GE Heng
Consultant doctor, Associate professor
Email: [email protected]
Tel: 86 13816991370
Research Fields: clinical and fundamental research on atherosclerosis
Biography
Dr. Ge Heng, graduated from Shanghai Jiao Tong University School of Medicine in 2006 with a medical doctor's degree. Since 2006, he has been working in Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine. Now he is the chief physician of Cardiovascular Medicine, associate professor and master tutor of Shanghai Jiao Tong University School of Medicine. From September 2021, he has been serving as the vice president of the Second People's Hospital of Kashgar, Xinjiang in a 1.5-year project to support Xinjiang district. From September 2010 to September 2011, he was a visiting scholar at the Cardiovascular Center of the University Hospital of Zurich with a scholarship from the Swiss Federal Government. He received training in interventional cardiac surgery and cardiac magnetic resonance examination during the staying. From February to May 2014, he studied transcatheter aortic valve replacement in the Cardiovascular and Pulmonary Hospital of the Second University of Lyon, France. And from May to September, 2018, he made studies about cardiac magnetic resonance imaging in the National Institution of health, USA. He is an interventional cardiologist of coronary heart disease, and structural heart disease as well as critical cardiovascular disease and cardiac magnetic resonance imaging. In research, he has presided over 2 National Natural Science Foundation of China projects and 6 provincial and ministerial level projects. He has published 20 SCI papers as the first and corresponding author, with the highest impact factor of 29. He also published one book. He is the member of several academic organizations such as the International Society of Cardiac Magnetic Resonance, China branch, Shanghai Medical Association, cardiovascular disease branch He is also an invited editorial board member of the Chinese Journal of Medical Imaging and a reviewer of PLOS One. He has won the third prize of the "Teaching and Educating Award" of Shanghai Jiao Tong University, and the "President's Special Award" of Shanghai Jiao Tong University.hysician Award" of the Great Wall International Conference on Cardiology (GW-ICC), the "Young Investigator Award" of the Asia Pacific Association of Echocardiography (AAE), and the second prize of the 3rd Shanghai Ultrasound Skills Competition. He participated in the publication of 21 SCI papers. As a co-author, he won the second prize of the Science and Technology Progress Award from Ministry of Education and the second prize of the Chinese Medical Science and Technology Award.
Publications
葛恒,， 王長謙. 《PPAR配體作用機制及新配體篩選研究進展》中國藥學雜志 2004年39卷3期： 170－172
葛恒,， 王長謙. 《PPAR及其配體藥物在預防冠脈再狹窄中的潛在作用》上海第二醫(yī)科大學學報 2005年25卷1期：82－84
葛恒,， 張俊峰， 王長謙 等. 《白藜蘆醇對PPARγ激動作用的研究》 中國藥學雜志 2005年40卷12期：905－908
葛恒,， 張俊峰， 郭炳詩 等.《胰島素對PPARγ配體結合轉錄活性的影響》 上海第二醫(yī)科大學學報 2005年25卷9期：894－896
葛恒,， 張俊峰,， 王長謙 等.《PPAR γ激動劑篩選模型的建立及其應用》上海交通大學醫(yī)學院學報. 2006年26卷3期：221－224
葛恒， 張清,， 何奔 等. 《雙胞胎同患急性心肌梗死一例》 中華心血管病雜志 2006年34卷2期：177－178
葛恒,， 張俊峰， 郭炳詩 等《白藜蘆醇抑制巨噬細胞細胞外基質金屬蛋白酶誘導物的表達》 藥學學報 2006年41卷7期：625－630
GE H,，Zhang J,，Guo BS, et al. Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma. Vascular Pharmacology 2007,；46(2):114-21
Zhang J，Ge H, Wang C, et al. Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells. International Journal of Cardiology 2007 ;117(3):373-80 (共同第一作者)
Ge H Inhibitory Effects of Resveratrol on CD40 Expression of Macrophages （摘要）The Society for cardiovascular angiography and interventions 2007年會及會刊收錄
王長謙,， 葛恒,， 王彬堯. 《肥厚型心肌病的臨床進展》 新醫(yī)學2004年35卷 9期：573－574
張俊峰，葛恒,，王長謙 等. 《高胰島素狀態(tài)下巨噬細胞PPARγ抗炎活性的變化》 心臟雜志 2006年18卷1期14－17
王彬堯,，葛恒 《冠心病介入治療及循證醫(yī)學評價》 新醫(yī)學2006年37卷6期：410－411
張俊峰，葛恒,，王長謙 等. 《PPARs配體對巨噬,、泡沫細胞細胞外基質金屬蛋白酶誘導因子(EMMPRIN)表達的影響》. 中國病理生理雜志 2006年22卷8期：1519－1523
張俊峰，葛恒,，王長謙 等. 《PPARα配體對泡沫細胞炎性介質分泌的影響》. 心臟雜志 2006年18卷3期：262－264
張俊峰,，葛恒，王長謙 等 《細胞外基質金屬蛋白酶誘導因子在巨噬,、泡沫細胞的表達變化》 上海第二醫(yī)科大學學報,2006年 26卷3期：225－228
張俊峰,，葛恒，王長謙 等. PPARγ配體抑制巨噬/泡沫細胞炎性介質的分泌. 中國動脈硬化雜志. 2006年14卷4期：281－285
張清,，葛恒,，韓志華 等. 《藥物洗脫支架和金屬裸支架治療冠狀動脈小血管病變的療效》 福建醫(yī)科大學學報 2007年41卷3期：231－233
何清，王長謙,，葛恒 等. 《特異性抑制單核細胞中EMMPRIN基因表達的SiRNA的篩選和鑒定》上海交通大學學報 醫(yī)學版2007年27卷6期：681－684
袁偉,，何奔，葛恒,?！都毎饣|金屬蛋白酶誘導因子在動脈粥樣硬化發(fā)展進程中的相關研究進展》 中國動脈硬化雜志 2008年16卷7期 582－584
Jiang M, He B, Zhang Q, Ge H, et al. Randomized controlled trials on the therapeutic effects of adult progenitor cells for myocardial infarction: meta-analysis. Expert Opin Biol Ther. 2010;10(5):667-80.
Zhou L, Shen LH, Hu LH, Ge H, Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages. Mol Cell Biochem. 2010 ;335(1-2):283-9
Ge H，Zhang Q,，Wang BY, He B. Therapeutic effect of statin on aortic stenosis: A review with Meta-analysis. Journal of Clinical Pharmacy and Therapeutics 2010 35,，385-393
Ge H, Zhang Q, He B, et al. Efficacy and safety of drug-eluting stent implantation for the treatment of in-stent restenosis occurring within bare-metal stent and drug-eluting stent. J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010 11(8):553-560
Yuan W, Ge H, He B, et al. Pro-inflammatory activities induced by CyPA–EMMPRIN interaction in monocytes. Atherosclerosis 2010;213(2):415-21 （共同第一作者）
Stähli BE, Bünzli R，Ge H, et al. Transcatheter aortic valve implantation (TAVI) outcome according to standardized endpoint definitions by the valve academic research consortium (VARC). J Invasive Cardiol. 2011 ;23(8):307-12
Zhang TT, Ge H, Zhang JF. Functions of cyclophilin A in atherosclerosis. Exp Clin Cardiol. 2013; 18(2):e118-24
28.Lyu T, Zhao Y, Zhang T, Zhou W, Yang F, Ge H, Ding S, Pu J, He B. Natriuretic peptides as an adjunctive treatment for acute myocardial infarction: insights from the meta-analysis of 1,389 patients from 20 trials. Int Heart J. 2014; 55(1):8-16
Ding S, Xu L, Yang F, Kong L, Zhao Y, Gao L, Wang W, Xu R, Ge H, Jiang M, Pu J, He B, Association between tissue characteristics of coronary plaque and distal embolization after coronary intervention in acute coronary syndrome patients: insights from a meta-analysis of virtual histology-intravascular ultrasound studies. PLoS One. 2014 ;9(11):e106583
Ge H, Yuan w, Ding S, Pu J, He B. Functional relevance of protein glycosylation to the pro-inflammatory effects of Extracellular Matrix Metalloproteinase Inducer（EMMPRIN）on monocytes/macrophages. Plos One 2015 ;10(2):e0117463
Ding S, Zhao H, Qiao ZQ, Yang F, Wang W, Gao LC, Kong LC, Xu RD, Ge H, Shen XD, Pu J, He B. Early resolution of ST-segment elevation after reperfusion therapy for acute myocardial infarction: Its relation to echocardiography-determined left ventricular global and regional function and deformation. J Electrocardiol. 2015 ;48(2):241-8
He B, Ge H, Yang F, Sun Y, Li Z, Jiang M, Fan Y, Pu J, Shen X. A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology. PLoS One. 2015;10(6):e0130158 （共同第一作者）
Ding S, Li Z, Ge H, Qiao ZQ, Chen YL, Andong AL, Yang F, Kong LC, Jiang M, He B, Pu J. Impact of Early ST-Segment Changes on Cardiac Magnetic Resonance-Verified Intramyocardial Haemorrhage and Microvascular Obstruction in ST-Elevation Myocardial Infarction Patients. Medicine (Baltimore). 2015;94(35):e1438
Zheng Y, Sun JP, Shen X, Qiao Z, Ge H, Li Z, He B, Yu CM. Subepicardial Aneurysm That Was Diagnosed by Cardiac Imaging and Underwent Successful Surgery. Circulation. 2015;132(12):e149-51
Ge H, Ding S, An D, Li Z, Ding H, Yang F, Kong L, Xu J, Pu J, He B. Frame counting improves the assessment of post-reperfusion microvascular patency by TIMI myocardial perfusion grade: Evidence from cardiac magnetic resonance imaging. Int J Cardiol. 2016 ;203:360-6
He B, Ding S, Qiao Z, Gao L, Wang W, Ge H, Shen X, Pu J. Influence of microvascular dysfunction on regional myocardial deformation post-acute myocardial infarction: insights from a novel angiographic index for assessing myocardial tissue-level reperfusion. Int J Cardiovasc Imaging. 2016 32(5):711-9
Zhao H, Lee AP, Li Z, Qiao Z, Fan Y, An D, Xu J, Pu J, Shen X, Ge H, He B. Impact of Intramyocardial Hemorrhage and Microvascular Obstruction on Cardiac Mechanics in Reperfusion Injury: A Speckle-Tracking Echocardiographic Study. J Am Soc Echocardiogr. 2016 (10):973-982（共同通訊作者）
Pu J, Ding S, Ge H, Han Y, Guo J, Lin R, Su X, Zhang H, Chen L, He B; EARLY-MYO Investigators. Efficacy and Safety of a Pharmaco-Invasive Strategy With Half-Dose Alteplase Versus Primary Angioplasty in ST-Segment-Elevation Myocardial Infarction: EARLY-MYO Trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment-Elevation Myocardial Infarction). Circulation. 2017;136(16):1462-1473.
Sheng X, Ding S, Ge H, Sun Y, Kong L, He J, Pu J, He B. Intracoronary infusion of alprostadil and nitroglycerin with targeted perfusion microcatheter in STEMI patients with coronary slow flow phenomenon. Int J Cardiol. 2018;265:6-11.
孔令璁;安東敖蕾;葛恒;許建榮;何奔;;使用心臟磁共振復查Watchman左心耳封堵器置入術后患者1例[J];中國介入心臟病學雜志;2018年03期,，179-180頁
Leng S, Ge H, He J, Kong L, Yang Y, Yan F, Xiu J, Shan P, Zhao S, Tan RS, Zhao X, Koh AS, Allen JC, Hausenloy DJ, Mintz GS, Zhong L, Pu J. Long-term Prognostic Value of Cardiac MRI Left Atrial Strain in ST-Segment Elevation Myocardial Infarction. Radiology. 2020;296(2):299-309 (共同第一作者) JCR Q1
He J, Kong LC, Zeng JT, Shi BZ, An DAL, Chen BH, Ding S, Li Z, Yang F, Yang YN, Yan FH, Xiu JC, Wang HW. Xu JR. Ge H, Pu J. Comparison of direct stenting with conventional strategy on myocardial impairments in ST-segment elevation myocardial infarction: a cardiac magnetic resonance imaging study. Int J Cardiovasc Imaging. 2020;36(6):1167-1175.（通訊作者）JCR Q3
He J, Ge H, Dong JX, Zhang W, Kong LC, Qiao ZQ, Zheng Y, Ding S, Wan F, Shen L, Wang W, Gu ZC, Yang F, Li Z, Pu J. Rationale and design of a prospective multi-center randomized trial of EARLY treatment by rivaroxaban versus warfarin in ST-segment elevation MYOcardial infarction with Left Ventricular Thrombus (EARLY-MYO-LVT trial). Annals of Translational Medicine 2020,8(6):392-40 (通訊作者) JCR Q3
Sun JT, Chen Z, Nie P, Ge H, Shen L, Yang F, Qu XL, Ying XY, Zhou Y, Wang W, Zhang M, Pu J. Lipid Profile Features and Their Associations With Disease Severity and Mortality in Patients With COVID-19. Front Cardiovasc Med. 2020;7:584987.
Gu ZC, Qiao ZQ, Hao ZY, Li Z, Jiang LS, Ge H, He B, Pu J. Initial anticoagulation experience with standard-dose rivaroxaban after Watchman left atrial appendage occlusion. Annals of Translational Medicine.2020,8(4):105-110 (通訊作者) JCR Q3
Gu ZC, Zhang C, Kong LC, Shen L, Li Z, Ge H, Lin HW, Pu J. Incidence of myocardial injury in coronavirus disease 2019 (COVID-19): a pooled analysis of 7,679 patients from 53 studies. Cardiovasc Diagn Ther. 2020;10(4):667-677.
Sheng X, Qiao Z, Ge H, Sun J, He J, Li Z, Ding S, Pu J. Novel application of quantitative flow ratio for predicting microvascular dysfunction after ST-segment-elevation myocardial infarction. Catheter Cardiovasc Interv. 2020 ;95 Suppl 1:624-632.
Lai W, Jie H, Jian-Xun D, Ling-Cong K, Jun-Tong Z, Bo-Zhong S, Dong-Ao-Lei A, Bing-Hua C, Song D, Zheng L, Fan Y, Yi-Ning Y, Fu-Hua Y, Jian-Cheng X, Hu-Wen W, Jian-Rong X, Heng G, Jun P. Impact of Concomitant Impairments of the Left and Right Ventricular Myocardial Strain on the Prognoses of Patients With ST-Elevation Myocardial Infarction. Front Cardiovasc Med. 2021;8:659364. (通訊作者) JCR Q2
Shi FH, Li H, Kong LC, Shen L, Jiang YH, Gu ZC, Ge H. Sulfonylureas Use Is Not Associated With Increased Infarct Size in Patients With Type 2 Diabetes and ST-Segment Elevation Myocardial Infarction. Front Cardiovasc Med. 2021;8:658059. (通訊作者) JCR Q2
Zhong FY, Zhao YC, Zhao CX, Gu ZC, Lu XY, Jiang WL, Gao LC, Li WL, Qin ZH, Ge H, Pu J. The Role of CD147 in Pathological Cardiac Hypertrophy Is Regulated by Glycosylation. Oxid Med Cell Longev. 2022;2022:6603296. IF=6.8 （通訊作者）JCR Q2
Ge H. Is diastolic dysfunction a new windsock in the risk stratification of patients with coronary heart disease? Int J Cardiol. 2022 ;346:103-104.. (第一和通訊作者) JCR Q2
Zhao Y, Lu X, Wan F, Gao L, Lin N, He J, Wei L, Dong J, Qin Z, Zhong F, Qiao Z, Wang W, Ge H, Ding S, Yang Y, Xiu J, Shan P, Yan F, Zhao S, Ji Y, Pu J. Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction. J Am Coll Cardiol. 2022;79(21):2097-2115.
Shi FH, Li H, Shen L, Xu L, Ge H, Gu ZC, Lin HW, Pu J. Beneficial Effect of Sodium-Glucose Co-transporter 2 Inhibitors on Left Ventricular Function. J Clin Endocrinol Metab. 2022;107(4):1191-1203.
Shen L, Qiu L, Liu D, Wang L, Huang H, Ge H, Xiao Y, Liu Y, Jin J, Liu X, Wang DW, Peterson ED, He B, Zhou N. The Association of Low Molecular Weight Heparin Use and In-hospital Mortality Among Patients Hospitalized with COVID-19. Cardiovasc Drugs Ther. 2022 ;36(1):113-120.
Liu XQ, Xue S, Xu JB, Ge H, Mao Q, Xu XH, Jiang HD. Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China. Acta Pharmacol Sin. 2022;43(1):64-75.
Zhao, Y., Lu, X., Wan, F., Gao, L., Lin, N., He, J., Wei, L., Dong, J., Qin, Z., Zhong, F., Qiao, Z., Wang, W., Ge, H., Ding, S., Yang, Y., Xiu, J., Shan, P., Yan, F., Zhao, S., Ji, Y., … Pu, J. (2022). Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction. Journal of the American College of Cardiology, 79(21), 2097–2115.
Lai W, Chen-Xu Z, Jian-Xun D, Jie H, Ling-Cong K, Dong-Ao-Lei A, Bing-Hua C, Song D, Zheng L, Fan Y, Hu-Wen W, Jian-Rong X, Heng G, Jun P. Prognostic implications of left ventricular torsion measured by feature-tracking cardiac magnetic resonance in patients with ST-elevation myocardial infarction. Eur Heart J Cardiovasc Imaging. 2022:jeac177. Epub ahead of print. （通訊作者） JCR Q1
