李亞?wèn)|Ph.D.
研究員，課題組長(zhǎng)
Songjiang Research Institute, Shanghai Jiao Tong University School of Medicine
上海交通大學(xué)醫(yī)學(xué)院松江研究院
個(gè)人信息:
出生年月: 1990-10
地 址: 上海市松江區(qū)中山中路746號(hào)18號(hào)樓203
手 機(jī): 021-67722409, (86)15711616541
郵 箱: [email protected],
網(wǎng) 站: https://www.x-mol.com/groups/yadleelab?lang=zh
教育經(jīng)歷:
2015.09–2018.06： 復(fù)旦大學(xué),，博士,，藥理學(xué),，導(dǎo)師：黃志力/曲衛(wèi)敏
2012.09–2015.06： 皖南醫(yī)學(xué)院/復(fù)旦大學(xué),，碩士,，藥理學(xué),，導(dǎo)師：黃志力/洪宗元
2008.09–2012.06： 皖南醫(yī)學(xué)院,，本科
工作經(jīng)歷:
2023.03–至今 上海交通大學(xué)醫(yī)學(xué)院松江研究院,，研究員，課題組長(zhǎng)
2018.10–2023.02 北卡羅來(lái)納大學(xué)教堂山分校,，博士后,，合作導(dǎo)師: Juan Song
研究興趣:
李亞?wèn)|博士主要研究方向?yàn)樗哂X(jué)醒發(fā)生機(jī)制及對(duì)學(xué)習(xí)記憶和情感的調(diào)控作用，重點(diǎn)關(guān)注：1）睡眠覺(jué)醒調(diào)控記憶和情感的神經(jīng)環(huán)路和分子機(jī)制,；2）阿爾茲海默病中認(rèn)知和情感損害的環(huán)路和分子機(jī)制,，開(kāi)創(chuàng)性的提出通過(guò)干預(yù)覺(jué)醒水平改善認(rèn)知和情感功能的新策略；3）慢性痛和麻醉相關(guān)睡眠障礙和認(rèn)知損害的病理機(jī)制及干預(yù)策略,。
學(xué)術(shù)成績(jī):
1）在生理性睡眠覺(jué)醒發(fā)生機(jī)制方面,，發(fā)現(xiàn)了腹側(cè)基底神經(jīng)節(jié)中伏隔核和腹側(cè)蒼白球調(diào)控動(dòng)機(jī)相關(guān)覺(jué)醒的關(guān)鍵作用；2）在睡眠障礙發(fā)生機(jī)制方面,，揭示了前扣帶回皮層-紋狀體環(huán)路調(diào)控慢性痛失眠的關(guān)鍵機(jī)制,，為睡眠障礙的干預(yù)提供了新靶點(diǎn)；3）在睡眠覺(jué)醒調(diào)控學(xué)習(xí)記憶機(jī)制方面,，闡明了覺(jué)醒核團(tuán)調(diào)控成體海馬神經(jīng)發(fā)生進(jìn)而改善記憶的新機(jī)制,，為改善阿爾茲海默病記憶障礙提供了新策略。以上研究成果為解析睡眠覺(jué)醒發(fā)生機(jī)制及對(duì)記憶調(diào)控作用提供了關(guān)鍵的理論基礎(chǔ),。李亞?wèn)|以第一或通訊作者身份在Nat Neurosci,、Cell Stem Cell和Neuron等期刊發(fā)表論文11篇，獲國(guó)自然海外優(yōu)青項(xiàng)目（國(guó)家級(jí)）和上海市青年領(lǐng)軍人才（省部級(jí)）項(xiàng)目的資助,。主持國(guó)自然面上項(xiàng)目等各類(lèi)項(xiàng)目5項(xiàng),。
學(xué)術(shù)兼職:
中國(guó)睡眠研究會(huì)理事
中國(guó)神經(jīng)科學(xué)會(huì)國(guó)際交流委員會(huì)委員
中國(guó)神經(jīng)科學(xué)會(huì)學(xué)習(xí)記憶基礎(chǔ)與臨床分會(huì)委員
中國(guó)神經(jīng)科學(xué)會(huì)神經(jīng)發(fā)育委員會(huì)委員
上海市情感腦功能解析與障礙干預(yù)重點(diǎn)實(shí)驗(yàn)室主任助理
學(xué)術(shù)期刊:
Sleep Research編委
《中國(guó)臨床藥理學(xué)與藥物治療學(xué)》（北大核心）編委
個(gè)人榮譽(yù):
2018 |
復(fù)旦大學(xué)優(yōu)秀畢業(yè)生 |
2020 |
美國(guó)NARSAD青年科學(xué)家獎(jiǎng) |
2020 2024 2024 |
UNC杰出博士后 JNS travel award 小米青年學(xué)者 |
發(fā)表文章:
1. Ya-Dong Li(李亞?wèn)|); Yan-Jia Luo; Wei-Kun Su, Jing Ge, Andrew Crowther, Ze-Ka Chen, Lu Wang, Michael Lazarus, Zi-Long Liu, Wei-Min Qu, Zhi-Li Huang, Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain,Neuron, 2024.02.14(first and leading corresponding author, IF = 18.688)
2. Ya-Dong Li(李亞?wèn)|); Yan-Jia Luo; Ling Xie; Dalton S Tart; Ryan N Sheehy; Libo Zhang; Leon G Coleman Jr; Xian Chen; Juan Song; Activation of hypothalamic-enhanced adult-born neurons is sufficient to restores cognitive and affective function in Alzheimer's disease,Cell Stem Cell, 2023,31 (first author, IF = 23.9)
3. Ya-Dong Li(李亞?wèn)|); Yan-Jia Luo; Juan Song; Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis,Current Opinion in Neurobiology, 2023, 79 (first author, IF = 7.07)
4. Ya-Dong Li(李亞?wèn)|); Yan-Jia Luo; Ze-Ka Chen; Luis Quintanilla; Yoan Cherasse; Libo Zhang; Michael Lazarus; Zhi-Li Huang; Juan Song; Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior,Nature Neuroscience, 2022, 25: 630-645 (first author, IF = 28.8)
5. Ya-Dong Li(李亞?wèn)|); Yan-Jia Luo; Wei Xu; Jin Ge; Yoan Cherasse; Yi-Qun Wang; Michael Lazarus; Wei-Min Qu; Zhi-Li Huang; Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway,Molecular Psychiatry, 2020, Oct(14): 2912-2928 (first author, IF = 15.9)
6. Yadong Li(李亞?wèn)|); Hechen Bao; Yanjia Luo; Cherasse Yoan; Heather Anne Sullivan; Luis Quintanilla; Ian Wickersham; Michael Lazarus; Yen-Yu Ian Shin; Juan Song; Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release,eLife, 2020, 9(e53129): 1-23 (first author, IF = 7.7)
7. Ya-Dong Li(李亞?wèn)|); Jing Ge; Yan-Jia Luo; Wei Xu; Juan Wang; Michael Lazarus; Zong-Yuan Hong; Wei-Min Qu; Zhi-Li Huang; High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice,PAIN, 2019, 161:288-299 (first author, IF = 7.926)
8. Yan-Jia Luo; Jing Ge; Ze-Ka Chen; Zi-Long Liu; Michael Lazarus; Wei-Min Qu; Zhi-Li Huang;Ya-Dong Li(李亞?wèn)|); Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections, iScience,2023, 26 (8) (Last corresponding author, IF = 5.75)
9. Connor M Wander,Ya-Dong Li(李亞?wèn)|), Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen, Juan Song; Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model,Journal of Translational Medicine, 2023, 21 (1), 258 (co-first and co-corresponding author, IF = 8.448)
10. Yan-Jia Luo;Ya-Dong Li(李亞?wèn)|); Lu Wang; Su-Rong Yang; Xiang-Shan Yuan; Juan Wang; Yoan Cherasse; Michael Lazarus; Jiang-Fan Chen; Wei-Min Qu; Zhi-Li Huang; Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors,Nature Communications, 2018, 9(1): 1576 (co-first author, IF = 17.694)
11. Yu-Er Wu;Ya-Dong Li(李亞?wèn)|); Yan-Jia Luo; Tian-Xiao Wang; Hui-Jing Wang; Shuo-Nan Chen; Wei-Min Qu; Zhi-Li Huang; Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice,Acta Pharmacologica Sinica, 2015, 11(36): 1308-1317
12. Ze-Ka Chen; Hui Dong; Cheng-Wei Liu; Wen-Ying Liu; Ya-Nan Zhao; Wei Xu; Xiao Sun; Yan-Yu Xiong; Yuan-Yuan Liu; Xiang-Shan Yuan; Bing Wang; Michael Lazarus; Yoan Chérasse;Ya-Dong Li(李亞?wèn)|); Fang Han; Wei-Min Qu; Feng-Fei Ding; Zhi-Li Huang ; A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy,Cell Discovery, 2022, 8(1)
13. Brent Asrican; Josh Wooten;Ya-Dong Li(李亞?wèn)|); Luis Quintanilla; Feiran Zhang; Connor Wander; Hechen Bao; Chia-Yu Yeh; Yan-Jia Luo; Reid Olsen; Szu-Aun Lim; Jessica Hu; Peng Jin; Juan Song; Neuropeptides modulate local astrocytes to regulate adult hippocampal neural stem cells,Neuron, 2020, 108(2): 349-366
14. Tian-Xiao Wang; Dou Yin; Wei Guo; Yuan-Yuan Liu;Ya-Dong Li(李亞?wèn)|); Wei-Min Qu; Wu-Jian Han; Zong-Yuan Hong; Zhi-Li Huang; Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice,Pharmacology Biochemistry and Behavior, 2015, (135): 31-39
15. Ze-Ka Chen; Luis Quintanilla; Yijing Su; Ryan N. Sheehy; Jeremy M. Simon; Yan-Jia Luo;Ya-Dong Li(李亞?wèn)|); Zhe Chen; Brent Asrican; Dalton S. Tart; W. Todd Farmer; Guo-Li Ming; Hongjun Song; Juan Song; Septo-dentate gyrus cholinergic circuits modulate function and morphogenesis of adult neural stem cells through granule cell intermediaries,Proceedings of the National Academy of Sciences, 2024, 121(40)
16. Yan-Jia Luo; Hechen Bao; Andrew Crowther;Ya-Dong Li(李亞?wèn)|); Ze-Ka Chen; Dalton S. Tart; Brent Asrican; Libo Zhang; Juan Song; Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice,Cell Reports, 2024, 43(5): 114140
科研項(xiàng)目：
2024-2027，國(guó)家自然科學(xué)基金面上項(xiàng)目, 32371028
2024-2026,，上海市科委啟明星A類(lèi)項(xiàng)目,，24QA2704800
2023-2026，上海市衛(wèi)計(jì)委面上項(xiàng)目, 202340046
2023-2024,，上海交通大學(xué)“交大2030”計(jì)劃C類(lèi)項(xiàng)目
2021-2023,，BBRF Young Investigators, 29600（結(jié)題）
人才項(xiàng)目：
2022上海市青年領(lǐng)軍人才（海外）
2023國(guó)家自然科學(xué)基金海外優(yōu)青
