個人簡介
顏崇淮,博士生導師,二級教授,上海交通大學醫(yī)學院附屬新華醫(yī)院研究員,,博士研究生導師,,享受國務院政府特殊津貼專家,。目前擔任教育部和上海市環(huán)境與兒童健康重點實驗室副主任,。兼任上海市微量元素學會理事長,;中華醫(yī)學會公共衛(wèi)生分會常務委員,,臨床與預防學組組長,;中華預防醫(yī)學會兒童保健分會常務委員兼秘書長,環(huán)境與兒童健康學組組長,;中國毒理學會神經(jīng)毒理分會副主任委員,;中國醫(yī)師學會兒童健康專委會委員。顏崇淮教授長期從事兒童營養(yǎng),、兒童重金屬中毒防治等兒童保健臨床,、科研及教學工作,先后主持國家自然科學基金,、973課題,、省部級課題20多項,發(fā)表學術論文200余篇,,主編參編專著10余部,,先后三次榮獲國家科技進步二等獎。
社會任職/學術頭銜
上海市微量元素學會理事長
中華醫(yī)學會公共衛(wèi)生分會常務委員
中華預防醫(yī)學會環(huán)境衛(wèi)生分會常務委員
中華預防醫(yī)學會兒童保健分會常務委員,、秘書長
中國毒理學會神經(jīng)毒理專業(yè)委員會副主任委員
中國醫(yī)師協(xié)會兒童健康專委會常務委員
上海市預防醫(yī)學會婦幼健康專委會副主任委員
世界華人兒科協(xié)會兒童健康專家委員會副主任委員
中華預防醫(yī)學會兒童保健分會環(huán)境與兒童健康學組組長
中華醫(yī)學會公共衛(wèi)生分會臨床與預防學組組長
承擔教學工作介紹
長期承擔臨床醫(yī)學,、預防醫(yī)學本科生及研究生的環(huán)境污染與兒童健康等課程的教學工作。
主要研究方向
1. 環(huán)境化學污染物復合暴露與基因交互作用研究:環(huán)境重金屬及有機污染物復合暴露情況下的神經(jīng)發(fā)育毒性機理,及環(huán)境與基因交互作用機理研究,。
2. 環(huán)境重金屬污染物神經(jīng)發(fā)育毒性機理研究:開展鉛,、甲基汞、錳,、砷等重金屬的神經(jīng)發(fā)育毒性及機制進行在體或體外研究,,并探討可能的預防措施。
3. 兒童食品重金屬污染與安全評估:研究兒童食品中重金屬污染現(xiàn)況,,開展安全風險評估,。
主要研究課題
1. 國家自然科學基金面上項目,2020-01-2023-12,,課題負責人,,膽固醇對生命早期大鼠鉛暴露所致學習記憶損傷的保護機制,81973062,。
2. 十三五國家重點研發(fā)計劃《食品安全關鍵技術研發(fā)》重點專項,,2018-01-2021-12,子課題負責人,,外暴露解析與中國總膳食研究,,2017YFC1600501。
3. 上海市教育委員會,,2016-07-2018-06,課題負責人,,大氣污染情況下空氣凈化器對不同教室條件的室內(nèi)空氣質(zhì)量干預效果研究,,HJTY-2016-A01。
4. 國家自然科學基金面上項目,,2015-01-2018-12,,課題負責人,DHA對發(fā)育期甲基汞暴露所致大腦皮層神經(jīng)細胞遷移障礙的影響,,81472993,。
5. 環(huán)保公益性項目,2013-01-2015-12,,課題負責人,,基于健康風險評價環(huán)境空氣鉛質(zhì)量標準限值制定方法研究,201309048,。
6. 科技部973課題,,2012-01-2016-12,課題負責人,,環(huán)境鉛污染影響我國兒童腦功能的狀況與科學評估,,2012CB525001。
7. 衛(wèi)生部行業(yè)公益性項目,2011-01-2013-12,,課題負責人,,兒童鉛中毒篩查方法和診斷標準研究,201002001,。
8. 衛(wèi)生部行業(yè)公益性項目,,2011-01-2013-12,課題負責人,,兒童鉛暴露篩查適宜技術農(nóng)村地區(qū)推廣應用研究,,201002006。
9. 上海市科委,,2009-07-2011-06,,課題負責人,我國城市胎兒期環(huán)境重金屬污染物暴露現(xiàn)狀調(diào)查及生物樣本庫建立,,09dz2200900,。
10. 神經(jīng)科學國家重點實驗室開放課題,2009-01-2010-12,,課題負責人,,低水平甲基汞暴露對大鼠大腦皮層發(fā)育的影響及機制研究,SKLN-2008B04,。
11. 國家自然科學基金委,,2008-01-2010-12,課題負責人,,青少年網(wǎng)絡成癮的神經(jīng)生物學機制探討,,30771814。
12. 國家自然科學基金委,,2001-01-2003-02,,課題負責人,鉛對發(fā)育腦海馬mGluRs及細胞信號傳遞機制影響的研究,,30070665,。
13. 國家自然科學基金委,1998-01-1999-12,,課題負責人,,鉛對幼年大鼠海馬G-蛋白mRNA表達影響的研究,39700121,。
近五年主要研究成果
1. Richard Fuller, Philip J Landrigan, Kalpana Balakrishnan, Glynda Bathan, Stephan Bose-O’Reilly, Michael Brauer, Jack Caravanos, Tom Chiles, Aaron Cohen, Lilian Corra, Maureen Cropper, Greg Ferraro, Jill Hanna, David Hanrahan, Howard Hu, David Hunter, Gloria Janata, Rachael Kupka, Bruce Lanphear, Maureen Lichtveld, Keith Martin, Adetoun Mustapha, Ernesto Sanchez-Triana, Karti Sandilya, Laura Schaefli, Joseph Shaw, Jessica Seddon, William Suk, Martha María Téllez-Rojo, Chonghuai Yan. Pollution and health: a progress update - The Lancet Planetary Health. https://doi.org/10.1016/S2542-5196(22)00090-0.
2. Wang Y, Wang Y, Yan C. Gender differences in trace element exposures with cognitive abilities of school-aged children: a cohort study in Wujiang city, China. Environ Sci Pollut Res Int. 2022 Apr 27. doi: 10.1007/s11356-022-20353-4.
3. Wang Y, Wang S, Wang Y, Lu A, Cao L, Wang J, Gao Z, Yan C. Effects of prenatal exposure to arsenic on neonatal birth size in Wujiang, China. Chemosphere. 2022 Mar 28;299:134441. doi: 10.1016/j.chemosphere.2022.134441.
4. Dong C, Liu J, Harvey P, Yan C. Characteristics and sources of Pb exposure via household dust from the urban area of Shanghai, China. Sci Total Environ. 2022 Mar 10;811:151984. doi: 10.1016/j.scitotenv.2021.151984.
5. Wang S, Hu C, Lu A, Wang Y, Cao L, Wu W, Li H, Wu M, Yan C. Association between prenatal exposure to persistent organic pollutants and neurodevelopment in early life: A mother-child cohort (Shanghai, China). Ecotoxicol Environ Saf. 2021 Jan 15;208:111479.
6. Zhang H, Wang S, Wang Y, Lu A, Hu C, Yan C. DHA ameliorates MeHg?induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway. Mol Med Rep. 2021 Aug;24(2):558.
7. Wang J, Cao LL, Gao ZY, Zhang H, Liu JX, Wang SS, Pan H, Yan CH. Relationship between thyroid hormone parameters and exposure to a mixture of organochlorine pesticides, mercury and nutrients in the cord blood of newborns. Environ Pollut. 2022 Jan 1;292(Pt A):118362.
8. Wu M, Wu D, Hu C, Yan C. How to Make a Cost Model for the Birth Cohort Biobank in China. Front Public Health. 2020 Feb 21;8:24.
9. Zhou CC, He YQ, Gao ZY, Wu MQ, Yan CH. Sex differences in the effects of lead exposure on growth and development in young children. Chemosphere. 2020 Jul;250:126294.
10. Wu M, Wang Y, Yan C, Zhao Y. Study on subclinical hypothyroidism in pregnancy: a bibliometric analysis via CiteSpace. J Matern Fetal Neonatal Med. 2022 Feb;35(3):556-567.
11. Li MM, Gao ZY, Dong CY, Wu MQ, Yan J, Cao J, Ma WJ, Wang J, Gong YL, Xu J, Cai SZ, Chen JY, Xu SQ, Tong S, Tang D, Zhang J, Yan CH. Contemporary blood lead levels of children aged 0-84?months in China: A national cross-sectional study. Environ Int. 2020 Jan;134:105288.
12. Wu MQ, Liu J, Wang YQ, Yang Y, Yan CH, Hua J. The Impact of Subclinical Hypothyroidism on Adverse Perinatal Outcomes and the Role of Thyroid Screening in Pregnancy. Front Endocrinol (Lausanne). 2019 Aug 6;10:522.
13. Wang J, Wu W, Li H, Cao L, Wu M, Liu J, Gao Z, Zhou C, Liu J, Yan C. Relation of prenatal low-level mercury exposure with early child neurobehavioral development and exploration of the effects of sex and DHA on it. Environ Int. 2019 May;126:14-23.
14. Wang J, El-Fahmawi A, Yan C, Liu J. Childhood lead poisoning from domestic products in China: A case study with implications for practice, education, and policy. Public Health Nurs. 2019 Nov;36(6):806-812.
15. Zhou CC, Gao ZY, He YQ, Wu MQ, Chen F, Wang J, Liu JX, Yan CH. Effects of lead, mercury, aluminium and manganese co-exposure on the serum BDNF concentration of pre-school children in Taizhou, China. Chemosphere. 2019 Feb;217:158-165.
16. Wu MQ, Wu DQ, Yang Y, Zhou CC, Yan CH. Impact of delivery mode on the levels of essential trace elements in breast milk. J Matern Fetal Neonatal Med. 2020 Oct;33(19):3293-3299. doi: 10.1080/14767058.2019.1571035. Epub 2019 Jan 31. PMID: 30646783.
17. Zhou CC, Gao ZY, Wang J, Wu MQ, Hu S, Chen F, Liu JX, Pan H, Yan CH. Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain. Toxicol Lett. 2018 Oct 15;296:173-183.
18. Gao ZY, Li MM, Wang J, Yan J, Zhou CC, Yan CH. Blood mercury concentration, fish consumption and anthropometry in Chinese children: A national study. Environ Int. 2018 Jan;110:14-21.
19. Chen F, Zhou CC, Yang Y, Liu JW, Yan CH. GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. Biol Trace Elem Res. 2019 Aug;190(2):425-436.
20. Ying XL, Gao ZY, Yan J, Zhang M, Wang J, Xu J, Markowitz M, Yan CH. Sources, symptoms and characteristics of childhood lead poisoning: experience from a lead specialty clinic in China. Clin Toxicol (Phila). 2018 Jun;56(6):397-403. doi: 10.1080/15563650.2017.1391392. Epub 2017 Oct 27. PMID: 29078718.
21. Ying XL, Markowitz M, Yan CH. Folk prescription for treating rhinitis as a rare cause of childhood lead poisoning: a case series. BMC Pediatr. 2018 Jul 6;18(1):219.
22. Yan J, Gao Z, Wang J, Ma W, Ying X, Zhou C, Yan C. Family environmental and dietary implications for low-level prenatal lead exposure in Wujiang City, China. Environ Sci Pollut Res Int. 2018 May;25(13):12780-12787.
獲得榮譽稱號
2001年榮獲上海市衛(wèi)生系統(tǒng)第八屆“銀蛇獎”,;
2001年被上海市衛(wèi)生局評為上海市衛(wèi)生系統(tǒng)優(yōu)秀工作者;
2003年榮獲中科院上海分院明治乳業(yè)生命科學獎,;
2004年國務院政府特殊津貼專家,;
2004年獲第五期“上海市引進海外高層次留學人員專項資金”資助,;
2007年獲得上海市白玉蘭科技人才基金資助;
2019年第三屆國之名醫(yī)盛典,,優(yōu)秀風范獎,;
2019年國慶榮獲中國中央國務院中央軍委頒發(fā)的70周年國慶紀念章。