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Lab Leader: Bin Li

Lab Name: Laboratory of Molecular Immunology Laboratory

Lab Info：Research in our laboratory mainly focuses on understanding molecular mechanism underlying the functional stability, plasticity and balance of FOXP3+ Regulatory T cells (Treg) and RORγt+ T helper 17 cells (Th17) in inflammatory diseases, as well as their therapeutically modulation, especially by compounds from Chinese Traditional Medicine. By using and developing Treg specifically depletion of key enzymatic subunits of FOXP3 complex animal models, as well as these state-of-art cutting-edge technologies in single cell sequencing and immune cell metabolism, we are revealing the functional role of peripheral tissue-specific Treg cells in vitro and in vivo in health and disease settings. We expect that our original findings will be translational to biomedical industry and be beneficial to human health.The recent research work of our lab has been accepted and publised in journals such as Nature Metabolism (Accepted), Nature Immunology (2021), Gastroenterology (2021), Jouranl of Immunology (2020), EMBO Reports (2020), Science Bulletin (2020, 2018)

Lab Members: