YU Shiyan / Richard
Professor, Principal Investigator
Research direction：Investigating how gut microbes interact with intestinal epithelial cells and lamina propria immune cells, affecting host health and disease.
E-mail：sciencie@@shsmu.edu.cn
Lab: http://www.shipm.cn/jyjz_web/html/jyjz_English/jyjz_eg_ysy_sysjj/List/index.htmm
Research Interests
Stem cell biology, particularly focusing on cell biology of stem cells derived from endoderm, niche development and tumorigenesis.
Host-microbe interactions at mucosal surfaces, mucosal inflammation and leveraging related knowledge towards assembling microbial consortia for disease management.
Education and Work Experience
EDUCATION
- Fudan University Shanghai Medical College
PhD, Medical Microbiology and Immunology, 06.2011
- Fudan University Shanghai Medical College
Master of Medicine, Biochemistry and Medical Virology, 12.2005
- Soochow University Medical School
Bachelor of Medicine & Surgery, 06.2002
WORK EXPERIENCES
09.2019-current Shanghai Institute of Precision Medicine
07.2005-06.2008 Shanghai Cancer Institute
Selected Publications
Yu S, Tong K, Zhao, Y, Balasubramanian I, Yap GS, Ferraris RP, Bonder EM, Gao N. Paneth cell multipotency induced by Notch activation following injury. Cell Stem Cell 2018 July 5, 23(7): 46-59 e5. doi: 10.1016/j.stem.2018.05.002
Nie Y, Yu S, Nirala NK, Amcheslavsky A, Edwards YJK, Shum PW, Jiang Z, Wang W, Zhang B, Gao N, Ip YT. Oncogenic Pathways and Loss of the Rab11 GTPase Synergize to Alter Metabolism in Drosophila. Genetics 2019 Aug 1, 212(4):1227-1239. doi:10.1534/genetics.119.302137
Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N. Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development. 2015 Jun 15, 142(12):2147-62. doi: 10.1242/dev.121046
Yu, D. H., Gadkari, M., Zhou, Q., Yu, S., Gao, N., Guan, Y., Schady, D., Roshan, T. N., Chen, M. H., Laritsky, E., Ge, Z., Wang, H., Chen, R., Westwater, C., Bry, L., Waterland, R. A., Moriarty, C., Hwang, C., Swennes, A. G., Moore, S. R., Shen, L. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015 Sep 30, 16(1):211. doi: 10.1186/s13059-015-0763-5
Sakamori R, Yu S*, Zhang X*, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez A, Taketo MM, Bonder EM, Verzi MP, Gao N. CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors. Cancer Res. 2014, Oct. 1, 74(19): 5480-92. doi: 10.1158/0008-5472.CAN-14-0267 (* co-first author)
Yu S, Yehia G, Wang J, Stypulkowski E, Sakamori R, Jiang P, Guo W, Hernandez-Enriquez EB, Tran TS, Bonder EM, Gao N. Global Ablation of Mouse Rab11a Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion. J Biol Chem. 2014, Nov 14, 289(46):32030-43. doi:10.1074/jbc.M113.538223
Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Das S, Douard V, Yang CS, Ferraris RP, Bonder EM, Goldenring JR, Tony Ip T, Gao N. TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014, Sep 1, 33(17): 1882-95. doi: 10.15252/embj.201487888
Sakamori R, Das S, Yu S, Feng S, Stypulkowski E, Guan Y, Douard V, Tang W, Ferraris RP, Harada A, Brakebusch C, Guo W, Gao N. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. J Clin Invest. 2012 Mar 1, 122(3):1052-65. doi: 10.1172/JCI60282.
