個(gè)人簡(jiǎn)介：
2006年畢業(yè)于中國(guó)科學(xué)院上海生命科學(xué)研究院生物化學(xué)與細(xì)胞生物學(xué)研究所,，獲生物化學(xué)與分子生物學(xué)博士學(xué)位,；2006-2020，中國(guó)科學(xué)院上海生命科學(xué)研究院,，生物化學(xué)與細(xì)胞生物學(xué)研究所,，期間聘任為副研究員。2020年3月加入上海交通大學(xué)醫(yī)學(xué)院公共衛(wèi)生學(xué)院?jiǎn)渭?xì)胞組學(xué)與疾病研究中心,，任質(zhì)譜平臺(tái)負(fù)責(zé)人,。2020年12月破格晉升為研究員。發(fā)表SCI研究論文22篇（Cancer Cell, Genomics, Proteomics & Bioinformatics, Cell Death Dis., J Mol Cell Biol., Cell Res., Nat Chem Biol.等），參與編撰國(guó)際系列叢書(shū)《Methods Mol Biol.》1部,、專業(yè)書(shū)籍《蛋白質(zhì)化學(xué)與蛋白質(zhì)組學(xué)》1部,。參與申請(qǐng)中國(guó)發(fā)明專利25項(xiàng)，其中12項(xiàng)獲得授權(quán),。
社會(huì)任職/學(xué)術(shù)頭銜：
擔(dān)任Genomics, Proteomics & Bioinformatics,、World Journal of Gastroenterology等期刊審稿人。入選浦東新區(qū)科學(xué)技術(shù)專家?guī)?/span>,、上海市科技專家?guī)臁?/span>
主要研究方向：
主要從事質(zhì)譜技術(shù)的開(kāi)發(fā)及其在癌癥,、疾病動(dòng)物模型、心血管疾病和信號(hào)轉(zhuǎn)導(dǎo)途徑研究的應(yīng)用,，結(jié)直腸癌,、胰腺癌、肺癌的蛋白質(zhì)基因組學(xué)等多組學(xué)研究,。
主要研究課題：
主持國(guó)家自然科學(xué)基金青年科學(xué)基金項(xiàng)目（1項(xiàng)）,、上海生科院優(yōu)秀青年人才領(lǐng)域前沿項(xiàng)目（1項(xiàng)）。參與科技部973計(jì)劃（3項(xiàng)）,、國(guó)家自然科學(xué)基金重大研究計(jì)劃（2項(xiàng)）,、國(guó)家自然科學(xué)基金面上項(xiàng)目（1項(xiàng)）、中國(guó)科學(xué)院戰(zhàn)略性先導(dǎo)科技專項(xiàng)（1項(xiàng)）,、國(guó)家重點(diǎn)研發(fā)計(jì)劃重點(diǎn)專項(xiàng)項(xiàng)目（1項(xiàng)）,。
獲得榮譽(yù)稱號(hào)：中國(guó)科學(xué)院院長(zhǎng)優(yōu)秀獎(jiǎng)學(xué)金，第八屆復(fù)旦大學(xué)談家楨基金生命科學(xué)九源獎(jiǎng)學(xué)金,，賽諾菲—中國(guó)科學(xué)院上海生命科學(xué)研究院優(yōu)秀青年人才,。
主要研究成果 (#第一作者, *通訊作者) ：
1. Wu Y, Cao Y, Xu K, Zhu Y, Qiao Y, Wu Y, Chen J, Li C*, Zeng R*, Ge G*. Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis. Cell Death Dis. 2021, 12(2): 163. (IF= 6.304)
2. Sun Y#, Li C#, Pang S, Yao Q, Chen L*, Li Y*, Zeng R*. Kinase-substrate edge biomarkers provide a more accurate prognostic prediction in ER-negative breast cancer. Genomics, Proteomics & Bioinformatics. 2021. [in press] (IF=7.051)
3. Li C#, Sun Y#, Yu G#, Cui J#, Lou Z#, Zhang H, Huang Y, Bai C, Deng L, Liu P, Zheng K, Wang Y, Wang Q, Li Q, Wu Q, Liu Q, Shyr Y, Li Y, Chen L, Wu J*, Zhang W*, Zeng R*. Integrated Omics of Metastatic Colorectal Cancer. Cancer Cell. 2020 Nov 9;38(5):734-747. (IF=26.602)
4. Han J#, Yu M#, Bai Y#, Yu J#, Jin F, Li C, Zeng R, Peng J, Li A, Song X, Li H*, Wu D*, Li L*. Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. Cancer Cell. 2020 Dec 14;38(6):844-856.
5. Tang Y#, He Y#, Li C# Mu W, Zou Y, Liu C, Qian S, Zhang F, Pan J, Wang Y, Huang H, Pan D, Yang P, Mei J*, Zeng R*, Tang QQ*. RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases. Cell Discov. 2018 Aug 21;4:52. (IF=4.600)
6. Li M#, Li C#, Liu W, Liu C, Cui J, Li Q, Ni H, Yang Y, Wu C, Chen C, Xing Z, Liu X, Zeng T, Zhao M, Chen L, Wu J*, Zeng R*, Chen L*. Dysfunction of PLA2G6 and CYP2C44 associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma. J Mol Cell Biol. 2017 Dec 1;9(6):489-503. (IF=5.595)
7. Zhu X, Yuan C, Tian C, Li C, Nie F, Song X, Zeng R, Wu D, Hao X, Li L*. The plant sesquiterpene lactone parthenoide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1. J Biol Chem. 2018 Apr 6;293(14):5335-5344.
8. He X#, Zhang W#, Yan C#, Nie F, Li C, Liu X, Fei C, Li S, Song X, Jia Y, Zeng R, Wu D, Pan W*, Hao X*, Li L*. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discovery. 2017, 3, 17003.
9. Liang J#, Cao R#, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W, Yang W*. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res. 2017 Mar;27(3):329-351.
10. Li F#, Fang Z#, Zhang J#, Li C, Liu H, Xia J, Zhu H, Guo C, Qin Z, Li F, Han X, Wang Y, Feng Y, Wang Y, Zhang W, Wang Z, Jin Y, Sun Y, Wei W, Zeng R, Chen H, Ji H*.Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma. Cell Res. 2016 Oct;26(10):1149-1164.
11. Sheng Q#, Li R#, Dai J#, Li Q, Su Z, Guo Y, Li C, Shyr Y*, Zeng R*. Preprocessing significantly improves the peptide/protein identification sensitivity of high-resolution isobarically labeled tandem mass spectrometry data. Mol Cell Proteomics. 2015 Feb;14(2):405-17.
12. Fei C, Li Z, Li C, Chen Y, Chen Z, He X, Mao L, Wang X, Zeng R, Li L*. Smurf1-mediated Lys29-linked non-proteolytic poly-ubiquitination of Axin negatively regulates Wnt/β-catenin signaling. Mol Cell Biol. 2013, 33(20):4095-105.
13. Wang S#, Yin J#, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X*, Li L*. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.
14. Li C#, Ruan HQ#, Liu YS#, Xu MJ, Dai J, Sheng QH, Tan YX, Yao ZZ, Wang HY, Wu JR, Zeng R*. Quantitative proteomics reveal up-regulated protein expression of the SET complex associated with hepatocellular carcinoma. J Proteome Res. 2012 Feb 3;11(2):871-85. (IF=5.056)
15. Wu C#, Wei W#, Li C, Li Q, Sheng Q, Zeng R*. J Proteome Res. Delicate analysis of post-translational modifications on Dishevelled 3. 2012 Jul 6;11(7):3829-37.
16. Liu YS#, Luo XY#, Li QR, Li H, Li C, Ni H, Li RX, Wang R, Hu HC, Pan YJ, Chen HQ*, Zeng R*. Shotgun and targeted proteomics reveal that pre-surgery serum levels of LRG1, SAA, and C4BP may refine prognosis of resected squamous cell lung cancer. J Mol Cell Biol. 2012 Oct;4(5):344-7.
17. Micutkova L, Diener T, Li C, Rogowska-Wrzesinska A, Mueck C, Huetter E, Weinberger B, Grubeck-Loebenstein B, Roepstorff P, Zeng R, Jansen-Duerr P*. Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts. Mech Ageing Dev. 2011 Oct;132(10):468-79.
18. Sun B, Guo S, Tang Q, Li C, Zeng R, Xiong Z, Zhong C, Ding J*. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274. Cell Res. 2011 Aug;21(8):1262-6.
19. Liu Y#, Li C#, Xing Z, Yuan X, Wu Y, Xu M, Tu K, Li Q, Wu C, Zhao M*, Zeng R*. Proteomic mining in the dysplastic liver of WHV/c-myc mice--insights and indicators for early hepatocarcinogenesis. FEBS J. 2010 Oct;277(19):4039-53. (IF=3.129)
20. Li C, Hong Y, Tan YX, Ai JH, Zhou H, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*, Zeng R*. Analysis of microdissected cells by two-dimensional LC-MS approaches. Methods Mol Biol. 2008;428:193-208.
21. Ding Y#, Xi Y#, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L*. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol. 2008 Sep 8;182(5):865-72.
22. Li C#, Tan YX#, Zhou H, Ding SJ, Li SJ, Ma DJ, Man XB, Hong Y, Zhang L, Li L, Xia QC, Wu JR, Wang HY*, Zeng R*. Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers. Proteomics. 2005 Mar;5(4):1125-39. (IF=6.088)
23. Li C, Hong Y, Tan YX, Zhou H, Ai JH, Li SJ, Zhang L, Xia QC, Wu JR, Wang HY*, Zeng R*, Accurate qualitative and quantitative proteomic analysis of clinical hepatocellular carcinoma using laser capture microdissection coupled with isotope-coded affinity tag and two-dimensional liquid chromatography mass spectrometry. Mol Cell Proteomics. 2004 Apr;3(4):399-409. (IF=9.624)
24. 屠成劍, 李辰, 第十三章, 樣品的全息制備; 丁士健, 唐柳婭, 李辰, 第二十三章, 蛋白質(zhì)組學(xué)在各領(lǐng)域中的應(yīng)用; 曾嶸、夏其昌主編, 《蛋白質(zhì)化學(xué)與蛋白質(zhì)組學(xué)》, 1 ed. 北京: 科學(xué)出版社, 2004
25. 曾嶸,張衛(wèi),吳家睿,李辰,孫怡迪,于冠宇,崔靜如,樓征,張杭,黃亞. 2020.8.28申請(qǐng),申請(qǐng)?zhí)?02010879274.8
26. 曾嶸,高笑靜,李辰. 2019.1.21申請(qǐng),申請(qǐng)?zhí)?01910053299X
27. 曾嶸,高笑靜,李辰. 2019.1.21申請(qǐng),申請(qǐng)?zhí)?019100537705
28. 曾嶸,李辰,高笑靜. 2019.1.21申請(qǐng),申請(qǐng)?zhí)?019100532839
29. 曾嶸,吳家睿,李辰,李青潤(rùn),袁亞俊. 2018.5.30申請(qǐng),申請(qǐng)?zhí)?01810538149.3
30. 曾嶸,吳家睿,李青潤(rùn),李辰,袁亞俊. 2018.5.30申請(qǐng),申請(qǐng)?zhí)?01810538815.3
31. 曾嶸,吳家睿,袁亞俊,李辰,李青潤(rùn). 2018.5.30申請(qǐng),申請(qǐng)?zhí)?01810538134.7
32. 曾嶸,吳家睿,金鋼,李辰,郭世偉,袁亞俊. 2018.5.30申請(qǐng),申請(qǐng)?zhí)?01810538083.8
33. 金鋼,曾嶸,吳家睿,郭世偉,李辰,袁亞俊. 2018.5.30申請(qǐng),申請(qǐng)?zhí)?01810538192.X
34. 曾嶸,陳海泉,吳慶慶,羅曉陽(yáng),李辰. 2017.7.14申請(qǐng),申請(qǐng)?zhí)?01710574961.7
35. 曾嶸, 陳洛南,王紅陽(yáng),陳磊,李辰,李美儀,楊應(yīng)成,劉偉鑫2017.6.5申請(qǐng),申請(qǐng)?zhí)?01710414593.X
36. 王紅陽(yáng),陳磊,陳洛南,曾嶸, 楊應(yīng)成,李美儀,李辰,劉偉鑫.2017.6.5申請(qǐng),申請(qǐng)?zhí)?01710413397.0
37. 陳洛南,曾嶸,王紅陽(yáng),陳磊,李美儀,李辰,楊應(yīng)成,劉偉鑫.2017.6.5申請(qǐng),申請(qǐng)?zhí)?01710414134.1
38. 曾嶸,阮宏強(qiáng),徐孟杰,李辰,武祎. 2013.10授權(quán),申請(qǐng)?zhí)朲L200910056784.9
39. 曾嶸,徐孟杰,李辰,武祎,阮宏強(qiáng). 2013.10授權(quán),申請(qǐng)?zhí)朲L200910056785.3
40. 曾嶸,王紅陽(yáng),夏其昌,李辰,談冶雄.2012.07授權(quán),申請(qǐng)?zhí)朲L200410025465.9
41. 曾嶸,王紅陽(yáng),夏其昌,李辰,談冶雄. 2012.07授權(quán),申請(qǐng)?zhí)朲L200410025464.4
42. 曾嶸,袁新雨,李辰,周曉. 2012.01授權(quán),申請(qǐng)?zhí)?/span>ZL200510029160.X
43. 曾嶸,袁新雨,李辰,周曉. 2012.01授權(quán),申請(qǐng)?zhí)朲L200510029165.2
44. 曾嶸,李辰,周曉,袁新雨. 2012.01授權(quán),申請(qǐng)?zhí)朲L200510029155.9
45. 曾嶸,李辰,周曉,袁新雨. 2011.09授權(quán),申請(qǐng)?zhí)朲L200510029158.2
46. 曾嶸,袁新雨,李辰,周曉. 2011.08授權(quán),申請(qǐng)?zhí)朲L200510029167.1
47. 曾嶸,周曉,李辰,袁新雨. 2011.05授權(quán),申請(qǐng)?zhí)朲L200610115883.6
48. 曾嶸,周曉,李辰,袁新雨. 2011.05授權(quán),申請(qǐng)?zhí)朲L200610115885.5
49. 曾嶸,周曉,李辰,袁新雨. 2011.05授權(quán),申請(qǐng)?zhí)朲L200610115888.9
