YANG Xiaomei
Ph.D., Associate Professor
Email:[email protected]
phone： 13651707727
Research interests: Molecule mechanisms of hepatocellular cancer and pancreatic cancer
Biography
I was graduated from Nanjing University and China Pharmaceutical University and received a Bachelor’s degree of Science at 2003. From 2003 to 2010, I studied at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, and received a Doctor’s degree of Science. From 2010 till now, I worked as a scientific researcher in “State key laboratory of oncogenes and cancer related genes” in Shanghai Cancer Institute, Renji Hospital.
My research interest is the mechanisms of the development of the digestive system neoplasms, including hepatocellular carcinogenesis (HCC) and pancreatic cancer, from the aspect of cellular basic biological function regulation and also combined with the microenviroment or systematic clues. We preferred to study the mechanisms from aspects of cell cycle, cell mitosis, nucleolar function and microenvironment inputs. Our research articles were published in Gastroenterology, Journal of Hepatology, Cancer Research and et al.
One of our main finding is to report the role of RacGAP1 in mediating cell cytokinesis in HCC and reveal new RacGAP1 dependent molecular links between cytokinesis and the Hippo pathway. As cytokinesis failure was tolerant in normal hepatocytes, strategies that blocking cancer cell cytokinesis might be promising in HCC treatment. Recently, we are interested in exploring mechanisms that specifically regulate cytokinesis and revealing their function in liver function and liver diseases. We are also interested in seeking important players that regulate nucleolar function and nuclear architecture to coordinate with cell cycle progress and microenvironment stress in cancers.
Publications
Yang XM*, Wu Z, Wang X, Zhou Y, Zhu L, Li D, Nie HZ, Wang YH, Li J, Ma X. Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability. BMC Pharmacol Toxicol. 2022 Jul 22;23(1):54.
Zhu L, Zhou KX, Ma MZ, Yao LL, Zhang YL, Li H, Du C, Yang XM#. Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation. J Immunol Res. 2022 Jun 19;2022:1590717.
Wu A, Lin L, Li X, Xu Q, Xu W, Zhu X, Teng Y, Yang XM#, Ai Z. Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis. Cancer Sci. 2021 Nov;112(11):4515-4525.
Wang X, Wang F, Zhang ZG, Yang XM#, Zhang R. STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells. J Immunol Res. 2020 Sep 29;2020:7263602.
Yang XM*, Cao XY, He P, Li J, Feng MX, Zhang YL, Zhang XL, Wang YH, Yang Q, Zhu L, Nie HZ, Jiang SH, Tian GA, Zhang XX, Liu Q, Ji J, Zhu X, Xia Q, Zhang ZG. Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis. Gastroenterology. 2018 Oct;155(4):1233-1249.
Zhang YL, Li Q, Yang XM*, Fang F, Li J, Wang YH, Yang Q, Zhu L, Nie HZ, Zhang XL, Feng MX, Jiang SH, Tian GA, Hu LP, Lee HY, Lee SJ, Xia Q, Zhang ZG. SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways. Cancer Res. 2018 May 1;78(9):2305-2317.
Li J, Yang XM*, Wang YH, Feng MX, Liu XJ, Zhang YL, Huang S, Wu Z, Xue F, Qin WX, Gu JR, Xia Q, Zhang ZG. Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. J Hepatol. 2014 Jun;60(6):1225-34.5.
