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姓名：曹建平               

性別: 男                  

出生年月：1964年10月 

學(xué)位/學(xué)歷：博士            

職稱：研究員、博士生導(dǎo)師                   

現(xiàn)任職務(wù)：中國(guó)疾病預(yù)防控制中心寄生蟲病預(yù)防控制所（國(guó)家熱帶病研究中心）副所長(zhǎng),、國(guó)家衛(wèi)生健康委寄生蟲病原與媒介生物學(xué)重點(diǎn)實(shí)驗(yàn)室副主任,，《中國(guó)寄生蟲學(xué)與寄生蟲病雜志》主編，《疾病監(jiān)測(cè)》副主編

電子郵件：[email protected]   

辦公地址：上海市黃浦區(qū)瑞金二路207號(hào)

辦公電話：021-64735258,，13651811278

傳真：021-64376308

教育經(jīng)歷

1982年9月至1987年7月,，南京醫(yī)學(xué)院，臨床醫(yī)療專業(yè),，大學(xué)本科,，學(xué)士學(xué)位

1989年9月至1992年7月,，南京醫(yī)學(xué)院，基礎(chǔ)醫(yī)學(xué)專業(yè),，碩士研究生,，碩士學(xué)位

1995年9月至1998年7月，中國(guó)預(yù)防醫(yī)學(xué)科學(xué)院,，病原生物學(xué),，博士研究生，博士學(xué)位

工作經(jīng)歷

1987年8月至1999年12月 鎮(zhèn)江醫(yī)學(xué)院工作

2000年1月至今 中國(guó)疾病預(yù)防控制中心寄生蟲病預(yù)防控制所（國(guó)家熱帶病研究中心）工作

社會(huì)/學(xué)術(shù)任職和活動(dòng)

任中華醫(yī)學(xué)科技獎(jiǎng)第二屆和第三屆評(píng)審委員會(huì)委員,、上?？萍及l(fā)展重點(diǎn)領(lǐng)域技術(shù)預(yù)見專家、上海市寄生蟲學(xué)會(huì)理事長(zhǎng),、中華醫(yī)學(xué)會(huì)熱帶病與寄生蟲學(xué)分會(huì)副主任委員,、中國(guó)微生物學(xué)會(huì)人獸共患病病原學(xué)專業(yè)委員會(huì)副主任委員、上海市免疫學(xué)會(huì)理事等

研究方向/主要研究?jī)?nèi)容

1.寄生蟲與宿主相互作用機(jī)制

2.寄生蟲感染免疫及其調(diào)控機(jī)制,，疫苗研制

3.新發(fā)寄生蟲病分子流行病學(xué),、致病機(jī)制與跨種傳播、監(jiān)測(cè)與風(fēng)險(xiǎn)評(píng)估關(guān)鍵技術(shù)研究

科研/教學(xué)研究項(xiàng)目

作為負(fù)責(zé)人先后承擔(dān)科研課題26項(xiàng),，其中包括國(guó)家“863”計(jì)劃、國(guó)家科技重大專項(xiàng),、國(guó)家科技攻關(guān)計(jì)劃,、國(guó)家自然科學(xué)基金和國(guó)家衛(wèi)生行業(yè)科研專項(xiàng)等國(guó)家級(jí)課題16項(xiàng)

1. 日本血吸蟲蟲卵外泌體源microRNA-1促進(jìn)肝臟纖維化的作用及其機(jī)制研究，No.81971969,，2020-2023,，國(guó)家自然科學(xué)基金面上項(xiàng)目

2. Vγ2γδT細(xì)胞促日本血吸蟲感染小鼠肝纖維化作用機(jī)制研究，No.81772225,，2018-2021,，國(guó)家自然科學(xué)基金面上項(xiàng)目

3. 日本血吸蟲感染晚期小鼠脾臟淋巴濾泡再形成及機(jī)制研究，No.81371841,，2014-2017,，國(guó)家自然科學(xué)基金面上項(xiàng)目

4. 日本血吸蟲致宿主脾臟淋巴濾泡破壞相關(guān)蟲源分子的研究，No.30872212,，2009-2011,，國(guó)家自然科學(xué)基金面上項(xiàng)目

5. 日本血吸蟲免疫逃避機(jī)制相關(guān)分子的研究，No.30371262,，2004-2006,，國(guó)家自然科學(xué)基金

6. 肉源性、水源性寄生蟲病監(jiān)測(cè)和風(fēng)險(xiǎn)評(píng)估關(guān)鍵技術(shù)研究及應(yīng)用,，201502021,，2016-2018,，國(guó)家衛(wèi)生行業(yè)科研專項(xiàng)

7. 我國(guó)未來病原體戰(zhàn)略研究（寄生蟲分課題），L1522033,，2015-2017,，中國(guó)工程院與國(guó)家自然基金委中長(zhǎng)期發(fā)展戰(zhàn)略研究

8. 日本血吸蟲病基因工程多價(jià)疫苗的研究，2006AA02Z444,，2006-2010,，國(guó)家“863”計(jì)劃

9. 日本血吸蟲基因工程疫苗的研究，2001AA215151,，2001-2003,；2004AA215240，2004-2005,，國(guó)家“863”計(jì)劃

10. 日本血吸蟲病基因工程多價(jià)疫苗和DNA疫苗的研究,，2004AA2Z3520，2004-2005,，國(guó)家科技重大專項(xiàng)

11. 隱孢子蟲病快速檢測(cè)方法及蟲株鑒別的研究,，2003BA712A03-06，2003-2005,，國(guó)家科技攻關(guān)計(jì)劃

12. 野生動(dòng)物與媒介攜帶的病原微生物種群,、分布特征及其發(fā)生規(guī)律研究（寄生蟲課題），2016YFC1201900,，2016-2019,，國(guó)家重點(diǎn)研發(fā)計(jì)劃

13. 隱孢子蟲病的診斷，20131601,，2013-2015,，國(guó)家衛(wèi)生行業(yè)標(biāo)準(zhǔn)

14. 自然疫源性傳染病病原譜流行規(guī)律及變異研究（寄生蟲子課題），2012ZX10004-201-004,，2012-2015,，國(guó)家傳染病重大專項(xiàng)

15. 特殊傳染病診斷試劑企業(yè)研發(fā)/產(chǎn)品評(píng)價(jià)用參考品的研制（寄生蟲子課題），2013ZX10004-805,，2012-2015,，國(guó)家科技重大專項(xiàng)

16. 自然疫源性傳染病病原譜流行規(guī)律及變異研究（寄生蟲子課題），2009ZX10004-201-004,，2009-2011,，國(guó)家傳染病重大專項(xiàng)

17. 寄生蟲病與病媒控制，No.GWV-10.1-XK13,，2020-2022,，上海市公共衛(wèi)生體系建設(shè)三年行動(dòng)計(jì)劃（2020-2022）重點(diǎn)學(xué)科項(xiàng)目

18. 重點(diǎn)學(xué)科-熱帶病學(xué)，15GWZK0101，2016-2019,，上海市公共衛(wèi)生體系建設(shè)三年行動(dòng)計(jì)劃重點(diǎn)學(xué)科項(xiàng)目

19. 日本血吸蟲病基因工程疫苗臨床前研究,，064319026，2007-2009,，上海市生物醫(yī)藥重點(diǎn)項(xiàng)目

20. 抗日本血吸蟲雌雄蟲合抱基因工程疫苗的研究,，03DZ19231，2004-2006,，上海市科技攻關(guān)重大計(jì)劃

主要學(xué)術(shù)成果

期刊論文

發(fā)表學(xué)術(shù)論文200余篇,，其中SCI論文100余篇。近5年部分論文：

1.      HuY,   Wang X, Wei Y, Liu H, Zhang J, Shen Y, Cao J*. Functional inhibition   of natural killer cells in a BALB/c mouse model of liver fibrosis induced by   Schistosoma japonicum infection. Front Cell Infect Microbiol. 2020;10:598987.

2.      Zhang   X, Gong W, Cao S, Yin J, Zhang J, Cao J*, Shen Y*. Comprehensive analysis   of non-coding RNA profiles of exosome-like vesicles from the protoscoleces   and hydatid cyst fluid of Echinococcus granulosus. Front Cell Infect   Microbiol. 2020;10:316.

3.      Xu   J, Wang X, Jing H, Cao S, Zhang X, Jiang Y, Yin J, Cao J*, Shen Y*.   Identification and genotyping of Enterocytozoon bieneusi in wild Himalayan   marmots (Marmota himalayana) and Alashan ground squirrels (Spermophilus   alashanicus) in the Qinghai-Tibetan Plateau area (QTPA) of Gansu Province,   China. Parasit Vectors. 2020;13(1):367.

4.      Sun   L, Gong W, Shen Y, Liang L, Zhang X, Li T, Chen TT, Hu Y*, Cao J*.   IL-17A-producing γδ T cells promote liver pathology in acute murine   schistosomiasis. Parasit Vectors. 2020;13(1):334.

5.      Khan   A, Ahmed H*, Simsek S, Liu H, Yin J, Wang Y, Shen Y, Cao J*. Molecular   characterization of human Echinococcus isolates and the first report of E.   canadensis (G6/G7) and E. multilocularis from the Punjab Province of Pakistan   using sequence analysis. BMC Infect Dis. 2020;20:262.

6.      Khan   A, Ahmed H*, Simsek S, Afzal MS, Cao J*. Spread of cystic   echinococcosis in Pakistan due to stray dogs and livestock slaughtering   habits: research priorities and public health importance. Front Public   Health. 2020;7:412.

7.      Liu   A*, Gong B, Liu X, Shen Y, Wu Y, Zhang W, Cao J*. A retrospective epidemiological   analysis of human Cryptosporidium infection in China during the past three   decades (1987-2018). PLoS Negl Trop Dis. 2020;14(3):e0008146.

8.      Shen   Y, Gong B, Liu X, Wu Y, Yang F, Xu J, Zhang X, Cao J*, Liu A*. First   identification and genotyping of Enterocytozoon bieneusi in humans in   Myanmar. BMC Microbiol. 2020;20(1):10.

9.      Xu   N, Liu H, Jiang Y, Yin J, Yuan Z, Shen Y*, Cao J*. First report of   Cryptosporidium viatorum and Cryptosporidium occultus in humans in China, and   of the unique novel C. viatorum subtype XVaA3h. BMC Infect Dis.   2020;20(1):16.

10.    Li   XH, Vance GM, Cartwright J, Cao JP*, Wilson RA*, Castro-Borges W.   Mapping the epitopes of Schistosoma japonicum esophageal gland proteins for   incorporation into vaccine constructs. PLoS One. 2020;15(2):e0229542.

11.    Cao   S, Xu M, Jiang Y, Liu H, Yuan Z, Sun L, Cao J*, Shen Y*. Prevalence   and genetic characterization of Cryptosporidium, Giardia and Enterocytozoon   in chickens from Ezhou, Hubei, China. Front Vet Sci. 2020;7:30.

12.    Wu   L, Xi C, Liu Y, Jiang X, Chen S*, Cao J*. Toxoplasma gondii Rhoptry   Protein 16 (ROP16) modifies apoptosis in human 293T cells. J Nanosci   Nanotechnol. 2020;20(1):24-30.

13.    Chen   TT, Peng S, Wang Y, Hu Y, Shen Y, Xu Y, Yin J, Liu C, Cao J*.   Improvement of mitochondrial activity and fibrosis by resveratrol treatment   in mice with Schistosoma japonicum infection. Biomolecules. 2019, 9, 658.

14.    Yin   K*, Zhao G, Xu C, Qiu X, Wen B, Sun H, Liu G, Liu Y, Zhao Q, Wei Q, Huang B,   Yan G, Cao J*. Prediction of Toxoplasma gondii virulence factor ROP18   competitive inhibitors by virtual screening. Parasit Vectors.2019;12:98.

15.    Wei   F, Gong W, Wang J, Yang Y, Liu J, Wang Y, Cao J*. Role of the lipoxin   A4 receptor in the development of neutrophil extracellular traps in   Leishmania infantum infection. Parasites & Vectors. 2019;12:275.

16.    Ugwu   CE#, Jiang YY#, Wu L Xu YX, Yin JH, Duan LP, Chen SX, Liu H, Pan W, Quan H,   Shen YJ*, Cao JP*. In vitro Screening of Ginkgolic Acids for   Antiparasitic Activity against Cryptosporidium andersoni. Biomed Environ Sci.   2019; 32(4): 143-147.

17.    Hua   Liu#, Ning Xu#, Jianhai Yin, Zhongying Yuan,Yujuan Shen*, Jianping Cao*.   Prevalence and multilocus genotyping of potentially zoonotic Giardia   duodenalis in pigs in Shanghai, China. Parasitology.   2019;146(9):1199-1205.

18.    Gong   W, Huang F, Sun L, Yu A, Zhang X, Xu Y, Shen Y, Cao J*. Toll-like   receptor-2 regulates macrophage polarization induced by excretory-secretory   antigens from Schistosoma japonicum eggs and promotes liver pathology in murine   schistosomiasis. PLoS Negl Trop Dis, 2018,12(12):e0007000.

19.    Yin   JH, Liu CH,, Yu AP, Yao JQ, Shen YJ*, Cao JP*. Pro-angiogenic activity   of monocytic-type myeloid-derived suppressor cells from Balb/C mice infected   with Echinococcus granulosus and the regulatory role of miRNAs. Cell Physiol   Biochem. 2018;51:1207-1220.

20.    Xu   M, Jiang Z, Huang W, Yin J, Ou S, Jiang Y, Meng L, Cao S, Yu A, Cao J*,   Shen Y*. Altered gut microbiota compositionin subjects infected with   Clonorchis sinensis. Front Microbiol. 2018;9:2292.

21.    Yu   A, Wang Y, Yin J, Zhang J, Cao S, Cao J*, Shen Y*. Microarray analysis   of long non-coding RNA expression profiles in monocytic myeloid-derived   suppressor cells in Echinococcus granulosus-infected mice. Parasit Vectors.   2018 May;11(1):327.

22.    Jiang   Y, Yuan Z, Zang G, Li D, Wang Y, Zhang Y, Liu H, Cao J*, Shen Y*.   Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai: a   retrospective case study. Front Med. 2018;12(1):98-103.

23.    Yin   J, Liu C, Shen Y, Zhang H, Cao J*. Efficacy of ursolic acid against   Echinococcus granulosus in vitro and in a murine infection model. Parasit   Vectors. 2018;11(1):58.

24.    Yin   J, Shen Y, Yu A, Liu C, Yao J, Gong W, Cao J*. The proangiogenic role   of polymorphonuclear myeloid-derived suppressor cells in mice infected with   Echinococcus granulosus.  BioScience Trends. 2018; 12(3):338-341.

25.    Hu   Y, Sun L, Yuan Z, Xu Y, Cao J*. High throughput data analyses of the   immune characteristics of Microtus fortis infected with Schistosoma   japonicum. Sci Rep.2017;7(1):11311.

26.    Zheng   L, Hu Y, Wang Y, Huang X, Xu Y, Shen Y*, Cao J*. Recruitment of   neutrophils mediated by Vγ2 γδ T Cells deteriorates liver fibrosis induced by   Schistosoma japonicum infection in C57BL/6 mice. Infect   Immun. 2017,85(8):e01020-16.

27.    Pan   W, Hao WT, Shen YJ, Li XY, Wang YJ, Sun FF, Yin JH, Zhang J, Tang RX, Cao   JP*, Zheng KY*. The excretory-secretory products of Echinococcus   granulosus protoscoleces directly regulate the differentiation of B10, B17   and Th17 cells. Parasit Vectors, 2017,10(1) :384.

28.    Zhang   W, Ren G, Zhao W, Yang Z, Shen Y, Sun Y, Liu A*, Cao J*. Genotyping of   Enterocytozoon bieneusi and subtyping of Blastocystis in cancer patients:   relationship to diarrhea and assessment of zoonotic transmission. Front   Microbiol.2017;8:1835.

29.    Liu   H, Shen Y, Liu A, Yin J, Yuan Z, Jiang Y, Pan W, Zhang Y, Zhao W, Cao J*.   Occurrence and multilocus genotyping of Giardia duodenalis in pets and zoo   animals in Shanghai, China.  J Infect Dev Ctries 2017; 11(6):479-486.

30.    Liu   H, Jiang Z, Yuan Z, Yin J, Wang Z, Yu B, Zhou D, Shen Y*, Cao J*.   Infection by and genotype characteristics of Enterocytozoon bieneusi in   HIV/AIDS patients from Guangxi Zhuang autonomous region, China. BMC Infect   Dis, 2017,17:684.

31.    Huang   YL, Huang DN, Geng YJ, Fang SS, Yang F, Wu CL, Zhang HL, Wang M, Zhang R,   Wang X, Wu S, Cao JP*, Zhang RL*. An integrated control strategy takes   Clonorchis sinensis under control in an endemic area in south China.   Vector-Borne and Zoonotic Diseases,2017;17(12):791-798.

32.    Shi   M, Lin XD, Tian JH, Chen LJ, Chen X, Li CX, Qin XC, Li J, Cao JP*, Eden JS,   Buchmann J, Wang W, Xu JG, Holmes EC, Zhang YZ. Redefining the invertebrate   RNA virosphere. Nature. 2016;540(7634):539-543.

33.    Liu   Z, Yin L, Li Y, Yuan F, Zhang X, Ma J, Liu H, Wang Y, Zheng K*, Cao J*.   Intranasal immunization with recombinant Toxoplasma gondii actin   depolymerizing factor confers protective efficacy against toxoplasmosis in   mice. BMC Immunol. 2016;17(1):37.

34.    Zhang   Y, Wang Y*, Jiang Y, Pan W, Liu H, Yin J, Shen Y, Cao J*. T follicular   helper cells in patients with acute schistosomiasis. Parasit Vectors.   2016;9(1):321.

35.    Zheng   Y*, Guo X, He W, Shao Z, Zhang X, Yang J, Shen Y, Luo X, Cao J*.   Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage   RAW264.7 cells. Int Immunopharmacol. 2016,34:259-262.

36.    Liu   Z, Yuan F, Yang Y, Yin L, Liu Y, Wang Y, Zheng K*, Cao J*. Partial   protective immunity against toxoplasmosis in mice elicited byrecombinant   Toxoplasma gondii malate dehydrogenase. Vaccine 2016,34(7):989–994.

37.    Wu   L, Wang X, Li Y, Liu Y, Su D, Fu T, Guo F, Gu L, Jiang X, Chen S*, Cao J*.   Toxoplasma gondii ROP18: potential to manipulate host cell mitochondrial   apoptosis. Parasitol Res. 2016;115(6):2415-2422.

38.    Yang   Z, Zhao W, Shen Y, Zhang W, Shi Y, Ren G, Yang D, Ling H, Yang F, Liu A*, Cao   J*. Subtyping of Cryptosporidium cuniculus and genotyping of   Enterocytozoon bieneusi in rabbits in two farms in Heilongjiang Province,   China. Parasite 2016, 23, 52.

39.    Han   S, Tang Q, Lu X, Chen R, Li Y, Shu J, Zhang X*, Cao J*. Dysregulation   of hepatic microRNA expression profiles with Clonorchis sinensis infection.   BMC Infect Dis.2016;16(1):724.

著作

1.《臨床微生物學(xué)手冊(cè)》（第12版）共同主譯,，中華醫(yī)學(xué)電子音像出版社,，北京，2020,，

2.《曼氏熱帶病》（第23版）,，副主譯，上?？茖W(xué)技術(shù)出版社,，上海，2020

3.《腹瀉癥候群病原學(xué)監(jiān)測(cè)與檢測(cè)技術(shù)》,，副主編,，中山大學(xué)出版社，廣州,，2016

4.《現(xiàn)代寄生蟲病學(xué)》（第2版）,，副主編，人民軍醫(yī)出版社,，北京，2015

專利

獲授權(quán)國(guó)家發(fā)明專利5件,，1件已轉(zhuǎn)化

1.     沈玉娟,，曹建平，劉華,，袁忠英,，姜巖巖，尹建海,，王燕娟. 多重PCR檢測(cè)腸道新發(fā)原蟲試劑盒及檢測(cè)方法,，ZL   201510093500.9，   2017.2

2.     沈玉娟,，陳盛霞,，金紅，李峰，潘雨青,，孫啟艷,，吳亮，曹建平. 基于圖像的寄生蟲蟲卵形狀識(shí)別方法,，ZL   201110022426.3,，2012.10   已轉(zhuǎn)化

3.     尹建海，曹建平,，劉叢珊,，張皓冰，沈玉娟. 熊果酸在制備抗包蟲藥物中的應(yīng)用,，ZL 2016 1 0517861.6,，2019.4

4.     曹建平、Ugwu Chidiebere   Emmanuel,、沈玉娟,、姜巖巖、段李平,、袁忠英. 銀杏酸在抗隱孢子蟲中的應(yīng)用,，

ZL   201310539693.7，2016.3

5.     曹建平,，蔡輝霞,，沈玉娟，韓秀敏,，胡媛,，王虎，盧濰媛,，徐馀信,，官亞宜. 診斷細(xì)粒棘球蚴病的重組抗原蛋白、其制備方法和用途,，ZL 201010284913.2,，2012.8

榮譽(yù)及獎(jiǎng)項(xiàng)

作為第一完成人獲醫(yī)學(xué)科技獎(jiǎng)4項(xiàng)，獲國(guó)家衛(wèi)生計(jì)生有突出貢獻(xiàn)中青年專家,、國(guó)家抗震救災(zāi)醫(yī)藥衛(wèi)生先進(jìn)個(gè)人,、全國(guó)血防衛(wèi)士、上海市職工創(chuàng)新工作室等

1. 我國(guó)重要新發(fā)腸道原蟲病原和分子檢測(cè)關(guān)鍵技術(shù)研究及應(yīng)用,，2019年,，以第一完成人獲中華醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)（中華醫(yī)學(xué)會(huì)）、上海市科技進(jìn)步獎(jiǎng)二等獎(jiǎng)（上海市人民政府）和華夏醫(yī)學(xué)科技獎(jiǎng)三等獎(jiǎng)（中國(guó)醫(yī)療保健國(guó)際促進(jìn)交流會(huì)）

2. 我國(guó)隱孢子蟲核酸檢測(cè)和基因分型技術(shù)的研究及應(yīng)用,，以第一完成人獲中華預(yù)防醫(yī)學(xué)科技獎(jiǎng)三等獎(jiǎng)（中華預(yù)防醫(yī)學(xué)會(huì),，2015）

開設(shè)課程

    講授研究生課程包括《寄生蟲感染免疫學(xué)》,、《專業(yè)英語(yǔ)—免疫學(xué)》、《被忽視熱帶病》,、《新發(fā)腸道原蟲病流行與挑戰(zhàn)》,、《實(shí)驗(yàn)室生物安全管理》、《動(dòng)物疾病與人類健康》等

Profile

Name：Cao Jianping  

Gender: male               

Date of birth：14 Oct,1964   

Degree：Doctor        

Title：Professor, Doctoral Supervisor

Present Position：Deputy Director,   National Institute of Parasitic Diseases, Chinese Center for Disease Control   and Prevention (Chinese Center for Tropical Diseases Research); Deputy   Director,  NHC Key   Laboratory of Parasite and Vector Biology, China; Editor-in-chief, Chinese   Journal of Parasitology and Parasitic Diseases; Associate Editor, Disease   Surveillance.

Email：[email protected], [email protected]

Address：No.207, Rui Jin 2^nd   Road, Shanghai, China                 

Office Tel：+8621-64735258,，+86 13651811278

Education

1982.9-1987.7   Nanjing Medical University, bachelor, clinical medicine

1989.9-1992.7   Nanjing Medical University, master, basic medicine

1995.9-1998.7   Chinese   Academy of Preventive Medicine, Ph.D.,Pathogen Biology

Appointments

Aug 1987   to Dec 1999 Zhenjiang   Medical College

Jan 2000   to present National   Institute of Parasitic Diseases, Chinese Center for Disease Control and   Prevention (Chinese Center for Tropical Diseases Research)

Academic Participation and Activities

Member, Chinese Medical Science and Technology Award   Committee;

President, Shanghai Association for Parasitology;

Deputy President, Branch of Tropical Diseases   and Parasitology, Chinese Medical Association;

Deputy President, Committee on   Aetiology of Zoonoses, Chinese Society for Microbiology;

Member, Shanghai Immunology Association;

Expert, Technology Foresight in Key areas of Science   and Technology Development, Shanghai.

Research Interest

1. Mechanisms involved in the   interaction between parasite and the host

2. Infection and immunity, Development   of vaccine

3. Molecular   epidemiology, pathogenic mechanism, cross-species transmission, key   techniques for surveillance and risk assessment of emerging infectious parasitic   diseases

Projects

1. Study on the role and its mechanism of microRNA-1 of exosome from   Schistosoma japonicum egg in promoting liver fibrosis. National Natural   Science Foundation of China, No.81971969, 2020-2023,

2.Study on the mechanism of Vγ2γδT cells derived from mice   infected with Schistosoma japonicum facilicate the liver fibrosis. National   Natural Science Foundation of China, No.81772225, 2018-2021

3.Study on the mechanism of re-generated spleen lymphoid follicles   in mice during advanced schistosomiasis japonica. National Natural Science   Foundation of China, No.81371841, 2014-2017

4. Study on the destruction of the spleen’s lymphoid follicles   in mice infected with Schistosoma japonicum by the schistosome-derived   molecules. National Natural Science Foundation of China, No.30872212,，2009-2011

5. Study on the molecular mechanism of immune evasion in mice   infected with Schistosoma japonicum. National Natural Science   Foundation of China, No.30371262，2004-2006

6. Study and application of the key technologies for monitoring   and risk assessment of meat-borne and water-borne parasitic diseases. Chinese   Special Program for Scientific Research of Public Health, 201502021,2016-2018

7. Study on genetic engineering polyvalent vaccine against   schistosomiasis japonica. National High Technology Research and Development   Programme of China (863 Programme), 2006AA02Z444, 2006-2010

8. Development of genetic engineering vaccine against Schistosoma   japonicum. National High Technology Research and Development Programme of   China (863 Programme), 2001AA215151, 2001-2003; 2004AA215240, 2004-2005

9. Development of geneticengineering polyvalent vaccine and DNA   vaccine against schistosomiasis japonica, National Science and Technology   Major Program of China, 2004AA2Z3520, 2004-2005

10. Study on rapid detection and identification techniques of Cryptosporidium.   National Programs for Science and Technology Development, 2003BA712A03-06, 2003-2005

11. Study on prevalence and variation of the pathogen spectrum   of parasitic diseases. National Science and Technology Major Program of   China, 2012ZX10004-201-004, 2012-2015

12. Development of reference materials for special infectious   disease diagnostic reagent enterprise R & D/product evaluation. National   Science and Technology Major Program of China, 2013ZX10004-805, 2012-2015

13. Study on prevalence and variation of the pathogen spectrum   of parasitic diseases. National Science and Technology Major Program of   China, 2009ZX10004-201-004, 2009-2011

14. Control of parasitic diseases and vectors. Key Discipline   Project of the Three-year Action Plan (2020-2022) for the Construction of   Shanghai Public Health System, No.GWV-10.1-XK13, 2020-2022

15. Tropical Medicine. Key Discipline Project of the Three-year Action   Plan for the Construction of Shanghai Public Health System, 15GWZK0101,，2016-2019

17. Preclinical study of genetic engineering vaccine against   schistosomiasis japonica. Key Biomedical Project Shanghai, 064319026, 2007-2009

16. Development of genetic engineering vaccine against pairing   of female and male of Schistosoma japonicum. Shanghai Science and Technology   Major Program, 03DZ19231, 2004-2006

Publications

More than 200 papers published. Some of the papers published   in the past 5 years are as follows:

1.      HuY, Wang X, Wei Y, Liu H, Zhang J,   Shen Y, Cao J*. Functional inhibition of natural killer cells in a   BALB/c mouse model of liver fibrosis induced by Schistosoma japonicum   infection. Front Cell Infect Microbiol. 2020;10:598987.

2.      Zhang   X, Gong W, Cao S, Yin J, Zhang J, Cao J*, Shen Y*.   Comprehensive analysis of non-coding RNA profiles of exosome-like vesicles   from the protoscoleces and hydatid cyst fluid of Echinococcus granulosus.   Front Cell Infect Microbiol. 2020;10:316.

3.      Xu   J, Wang X, Jing H, Cao S, Zhang X, Jiang Y, Yin J, Cao J*, Shen Y*.   Identification and genotyping of Enterocytozoon bieneusi in wild   Himalayan marmots (Marmota himalayana) and Alashan ground squirrels (Spermophilus   alashanicus) in the Qinghai-Tibetan Plateau area (QTPA) of Gansu   Province, China. Parasit Vectors. 2020;13(1):367.

4.      Sun   L, Gong W, Shen Y, Liang L, Zhang X, Li T, Chen TT, Hu Y*, Cao J*.   IL-17A-producing γδ T cells promote liver pathology in acute murine   schistosomiasis. Parasit Vectors. 2020;13(1):334.

5.      Khan   A, Ahmed H*, Simsek S, Liu H, Yin J, Wang Y, Shen Y, Cao J*. Molecular   characterization of human Echinococcus isolates and the first report   of E. canadensis (G6/G7) and E. multilocularis from the Punjab   Province of Pakistan using sequence analysis. BMC Infect Dis. 2020;20:262.

6.      Khan   A, Ahmed H*, Simsek S, Afzal MS, Cao J*. Spread of cystic   echinococcosis in Pakistan due to stray dogs and livestock slaughtering   habits: research priorities and public health importance. Front Public   Health. 2020;7:412.

7.      Liu   A*, Gong B, Liu X, Shen Y, Wu Y, Zhang W, Cao J*. A retrospective   epidemiological analysis of human Cryptosporidium infection in China   during the past three decades (1987-2018). PLoS Negl Trop Dis.   2020;14(3):e0008146.

8.      Shen   Y, Gong B, Liu X, Wu Y, Yang F, Xu J, Zhang X, Cao J*, Liu A*. First   identification and genotyping of Enterocytozoon bieneusi in humans in   Myanmar. BMC Microbiol. 2020;20(1):10.

9.      Xu   N, Liu H, Jiang Y, Yin J, Yuan Z, Shen Y*, Cao J*. First report of Cryptosporidium   viatorum and Cryptosporidium occultus in humans in China, and of   the unique novel C. viatorum subtype XVaA3h. BMC Infect Dis.   2020;20(1):16.

10.    Li   XH, Vance GM, Cartwright J, Cao JP*, Wilson RA*, Castro-Borges W. Mapping   the epitopes of Schistosoma japonicum esophageal gland proteins for   incorporation into vaccine constructs. PLoS One. 2020;15(2):e0229542.

11.    Cao   S, Xu M, Jiang Y, Liu H, Yuan Z, Sun L, Cao J*, Shen Y*. Prevalence   and genetic characterization of Cryptosporidium, Giardia and Enterocytozoon   in chickens from Ezhou, Hubei, China. Front Vet Sci. 2020;7:30.

12.    Wu   L, Xi C, Liu Y, Jiang X, Chen S*, Cao J*. Toxoplasma gondii   Rhoptry Protein 16 (ROP16) modifies apoptosis in human 293T cells. J Nanosci   Nanotechnol. 2020;20(1):24-30.

13.    Chen   TT, Peng S, Wang Y, Hu Y, Shen Y, Xu Y, Yin J, Liu C, Cao J*.   Improvement of mitochondrial activity and fibrosis by resveratrol treatment   in mice with Schistosoma japonicum infection. Biomolecules. 2019, 9,   658.

14.    Yin   K*, Zhao G, Xu C, Qiu X, Wen B, Sun H, Liu G, Liu Y, Zhao Q, Wei Q, Huang B,   Yan G, Cao J*. Prediction of Toxoplasma gondii virulence factor   ROP18 competitive inhibitors by virtual screening. Parasit   Vectors.2019;12:98.

15.    Wei   F, Gong W, Wang J, Yang Y, Liu J, Wang Y, Cao J*. Role of the lipoxin   A4 receptor in the development of neutrophil extracellular traps in   Leishmania infantum infection. Parasites & Vectors. 2019;12:275.

16.    Ugwu CE^#, Jiang YY^#,   Wu L Xu YX, Yin JH, Duan LP, Chen SX, Liu H, Pan W, Quan H, Shen YJ*, Cao   JP*. In vitro Screening of Ginkgolic Acids for Antiparasitic
  Activity against Cryptosporidium andersoni. Biomed Environ Sci. 2019;   32(4): 143-147.

17.     Hua Liu^#, Ning Xu^#,   Jianhai Yin, Zhongying Yuan,Yujuan Shen*, Jianping Cao*. Prevalence   and multilocus genotyping of potentially zoonotic Giardia duodenalis in pigs   in Shanghai, China. Parasitology. 2019;146(9):1199-1205.

18.    Gong W, Huang F, Sun L, Yu A, Zhang X, Xu Y, Shen Y, Cao J*. Toll-like   receptor-2 regulates macrophage polarization induced by excretory-secretory   antigens from Schistosoma japonicum eggs and promotes liver pathology   in murine schistosomiasis. PLoS Negl Trop Dis, 2018,12(12):e0007000.

19.    Yin   JH, Liu CH,, Yu AP, Yao JQ, Shen YJ*,   Cao JP*.   Pro-angiogenic   activity of monocytic-type myeloid-derived suppressor cells from Balb/C mice   infected with Echinococcus granulosus and the regulatory role of   miRNAs. Cell Physiol Biochem. 2018;51:1207-1220.

20.    Xu   M, Jiang Z, Huang W, Yin J, Ou S, Jiang Y, Meng L, Cao S, Yu A, Cao J*,   Shen Y*. Altered gut microbiota compositionin subjects infected with   Clonorchis sinensis. Front Microbiol. 2018;9:2292.

21.    Yu A, Wang Y, Yin J, Zhang J, Cao S, Cao J*, Shen Y*. Microarray analysis of   long non-coding RNA expression profiles in monocytic myeloid-derived   suppressor cells in Echinococcus granulosus-infected mice. Parasit   Vectors. 2018 May;11(1):327.

22.    Jiang   Y, Yuan Z, Zang G, Li D, Wang Y, Zhang Y, Liu H, Cao J*, Shen Y*.   Cyclospora cayetanensis infections among diarrheal outpatients in   Shanghai: a retrospective case study. Front Med. 2018;12(1):98-103.

23.    Yin   J, Liu C, Shen Y, Zhang H, Cao J*. Efficacy of ursolic acid against   Echinococcus granulosus in vitro and in a murine infection model. Parasit   Vectors. 2018;11(1):58.

24.    Yin   J, Shen Y, Yu A, Liu C, Yao J, Gong W, Cao J*. The proangiogenic role   of polymorphonuclear myeloid-derived suppressor cells in mice infected with   Echinococcus granulosus.  BioScience Trends. 2018; 12(3):338-341.

25.    Hu   Y, Sun L, Yuan Z, Xu Y, Cao J*. High throughput data analyses of the   immune characteristics of Microtus fortis infected with Schistosoma   japonicum. Sci Rep.2017;7(1):11311.

26.    Zheng   L, Hu Y, Wang Y, Huang X, Xu Y, Shen Y*, Cao J*. Recruitment of neutrophils   mediated by Vγ2 γδ T Cells deteriorates liver fibrosis induced by Schistosoma   japonicum infection in C57BL/6 mice. Infect   Immun. 2017,85(8):e01020-16.

27.    Pan   W, Hao WT, Shen YJ, Li XY, Wang YJ, Sun FF, Yin JH, Zhang J, Tang RX, Cao   JP*, Zheng KY*. The   excretory-secretory products of Echinococcus granulosus protoscoleces   directly regulate the differentiation of B10, B17 and Th17 cells. Parasit   Vectors, 2017,10(1) :384.

28.    Zhang W, Ren G, Zhao W, Yang Z, Shen Y, Sun Y, Liu A*, Cao J*.   Genotyping of Enterocytozoon bieneusi and subtyping of Blastocystis in   cancer patients: relationship to diarrhea and assessment of zoonotic   transmission. Front Microbiol.2017;8:1835.

29.    Liu H, Shen Y, Liu A, Yin J, Yuan Z, Jiang Y, Pan W, Zhang Y,   Zhao W, Cao J*. Occurrence and multilocus genotyping of Giardia   duodenalis in pets and zoo animals in Shanghai, China.  J Infect Dev   Ctries 2017; 11(6):479-486.

30.    Liu H, Jiang Z, Yuan Z, Yin J, Wang Z, Yu B, Zhou D, Shen Y*, Cao   J*. Infection by and genotype characteristics of Enterocytozoon   bieneusi in HIV/AIDS patients from Guangxi Zhuang autonomous region,   China. BMC Infect Dis, 2017,17:684.

31.    Huang YL, Huang DN, Geng YJ, Fang SS, Yang F, Wu CL, Zhang HL,   Wang M, Zhang R, Wang X, Wu S, Cao JP*, Zhang RL*. An integrated   control strategy takes Clonorchis sinensis under control in an endemic area   in south China. Vector-Borne and Zoonotic Diseases,2017;17(12):791-798.

32.    Shi   M, Lin XD, Tian JH, Chen LJ, Chen X, Li CX, Qin XC, Li J, Cao JP, Eden   JS,  Buchmann J, Wang W, Xu JG, Holmes EC, Zhang YZ. Redefining the   invertebrate RNA virosphere. Nature. 2016;540(7634):539-543.

33.    Liu   Z, Yin L, Li Y, Yuan F, Zhang X, Ma J, Liu H, Wang Y, Zheng K*,   Cao J*.   Intranasal immunization with recombinant Toxoplasma gondii actin   depolymerizing factor confers protective efficacy against toxoplasmosis in   mice. BMC Immunol. 2016;17(1):37.

34.    Zhang Y, Wang Y*, Jiang Y, Pan W, Liu H, Yin J, Shen Y, Cao J*. T follicular helper cells in patients with acute   schistosomiasis. Parasit Vectors. 2016;9(1):321.

35.    Zheng Y*, Guo X,   He W, Shao Z, Zhang X, Yang J, Shen Y, Luo X, Cao J*. Effects of Echinococcus   multilocularis miR-71 mimics on murine macrophage RAW264.7 cells. Int   Immunopharmacol. 2016,34:259-262.

36.    Liu Z, Yuan F,   Yang Y, Yin L, Liu Y, Wang Y, Zheng K*, Cao J*. Partial protective   immunity against toxoplasmosis in mice elicited byrecombinant Toxoplasma   gondii malate dehydrogenase. Vaccine 2016,34(7):989–994.

37.    Wu L, Wang X, Li   Y, Liu Y, Su D, Fu T, Guo F, Gu L, Jiang X, Chen S*, Cao J*. Toxoplasma   gondii ROP18: potential to manipulate host cell mitochondrial apoptosis.   Parasitol Res. 2016;115(6):2415-2422.

38.    Yang Z, Zhao W,   Shen Y, Zhang W, Shi Y, Ren G, Yang D, Ling H, Yang F, Liu A*, Cao J*. Subtyping of Cryptosporidium   cuniculus and genotyping of Enterocytozoon bieneusi in rabbits in   two farms in Heilongjiang Province, China. Parasite 2016, 23, 52.

39.    Han S, Tang Q, Lu   X, Chen R, Li Y, Shu J, Zhang X*, Cao J*. Dysregulation   of hepatic microRNA expression profiles with Clonorchis sinensis infection.   BMC Infect Dis.2016;16(1):724.

Books

1.《Manual of   Clinical Microbiology (12th Edition), Co-Chief-Translator, Chinese Medical Multimedia   Press, Beijing, 2020

2.《Manson’s   Tropical Diseases》(23rd   Edition), Deputy Chief-translator, Shanghai Science & Technology   Publishers, Shanghai, 2020

3.《Pathogen   Surveillance and Detection Techniques: Diarrhea Syndrome》,Associate   Editor, Sun Yat-sen University Press, Guangzhou, 2016

4.《Modern   Parasitology》(2nd Edition), Associate   Editor,，People's   Military Medical Press, Beijing, 2015

Patents

1. Yujuan Shen，Jianping Cao,，Hua Liu,，Zhongyin Yuan，Yanyan Jiang,，Jianhai Yin,，Yanjuan Wang.   Multiplex PCR kit and detection method for detecting emerging intestinal protozoan. ZL   201510093500.9, 2017

2. Yujuan Shen，Shengxia Chen,，Hong Jin,，Feng Li，Yuqin Pan,，Qiyan Sun,，Liang Wu，Jianping Cao. Recognition   Method for Parasite Egg Based Shape Image. ZL 201110022426.3, 2012

3. Jianhai Yin,，Jianping Cao,，congshan Liu，Haobing Zhang,，Yujuan Shen.   Application of ursolic acid in preparation of anti-hydatid drugs. ZL 2016 1   0517861.6, 2019.

4. Jianping Cao, Ugwu   Chidiebere Emmanuel, Yujuan Shen,，Yanyan   Jiang，Liping Duan,   Zhongying Yuan. Application of ginkgo acid against cryptosporidium. ZL   201310539693.7, 2016

5. Jianping Cao, Huixia Cai,   Yujuan Shen,，Xiumin Han,，Yuan Hu，Hu Wang,，Weiyuan Lu，Yuxin Xu,，Yayi Guang.   Recombinant antigen protein for diagnosis of echinococcus granulosus, its   preparation method and application. ZL 201010284913.2, 2012

Honors and Awards

1. Study on the pathogens and key techniques of   molecular detection for important emerging intestinal protozoan and their   application in China. Second Prize of China Medical Science   and Technology Award, second Prize of Shanghai Science and Technology   Progress Award, and third Prize in the Huaxia Medical Technology Awards in 2019.

2. Establishment and application of   nucleic acid assays and genotyping techniques for Cryptosporidium in   China. Third prize of China Preventive Medicine Science and Technology Award   (2015)

Lectures

Parasitic   infection and immunity, Professional English -- Immunology, Neglected tropical   diseases, Epidemiology and challenges of emerging infectious parasitic   diseases, Laboratory Biosafety Management, Zoonotic parasitic diseases