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Lab Leader: Bing Li

Lab Name: Laboratory of Cancer Epigenetics

Lab Info：Our group has long been committed to the basic research of chromatin biology and gene expression regulation. In recent years, we have focused on both the basic and translational research of cancer epigenetics, as well as the exploration of the molecular mechanism of early embryonic development regulation. Specific research directions include: (1) Structural and functional studies of epigenetic regulators and development of next-generation anti-cancer drugs: We will explore the high-order assembly of transcription machinery and their spatial-temporal regulation in the three dimensional chromosomal environment; we will leverage our mechanistic understanding of regulatory specificity of multi-subunit epigenetic complexes to develop new drug targets and therapeutic strategies; (2) We will explore the molecular mechanisms of epigenetic reprogramming in physiological processes including acquired trait inheritance, stem cell lineage differentiation, T cell activation and sperm development etc., and develop clinical applications to relevant diseases.

Lab Members: