-
YUAN Yuanzhi
MD. MSc.
email: [email protected]
cell-phone number: 18616881220
Research direction: Evidence-based Medicine, Clinical Epidemiology, Ophthalmology
-
Review, Comment & Letter:
徐雅慧, 袁源智*. 視網(wǎng)膜α-crystallins在增生性視網(wǎng)膜疾病中的研究進展. 中國臨床醫(yī)學, 2020, 27(5): 866-870.
孫彩俠,袁源智*.視盤旁萎縮的研究進展 國際眼科縱覽.2020, 44(3):163-169
Zou R, Xu Y, Feng Y, Shen M, Yuan F, Yuan Y*. YAP nuclear‐cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism. Cell Biol Int. 44 (2020) 1416–1425
鄒蓉,袁源智*. PFKFB3在缺氧條件下調(diào)節(jié)血管新生的作用.復旦大學學報（醫(yī)學版）,2019,46(5):691-695.
Sun C, Shen J, Yuan YZ*. Re: Baek et al.: Development of topographic scoring system for identifying glaucoma in myopic eyes: a spectral-domain OCT study. Ophthalmology. 2019:126(5), e38.
Zhang Y, Yuan YZ*. LETTER TO EDITOR：Comparison of effectiveness and safety between conbercept and ranibizumab for treatment of neovascular age-related macular degeneration. A retrospective case-controlled non-inferiority multiple center study. EYE. 2018: 32, 1418–1419.
Book Chapters:
After graduated from Shanghai Medical University in June 1998, Yuan Yuanzhi became an ophthalmologist in Zhongshan Hospital, Shanghai, PR. China. He obtained a Master’s Degree in Ophthalmology in June 2007 from Fudan University for his study on the mechanism of diabetic retinopathy. In the same year, Yuan won a scholarship from EU and became a Master’s student in Erasmus University Rotterdam, the Netherlands. Majored in clinical epidemiology, he had been well trained in epidemiology and statistics in Rotterdam. In August 2009, Yuan received a Master of Science in clinical epidemiology from Erasmus University Rotterdam for his study on the association of retinal vascular calibers and metabolic diseases in a community-based population in Shanghai.
Practicing at the Department of Ophthalmology, Zhongshan Hospital affiliated to Fudan University, Yuan Yuanzhi is a specialist in Medical Retina, a fast-growing sub-specialty in the past 2 decays. He organized and took part in several clinical or population-based studies on the detection, diagnosis, treatment and prevention of age-related macular degeneration, retinal vein or artery occlusion, diabetic retinopathy and other retinal diseases; he also conducted the lab research, especially on the mechanism of ocular neovascularization. Currently, collaborated with both the scientists from the Institute of Brain Science and Department of Chemistry of Fudan University, Yuan is working on a project which aims to restore vision by planting titanium oxide nanowires under retina as artificial photoreceptors to replace the photorecept cells damaged by various diseases or injures. While being a highly specialized ophthalmologist, Yuan is also interested in the medical research on other areas/specialties and the medical education, which is attributed to his immense intellectual curiosity about the medicine, as well as his educational background in clinical epidemiology.
Since he came back to Shanghai from Rotterdam, Yuan Yuanzhi has been a lecturer of the Center for Evidence-based Medicine of Fudan University. With great passion and enthusiasm, Yuan teaches university students, postgraduates, medical doctors or researchers about clinical epidemiology, evidence-based medicine, statistics and study design with vivid cases of clinical practice and research. He enjoys the interaction and discussion with intelligent youngsters, and he believes that he is not only teaching the tools of medical investigation and practice, but also, and more importantly, he is conveying the idea of critical thinking. After carried out a survey of more than 500 ophthalmologist in China, He published a paper in 2018 showing that there was a relative lack of the knowledge among the participants of evidence-based medicine and clinical practice guidelines, though their importance was generally recognized and acknowledged. He then works harder on the education of clinical epidemiology and evidence-based medicine for a wider spectrum of audience. He conducted an education reform for residency training program, namely To Teach a Person to Fish with Evidence-based Clinical Practice Cases which receives a warm welcome. Yuan has been in charge of a national continuous medical education program for 6 years.
Yuan Yuanzhi is currently the vice director of the Department of Ophthalmology, Zhongshan Hospital affiliated to Fudan University. He is also the committee members of several national and regional academic associations including Chinese Medical Association and Chinese Medical Doctors Association.
徐雅慧, 袁源智*. 視網(wǎng)膜α-crystallins在增生性視網(wǎng)膜疾病中的研究進展. 中國臨床醫(yī)學, 2020, 27(5): 866-870.
孫彩俠,袁源智*.視盤旁萎縮的研究進展 國際眼科縱覽.2020, 44(3):163-169
Zou R, Xu Y, Feng Y, Shen M, Yuan F, Yuan Y*. YAP nuclear‐cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism. Cell Biol Int. 44 (2020) 1416–1425
鄒蓉,袁源智*. PFKFB3在缺氧條件下調(diào)節(jié)血管新生的作用.復旦大學學報（醫(yī)學版）,2019,46(5):691-695.
Sun C, Shen J, Yuan YZ*. Re: Baek et al.: Development of topographic scoring system for identifying glaucoma in myopic eyes: a spectral-domain OCT study. Ophthalmology. 2019:126(5), e38.
Zhang Y, Yuan YZ*. LETTER TO EDITOR：Comparison of effectiveness and safety between conbercept and ranibizumab for treatment of neovascular age-related macular degeneration. A retrospective case-controlled non-inferiority multiple center study. EYE. 2018: 32, 1418–1419.
Yuan YZ*, Shi P. CORRESPONDENCE: Degradation of Contrast Sensitivity Function Following Posterior Vitreous Detachment. Am J Ophthalmol 2017;177:225.
Book Chapters:
袁源智“糖尿病視網(wǎng)膜病變”.《全科醫(yī)師眼科學》陳夫勝,，王歷陽主編. 北京科學技術(shù)出版社.2021年. ISBN: 9787530498507
《Gass黃斑病圖譜》.孫曉東主譯,汪楓樺,宮媛媛,袁源智副主譯.上?？茖W技術(shù)出版社. 2021年. ISBN：9787547849187
袁源智.第4-6章“隊列研究：邁向結(jié)局”,，“病例對照研究：反方向的研究”,，“與什么做比較,？病例對照研究中對照的選擇”.《臨床研究基本概念》 主譯：王吉耀,，第2版，ISBN9787117300865人民衛(wèi)生出版社:2020:52-94.
袁源智. 第十四章第三節(jié)“缺血性視神經(jīng)病變”.《循證眼科學》王寧利,李仕明,李文生主編.人民衛(wèi)生出版社. 2020 ISBN：9787117298063
袁源智, 王吉耀. 第17章“治療性研究與評價”,；袁源智, 馮一帆. 第36章“非動脈炎性前部缺血性視神經(jīng)病變的循證治療”《循證醫(yī)學與臨床實踐》（第四版）.主編:王吉耀. 科學出版社. 2019-2. ISBN: 9787030605115.
陳世耀. 袁源智. “診斷試驗評價與疾病診斷”,，“臨床指南的評價與應用”.《畢業(yè)后醫(yī)學教育系列 綜合知識》（第二版）. 王吉耀主編. 科學出版社. 2019-09. ISBN:9787030620514
-
Yuan YZ*, Shi P. CORRESPONDENCE: Degradation of Contrast Sensitivity Function Following Posterior Vitreous Detachment. Am J Ophthalmol 2017;177:225.
Wang DH, Gu C and Yuan YZ*. Case Report: A Case of Cystoid Macular Edema in Retinitis Pigmentosa With Central Retinal Vein Occlusion. Front. Med. 2022. 9:877429. doi: 10.3389/fmed.2022.877429
Xu YH, Feng YF, Zou R*, Yuan F, Yuan YZ*. Silencing of YAP attenuates pericyte-myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization. Cell Biol Int. 2022;46:1249–1263. Doi:10.1002/cbin.11809.
Zou R, Feng YF, Xu YH, Shen MQ, Zhang X, Yuan YZ*. Yes-associated protein promotes endothelial-to-mesenchymal transition of endothelial cells in choroidal neovascularization fibrosis. Int J Ophthalmol 2022;15(5):701-710
4.Shen JJ, Wang R, Wang LL, Lyu CF, Liu S, Xie GT, Zeng HL, Chen LY, Shen MQ, Gao X, Lin HD*, Yuan YZ*. Image enhancement of color fundus photographs for age-related macular degeneration: the Shanghai Changfeng Study. Int J Ophthalmol 2022;15(2):268-275, doi:10.18240/ijo.2022.02.12
Wang Z, Feng C, Yang R, Liu T, Chen Y, Chen A, Yan B*, Yuan YZ*, Zhang JY*. Large-Area Photoreceptor Degeneration Model in Rabbits by Photocoagulation and Oxidative Stress in the Retina. Frontiers in Neuroscience. 2021;15(640). Doi:10.3389/fnins.2021.617175
6.Feng Y., Zou R., Zhang X., Shen M, Chen X, Wang J, Niu W, Yuan YZ*, Fei Yuan*. YAP promotes ocular neovascularization by modifying PFKFB3-driven endothelial glycolysis. Angiogenesis (2021). 24(3), 489-504. Doi: 10.1007/s10456-020-09760-8
Ma Y., Ma Y., Feng C., Shen M., Yuan YZ*. Ocular biometric parameters are associated with non-contact tonometry measured intraocular pressure in non-pathologic myopic patients. Int Ophthalmol. 2020, 40: 431–437
Xiang DN, Feng YF, WANG J, ZHANG X, SHEN JJ, ZOU R, Yuan YZ*, PDGF-B promotes the proliferation and migration of retinal microvascular pericytes by up-regulation of CXCR4 and CXCR7 expression. EXPERIMENTAL AND THERAPEUTIC MEDICINE 2019;18: 4022-4030.
李優(yōu), 沈旻倩, 馮一帆, 袁源智*. 我國部分綜合性眼科雜志2019年發(fā)表臨床研究類論文的研究設計[J]. 眼科學報, 2020, 35(5): 296-303. doi: 10.3978/j.issn.1000-4432.2020.11.21
周彥萍,宋珉璐,袁源智*,汪楓樺.病理性近視后鞏膜葡萄腫與脈絡膜厚度的關(guān)聯(lián)分析.中國臨床醫(yī)學.2019, 26(3): 471-476.
Feng Y*, Wang J*, Yuan YZ*, et al. miR-539-5p inhibits experimental choroidal neovascularization by targeting CXCR7. FASEB J 2018;32(3):1626-1639. (* equal contribution)
申晶晶, 董春瓊, 向丹妮, 沈旻倩, 袁源智*. 眼科醫(yī)師對臨床指南的認知與應用情況調(diào)查. 中國臨床醫(yī)學. 2018, 25(6):972-976.
王余萍;王靖;袁源智*. 壓力升高誘導的視網(wǎng)膜神經(jīng)節(jié)細胞-5的凋亡和自噬.中華實驗眼科雜志,2017,35(4):293-298
