研究方向
從事線粒體和衰老的分子機(jī)制研究,，利用蛋白質(zhì)組學(xué)的方法研究線粒體蛋白動態(tài)變化及其與衰老及相關(guān)疾病的關(guān)系,。主要關(guān)注衰老和相關(guān)疾病中線粒體蛋白水平修飾（包括乙酰化,、琥珀?；脱趸龋€粒體功能的調(diào)節(jié)和反向信號傳導(dǎo)的影響,，以及在衰老相關(guān)疾病中的作用。
獎勵
2015: Charles A. King Trust Postdoctoral Research Fellowship
2017: Harvard Chinese life Science YongJin Distinguished Research Award
2017: 第十四批國家高層次人才計劃
2022: 教學(xué)比賽三等獎
重要文獻(xiàn)和書籍
1. Wang Jiahui, Yu Xiang, Zhong Youhuan, Ma Xiaomin, Gao Yuanzhu, Zhou Dejian, Wang Jie, Fu Yinkun, Shi fan, Su Juncheng, Huang Masha, Haigis Marcia, Wang Peiyi, Xu Yingjie*,Yang Wen*. The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.Mol Cell. 2025 Feb 6;85(3):638-651.e9.
2. Jiahui Wang, Ziyi Cao, Qun Zhang, Xiang Yu, Zhida Lan, Leiwen Zhao, Jie Wang, Wenjing Wang, Yu Zhang Zikan Zhong, Yutong Hou, Xiang He, Zhiyin An, Hang Yu, Yingjie Xu*,Wen Yang*. mRNA-encoded fluorescent proteins enable superior organelle labeling for live cell imaging.FASEB J. 2024 Dec 15;38(23):e70244.
3. Xiang He, Jiahui Zhang, Masha Huang, Jie Wang, Simin Yang, Xiang Yu*, Yingjie Xu*,Wen Yang*. Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition.Cell Death Dis. 2024 Oct 1;15(10):718.
4. Wei Li, Masha Huang, Zhaoping Wu, Yu Zhang, Ying Cai, Juncheng Su, Jia Xia, Fan Yang, Desheng Xiao, Wen Yang*, Yingjie Xu*, Zhaoqian Liu*, mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer,Adv. Sci, 2024; 2309988.
5. Ying Cai, Yun Li, Yingjie Xu,Wen Yang*, Masha Huang*, TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1,FASEB J, 2024; 38(8) e23625. doi: 10.1096/fj.202400249RR.
6. Han Sun, Yu Zhang, Jiahui Wang, Juncheng Su, Dejian Zhou, Xiang Yu*, Yingjie Xu*,Wen Yang*, Application of Lung-Targeted Lipid Nanoparticle-delivered mRNA of soluble PD-L1 via SORT Technology in Acute Respiratory Distress Syndrome,Theranostics, 2023; 13(14):4974-4992.
7. Luo, X., Zhang, Z. H., Wang, J., Wang, X. L., Zhang, Y. N., Chen, J. Q., Ge, G. B.,Yang, W.*, Qian, X. H.*, Tian, Y.* and Yang, Y. J.*,；Acyl-caged rhodamines: photo-controlled and self-calibrated generation of acetyl radicals for neural function recovery in early AD mice,Chemical Science, 2023; DOI: 10.1039/d3sc03035
8. Yutong Hou, Sihao Lin, Jia Xia, Yu Zhang, Yanan Yin, Masha Huang, Yingjie Xu*,Wen Yang*, Yingjian Zhu*; Alleviation of ischemia–reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles,Molecular Therapy Nucleic Acids,2023 Oct 26:34:102067.
9. Ran Yan, Wenjing Wang,Wen Yang*, Masha Huang* and Wei Xua*; Mitochondria-Related Candidate Genes and Diagnostic Model to Predict Late-Onset Alzheimer’s Disease and Mild Cognitive Impairment;Journal of Alzheimer’s Disease, 2023; DOI: 10.3233/JAD-230314
10. Yun Li, Jingjing Zhang, Ying Cai, Hua Liu,Wen Yang*, Yingjie Xu*, Masha Huang*; VSTM2L contributes to anoikis resistance and acts as a novel biomarker for metastasis and clinical outcome in ovarian cancer,BBRC, Apr 2023; DOI: 10.1016/j.bbrc.2023.03.073
11. Xiang Yu, Zheng Yang, Yu Zhang, Jia Xia, Jiahui Zhang, Qi Han, Hang Yu, Chengbiao Wu, Yingjie Xu, Wei* Xu*,Wen Yang*, Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy,Advanced Health Care Materials, 2023 Jan;12(3):e2202127.
12. Youhuan Zhong,， Yuanzhu Gao， Dejian Zhou, Xiaomin Ma, Huan Chen, Yingjie Xu,Wen Yang*, Xiang* Yu, Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM,Biochemical and Biophysical Research Communications, 2022, 602:120-126
13. Jingjing Zhang, Yun Li, Hua Liu, Jiahui Zhang, Jie Wang, Jia Xia, Yu Zhang, Xiang Yu, Jinyan Ma, Masha Huang, Jiahui Wang, Liangzhe Wang, Qian Li, Rutao Cui,Wen Yang*, Yingjie Xu* and Weiwei Feng*, Genome?wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis,Journal of Experimental &Clinical Cancer Research, 2022, 41:24
14. Jia Xia, Jiahui Zhang, Liangzhe Wang, Hailong Liu, Jie Wang, Junyan Liu, Zhaoqian Liu, Yingjian Zhu, Yingjie Xu*,Wen Yang* and Yongjiang Yu*,， Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation,Cell death and diseases, 2021, 12:833
15. Jing Xu, Jiahui Wang, Xiaoli Wang, Ruoming Tan, Xiaoling Qi, Zhaojun Liu, Hongping Qu, Tingting Pan, Qingyuan Zhan, Yong Zuo*,Wen Yang*, Jialin Liu*, Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages,Cell death and diseases, 2020, 11: 934
16. Kai Xin, Xinxing Li, Yinghua Guo, Youhuan Zhong, Jungang Wang, Haotian Yang, Jie Zhao, Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo, Haolu Wang, Xuhong Qian,Wen Yang*, Xiaowen Liang* & Youjun Yang*, A Monochromophoric Approach to Succinct Ratiometric Fluorescent Probes Without Probe-Product Crosstalk,CCS Chemistry, 2020, 2, 2307–2315
17. Wen Yang et al. Mitochondrial Sirtuins Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks, Introductory Review on Sirtuins in Biology, Aging, and Disease,2018, Pages 95-115
18. Wen Yang, Koji Nagasawa, Christian Münch, Yingjie Xu, Kyle Satterstrom, Seungmin Jeong, Sebastian D Hayes, Mark P. Jedrychowski, F. Sejal Kamlesh Vyas; Elma Zaganjor, Virginia Guarani, Alison Ringle, Steven P Gygi, J. Wade Harper, and Marcia C Haigis: Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane Depolarization.Cell,2016,167(4): 985–1000.e21.
19. Xu Y,Yang W, Shi J, Zetter BR, Shi J.: Prohibitin 1 regulates tumor cell apoptosis via interaction with X-linked Inhibitor of Apoptosis Protein. J Mol Cell Biol,2016, 8 (3): 282-285.
20. Callista Yee,Wen Yang, and Siegfried Hekimi.: The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS inC. elegans.Cell, 2014, 157(4):897-909
21. Inuzuka,H., Gao,D., Finley,L.W.,Yang,W., Wan,L., Fukushima,H., Chin,Y.R., Zhai,B., Shaik,S., Lau,A.W., Wang,Z., Gygi,S.P., Nakayama,K., Teruya-Feldstein,J., Toker,A., Haigis,M.C., Pandolfi,P.P., and Wei,W.: Acetylation-dependent regulation of Skp2 function.Cell, 2012,150:179-193.
書籍
專利
徐穎潔,，于翔，徐瑋,，楊文,，楊崢，張宇,。“神經(jīng)生長因子突變體重組蛋白及應(yīng)用”,， 專利號：CN202210147754.4
美國/日本申請?zhí)枺篜CT/CN2022/114516; 歐洲專利申請?zhí)枺篍P22860539.0
楊文,，徐穎潔，孫涵,，張宇,。肺靶向可溶性PD-L1 mRNA脂質(zhì)納米顆粒及其應(yīng)用。 專利申請?zhí)枺?023110858249
楊文,徐穎潔,王佳惠,俞航,。細(xì)胞器熒光標(biāo)記 mRNA 及其應(yīng)用,。專利申請?zhí)枺?023116322023
研究經(jīng)費(fèi)
項目批準(zhǔn)號：91954120; 項目名稱：解析線粒體參與細(xì)胞器互作的蛋白網(wǎng)絡(luò)及分子機(jī)制; 重大研究計劃
項目批準(zhǔn)號：31871430; 項目名稱：神經(jīng)細(xì)胞中C3orf23調(diào)控酮戊二酸脫氫酶的作用與機(jī)制研究; 面上項目
項目批準(zhǔn)號：2019YFA0508601; 項目名稱：蛋白質(zhì)機(jī)器與生命過程調(diào)控重點(diǎn)專項
