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Lab Leader: Dengli Hong

Lab Name: Laboratory of Medical Stem Cell Research (Lab-MSCR)

Lab Info：Laboratory of Medical Stem Cell Research (Lab-MSCR) was established in 2009. The head of Lab-MSCR is Dengli Hong, PI & Distinguished Professor. Lab-MSCR has undertaken the State Key Program of National Natural Science Foundation of China, the Projects of International Cooperation and Exchanges NSFC, the Key Project of Chinese National Programs for Fundamental Research and Development (973 Program). Main research directions: 1. Initiation and evolution of leukemic stem cells and their niches. 2. Function and genome instability of hematopoietic stem cell in physiological and abnormal niches. The members of LAB-MSCR have published in Science, Cancer Cell, Blood and Leukemia. First identification of pre-leukemia stem cells (Hong D, et al. Science 2008), demonstrating the origin of childhood leukemias. The discovery and its scientific significance were reported by other journals such as Nature. Recently, we found that leukemia-propagating cells (LPCs) build a protective niche in the BM to evade therapy (Duan C, et al. Cancer Cell 2014). The niche is called therapy-induced niche (TI-niche). Nature, Cancer Discovery and other journals published special report. This achievement won the first prize of Shanghai Natural Science Award 2017.

Lab Members: