個(gè)人簡(jiǎn)介
歐陽(yáng)鳳秀,，教授、博士生導(dǎo)師,。上海交通大學(xué)醫(yī)學(xué)院附屬新華醫(yī)院教育部和上海市環(huán)境與兒童健康重點(diǎn)實(shí)驗(yàn)室研究員,。
上海醫(yī)科大學(xué)（現(xiàn)復(fù)旦大學(xué)）醫(yī)學(xué)學(xué)士、美國(guó)西北大學(xué)醫(yī)學(xué)院科學(xué)碩士,、復(fù)旦大學(xué)流行病學(xué)與衛(wèi)生統(tǒng)計(jì)學(xué)博士,。2004-2011年曾在美國(guó)哈佛大學(xué)公共衛(wèi)生學(xué)院和美國(guó)西北大學(xué)醫(yī)學(xué)院兒童醫(yī)院先后進(jìn)行博士后及專職科研工作。2013年曾到美國(guó)約翰霍普金斯大學(xué)公共衛(wèi)生學(xué)院做3個(gè)月短期訪問(wèn)教授,。
主持國(guó)家重點(diǎn)研發(fā)計(jì)劃“政府間國(guó)際科技創(chuàng)新合作”重點(diǎn)專項(xiàng)1項(xiàng),、國(guó)家自然科學(xué)基金委員會(huì)與美國(guó)國(guó)立衛(wèi)生研究院合作研究重點(diǎn)項(xiàng)目1項(xiàng)、國(guó)家自然科學(xué)基金青年及面上項(xiàng)目3項(xiàng),、國(guó)際原子能機(jī)構(gòu)國(guó)際合作項(xiàng)目2項(xiàng),、美國(guó)蓋茨基金會(huì)項(xiàng)目1項(xiàng)。承擔(dān)國(guó)家自然科學(xué)基金中加國(guó)際合作重大項(xiàng)目子課題1項(xiàng),。入選上海浦江人才計(jì)劃，2015年,、2019年上海市教育委員會(huì)高峰高原學(xué)科建設(shè)計(jì)劃,。
在國(guó)內(nèi)外學(xué)術(shù)期刊如Environmental Health Perspectives、American Journal of Clinical Nutrition,、Journal of Allergy and Clinical Immunology,、Bulletin of the World Health Organization、Obesity發(fā)表論文100余篇,，其中SCI收錄70余篇,。
社會(huì)任職/學(xué)術(shù)頭銜
中華醫(yī)學(xué)會(huì)兒科分會(huì)臨床流行病學(xué)學(xué)組（籌），副組長(zhǎng)
中華醫(yī)學(xué)會(huì)組臨床流行病學(xué)和循證醫(yī)學(xué)分會(huì),，委員
上海市臨床流行病學(xué)與循證醫(yī)學(xué)分會(huì),，委員
全國(guó)衛(wèi)生產(chǎn)業(yè)企業(yè)管理協(xié)會(huì)（NAHIEM）抗衰老分會(huì)(Anti-aging Association)，理事
上海市微量元素學(xué)會(huì),，理事
承擔(dān)教學(xué)工作介紹
參加研究生課程“公共衛(wèi)生進(jìn)展概述”和“公共衛(wèi)生研究前沿”（上海交通大學(xué)公共衛(wèi)生學(xué)院）,、“循證臨床實(shí)踐”（上海交通大學(xué)醫(yī)學(xué)院）的教學(xué)任務(wù)。
主要研究方向
生命早期暴露因素與胎兒生長(zhǎng),、兒童健康的流行病學(xué)研究,；
肥胖/心血管代謝健康的相關(guān)遺傳、環(huán)境因素及生物標(biāo)志物,；
肥胖早期綜合干預(yù)臨床試驗(yàn),，從孕前,、孕期及兒童早期的全程綜合干預(yù)研究。
主要研究課題
1. 國(guó)家自然科學(xué)基金中美國(guó)際合作重點(diǎn)項(xiàng)目,，孕婦低劑量汞暴露對(duì)代謝組學(xué)及兒童心血管代謝健康的影響,，中美合作前瞻性出生隊(duì)列研究，在研,，中方項(xiàng)目負(fù)責(zé)人,。
2. 國(guó)家重點(diǎn)研發(fā)計(jì)劃“政府間國(guó)際科技創(chuàng)新合作”重點(diǎn)專項(xiàng)（科技部）中加合作多中心隨機(jī)對(duì)照臨床試驗(yàn)數(shù)據(jù)信息整合管理平臺(tái)建設(shè)，在研,，項(xiàng)目負(fù)責(zé)人,。
3. 上海交通大學(xué)醫(yī)學(xué)院高峰高原計(jì)劃—臨床專職科研隊(duì)伍（上海市教育委員會(huì)高峰高原學(xué)科建設(shè)計(jì)劃），環(huán)境內(nèi)分泌干擾物暴露對(duì)妊娠期內(nèi)分泌疾病及出生結(jié)局的影響,，在研,，項(xiàng)目負(fù)責(zé)人。
4. 國(guó)際原子能機(jī)構(gòu)IAEA協(xié)調(diào)研究項(xiàng)目,，生命早期綜合干預(yù)與兒童體脂成分,，在研，項(xiàng)目負(fù)責(zé)人,。
5. 國(guó)際原子能機(jī)構(gòu)（IAEA）亞太地區(qū)RAS6092項(xiàng)目IAEA技術(shù)合作（TC）亞太地區(qū)15國(guó)項(xiàng)目（中國(guó)協(xié)調(diào)員）,，利用穩(wěn)定同位素技術(shù)監(jiān)測(cè)和干預(yù)促進(jìn)嬰幼兒營(yíng)養(yǎng), 1/1/2018-12/31/2021，項(xiàng)目負(fù)責(zé)人,。
6. 國(guó)家自然科學(xué)基金-加拿大健康研究院合作重大項(xiàng)目,，中加合作健康生命軌跡計(jì)劃：預(yù)防兒童肥胖的社區(qū)-家庭-母嬰綜合干預(yù)隊(duì)列研究，在研,，子課題負(fù)責(zé)人/骨干,。
7. 國(guó)家自然科學(xué)基金面上項(xiàng)目，生命早期三氯生暴露對(duì)嬰幼兒腸道菌群及肥胖的影響,，2017.01-2020.12,，結(jié)題，項(xiàng)目負(fù)責(zé)人,。
8. 國(guó)家自然科學(xué)基金面上項(xiàng)目,，雙酚A宮內(nèi)暴露對(duì)兒童肥胖的影響及作用機(jī)理，2014.01-2017.12,，結(jié)題,，項(xiàng)目負(fù)責(zé)人。
9. 國(guó)家自然科學(xué)基金青年項(xiàng)目,，兒童肥胖的生命早期危險(xiǎn)因素及生物標(biāo)記物研究,，2012.01-2014.12，結(jié)題,，項(xiàng)目負(fù)責(zé)人,。
10. 蓋茨基金會(huì)（Gates Foundation）,，Grant Challenges Conference HBGDki，A consortium project on child growth in China,，結(jié)題,，課題負(fù)責(zé)人。
11. 2012年上海市浦江人才計(jì)劃,，已結(jié)題,。
12. 上海交通大學(xué)國(guó)際合作與交流處引智項(xiàng)目，預(yù)防兒童肥胖的營(yíng)養(yǎng)干預(yù)隊(duì)列研究, 邀請(qǐng)專家-Lise Dubois（渥太華大學(xué)教授）, 2016.1-2016.12和2017.1-2017.12,，課題負(fù)責(zé)人,。
13. 上海交通大學(xué)醫(yī)學(xué)院附屬新華醫(yī)院“優(yōu)青后人才計(jì)劃”，2012.07-2015.06,。
主要研究成果
1. Yang M-N#, Huang R#, Liu X, ..., Ouyang F* and Luo Z-C*.Fibroblast Growth Factor 19 in Gestational Diabetes Mellitus and Fetal Growth.Front Endocrinol. 2022; 12:805722.
2. Fan P, Chen Y, Luo Z-C, ..., Ouyang F*. Cord blood thyroid hormones and neurodevelopment in 2-year-old boys and girls. Frontiers in Nutrition, section Nutritional Epidemiology. 2021; 8:773965.
3. Ma R, Tang N, Feng L, ..., Ouyang F*. Effects of Triclosan exposure on placental extravillous trophoblast motility, relevant IGF2/H19 signaling and DNA methylation-related enzymes of HTR-8/SVneo cells. Ecotoxicology and Environmental Safety. 2021; 228:113051.
4. Tang N#, Fan P#, Yu X, ..., Ouyang F*. Effects of Long-Term Triclosan Exposure on Microbiota in Zebrafish. Front Microbiol. 2021; 12:604313.
5. Ouyang F*, Zhang GH, Du K, Shen L, Ma R, Wang X, Wang X, Zhang J. Maternal prenatal urinary bisphenol A level and child cardio-metabolic risk factors: A prospective cohort study. Environ Pollut. 2020; 265:115008.
6. Ouyang F*, Tang N, Zhang HJ, Wang X, Zhao S, Wang W, Zhang J, Cheng W. Maternal urinary triclosan level, gestational diabetes mellitus and birth weight in Chinese women. Sci Total Environ. 2018; 626:451-457.
7. Wang X, Ouyang F*(corresponding author), Feng L, Wang X, Liu Z, Zhang J. Maternal urinary triclosan concentration in relation to maternal and neonatal thyroid hormone levels: a prospective study. Environmental Health Perspectives. 2017; 125 (6): 067017.
8. S Rothenberg, S Korrick, J Liu, ..., F Ouyang. Maternal methylmercury exposure through rice ingestion and child neurodevelopment in the first three years: a prospective cohort study in rural China. Environ Health. 2021; 20:50.
9. N Tang, Z-C Luo, L Zhang, ..., F Ouyang*. The Association between Gestational Diabetes and Microbiota in Placenta and Cord Blood. Frontiers in Endocrinology, section Clinical Diabetes. 2020; 11:550319.
10. Wang W-J#, Wang S#, Yang M-N#, Dong Y#, He H#, ..., Ouyang F* and Luo Z-C*. Fetuin-A in Infants Born Small- or Large-for-Gestational-Age. Front. Endocrinol. 2020; 11:567955.
11. Wang X, Tang N, Nakayama SF, ..., Ouyang F*. Maternal urinary bisphenol A concentration and thyroid hormone levels of Chinese mothers and newborns by maternal body mass index. Environ Sci Pollut Res Int. 2020; 27:10939-10949.
12. Fan P, Luo ZC, Tang N, ..., Ouyang F*. Advanced Maternal Age, Mode of Delivery, and Thyroid Hormone Levels in Chinese Newborns. Front Endocrinol (Lausanne). 2020; 10:913.
13. Wang WJ#, Zhang L#, Zheng T, ..., Ouyang F*, Luo ZC* . Fetuin-A and fetal growth in gestational diabetes mellitus. BMJ Open Diab Res Care 2020; 8:e000864.
14. 歐陽(yáng)鳳秀*, 熱伊萊·塔伊爾, 范翩翩, 陳 磊, 張 軍, 王偉業(yè). REDCap在母嬰干預(yù)隊(duì)列數(shù)據(jù)采集及管理中的應(yīng)用. 上海交通大學(xué)學(xué)報(bào)（醫(yī)學(xué)版）2020; 40 (9):1309-14.
15. Wang WJ#, Zhang L#, Zhang DL, ..., Ouyang F*, Luo ZC*, Shanghai Birth Cohort Study. Exploring Fetal Sex Dimorphism in the Risk Factors of Gestational Diabetes Mellitus-A Prospective Cohort Study. Front Endocrinol (Lausanne). 2019; 10:848.
16. Wang XR#, Wang WJ#, Yu X, Hua X, Ouyang F*, Luo ZC*. Insulin-Like Growth Factor Axis Biomarkers and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2019; 10:444.
17. Aimuzi R#, Luo K#, Chen Q, ..., Ouyang F*, Zhang J*. Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery. Environ Int. 2019; 130:104929.
18. Zhang Q, Chen H, Wang Y, ..., Ouyang F, Huang H, Liu Z. Severe vitamin D deficiency in the first trimester is associated with placental inflammation in high-risk singleton pregnancy. Clin Nutr. 2019; 38(4):1921-1926.
19. Zhu W, Zhou W, Huo X, ..., Ouyang F, Wang W, Tian Y, Zhang J, Shanghai Birth Cohort Study. Triclosan and Female Reproductive Health: A Preconceptional Cohort Study. Epidemiology. 2019; 30 Suppl 1:S24-S31.
20. Liao XP, Yu Y, Marc I, ..., Ouyang F, Huang HF, Fraser WD. Prenatal determinants of childhood obesity: a review of risk factors. Can J Physiol Pharmacol. 2019; 97(3):147-154.
21. Zhang J, Tian Y, Wang W, Ouyang F, ..., Shanghai Birth Cohort. Cohort profile: the Shanghai Birth Cohort. Int J Epidemiol. 2019; 48(1):21-21g.
22. Zhang Y#, Ji L#, Hu Y, ..., Ouyang F, Zhang J, Gao Y*, Tian Y*, Shanghai Birth Cohort Study. Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women. Am J Epidemiol. 2020; 189(5):375-383.
23. 唐寧, 歐陽(yáng)鳳秀（通訊作者）. 生命早期環(huán)境內(nèi)分泌干擾物暴露與兒童過(guò)敏性疾病關(guān)系的研究進(jìn)展. 上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版) 2019, 第39卷第9期:1100-1106.
24. Ouyang F*, Jiang F, Tao F, ..., Zhang J*. Growth patterns from birth to 24 months in Chinese children: a birth cohorts study across China. BMC Pediatr. 2018; 18(1):344.
25. Wang H, Yu X, Huang L, Chen Q, Ouyang F, Wang X, Zhang J. Fetal vitamin D concentration and growth, adiposity and neurodevelopment during infancy. Eur J Clin Nutr. 2018; 72(10):1396-1403.
26. Shi L, Jiang F, Ouyang F, Zhang J, Wang Z, Shen X. DNA methylation markers in combination with skeletal and dental ages to improve age estimation in children. Forensic Sci Int Genet. 2018; 33:1-9.
27. Shi L, Jiang F, Ouyang F, Zhang J, Shen X. Using physical examinations to estimate age in elementary school children: A Chinese population-based study. J Sport Health Sci. 2017; 6(3):352-358.
28. Wang Xu, Gao X, Yang Q, Wang Xia, Li S, Jiang F, Zhang J, Ouyang F (corresponding author). Sleep Disorders and Allergic Diseases in Chinese Toddlers. Sleep Medicine. 2017; 37: 174-179.
29. Wang X*, Wang X, Chen Q, ..., Ouyang F*. Urinary bisphenol A concentration and gestational diabetes mellitus in Chinese women. Epidemiology2017, Suppl 2017; Suppl 1:S41-S47.
30. 唐寧, 王霞, 王旭, 趙莎莎, 余曉剛, 歐陽(yáng)鳳秀*. 孕婦尿酚類環(huán)境內(nèi)分泌干擾物濃度檢測(cè)的尿樣收集方法比較. 上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版) 2017(06):816-21.
31. 歐陽(yáng)鳳秀, 王旭. 生命早期腸道菌群的影響因素與兒童肥胖. 上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版) 2016(09):1378-82.
32. Ouyang F, Parker MG, Luo ZC, Wang X, Zhang HJ, Jiang F, Wang X, Gillman MW, Zhang J. Maternal BMI, Gestational Diabetes and Weight Gain in Relation to Childhood Obesity: The Mediation Effect of Placental Weight. Obesity.2016; 24(4): 938-46.
33. Ouyang F, Longnecker MP, Venners SA, Johnson S, Korrick S, Zhang J, Xu X, Christian P, Wang MC, Wang X. Preconception serum 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane and B-vitamin status: independent and joint effects on women's reproductive outcomes. The American Journal of Clinical Nutrition. 2014; 100(6):1470-8.
34. Ouyang F, Zhang J, Betran Lazaga AP, Yang Z, Souza JP, Merialdi M. Recurrence of Adverse Perinatal Outcomes in Developing Countries. Bulletin of the World Health Organization 2013; 91:357-367
35. Ouyang F, Parker M, Cerda S, Pearson C, Fu L, Gillman MW, Zuckerman B, Wang X. Placental Weight Mediates the Effects of Prenatal Factors on Fetal Growth: the Extent Differs by Preterm Status. Obesity. 2013; 21:609-620.
36. Ouyang F, Christoffel KK, Brickman WJ, Zimmerman D, Wang B, Xing H, Zhang S, Arguelles LM, Wang G, Liu R, Xu X, Wang X. Adiposity is inversely related to insulin sensitivity in relatively lean Chinese adolescents: A population based twin study. American Journal of Clinical Nutrition. 2010; 91(3):662-71.
37. Ouyang F, Kumar R, Pongracic J, Story R, Liu X, Wang B, Xing H, Liu X, Li Z, Zhang W, Fang Y, Zhang S, Xu X, Wang X. Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women. Journal of Allergy and Clinical Immunology. 2009; 123 (4): 940-8.
38. Ouyang F, Lu B, Wang B, Yang J, Li Z, Wang L, Tang G, Xing H, Xu X, Chervin R, Zee P, Wang X. Sleep patterns among Rural Chinese Twin Adolescents. Sleep Medicine. 2009; 10 (4): 479-89.
39. Ouyang F, Necheles J, Wang B, Ma W, Li Z, Liu X, Tang G, Xing H, Xu X, Venners S, Brickman W, Christoffel KK, Zimmerman D, Wang X. Association of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women. European Journal of Nutrition. 2009; 48 (6): 323-32.
40. Ouyang F, Wang X, Arguelles L, Rosul L, Venners S, Chen C, Hsu Y, Terwedow H, Wu D, Tang G, Yang J, Xing H, Zang T, Wang B, Xu X. Menstrual cycle lengths and bone mineral density: a cross-sectional, population-based study in rural Chinese women ages 30-49 years. Osteoporosis International. 2007;18(2):221-233.
41. Perry MJ, Ouyang F, Korrick S, Venners SA, Chen C, Xu X, Lasley BL, Wang X. A prospective study of serum DDT and progesterone and estrogen levels across the menstrual cycle in nulliparous women of reproductive age. American Journal of Epidemiology. 2006; 164(11):1056-1064.
42. Perry M, Ouyang F, Korrick S, Venners S, Altshul L, Xu X, Wang X. Body Mass Index and Serum 1,1,1-Trichloro-2,2-Bis(p-Chlorophenyl)Ethane in Nulliparous Chinese Women. Cancer Epidemiology, Biomarkers and Prevention. 2005; 14(10):2433–8.
43. Ouyang F, Perry M, Venners S, Chen C, Wang B, Yang F, Fang Z, Zang T, Wang L, Xu X, Wang X. Serum DDT, Age at Menarche, and Abnormal Menstrual Cycle Length. Occupational and Environmental Medicine. 2005; 62:878-884.
