個人簡介
2003-2007年畢業(yè)于英國愛丁堡大學，獲生物技術學士學位,；2008-2009年畢業(yè)于英國劍橋大學,，獲生物信息學碩士學位；2012-2016年畢業(yè)于英國劍橋大學,，獲生物信息學博士學位,。期間曾在輝瑞制藥，桑格基因研究所,，劍橋大學血液系工作實習,。2016-2020年于英國劍橋大學干細胞所Bertie Gottgens教授實驗室任博士后，主要負責生物大數據分析,、分析流程的構建以及相關算法的優(yōu)化和開發(fā),。特別是利用單細胞多組學測序技術，研究心臟早期發(fā)育,、心臟損傷修復以及血液分化和各種血液疾病模型,，通過生物信息學方法揭示細胞異質性，并開發(fā)新的細胞分化途徑算法,，以闡明底層的分子調控機制,。共發(fā)表論文15篇，其中近5年發(fā)表Science 1篇（2018,，IF 41.845,，共同一作第二位），Nature Communications 1篇（2020,，IF 12.124,，共同一作第二位），OncoImmunology 1 篇（2021,，IF 5.869,，一作），Development 1篇（2020,，IF 5.843,，共同一作第二位）。
主要研究方向
通過單細胞多組學測序,，從造血角度,，在細胞和分子層面解讀心血管疾病，特別是動脈粥樣硬化的發(fā)生與發(fā)展,。相關結果將為未來醫(yī)療轉化提供一個新的視角,，可以通過調控造血的方式,，來防范動脈粥樣硬化和/或減輕疾病癥狀。
主要研究成果
1. Wang X, Peticone C, Kotsopoulou E, Gottgens B, Calero-Nieto FJ. Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures. OncoImmunology. 2021 Jan 06;10(1): 1866287. doi:10.1080/2162402X.2020.1866287
2. Koth J*, Wang X*, Killen AC*, Stockdale WT, Potts HG, Jefferson A, Bonkhofer F, Riley PR, Patient RK, Göttgens B, Mommersteeg MTM. Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration. Development. 2020 Apr 27;147(8):dev186569. doi: 10.1242/dev.186569.
3. Basilico S*, Wang X*, Kennedy A, Tzelepis K, Giotopoulos G, Kinston SJ, Quiros PM, Wong K, Adams DJ, Carnevalli LS, Huntly BJP, Vassiliou GS, Calero-Nieto FJ, Göttgens B. Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML. Nat Commun. 2020 Mar 16;11(1):1407. doi: 10.1038/s41467-020-15220-0.
4. Lescroart F*, Wang X*, Lin X*, Swedlund B, Gargouri S, Sànchez-Dànes A, Moignard V, Dubois C, Paulissen C, Kinston S, Göttgens B, Blanpain C. Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq. Science. 2018 Mar 9;359(6380):1177-1181.
5. Hérault A, Binnewies M, Leong S, Calero-Nieto FJ, Zhang SY, Kang YA, Wang X, Pietras EM, Chu SH, Barry-Holson K, Armstrong S, Göttgens B, Passegué E. Myeloid progenitor cluster formation drives emergency and leukaemicmyelopoiesis. Nature. 2017 Apr 6;544(7648):53-58.
6. Wilson NK1, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010 Oct 8;7(4):532-44.
1. Hamey FK, Lau WWY, Kucinski I, Wang X, Diamanti E, Wilson NK, Göttgens B, Dahlin JS. Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development. Allergy. 2020 Oct 20. doi: 10.1111/all.14633.
2. Vink CS, Calero-Nieto FJ, Wang X, Maglitto A, Mariani SA, Jawaid W, Göttgens B, Dzierzak E. Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells. Cell Rep. 2020 May 12;31(6):107627. doi: 10.1016/j.celrep.2020.107627.
3. Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A. Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation. EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270. Epub 2020 Mar 9.
4. Castaño J, Aranda S, Bueno C, Calero-Nieto FJ, Mejia-Ramirez E, Mosquera JL, Blanco E, Wang X, Prieto C, Zabaleta L, Mereu E, Rovira M, Jiménez-Delgado S, Matson DR, Heyn H, Bresnick EH, Göttgens B, Di Croce L, Menendez P, Raya A, Giorgetti A. GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm. Stem Cell Reports. 2019 Sep 10;13(3):515-529. doi: 10.1016/j.stemcr.2019.07.009. Epub 2019 Aug 8
5. Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambile D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P. Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions. Haematologica. 2019 Jan 24.
6. Belluschi S, Calderbank EF, Ciaurro V, Pijuan-Sala B, Santoro A, Mende N, Diamanti E, Sham KYC, Wang X, Lau WWY, Jawaid W, Göttgens B, Laurenti E. Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors. Nat Commun. 2018 Oct 5;9(1):4100.
7. Gracia T, Wang X, Su Y, Norgett EE, Williams TL, Moreno P, Micklem G, Frankl FE. Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney. Sci Rep. 2017 Jan 17;7:40601.
8. Dawson MA, Foster SD, Bannister AJ, Robson SC, Hannah R, Wang X, Xhemalce B, Wood AD, Green AR, Göttgens B, Kouzarides T. Three distinct patterns of histone H3Y41 phosphorylation mark active genes. Cell Rep. 2012 Sep 27;2(3):470-7.
9. Tijssen MR1, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, Oram SH, Smethurst PA, Wilson NK, Wang X, Ottersbach K, Stemple DL, Green AR, Ouwehand WH, Göttgens B. Ouwehandand Berthold Göttgens. Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators. Dev Cell. 2011 May 17;20(5):597-609.
10. Joshi N., Wang X, Montgomery, L., Elfick, A., and French, C. Novel approaches to biosensors for detection of arsenic in drinking water. Desalination 2010. 252, 100-106.
11. Wang X, Burrows J. Assessment of Dry Powder Lactose Formulation Characteristics for Delivery to Rat Airways. DDL17, 2006.
