個人簡介:
程薇,女,,2017年畢業(yè)于上海交通大學(xué),,獲醫(yī)學(xué)博士學(xué)位。現(xiàn)就職于上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院食品安全與毒理學(xué)系,。中國毒理學(xué)會認(rèn)證毒理學(xué)家,。主持國家級、省部級科研項目3項,,申報發(fā)明專利9項(已授權(quán)2項),,參與2項團(tuán)體標(biāo)準(zhǔn)編制,。以第一作者/通訊作者在Environ Int、Sci Total Environ,、Toxicol Appl Pharmacol,、Cell Biol Toxicol等環(huán)境與健康、毒理學(xué)領(lǐng)域的權(quán)威期刊發(fā)表SCI論文13篇(累計影響因子大于100),。
研究方向:
1. 毒性測試替代方法與新途徑技術(shù)方法,;
2. 基于類器官、器官芯片的新污染物毒性篩選和靶器官毒性機(jī)制,;
3. 微塑料的危害識別和風(fēng)險評估,;
代表性研究成果(近三年):
1. Cheng W*, Zhou Y, Chen H, Wu Q, Li Y, Wang H, Feng Y, Wang Y*. The iron matters: Aged microplastics disrupted the iron homeostasis in the liver organoids. Sci Total Environ. 2023. (just accepted)
2. Zhou Y, Wu Q, Li Y, Feng Y, Wang Y*, Cheng W*. Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids. Environ Int, 2023, 179:108171.
3. Cheng W*, Zhou Y, Xie Y, Li Y, Zhou R, Wang H, Feng Y, Wang Y*. Combined effect of polystyrene microplastics and bisphenol A on the human embryonic stem cells-derived liver organoids: the hepatotoxicity and lipid accumulation. Sci Total Environ, 2023, 854:158585.
4. Xie Y, Li Y, Feng Y, Cheng W*, Wang Y*. Inhalable microplastics prevails in air: exploring the size detection limit. Environ Int, 2022, 162:107151.
5. Cheng W*, Li X, Zhou Y, Yu H, Xie Y, Wang H, Li Y, Feng Y, Wang Y*. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids. Sci Total Environ, 2022, 806 (Pt 1): 150328.
6. Cheng W#, Li X#, Yang S, Wang H, Li Y, Feng Y, Wang Y*. Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol, 2022, 38:409-426.
7. Cheng W, Yang S, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes. Toxicol Appl Pharmacol.2020, 388:114850.
8. Cheng W, Yang S, Liang F, Zhou R, Li Y, Feng Y, Wang Y*. Low-dose exposure to triclosan disrupted osteogenic differentiation of mouse embryonic stem cells via BMP/ERK/Smad/Runx-2 signalling pathway. Food Chem Toxicol. 2019, 127:1-10.
9. Li X, Cheng W*, Yang S, Liang F, Wang H, Feng Y, Wang Y*. Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett, 2022, 355:1-18.
10. Wang L#, Cheng W#, Zhu J#, Li W*, Li D, Fu Q, Mo X, Yang X, Zhao W, Ren M, Ren J, Zhang K*. Electrospun nanoyarn and exosomes of adipose-derived stem cells for urethral regeneration: evaluations in vitro and in vivo. Colloids Surf B Biointerfaces, 2022, 209: 112218.
11. Zhou R, Cheng W, Feng Y, Wang W, Liang F, Luo F, Yang S, Wang Y*. Combined effects of BPA and PFOS on fetal cardiac development: In vitro and in vivo experiments. Environ Toxicol Pharmacol, 2020, 80: 103434.
12. Yang S, Cheng W, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER/CAM/eNOS pathway. Toxicology, 2020,432:152380.
13. Yu H, Guo H, Feng Y, Cheng W, Wang Y*. Exosomes from PM2.5-treated Human Bronchial Epithelial Cells Increase Lung Cancer Metastatic Potential. Biomed Environ Sci, 2022, 35(6):473-484.
14. Guo H#, Yu H#, Feng Y, Cheng W, Li Y, Wang Y*. The role of estrogen receptor β in fine particulate matter (PM 2.5) organic extract-induced pulmonary inflammation in female and male mice. Environ Sci Pollut Res Int, 2022, 29:60922-60932.
15. Zhou R, Xia M, Zhang L, Cheng W, Yan J, Sun Y, Wang Y*, Jiang H*. Individual and combined effects of BPA, BPS and BPAF on the cardiomyocyte differentiation of embryonic stem cells. Ecotoxicol Environ Saf, 2021,220:112366.
16. Zhou R, Cheng W, Feng Y, Wang W, Liang F, Luo F, Yang S, Wang Y*. Combined effects of BPA and PFOS on fetal cardiac development: In vitro and in vivo experiments. Environ Toxicol Pharmacol, 2020, 80: 103434.