上海交通大學(xué)公共衛(wèi)生學(xué)院婦女兒童健康系副教授,，碩導(dǎo),。臨床醫(yī)學(xué)專業(yè)和流行病與生物統(tǒng)計(jì)學(xué)背景，從事工作涉及腫瘤,、心腦血管疾病,、代謝性疾病,、藥物流行病、營(yíng)養(yǎng)及運(yùn)動(dòng)干預(yù),、婦產(chǎn)科等方面的流行病學(xué)研究,。上海交通大學(xué)醫(yī)學(xué)院“九龍醫(yī)學(xué)優(yōu)秀青年人才提名獎(jiǎng)”，上海市教委“優(yōu)秀青年教師”資助培養(yǎng),，上海交通大學(xué)SMC-晨星優(yōu)秀青年教師,，上海交通大學(xué)醫(yī)學(xué)院“優(yōu)秀青年教師”資助培養(yǎng)。近五年,，以第一/共一作者或通訊作者在Nature Communcations,、Cell Reports、Diabetes等發(fā)表SCI論文8篇,，累積影響因子分50分,。
承擔(dān)教學(xué)工作介紹
流行病學(xué)與生物統(tǒng)計(jì)學(xué)團(tuán)隊(duì)教學(xué)首席，承擔(dān)本科生和研究生流行病學(xué),、營(yíng)養(yǎng)流行病學(xué),、醫(yī)學(xué)統(tǒng)計(jì)學(xué)、衛(wèi)生統(tǒng)計(jì)學(xué),、科研設(shè)計(jì)與統(tǒng)計(jì)分析等課程主講
主要研究方向
1. 腫瘤流行病學(xué),；
2. 心血管疾病流行病學(xué)；
3. 婦產(chǎn)科流行病學(xué),；
4. 行為干預(yù),。
主要研究課題
1.國(guó)家自然科學(xué)基金青年項(xiàng)目,，81301689，糖尿病AGE/AGER信號(hào)通路調(diào)控YAP活性與 肝癌發(fā)生的機(jī)制及流行病學(xué)研究,，2014/01-2016/12,，23萬(wàn)，結(jié)題,，主持,；
2.國(guó)家自然科學(xué)基金面上項(xiàng)目，81872288,，豆蔻?；俑伟┑姆肿訖C(jī)制研究，2019/1-2022/12,，57萬(wàn),，在研，主持,。
主要研究成果
1,、Jiayi Wang, Lifang Ma, Yue Zhang,Yongxia Qiao, Wenhao Weng, Jiangtu He, Qiuhui Pan, Yongchun Yu, Fenyong Sun. (2013). Mutual interaction between YAP and CREB promotes tumorigensis in liver cancer. Hepatology 58: 1011-1020 (IF: 11.665).
2、Jiayi Wang, Yue Zhang, Wenhao Weng,Yongxia Qiao, Lifang Ma, Weifan Xiao, Yongchun Yu, Qiuhui Pan*and Fenyong Sun*. Impaired phosphorylation and ubiquitination by P70 S6 kinase (P70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promotes Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer. (2013).J. Biol Chem.288: 33667-33681.
3,、Jiayi Wang, Hongmei Wang, Yue Zhang, Ni Zhen, Li Zhang,Yongxia Qiao, WenhaoWeng, Xiangfan Liu, Lifang Ma, Weifan Xiao, Wenjun Yu, Qinghua Chu, Qiuhui Pan, Fenyong Sun*. Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1 induced tumorigenesis in liver cancer. (2014).Cell signal.26: 1048-1059.
4,、Yongxia Qiao, Yue Zhang*, Jiayi Wang*.Ubiquitin E3 ligase SCFβ-TRCPregulates TRIB2 stability in liver cancer cells. (2013).Biochem. Biophy. Res. Commun.441: 555-559. (第一作者)
5、Lanlan Li, Jiayi Wang*, Yue Zhang, Yan Zhang, Lifang Ma, Wenhao Weng,Yongxia Qiao, Weifan Xiao, Hongmei Wang, Wenjun Yu, Qiuhui Pan, Yunyan He, Fenyong Sun*. MEK1 promotes YAP and their interaction is critical for tumorigensis in liver cancer. (2013).FEBS Lett.587：3921-3927.
6,、Qiao Y, Tinker L, Olendzki B, Hébert JR, Balasubramanian R, Rosal MC, Hingle M, Song Y, Schneider KL, Liu S, Sims S, Ockene JK, Sepavich DM, Shikany JM, Persuitte G, and Ma Y*. Racial/Ethnic disparities in association between dietary quality and incident diabetes in postmenopausal women in the United States: The Women’s Health Initiative 1993- 2005. Ethnicity and Health.2014 Jun;19(3):328-47.(IF:1.2)
7,、Yu W,Qiao Y, Tang X, Ma L, Wang Y, Zhang X, Weng W, Pan Q, Yu Y, Sun F, Wang J. Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. Cell Signal.2014 Sep 28;26(12):2961-2968（共同第一作者4.471）
8,、Wenjun Yu, Jiayi Wang, Lifang Ma, Xun Tang,Yongxia Qiao, Quihui Pan, Yongchun Yu*, Fenyong Sun*. CD166 plays a pro-carcinogenic role in liver cancer cells via inhibition to FOXO proteins through AKT. (2014).Onco Rep.32: 677-683.
9,、Wenjun Yu#,Yongxia Qiao#, Xun Tang, LifangMa, Yulan Wang, Xiao Zhang, Wenhao Weng ,Qiuhui Pan, Yongchun Yu, Fenyong Sun*, Jiayi Wang*. Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. (2014).Cell Signal.26: 2961–2968. (#，共同第一作者)
10,、Shanshan Xu, Minghong Tong, Jingqin Huang, Yue Zhang,Yongxia Qiao, Wenhao Weng, Weiwei Liu, Jiayi Wang*, Fenyong Sun*. TRIB2 inhibits Wnt/b-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, b-TrCP, COP1 and Smurf1, in liver cancer cells. (2014).FEBS Lett.588: 4334-4341.
11,、Lifang Ma, Jiafei Lin,Yongxia Qiao, Wenhao Weng, Weiwei Liu, Jiayi Wang*, Fenyong Sun*. Serum CD166: A novel hepatocellular carcinoma tumor marker. (2015).Clin Chim Acta.441: 156-162.
12、Jiayi Wang, Xun Tang, Wenhao Weng,Yongxia Qiao, Jiafei Lin, Weiwei Liu, Rui Liu, Lifang Ma, Wenjun Yu, Yongchun Yu, Qiuhui Pan*, Fenyong Sun*. The membrane protein Melanoma Cell Adhesion Molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. (2015).Oncogene.34: 5781-5795.
13,、Xun Tang, Xianzhen Chen, Yanfeng Xu,Yongxia Qiao, Xiao Zhang, Yulan Wang, Yu Guan, Fenyong Sun*, Jiayi Wang*. CD166 positively regulates MCAM via inhibition to Ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. (2015).Cell Signal.27: 1694-1702.
14,、Jiayi Wang*, Lifang Ma, Xun Tang, Xiao Zhang,Yongxia Qiao, Yulin Shi, Yanfeng Xu, Zhongyong Wang, Yongchun Yu, Fenyong Sun*. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. (2015)Oncotarget. 6: 24075-24091.
15、Yongxia Qiao#, Xiao Zhang#, Yue Zhang#, Yulan Wang, Yanfeng Xu, Xiangfan Liu, Fenyong Sun*, Jiayi Wang*. High glucose stimulates tumorigenesis in hepatocellular carcinoma (HCC) cells through AGER-dependent O-GlcNAcylation of c-Jun. (2016).Diabetes. 65:619-632. (#,，共同第一作者8.684)
16,、Yulan Wang, Ran Cui, Xiao Zhang,Yongxia Qiao, Xiangfan Liu, Yefei Chang, Yongchun Yu, Fenyong Sun, Jiayi Wang. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma.Oncotarget.2016，7 (10) :11284-11298
17,、Yongxia Qiao#, Yunxia Qian,#Jiayi Wang,et.al. MCAM stimulates YAP transcription through enhancing CREB activity by c-Jun/c-Fos in hepatocellular carcinoma cells.Oncology letters. 11:3702-3708, 2016（#,，共同第一作者IF：1.482）
18、Zhang X#, Sun F#,Qiao Y#, Zheng W, Liu Y, Chen Y, Wu Q, Liu X, Zhu G, Chen Y, Yu Y, Pan Q*, Wang J*.TFCP2 is required for YAP-dependent transcription to stimulate liver malignancy, Cell Reports, 2017, 21(5): 1227~1239(共同第一作者,，IF:8.282)
19,、Zhang X(#),Qiao Y(#), Wu Q, Chen Y, Zou S, Liu X, Zhu G, Zhao Y, Chen Y, Yu Y, Pan Q, Wang J(*), Sun F(*). The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis. Nature Communcations. 2017 May 5;8:15280.(共同第一作者，IF:12.124)
20、Chen Y, Liu R, Chu Z, Le B, Zeng H, Zhang X, Wu Q, Zhu G, Chen Y, Liu Y, Sun F, Lu Z,Qiao Y*, Wang J*. High glucose stimulates proliferative capacity of liver cancer cells possibly via O-GlcNAcylation-dependent transcriptional regulation of GJC1. J Cell Physiol. 2019Jan;234(1):606-618.(共同通訊作者,，IF:3.923)
21,、Xiao Zhang#, Lutao Du#,Yongxia Qiao#, Xiaobai Zhang#, Weisheng Zheng#, Qi Wu, Yan Chen, Guoqing Zhu, Ya Liu, Zhixuan Bian, Susu Guo, Yueyue Yang, Lifang Ma, Yongchun Yu, Qiuhui Pan*, Fenyong Sun*, Jiayi Wang*. Ferroptosis is governed by differential regulation of transcription in liver cancer. Redox Biol. 2019Jun;24:101211.(共同第一作者，IF=7.79)
獲得榮譽(yù)稱號(hào)
1.2013.9上海交通大學(xué)醫(yī)學(xué)院 優(yōu)秀青年教師培養(yǎng)
2.2014.9上海交通大學(xué)醫(yī)學(xué)院 九龍醫(yī)學(xué)優(yōu)秀青年人才提名獎(jiǎng)
3.2016.3上海交通大學(xué)醫(yī)學(xué)院 優(yōu)秀夜大學(xué)教師
4.2016年10月 上海交通大學(xué) SMC-晨星優(yōu)秀青年教師（C類）
