王兆軍 教授 博士生導(dǎo)師
上海交通大學(xué)醫(yī)學(xué)院全球健康學(xué)院 副院長
上海交通大學(xué)醫(yī)學(xué)院黨委教師工作部 副部長
上海交通大學(xué)基礎(chǔ)醫(yī)學(xué)院 課程組長
上海市免疫學(xué)研究所 課題組長
聯(lián)系方式
辦公室：上海市重慶南路280號西區(qū)5號樓1207室,，郵編200025
電話：021-63846590（x776349）
郵箱：[email protected]
教育經(jīng)歷
2006/6 上海交通大學(xué),，博士
2002/6 上海第二醫(yī)科大學(xué)，碩士
1996/6 上海第二醫(yī)科大學(xué),，學(xué)士
工作經(jīng)歷
2023/2-至今 上海交通大學(xué)全球健康學(xué)院，副院長
2021/5-至今 上海市免疫學(xué)研究所,，課題組長
2017/7-至今 上海交通大學(xué)醫(yī)學(xué)院,，黨委教師工作部，副部長
2014/12-至今 上海交通大學(xué)醫(yī)學(xué)院,，免疫學(xué)與微生物學(xué)系,，教授
2008/11-2012/6 [美國]賓夕法尼亞大學(xué)醫(yī)學(xué)院，博士后研究人員
2006/12-2014/12 上海交通大學(xué)醫(yī)學(xué)院,，副教授
2003/1-2006/12 上海第二醫(yī)科大學(xué)（現(xiàn)上海交通大學(xué)醫(yī)學(xué)院）,，講師
1996/7-2002/12 上海第二醫(yī)科大學(xué)，助教
研究方向
長期致力于感染免疫研究,，尤其是熱帶病與炎癥微環(huán)境中天然免疫細(xì)胞的功能調(diào)控方面,，取得了一系列原創(chuàng)性科學(xué)發(fā)現(xiàn)。主持國家自然基金項(xiàng)目6項(xiàng),、教育部與省部級課題8項(xiàng),，在Nature Immunology、Nature communication,、 Journal of Clinical Investigation,、PNAS、Cell death and differentiation,、PLoS Neglected Tropical Diseases,、Frontiers in Immunology等高水平雜志上發(fā)表第一或通訊作者論文30余篇。研究成果曾獲全國百篇優(yōu)秀博士論文,。個(gè)人曾獲中國免疫學(xué)青年學(xué)者獎(jiǎng),、寶鋼優(yōu)秀教師獎(jiǎng)，入選東方英才拔尖項(xiàng)目,、上海市浦江人才等,。
代表性研究論文
[1] DU X, REN B, LI C, et al. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury [J]. Nature communications, 2024, 15(1).
[2] LEI Y, GUO X, LUO Y, et al. Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis [J]. Nature communications, 2024, 15(1).
[3] SUN Z-S, WAN E-Y, AGBANA Y L, et al. Global One Health index for zoonoses: A performance assessment in 160 countries and territories [J]. iScience, 2024.
[4] LI Q, YUE T, DU X, et al. HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction [J]. Cell Death & Differentiation, 2023, 30(3): 647-59.
[5] ZHANG X-X, LI X-C, ZHANG Q-Y, et al. Tackling global health security by building an academic community for One Health action [J]. Infectious Diseases of Poverty, 2023, 12(1).
[6] LI Q, LI X, KAN S, et al. Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes [J]. Frontiers in Cellular and Infection Microbiology, 2023, 13.
[7] KAN S, LI Q, LI H-M, et al. Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex [J]. PLoS neglected tropical diseases, 2022, 16(9).
[8] WU C, DU X, TANG L, et al. Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) [J]. Frontiers in immunology, 2020, 11.
[9] DU X, ZHANG Y, LI X, et al. PRL2 serves as a negative regulator in cell adaptation to oxidative stress [J]. Cell & bioscience, 2019, 9(1).
[10] YIN C, WU C, DU X, et al. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS [J]. Frontiers in immunology, 2018, 9.
[11] FAYNGERTS S A, WANG Z, ZAMANI A, et al. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2 [J]. Nature immunology, 2017, 18(12): 1353-60.
[12] FANG Y, WU C, CHEN Q, et al. SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development [J]. Acta tropica, 2015, 149: 49-58.
[13] WANG Z, FAYNGERTS S, WANG P, et al. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection [J]. Proceedings of the National Academy of Sciences, 2012, 109(38): 15413-8.
[14] WANG Z, QIU J, GUO T B, et al. Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis [J]. The Journal of Immunology, 2007, 179(9): 5958-65.
[15] HU W, YAN Q, SHEN D-K, et al. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource [J]. Nature genetics, 2003, 35(2): 139-47.
英文：
Name：Zhaojun Wang
Title：Professor, Doctoral Supervisor
Deputy Dean, School of Global Health, Shanghai Jiao Tong University School of Medicine
Deputy Director, Department of Teachers' Work of the Party Committee, Shanghai Jiao Tong University School of Medicine
Course leader, School of Basic Medicine, Shanghai Jiao Tong University
PI, Shanghai Institute of Immunology
Contact Methods:
Office Address: 280 South Chongqing Road, Room 1207
Office Tel:021-63846590 (x776349)
Email Address: [email protected]
Education：
Ph.D in Immunology, Shanghai Jiao Tong University, China
Master in Microbiology and Parasitology, Shanghai Second Medical University, China
Bachelor in Medical laboratory science, Shanghai Second Medical University, China
Appointments:
2023/2-present Deputy Dean, School of Global Health, Shanghai Jiao Tong University
2021/5-now PI, Shanghai Institute of Immunology
2017/7-present Deputy director, Department of Teachers' work of the party committee, Shanghai Jiao Tong University School of Medicine
2014/12-present Professor, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
2008/11-2012/6 [USA] Postdoctoral researcher, University of Pennsylvania School of Medicine
12/2006-12/2014 Associate Professor, Shanghai Jiao Tong University School of Medicine
2003/1-2006/12 Lecturer, Shanghai Second Medical University (now Shanghai Jiao Tong University School of Medicine)
1996/7-2002/12 Assistant Professor, Shanghai Second Medical University
Research Direction:
Prof. Wang has been committed to infection immunity research for a long time, especially in the functional regulation of natural immune cells in tropical diseases and inflammatory microenvironments, and has made a series of original scientific discoveries. Presided over 6 National Natural Fund projects, 8 projects of the Ministry of Education and provincial and ministerial level, In Nature Immunology, Nature communication, Journal of Clinical Investigation, PNAS, Cell death and differentiation, PLoS Neglected Tropical Diseases, Frontiers in Immunology and other high-level journals published more than 30 first or corresponding author papers. His research results have been awarded one hundred outstanding doctoral dissertations nationwide. He has won the China Immunology Young Scholar Award, Baosteel Excellent Teacher Award, selected as the Oriental Outstanding Talent Project, Shanghai Pujiang Talent and so on.
Representative Publications:
[1] DU X, REN B, LI C, et al. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury [J]. Nature communications, 2024, 15(1).
[2] LEI Y, GUO X, LUO Y, et al. Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis [J]. Nature communications, 2024, 15(1).
[3] SUN Z-S, WAN E-Y, AGBANA Y L, et al. Global One Health index for zoonoses: A performance assessment in 160 countries and territories [J]. iScience, 2024.
[4] LI Q, YUE T, DU X, et al. HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction [J]. Cell Death & Differentiation, 2023, 30(3): 647-59.
[5] ZHANG X-X, LI X-C, ZHANG Q-Y, et al. Tackling global health security by building an academic community for One Health action [J]. Infectious Diseases of Poverty, 2023, 12(1).
[6] LI Q, LI X, KAN S, et al. Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes [J]. Frontiers in Cellular and Infection Microbiology, 2023, 13.
[7] KAN S, LI Q, LI H-M, et al. Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex [J]. PLoS neglected tropical diseases, 2022, 16(9).
[8] WU C, DU X, TANG L, et al. Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) [J]. Frontiers in immunology, 2020, 11.
[9] DU X, ZHANG Y, LI X, et al. PRL2 serves as a negative regulator in cell adaptation to oxidative stress [J]. Cell & bioscience, 2019, 9(1).
[10] YIN C, WU C, DU X, et al. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS [J]. Frontiers in immunology, 2018, 9.
[11] FAYNGERTS S A, WANG Z, ZAMANI A, et al. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2 [J]. Nature immunology, 2017, 18(12): 1353-60.
[12] FANG Y, WU C, CHEN Q, et al. SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development [J]. Acta tropica, 2015, 149: 49-58.
[13] WANG Z, FAYNGERTS S, WANG P, et al. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection [J]. Proceedings of the National Academy of Sciences, 2012, 109(38): 15413-8.
[14] WANG Z, QIU J, GUO T B, et al. Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis [J]. The Journal of Immunology, 2007, 179(9): 5958-65.
[15] HU W, YAN Q, SHEN D-K, et al. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource [J]. Nature genetics, 2003, 35(2): 139-47.
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