病理生理學系是在上海第二醫(yī)科大學基礎醫(yī)學院病理生理學教研室的基礎上發(fā)展而來,。該教研室于1956年在章德馨副教授領導下建立,。1977-1989年間,，上海第二醫(yī)科大學校長王振義教授（1992年任法國科學院外籍院士,，1994年任中國工程院院士,，獲得2010年度國家最高科學技術獎）擔任教研室主任,，相關工作先后獲得了上海市科學技術進步二等獎,、中醫(yī)藥科技進步三等獎,、上海市衛(wèi)生系統(tǒng)“銀蛇獎”等一批科技獎項,，該學科也于1984年成為首批上海市地方高校重點學科,。進入上世紀90年代后，徐也魯教授和張啟良教授先后擔任教研室主任,。2000年該學科成為博士點學科,。2002年，國家杰出青年基金獲得者,、上海市十大杰出青年陳國強教授（2015年任中國科學院院士）擔任學科帶頭人,，開始新一輪的以內涵建設和創(chuàng)新人才培養(yǎng)為核心的學科建設。致力于白血病細胞分化和凋亡化學生物學研究，成為211工程重點建設學科和國家重點學科,，并獲得“全國工人先鋒號”,、“上海市教育系統(tǒng)文明組室”、“上海市文明班組”,、“上海市勞模集體”等稱號,。2018年鐘清研究員在病理生理學教研室的基礎上正式成立病理生理學系并擔任系主任。
系主任全面負責實驗室的總體運行,，實行民主管理,、研究組長負責制，制定學科發(fā)展計劃,，對各研究組在人才培養(yǎng),、科研投入、科研產出等方面實現(xiàn)目標責任制,。目前,，本系在職人員55名，70%以上擁有博士學位和海外工作經歷,，正高職稱19名（含三位沒有正式職稱的PI）,，副高職稱10名。中國科學院院士1人,，國家高層次人才計劃3人,，國家高層次人才計劃青年項目5人，上海市高層次人才2人,，國家杰出青年科學基金獲得者3人,，國家自然科學基金委優(yōu)秀青年基金獲得者3人。
病理生理學系圍繞腫瘤細胞命運決定的醫(yī)學生物學研究及靶向治療等方向,，開展多學科交叉，系統(tǒng)開展發(fā)病學及治療學的基礎和轉化醫(yī)學研究,。先后承擔包括國家科技部十二五支撐計劃,、“973”計劃和“863”計劃、國家自然科學基金重大集成,、重點,、面上項目和上海市科研項目等200余項，取得系列重要發(fā)現(xiàn),，在國際權威學術刊物Nature,、Cell Metabolism、Cancer Cell,、Nature Chemical Biology,、Nature Cell Biology、PNAS,、Blood等發(fā)表SCI論文300余篇,，并獲得國家自然科學二等獎,、中華醫(yī)學科技一等獎、上海市科技進步一等獎,、上海市自然科學一等獎等獎項,。授權六項發(fā)明專利。期間,，病理生理學系共培養(yǎng)了120余位碩,、博士研究生，并有多名學生獲國家及地方優(yōu)秀研究生獎勵,。
Department of Pathophysiology
【Development History】
The Department of Pathophysiology was established by Associate Professor Zhang Dexin in Shanghai Jiaotong University School of Medicine (formerly Shanghai Second Medical University) in 1956. Between 1977 and 1989, Professor Wang Zhenyi, President of the University (foreign academician of the French Academy of Sciences in 1992 and an academician of the Chinese Academy of Engineering in 1994,，winner of the State Preeminent Science and Technology Award in 2010) served as the chair of the department, dedicated to the study of atherosclerosis and hemostasis and thrombosis, and achieved a series of extraordinary results, which has won the second prize of Shanghai Science and Technology Progress Award, the third prize of Traditional Chinese Medicine Science and Technology Progress Award, the Shanghai Health System “Silver Snake Award” and etc. The discipline was also among the first to be the core subject of Shanghai city universities in 1984.
Ever since the 1990s, Professor Xu Yelu and Professor Zhang Qiliang served successively as chairs of the department, which became a doctoral discipline in 2000. In 2002, Prof. Chen Guoqiang, the winner of the National Science Fund for Distinguished Young Scholars and one of Shanghai's Top Ten Outstanding Young People, took the lead and initiated the discipline construction focusing on connotation construction and innovative talent cultivation. Adhering to the scientific innovation spirit of “courageous to think, speak and operate with perseverance and dedication”, the research direction was focused on leukemia cell differentiation and apoptosis, chemical biology, proteomics, leukemia etiology. The department under his leadership has won many honors. The pathology discipline became the key discipline of 211 projects and one of the national key disciplines. The research team won the "National Working Leading Organization", "Shanghai Education System Distinguished Group", "Shanghai Outstanding Team", "Shanghai Model Team" and other titles. In 2018, Dr. Zhong Qing served as the chair of the Department of Pathophysiology.
【Team of Expertise】
The chair of the department is dedicated to the overall operation of the laboratory, implementing democratic management, research team leader responsibility system, formulating the discipline development plan, and setting the work objectives and incentive mechanism in terms of personnel training, scientific research input & output. Meanwhile, outstanding young scholars are encouraged to cooperate with internationally renowned scholars to carry out high-level cooperative research, and on the other side, the department is open to cooperation. Currently, the department is composed of 55 in-service staff, more than 70% of whom have doctoral degrees and overseas work experience, 19 of full investigators and 10 associate investigators, 1 academician of the Chinese Academy of Sciences, 3 National High-level Talent Plan, 5 National High-level Youth Talent Plan, 3 National Distinguished Young Scholars winners, 3 Outstanding Youth Fund winners of the National Natural Science Foundation of China, 2 High-Level Talent Programs of Shanghai.
【Research Overview】
The Department of Pathophysiology is involved in biomedical research areas that span a broad range of tumor cell fate determination, including mechanisms of initiation and development of solid tumors and hematopoietic tumors, hematopoietic and leukemia stem cells, tumor molecular markers research and targeted therapy, disease proteomics, structural biology and bioinformatics, and basic research on cardiovascular and cerebrovascular diseases, etc. The department carries out basic and translational medical research in pathogenesis and therapeutics with the multidisciplinary and cross-disciplinary principle. The department has undertaken more than 200 projects including the 12th Five-Year Support Plan of the Ministry of Science and Technology, the "973" Plan and the "863" Plan, the National Natural Science Foundation's Major Integration, Key Project, General Projects and Shanghai Research Projects. Nearly 300 SCI papers were published on the internationally high-profile academic journals such as Nature, Cell metabolism, Cancer Cell, Nature Chemical Biology, Nature Cell Biology, Nature Communication, PNAS, Blood, etc. In addition, the department has won the second prize of the National Natural Science Award, the first prize of China Medical Science and Technology, the Shanghai Science and Technology Progress Award, Shanghai Natural Science First Prize and other awards. Six patents have been authorized. The Department of Pathophysiology has trained more than 120 masters and doctoral students, one of whom won 100 National Excellent Doctoral Thesis, 7 the Shanghai Graduate Outstanding Achievement Award, and 1 the Wurui Scholarship.
