上海市免疫研究所是上海市政府和上海交通大學(xué)醫(yī)學(xué)院（原上海第二醫(yī)學(xué)院）于1979年共建的我國第一個(gè)免疫學(xué)專職研究機(jī)構(gòu)，致力于免疫相關(guān)疾病的基礎(chǔ)和轉(zhuǎn)化研究。一級(jí)教授余?先生是上海市免疫學(xué)研究所創(chuàng)始人和首任所長,。余?先生也是國內(nèi)第一個(gè)免疫學(xué)專業(yè)學(xué)術(shù)團(tuán)體—上海市免疫學(xué)會(huì)的重要?jiǎng)?chuàng)始人和第一屆理事長,，并創(chuàng)辦我國第一個(gè)免疫學(xué)專科雜志《上海免疫學(xué)雜志》,，成立國內(nèi)首個(gè)世界衛(wèi)生組織免疫遺傳合作中心，先后由余?教授、陳仁彪教授和周光炎教授擔(dān)任該合作中心主任,。免疫所率先在國內(nèi)完成HLA抗血清的制備和特異性鑒定，是我國免疫遺傳學(xué)發(fā)展的重要里程碑之一,，獲衛(wèi)生部甲級(jí)科學(xué)技術(shù)成果獎(jiǎng),。2003年，免疫所領(lǐng)銜組建了上海高校E-免疫學(xué)研究院，由第六任所長臧敬五教授擔(dān)任首席主任,，被上海市教委評(píng)為全市E－研究院的典范,。2005年獲教委“優(yōu)勢(shì)學(xué)科”稱號(hào)，2006年入選“教育部免疫學(xué)創(chuàng)新團(tuán)隊(duì)”,。
2012年上海交通大學(xué)醫(yī)學(xué)院從耶魯大學(xué)引進(jìn)國家高層次人才,、上海交通大學(xué)“王寬誠”講席教授蘇冰教授擔(dān)任免疫所第八任所長。近年來,，利用國家“雙一流”建設(shè)項(xiàng)目,、上海“高原高峰”計(jì)劃,、和地方高水平大學(xué)項(xiàng)目建設(shè)契機(jī),，免疫所以推動(dòng)科技創(chuàng)新發(fā)展和高水平人才培養(yǎng)為目標(biāo)，全面實(shí)施所長領(lǐng)導(dǎo)下的課題組長負(fù)責(zé)制,，積極推動(dòng)體制機(jī)制改革,，實(shí)現(xiàn)了免疫所在學(xué)科建設(shè)、科研水平,、人才培養(yǎng)和師資隊(duì)伍等方面的跨越式發(fā)展,。2015年，在醫(yī)學(xué)院的有力支持下賦予上海市免疫學(xué)研究所“學(xué)術(shù)特區(qū)”新使命,，并在2021年繼續(xù)全面實(shí)施“學(xué)術(shù)特區(qū)”2.0版發(fā)展規(guī)劃,。近年來免疫所裝修了7個(gè)樓層近3500平米的實(shí)驗(yàn)空間，組建了一流的公共儀器平臺(tái),，包括流式分析平臺(tái),、顯微成像平臺(tái)、免疫組化平臺(tái),、生物標(biāo)記物研究與開發(fā)平臺(tái),、測(cè)序診斷平臺(tái)、基因工程小鼠實(shí)驗(yàn)與分析平臺(tái),，平臺(tái)實(shí)施的課題組長負(fù)責(zé)制使公共平臺(tái)的高效運(yùn)轉(zhuǎn)得到了學(xué)術(shù)和體制保障,。
2013年，在上海交通大學(xué)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院支持下,，通過合并免疫和微生物學(xué)科成立了免疫學(xué)與微生物學(xué)系,，蘇冰教授擔(dān)任創(chuàng)系系主任。在蘇冰教授的領(lǐng)導(dǎo)下,，免疫所同免微系近年來進(jìn)行全面整合,。目前系所共有教職工109人，其中博導(dǎo)26人,，碩導(dǎo)8人,，在站博士后25人,，在讀研究生140人。現(xiàn)有22個(gè)獨(dú)立課題組,，課題組長中包括國家自然科學(xué)基金委杰出青年基金項(xiàng)目獲得者,、國家自然科學(xué)基金委優(yōu)秀青年項(xiàng)目獲得者、國家高層次青年人才,、上海優(yōu)秀學(xué)科帶頭人,、以及上海高層次人才、浦江學(xué)者等,。主要聚焦腫瘤免疫,、感染免疫、移植免疫,、區(qū)域免疫、自身免疫,、耐藥細(xì)菌控制,、病原基因組學(xué)、分子微生態(tài)學(xué),、微生物與宿主相互作用等研究方向,，并下設(shè)免疫學(xué)科課程組和病原學(xué)科課程組，承擔(dān)醫(yī)學(xué)院本科生與研究生的免疫學(xué),、微生物學(xué)理論和實(shí)驗(yàn)課教學(xué)任務(wù),。免疫所/免微系在研究生培養(yǎng)中以培養(yǎng)具有國際視野的高水平人才為目標(biāo)定位，通過實(shí)驗(yàn)室輪轉(zhuǎn),、成立研究生論文指導(dǎo)委員會(huì)以及研究生科研進(jìn)展報(bào)告等全過程培養(yǎng)體系的建設(shè)和實(shí)施,，并設(shè)立“余?研究生獎(jiǎng)學(xué)金”和“中-以博士雙學(xué)位”項(xiàng)目等舉措，逐步建立了與國際接軌的高水平免疫學(xué)人才培養(yǎng)的新模式,。
國際化建設(shè)也是免疫所/免微系持續(xù)發(fā)展的必由之路,。自2012年以來，免疫所與包括美國,、法國,、英國、澳大利亞以及中國香港,、中國臺(tái)灣,、大陸地區(qū)在內(nèi)的近五十所知名院校、研究機(jī)構(gòu)開展了積極深入的合作交流,，邀請(qǐng)超過300人次的國內(nèi)外頂尖專家學(xué)者來訪交流并作學(xué)術(shù)報(bào)告等,；建立上海交通大學(xué)醫(yī)學(xué)院-耶魯大學(xué)免疫代謝研究院，法國國立馬賽呂米尼免疫中心(CIML)共建免疫調(diào)控聯(lián)合中心,，推動(dòng)國際化發(fā)展的實(shí)體機(jī)構(gòu)建設(shè),。同時(shí),，免疫所也是科技部國際科技合作基地“上海轉(zhuǎn)化醫(yī)學(xué)國際聯(lián)合研究中心”的重要基地，在2021年全國評(píng)估中獲“優(yōu)秀”,。
最后,，免疫所/免微系的研究團(tuán)隊(duì)近年來承擔(dān)多項(xiàng)國家科技部重大/重點(diǎn)研發(fā)計(jì)劃、國家自然科學(xué)基金重大/重點(diǎn)項(xiàng)目,，在國際頂尖期刊如Nature,、Cell、Nature Immunology,、Cell Metabolism,、Immunity、Molecular Cell,、Nature Medicine,、Nature Neuroscience、Nature Communications等發(fā)表原創(chuàng)性科研成果,，為免疫所乃至醫(yī)學(xué)院不斷實(shí)現(xiàn)零的突破,。通過加強(qiáng)與各附屬醫(yī)院的合作，以疾病為導(dǎo)向的基礎(chǔ)-臨床研究團(tuán)隊(duì)成為推動(dòng)免疫所科研不斷突破的新的亮點(diǎn),。
Shanghai Institute of Immunology &
Department of Immunology and Microbiology
Shanghai Institute of Immunology (SII), established in 1979 by the Shanghai Municipal Government and Shanghai Jiao Tong University School of Medicine (formerly Shanghai Second Medical College), is the first immunology research institute in China dedicated to basic and clinical research on immune system and immune-related diseases. The founding Director was Dr. He Yu, a first-class Professor and a pioneer for modern immunology research in China. Dr. Yu was also the key founder and first president of the Shanghai Immunology Society, which is also the first professional academic society for immunology community in China. Under the leadership of Dr. Yu, SII also launched the first specialized immunology journal in China, the Shanghai Journal of Immunology. The first WHO Collaborating Center for Immunogenetics in China was also established here at SII, which was led successively by Drs He Yu, Renbiao Chen, and Guangyen Chou. Immunologists at SII were the first to use antisera to study and identify HLA polymorphism in China, an important milestone in immunogenetics study in China. Its work won top “Science and Technology Achievement Award” from the National Health Commission. In 2003, SII established the E-Immunology Institute, the first Shanghai Institutions of Higher Learning under the leadership of then SII Director, Dr. Jingwu Zang. The E-Immunology Institute was a highly successful model recognized by the Shanghai Municipal Education Commission. In 2005, SII also won the "Key Discipline" title given by Shanghai Municipal Education Commission, and was awarded the "Innovative Team” for immunology research by the Ministry of Education China in 2006.
In 2012, Professor Bing Su, the National High-level Talent Distinguished Expert and KC Wong Endowed Chair Professor of Shanghai Jiao Tong University, joined SII as the 8th Director from Yale University. With the strong support from Shanghai Jiao Tong University School of Medicine, SII has become a Special Academic Zone in 2015, which is successfully renewed in in 2021. In 2013, a brand-new Department of Immunology and Microbiology (DIM) was established in the College of Basic Medical Sciences at Shanghai Jiao Tong University School of Medicine with Professor Bing Su as its founding Chair. Since then, the Department and SII has been fully integrated as one unit with the support from both Shanghai Municipal Government and Shanghai Jiao Tong University School of Medicine.
At the moment, SII/DIM has 109 faculty and staff members including twenty-six Ph.D. supervisors and eight MS supervisors in SII/DIM. We also have twenty-five talented postdoctoral fellows and 140 graduate students. SII & DIM now have twenty-two independent research groups lead by twenty-two highly energetic and enthusiastic Principal Investigator (PI), focusing on different aspects of immunology including cancer immunity, infection immunity, transplantation immunity, regional immunity, autoimmunity, drug-resistant bacteria control, pathogen Many of our PI are recipients of prestigious awards such as the National Science Fund for Distinguished Young Scholars, the National Science Fund for Excellent Young Scholars, National High-Level Young Talents, Shanghai Subject Chief Scientists, and Shanghai High-Level Talents, etc. We also have two key course teams for Immunology and Pathogenesis Course, respectively, responsible for teaching theoretical and laboratory courses of immunology and microbiology for undergraduate and graduate students at our medical school. In terms of graduate student training, the supervisory committee of SII has established the management and training system for graduate student rotation, Research in Progress seminar held weekly in English and the "Yu He Graduate Student Scholarship". By cooperating with the Hebrew University of Jerusalem, a Joint Ph.D. Degree Program was launched in 2018 to explore a new model of international training for graduate students. In addition, SII/DIM is currently equipped with cutting-edge core facilities, including Flow Cytometry Core, Imaging Core, Immunohistochemistry Core, Biomarker Research & Development Core, Sequencing Core, and Mouse Common Strain Collection Core. Our Cores are managed and supervised by our Principal Investigator.
SII/DIM actively interact and collaborate nationally and internationally with renowned universities and research institutes from the United States, France, the United Kingdom, Australia, as well as within China including Hong Kong and Taiwan. World and national renowned scientists have been invited to visit the institute and give seminars to our faculty and students. We established the Shanghai Jiao Tong University School of Medicine-Yale University Institute of Immune Metabolism (SYIIM), a joint center for immune regulation with the Centre d'Immunologie de Marseille-Luminy (CIML). In recent years, our teams have won many Major/Key Program grants from the Ministry of Science and Technology and National Natural Science Foundation of China, and have published breakthrough original research papers in top journals including Nature, Cell, Nature Immunology, Cell Metabolism, Immunity, Molecular Cell, Nature Medicine, Nature Neuroscience, Nature Communications, Nature Neuroscience, Nature Communications, etc., and many are considered "0 to 1 breakthrough" for SII and our Medical School. SII is also the home of "Shanghai International Joint Research Center for Translational Medicine", supported by the prestigious “International Science and Technology Cooperation Base of the Ministry of Science and Technology”. We are glad to report that our Center was awarded "Super achievement" in Year 2021 national assessment.
