HUA Yunfeng
Professor, Principal Investigator
Research direction：Plasticity and aging of brain circuits
E-mail：yunfeng.hua@@outlook.com
Lab: http://www.shipm.cn/jyjz_web/html/jyjz_English/jyjz_eg_hyf_sysjj/List/index.htm
Research Interests
Brain is a complex functional network, which consists of highly interconnected nerve cells via synapses. It is essential for distinct brain functions to implement different neuron types in a well-organized architecture with specific connectivity pattern. Our team focuses on the plasticity changes of neural network under normal, aging, and pathological conditions. By means of state-of-the-art microscopy techniques including multi-photon calcium imaging, super-resolution light microscopy and three-dimensional electron microscopy, we set out to understand the neural wiring principles underlying sensation, memory, and learning, as well as reveal pathological mechanisms behind brain dysfunction by characterizing aging- and disease-related structural changes.
Education and Work Experience
2001 – 2005 Tongji University Chemistry（BSc）
2005 – 2008 University of Munich Chemistry（MSC）
2008 – 2012 Max-Planck-Institute of Biophysical Chemistry Neurobiology（PhD/PostDoc）
2012 – 2014 Max-Planck-Institute of Neurobiology Neurobiology（PostDoc）
2014 – 2018 Max-Planck-Institute for Brain Research Neurobiolog（PostDoc）
2018 – now Shanghai Institute of Precision Medicine (Principal investigator)
Selected Publications
Y Hua*, S Loomba, V Pawlak, KM Voit,P Laserstein, KM Boergens, D Wallace, JN Kerr*, M Helmstaedter*. Connectomic analysis of thalamus-driven disinhibition in cortical layer 4, Cell Reports, 2022, 41(2):111476.
Y Hua*, X Ding, H Wang, F, Wang, Y Lu, J Neef, Y Gao, T Moser*, H Wu*. Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea, Cell Reports, 2021, 34(1): 108551
Y Hua*, P Laserstein, M Helmstaedter*. Large-volume en-bloc staining for electron microscopy-based connectomics, Nature Communications, 2015, 6: 7923
Y Hua, A Woehler, M Kahms, V Haucke, E Neher*, J Klingauf *. Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles, Neuron, 2013, 80(2): 247~249
Y Hua, R Sinha, CS Thiel, R Schmidt, J Hüve, H Martens, SW Hell, A Egner, J Klingauf *. A readily retrievable pool of synaptic vesicles, Nature Neuroscience, 2011, 14(7):833~839
Y Hua, R Sinha, M Martineau, M Kahms, J Klingauf*. A common origin of synaptic vesicles undergoing evoked and spontaneous fusion, Nature Neuroscience, 2010, 13(12): 1451~1453
