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Shanghai Cancer Institute

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HE Yongning

Professor

Email:  [email protected]

Research field：Cancer and cell surface receptors

Biography

  • Dr. He obtained BS and MS from Fudan University and graduated from Purdue University with a Ph.D. in biochemistry and molecular biology. He did postdoctoral research at California Institute of Technology, then moved to Shanghai Institute of Biochemistry and Cell Biology as a principal investigator in 2011. He is now a professor at Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine and PI of State Key Laboratory Oncogene and Related Genes. He was supported by Hundred Talent program of CAS and Shanghai Pujiang program.

  • Our group studies the structure and function of cell surface receptors, especially their roles in tumorigenesis and metastasis, using multiple biochemical and biophysical techniques including crystallography and electron microscopy, and also design and screen anti-tumor drugs based on the structures of the receptors.

Publications

  1. Guo L, Wu Y, Chang H, Zhang Z, Tang H, Yu Y, Xin L, Liu Y, He Y*. (2021). Structure of cell–cell adhesion mediated by the Down syndrome cell adhesion molecule. Proc Natl Acad Sci USA. 118 (39) e2022442118.

  2. Cheng C, Zheng E, Yu B, Zhang Z, Wang Y, Liu Y, He Y* (2021). Recognition of lipoproteins by scavenger receptor class A members. J Biol Chem. 297(2):100948.

  3. Yu B, Cheng C, Wu Y, Guo L, Kong D, Zhang Z, Wang Y, Zheng E, Liu Y, He Y* (2020). Interactions of ferritin with scavenger receptor class A members. J Biol Chem. 295(46):15727-15741.

  4. Cheng C, Hu Z, Cao L, Peng C, He Y* (2019). The scavenger receptor SCARA1(CD204) recognizes dead cells through spectrin. J Biol Chem. 294(49):18881-18897.

  5. Cao L, Yu B, Kong D, Cong Q, Yu T, Chen Z, Hu Z, Chang H, Zhong J, Baker D, He Y*. (2019). Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus. PLoS Pathog. 15(5):e1007759.

  6. Tang H, Chang H, Dong Y, Guo L, Shi X, Wu Y, Huang Y, He Y*. (2018). Architecture of cell-cell adhesion mediated by sidekicks. Proc Natl Acad Sci USA. 115, 9246-9251.

  7. Hu Z, Shi X, Yu B, Li N, Huang Y, He Y*. (2018). Structural insights into the pH-dependent conformational change and collagen recognition of the human mannose receptor. Structure 26, 60-71.e3.

  8. Dong Y, Cao L, Tang H, Shi X, He Y*. (2017). Structure of human M-type phospholipase A2 receptor revealed by cryo-electron microscopy. J Mol Biol. 429, 3825-3835.

  9. Cao L, Chang H, Shi X, Peng C, He Y*. (2016). Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205. Proc Natl Acad Sci USA.113, 13438-13443.

  10. Cao L, Shi X, Chang H, Zhang Q, He Y*. (2015). pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205. Proc Natl Acad Sci USA.112, 7237-42.