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單細胞組學與疾病研究中心

何牮/ 職稱:副研究員

學歷學位:博士 研究生

Email: [email protected]

何牮,,博士,上海交通大學醫(yī)學院副研究員、碩士生導師,單細胞組學與疾病研究中心基因組學平臺主任,。

個人簡介

于吉林大學/美國加州大學圣迭戈分校(University of California,  San Diego)博士聯(lián)合培養(yǎng)畢業(yè),。先后于美國洛斯阿拉莫斯國家實驗室(Los Alamos National Laboratory),、中國科學院,、上海交通大學等單位工作,。

2019年加入上海交大醫(yī)學院單細胞組學與疾病研究中心任基因組學平臺主任,。長期從事單細胞多組學分析技術(shù)的研發(fā)及腫瘤基因組學研究,運用新技術(shù)新策略在單細胞層面探究腫瘤等重大疾病的發(fā)病機制和在營養(yǎng)及藥物干預(yù)下腫瘤微環(huán)境中腫瘤細胞與免疫細胞間的相互作用,;篩選發(fā)現(xiàn)腫瘤防控新靶標,,探討診療腫瘤的新方法。

截止20219月,,發(fā)表SCI收錄的論文50余篇,,其中35篇為近五年發(fā)表,總引用1100余次,,H指數(shù)(h-index17,,其中第一或通訊作者20篇。主持多項國家級,、省部級及校級項目,,參與多項國家級、科技部,、醫(yī)工交叉及橫向課題,。申請專利十余項(已授權(quán)兩項),受邀撰寫綜述文章并推薦為封面文章,,并多次于國內(nèi)外重要學術(shù)會議進行報告并獲獎,。擔任人衛(wèi)出版社教材《基礎(chǔ)醫(yī)學概論》編委,多家學術(shù)期刊編委,、審稿人及ISBRA會議program committee,,美國癌癥研究學會、中國生物化學與分子生物學會,、中國抗癌協(xié)會,、中國生物醫(yī)學工程學會等多家學會會員,上海市決策咨詢類科技專家,,上海市中醫(yī)藥科技評審咨詢專家,,上海市衛(wèi)生健康委員會醫(yī)學科技評審專家等。

E-mail: [email protected]

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近五年第一或通訊作者文章

1.    Jian He#et al. Int J Environ Res Public Health. 2021 Accepted.

2.    Jian He#et al. Construction of a human cell landscape of COVID-19 Infection at single-cell level. Clin Cancer Res 2021;27(6_Suppl): P42. DOI: https://doi.org/10.1158/1557-3265.COVID-19-21-P42.

3.    Jian He#, et al. A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates. J Clin Transl Hepatol. Published online: Sep 17, 2021. DOI: 10.14218/JCTH.2021.00047

4.    Jian He, et al. Aging and disease. 2021, 12, 5;

5.    Jian He#, et al. MedComm. 2021;1-13.

6.    Jian He, et al. Chem Biodivers. 2019 Sep;16(9):e1900176.

7.    Jian He, et al. Single-Cell RNA-Seq Reveals Naïve B cells Associated with Better Prognosis of HCC. Preprint BioRxiv. doi: https://doi.org/10.1101/ 731935

8.    Jian He, et al. EBioMedicine. 2016 Oct;12:4-5.

9.    Jian He. Current organic chemistry. 2017, 21(19): 1-22.

10.  Jian He, et al. Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma. Oncotarget. 2017 Nov 28; 8(61): 103968–103974.

11.  Jian He. Scientific Reports, 2017 Aug 21;7(1):8867.

12.  Xinyu Hu, Yidi Qu, Qiubo Chu, Wenshu Li, Jian He#. Molecular Medicine Reports, 2018,17: 3599-3606.

13.  Jian He, et al. Organic Process Research & Development. 2016, 20 (6), pp 1093–1096.

14.  Jian He, et al. BioTechniques. 2016; 60 (3):129-135.

 

Jian He, Ph.D., Associate Professor

Director of Single-cell Genomics Core

The Center for Single-Cell Omics (CSCOmics) , School of Public Health,

Shanghai Jiao Tong University School of Medicine

Address: 227 South Chongqing Road, Shanghai, China

Email: [email protected]

 

Dr. He obtained her Ph.D. degree from a joint Ph.D. program in Jilin University and University of California, San Diego, which was supported by China Scholarship Council. Dr. He then worked in Los Alamos National Laboratory in the United States, Chinese Academy of Sciences and Shanghai Jiao Tong University in China.

 

In 2019, Dr. He joined the Center for Single-Cell Omics in Shanghai Jiao Tong University School of Medicine as the core director of the genomics core.

 

Dr. He research focused on developing more sophisticated protocols of single-cell multiple-omics, and studying major diseases, especially oncology using single-cell omics strategies. As of Sept. 2021, Dr. He has authored 56 high-quality scholarly articles including twenty first-authored and correspondence author papers, which has been extensively cited. Also, Dr. He has filed 11 patents (2 issued). Also, she has been awarded research grants and awards from National Natural Science Foundation, China Postdoctoral Science Special Foundation, and so on. Dr. He was invited to contribute review articles by high influential research journals in her field and give oral presentations at national and international conferences. Dr. He also serves as an article reviewer of numerous notable international journals.

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Recent 5 years selected publications:

15.  Jian He#et al. Int J Environ Res Public Health. 2021 Accepted.

16.  Jian He#et al. Construction of a human cell landscape of COVID-19 Infection at single-cell level. Clin Cancer Res 2021;27(6_Suppl): P42. DOI: https://doi.org/10.1158/1557-3265.COVID-19-21-P42.

17.  Jian He#, et al. A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates. J Clin Transl Hepatol. Published online: Sep 17, 2021. DOI: 10.14218/JCTH.2021.00047

18.  Jian He, et al. Aging and disease. 2021, 12, 5;

19.  Jian He#, et al. MedComm. 2021;1-13.

20.  Jian He, et al. Chem Biodivers. 2019 Sep;16(9):e1900176.

21.  Jian He, et al. Single-Cell RNA-Seq Reveals Naïve B cells Associated with Better Prognosis of HCC. Preprint BioRxiv. doi: https://doi.org/10.1101/ 731935

22.  Jian He, et al. EBioMedicine. 2016 Oct;12:4-5.

23.  Jian He. Current organic chemistry. 2017, 21(19): 1-22.

24.  Jian He, et al. Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma. Oncotarget. 2017 Nov 28; 8(61): 103968–103974.

25.  Jian He. Scientific Reports, 2017 Aug 21;7(1):8867.

26.  Xinyu Hu, Yidi Qu, Qiubo Chu, Wenshu Li, Jian He#. Molecular Medicine Reports, 2018,17: 3599-3606.

27.  Jian He, et al. Organic Process Research & Development. 2016, 20 (6), pp 1093–1096.

28.  Jian He, et al. BioTechniques. 2016; 60 (3):129-135.