ZHU Minmin
Professor
Graduate Supervisor
Shanghai General Hospital ,Shanghai Jiao Tong University ,School of Medicine
Research area: Anesthesiology
Email: [email protected]
Tel: 021-
Research Interests
Mechanism of vascular endothelial injury induced by hyperglycemia and hyperglycemic memory.
Hyperglycemia can induce multiple organ dysfunction by mediating vascular endothelial injury during peri-operative period. Recently, epigenetics has been reported to play an important role in hyperglycemia-induced vascular endothelial injury. By building hyperglycemic in vivo and in vitro models, our studies explored the underlying molecular mechanism by which histone modification-mediated epigenetic regulation participates in hyperglycemia-mediated endothelial injury. So far, our research indicated that deacetyl-transferase sirt7 and methyltransferase SET8 plays a crucial role in hyperglycemia-mediated endothelial injury. Our results may provide a new theoretical basis for prevention and treatment of hyperglycemia-related complications during peri-operative period.
