ZHU Tianwen
Chief of Pediatrics
Email: [email protected]
Research Interests: Congenital inherited metabolic diseases
Educational Background
2003. 09 - 2009. 06, Shanghai Jiao Tong University School of Medicine, PhD in pediatrics
1990. 09 - 1995. 06, Shanghai Second Medical University, M.B. in pediatricse
Professional Experience
2021. 08 - Present, Chief physician, Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
2014. 08 - 2021. 07, Associate chief physician, Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
2002. 08 - 2014. 07, Attending physician, Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
1995. 08 - 2002. 07, Physician, Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Research Projects
Youth Project of National Natural Science Foundation of China, Mechanism of synaptic injury in phenylketonuria mice, Major project participants, 170 thousand, 2017.01 - 2019.12.
Shanghai Municipal Health and Family Planning Commission, Bureau level project, Study on the status of blood carnitine in patients with phenylketonuria and preliminary study on carnitine addition therapy, Major project participants, 30 thousand, 2015.01 - 2017.12.
Shanghai Municipal Education Commission, Provincial and ministerial project, Aberrant histone acetylation impinges synaptic morphology and cognitive function in BTBT-Pahenu2 mice: epigenetic mechanisms of brain injury in PKU, Major project participants, 80 thousand, 2015.01 - 2017.12.
Youth Project of National Natural Science Foundation of China, Role of ubiquitination modification and stability regulation of phenylalanine hydroxylase in tetrahydrobiopterin responsive phenylketonuria, Principle Investigator, 230 thousand, 2013.01 - 2015.12.
Surface Project of Shanghai Public Health Bureau, Functional identification of a novel BH4-reactive PKU mutant protein, Principle Investigator, 30 thousand, 2013.01 - 2015.12.
Publications
Hong Sha, Tianwen Zhu*, Zheng S, Zhan X, Xu F, LiliLiang, Xuefan Gu. Gene expression profiles in the brain of phenylketonuria mouse model reversed by the low phenylalanine diet therapy. Metab Brain Dis. 2021;36(8):2405-2414.
Tianwen Zhu*, Xiaohui Gong, Fei Bei, Li Ma, Jingjing Sun, Jian Wang, Gang Qiu, Jianhua Sun, Yu Sun, Yongjun Zhang. Primary immunodeficiency-related genes in neonatal intensive care unit patients with various genetic immune abnormalities: a multicenter study in China. Clinical & Translational Immunology. 2021;10(3):e1266.
Tianwen Zhu*, Xiaohui Gong, Fei Bei, Li Ma, Yan Chen, Yonghong Zhang, Xia Wang, Jingjing Sun, Jian Wang, Gang Qiu, Jianhua Sun, Yu Sun, Yongjun Zhang. Application of Next-Generation Sequencing for Genetic Diagnosis in Neonatal Intensive Care Units: Results of a Multicenter Study in China. Front Genet. 2020;11:565078.
Qingnv Zhou, Huafei Huang, Li Ma, Tianwen Zhu*. The Application of Next-Generation Sequencing (NGS) in Neonatal-Onset Urea Cycle Disorders (UCDs): Clinical Course, Metabolomic Profiling, and Genetic Findings in Nine Chinese Hyperammonemia Patients. Biomed Res Int. 2020;2020:5690915.
鄭思敏,張永紅,趙冬瑩,譚金童,何振娟,朱天聞*. 新生兒驚厥33例臨床特征及高通量測(cè)序檢測(cè)分析.中華新生兒科雜志, 2020(03):202-206.
Sha Hong; Li Wang; Dongying Zhao; Yonghong Zhang; Yan Chen; Jingtong Tan; Lili Liang; Tianwen Zhu*; Clinical utility in infants with suspected monogenic conditions through next-generation sequencing, Molecular genetics & genomic medicine, 2019;7:e684.
Tianwen Zhu*; Jun Ye; Lianshu Han; Wenjuan Qiu; Huiwen Zhang; Lili Liang; Xuefan Gu; The Predictive Value of Genetic Analyses in the Diagnosis of Tetrahydrobiopterin (BH4)-Responsiveness in Chinese Phenylalanine Hydroxylase Deficiency Patients, Scientific Reports, 2017,7(6762):1-12.
Tianwen Zhu*, Jun Ye, Lianshu Han, Wenjuan Qiu, Huiwen Zhang, LiliLiang, Xuefan Gu. Variations in genotype-phenotype correlations in phenylalanine hydroxylase deficiency in Chinese Han population. Gene. 2013;529:80-7.
