nutr, 2019, 122(3):343-351.

51.Wang YX, Pan A, Feng W, Liu C, Huang LL, Ai SH, Zeng Q, Lu WQ. Variability and exposure classification of urinary levels of non-essential metals aluminum, antimony, barium, thallium, tungsten and uranium in healthy adult men. J Expo Sci Environ Epidemiol, 2019, 29(3):424-434.

52.Wang YX, Liu C, Chen YJ, Duan P, Wang Q, Chen C, Sun Y, Huang LL, Wang L, Chen C, Li J, Ai SH, Huang Z, Sun L, Wan ZZ, Pan A, Meng TQ, Lu WQ. Profiles, variability and predictors of concentrations of blood trihalomethanes and urinary haloacetic acids along pregnancy among 1760 Chinese women. Environ Res, 2019, 172:665-674.

53.Chen YJ, Liu C, Huang LL, Ai SH, Sun Li, Huang Z, Li J, Lei HS, Li J, Liu YA, Wang X, Liu XY, Cheng YH, Wang YX*, Pan A*, Lu WQ*. First-trimester blood concentrations of drinking water trihalomethanes and neonatal neurobehavioral development in a Chinese birth cohort. J Hazard Mater, 2019, 362:451-457.

54.Wang YX#, Liu C#, Shen Y#, Wang Q, Pan A, Yang P, Chen YJ, Deng YL, Lu Q, Cheng LM, Miao XP, Xu SQ, Lu WQ, Zeng Q. Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis. Environ Int, 2019, 123:301-309.

55.Sun B, Messerlian C, Sun ZH, Duan P, Chen HG, Chen YJ, Wang P, Wang L, Meng TQ, Wang Q, Arvizu M, Chavarro JE, Wang YX*, Xiong CL*, Pan A*. Physical Activity and Sedentary Time in Relation to Semen Quality in Healthy Chinese Men Screened as Potential Sperm Donors. Hum Reprod, 2019, 34(12):2330-2339.

56.Liu C, Messerlian C, Chen C, Meng TQ, Duan P, Hu SH, Liu Y, Chen HG, Sheng LT, Sun B, Wang Q, Wang L, Chavarro J, Arvizu M, Xiong CL, Pan A*, Lu WQ*,Wang YX*. Mediation of the Relationship between Phthalate Exposure and Semen Quality by Oxidative Stress among 1034 Reproductive-aged Chinese Men. Environ Res, 2019,108778.

57.Wang YX, Zhou B, Chen YJ, Liu C, Huang LL, Liao JQ, Hu XJ, Lu WQ, Zeng Q, Pan A. Thyroid function, phthalate exposure and semen quality: Exploring associations and mediation effects in reproductive-aged men. Environ Int, 2018, 116:278-285.

58.Wang YX, Liu C, Chen YJ, Chen HG, Yang P, Wang P, Huang LL, Ai SH, Duan P, Pan A, Zeng Q, Lu WQ. Predictors and correlations of phthalate metabolite concentrations in urine and seminal plasma among reproductive-aged men. Environ Res, 2018,161:336-344.

59.Wan ZZ, Chen HG, Lu WQ, Wang YX*, Pan A*. Metal/metalloid levels in urine and seminal plasma in relation to computer-aided sperm analysis motion parameters. Chemosphere, 2018, 214:791-800.

60.Huang LL, Zhou B, Ai SH, Yang P, Chen YJ, Liu C, Deng YL, Lu Q, Miao XP, Lu WQ, Wang YX*, Zeng Q*. Prenatal phthalate exposure, birth outcomes and DNA methylation of Alu and LINE-1 repetitive elements: A pilot study in China. Chemosphere, 2018, 206:759-765.

61.Wang YX, Chen HG,c Li XD, Chen YJ, Liu C, Feng W, Zeng Q, Wang P, Pan A, Lu WQ. Concentrations of vanadium in urine and seminal plasma in relation to semen quality parameters, spermatozoa DNA damage and serum hormone levels. Sci Total Environ, 2018, 645:441-448.

62.Hu D#, Wang YX#, Chen WJ, Zhang Y, Li HH, Xiong L, Zhu HP, Chen HY, Peng SX, Wan ZH, Zhang Y, Du YK. Associations of phthalates exposure with attention deficits hyperactivity disorder: A case-control study among Chinese children. Environ Pollut. 2017, 229:375-385.

63.Wang YX, Wang P, Feng W, Liu C, Yang P, Chen YJ, Sun L, Sun Y, Yue J, Gu LJ, Zeng Q, Lu WQ. Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity. Environ Pollut, 2017, 224:224-234.

64.Wang YX, Feng W, Zeng Q, Sun Y, Wang P, You L, Yang P, Huang Z, Yu SL, Lu WQ*. Variability of Metal Levels in Spot, First Morning, and 24-Hour Urine Samples over a 3-Month Period in Healthy Adult Chinese Men. Environ Health Perspect. 2016,124(4):468-476.

65.Wang YX, Sun Y#, Huang Z, Wang P, Feng W, Li J, Yang P, Wang M, Sun L, Chen YJ, Liu C, Yue J, Gu LJ, Zeng Q, Lu WQ. Associations of urinary metal levels with serum hormones, spermatozoa apoptosis and sperm DNA damage in a Chinese population. Environ Int, 2016,177-188.

66.Wang YX, Zeng Q, Sun Y, Yang P, Wang P, Li J, Huang Z, You L, Huang YH, Wang C, Li YF, Lu WQ. Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: A cross-sectional study in China. Environ Pollut, 2016, 211:173-182.

67.Wang YX, Sun Y, Feng W, Wang P, Yang P, Li J, Huang Z, Chen YJ, Liu C, Sun L, Yue J, Gu LJ, Zeng Q, Lu WQ. Association of urinary metal levels with human semen quality: A cross-sectional study in China. Environ Int, 2016, 51-59.

68.Wang YX, Zeng Q, Sun Y, You L, Wang P, Li M, Yang P, Li J, Huang Z, Wang C, Li S, Dan Y, Li YF, Lu WQ. Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China. Environ Res,2016,150:557-565.

69.Wang YX, You L, Zeng Q, Sun Y, Huang YH, Wang C, Wang P, Cao WC, Yang P, Li YF, Lu WQ. Phthalate exposure and human semen quality: Results from an infertility clinic in China. Environ Res, 2015,142:1-9.

70.Wang YX#, Zeng Q#, Wang L, Huang YH, Lu ZW, Wang P, He MJ, Huang X, Lu WQ. Temporal variability in urinary levels of drinking water disinfection byproducts dichloroacetic acid and trichloroacetic acid among men. Environ Res, 2014,135:126-132.


個人學術網(wǎng)站:

https://www.researchgate.net/profile/Yixin-Wang-11

https://www.webofscience.com/wos/author/record/AAI-2758-2021

https://www.hsph.harvard.edu/profile/yixin-wang/