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徐雅倩

職稱：助理研究員

地址：上海市黃浦區(qū)重慶南路280號1號樓412室

電話：021-63846590*776974

郵箱：[email protected]

工作經(jīng)歷

2023.12~至今，上海交通大學(xué)，全球健康學(xué)院,，助理研究員

2021.11~2023.11,，中國科學(xué)院生態(tài)環(huán)境研究中心環(huán)境化學(xué)與生態(tài)毒理學(xué)國家重點(diǎn)實(shí)驗(yàn)室-國科大杭州高等研究院環(huán)境學(xué)院,，博士后

教育經(jīng)歷

2015.09~2021.08,，同濟(jì)大學(xué)，環(huán)境科學(xué)與工程學(xué)院,，博士

2019.09~2020.10，哥本哈根大學(xué),，植物與環(huán)境科學(xué)學(xué)院,，聯(lián)合培養(yǎng)博士

2011.09~2015.06,，上海海洋大學(xué)，水產(chǎn)與生命學(xué)院,，學(xué)士

社會/學(xué)術(shù)任職和活動

2024~至今,，Eco-Environment Health，青年編委

2023~至今,，中國毒理學(xué)會,，成員

2023~至今，中國化學(xué)會,，成員

2019~至今,，Society of Environmental Toxicology and Chemistry (SETAC)，成員

教授課程

負(fù)責(zé)《全球健康與全健康》“全球環(huán)境健康”章節(jié)教學(xué)

獎勵

2024年度Eco-Environment Health期刊優(yōu)秀青年編委

研究方向

環(huán)境污染與健康

研究興趣

應(yīng)用環(huán)境化學(xué)與流行病學(xué)等多學(xué)科研究方法,，探討環(huán)境中污染物與人體健康不良結(jié)局的關(guān)聯(lián),，尤其關(guān)注具有Hormesis現(xiàn)象的污染物，為污染物的管控和人口可持續(xù)發(fā)展提供科學(xué)支撐,。

科研項(xiàng)目

1. 上海交通大學(xué)“新進(jìn)青年教師啟動計(jì)劃”(2023.12~2026.12),，全氟化合物暴露與美國成年人死亡的相關(guān)性研究，主持

2. 長江水環(huán)境教育部重點(diǎn)實(shí)驗(yàn)室開放基金(重點(diǎn))(2022.01~2024.12),，合成酚類抗氧化劑及其轉(zhuǎn)化產(chǎn)物在長江三角洲的賦存特征與聯(lián)合風(fēng)險(xiǎn)評估(YRWEF202201),，主持

3. 國科大杭州高等研究院自主立項(xiàng)交叉項(xiàng)目課題(2022.12~2024.12)，典型工業(yè)熱過程鹵代芳烴類新污染物識別和催化轉(zhuǎn)化的自由基機(jī)制研究(2022ZZ01017),，主持

4. 國科大杭州高等研究院博士后啟動基金(2021.11~2023.11),，合成抗氧化劑及其轉(zhuǎn)化產(chǎn)物的人體暴露特征與環(huán)境聯(lián)合風(fēng)險(xiǎn)研究(B065C40723006)，主持

5. 中國科學(xué)院戰(zhàn)略性先導(dǎo)科技專項(xiàng)(B類)課題(2023.12~2028.11),，新污染物多介質(zhì)環(huán)境遷移與轉(zhuǎn)化(XDB0750200),，骨干

6. 國家自然科學(xué)基金面上項(xiàng)目(2020.01~2023.12)，個(gè)人護(hù)理品時(shí)間依賴Hormesis及在混合物中的傳遞規(guī)律與機(jī)理探索(21976139),，骨干

7. 國家食品安全關(guān)鍵技術(shù)研發(fā)計(jì)劃項(xiàng)目子課題(2018.12~2021.12),，混合污染物聯(lián)合作用劑量-效應(yīng)評價(jià)模型研究(2018YFC1603003)，骨干

8. 十三五水體污染控制與治理重大專項(xiàng)子課題(2017.01~2020.12),，標(biāo)準(zhǔn)外污染物濃度限值研究(2017ZX07201005),，骨干

9. 國家自然科學(xué)基金面上項(xiàng)目(2017.01~2020.12)，多元混合物合理有效表征及混合毒性預(yù)測模型研究(21677113),，骨干

代表性學(xué)術(shù)論文

1. Li, K., Li, X.W., Xu, Y.Q.* Chemical ingredients in personal care products and their hormetic effects on freshwater photobacteria. Journal of Environmental Exposure Assessment, 2024, 3, 30.

2. Xu, Y.Q., Hao, Y.Q., Chen, T.C., Li, X.W.* Structural and policy overview of medical education in Germany. Global Medicine Education, 2024, 1, 1-13.

3. Xu, Y.Q., Huang, P., Li, X.W., Liu, S.S., Lu, B.Q.* Derivation of water quality criteria for paraquat, bisphenol A and carbamazepine using quantitative structure-activity relationship and species sensitivity distribution (QSAR-SSD). Science of the Total Environment, 2024, 948, 174739.

4. Xu, Y.Q., Ding, T.T., Zhu, Q.Q., Tao, L., Liu, S. S., Hu, L.G., Liao, C.Y.* Ecological risk of synthetic phenolic antioxidants: A study based on their spatial distribution in water, sediment, and soil from the Yangtze River Delta. China. Environmental Research, 2024, 262(Pt 2), 119920.

5. Xu, Y.Q., Wang, T., Yin, J., Hu, L.G., Liao, C.Y.* The silent threat and countermeasures: Navigating the mixture risk of endocrine-disrupting chemicals on pregnancy loss in China. Eco-Environment Health, 2024, 3(3), 266-270.

6. Xu, Y.Q., Zhang, N., Hu, Y., Chen, F., Hu, L.G., Liao, C.Y.*, Jiang, G.B. A preliminary understanding of the relationship between synthetic phenolic antioxidants and early pregnancy loss: Uncovering the potential molecular mechanisms. Science of the Total Environment, 2024, 927, 171972.

7. Ding, T.T., Wang, Z.J., Tao, M.T., Gu, Z.W., Chen, R.J., Xu, Y.Q., Liu, S.S.* An innovative mixture sampling strategy with uniform design: Application to global sensitivity analysis of mixture toxicity. Environment International, 2024, 191, 108968.

8. Tao, M.T., Sun, X., Ding, T.T., Xu, Y.Q., Liu, S.S.* Screening for frequently detected quaternary ammonium mixture systems in waters based on frequent itemset mining and prediction of their toxicity. Ecotoxicology and Environmental Safety, 2024, 280, 116581.

9. Li, Y.T., Wang, X., Zhu, Q.Q., Xu, Y.Q., Fu, Q., Wang, T., Liao, C.Y.*, Jiang, G.B. Organophosphate flame retardants in pregnant women: Sources, occurrence, and potential risks to pregnancy outcomes. Environmental Science & Technology, 2023, 57(18), 7109-7128.

10. Xu, Y.Q., Hu, Y., Ding, T.T., Wang, Z.J., Wang, T., Hu, L.G., Liu, S.S., Liao, C.Y.*, Gan, J., Jiang, G.B. Novel macromolecular synthetic phenolic antioxidants in sludge on a national scale in China: Their distribution, potential transformation products, and ecological risk. Science of the Total Environment, 2023, 894, 164928.

11. Xu, Y.Q., Hu, Y., Wang, X., Hu, L.G., Liao, C.Y.*, Jiang, G.B. Profiles of novel high-molecular-weight synthetic antioxidants in urine and associated child exposure in China. Science of the Total Environment, 2023, 870, 161844.

12. Xu, Y.Q., Li, K., Wang, Z.J., Huang, P., Liu, S.S*. Transfer pattern of hormesis into personal care product mixtures from typical hormesis-inducing compounds. Science of the Total Environment, 2023, 855, 158981.

13. Huang, P., Wang, Y., Liu, S.S.*, Wang, Z.J., Xu, Y.Q. SAHmap: Synergistic-antagonistic heatmap to evaluate the combined synergistic effect of mixtures of three pesticides on multiple endpoints of Caenorhabditis elegans. Environmental Pollution, 2022, 315, 120378.

14. Huang, P., Liu, S.S.*, Wang, Z.J., Ding, T.T., Xu, Y.Q. Deriving the predicted no effect concentrations of 35 pesticides by the QSAR-SSD method. Chemosphere, 2022, 298, 134303.

15. Wang, Z.J., Zheng, Q. F., Liu, S.S.*, Huang, P., Ding, T.T., Xu, Y.Q. New methods of top-to-down mixture toxicity prediction: A case study of eliminating of the effects of cosolvent from binary mixtures. Chemosphere, 2022, 289, 133190.

16. Huang P., Liu S.S.*, Xu Y.Q., Wang Y., Wang Z.J. Combined lethal toxicities of pesticides with similar structures to Caenorhabditis elegans are not necessarily concentration additives. Environmental Pollution, 2021, 286, 117207.

17. Wang, Z.J., Liu, S.S.*, Huang, P., Xu, Y.Q. Mixture predicted no-effect concentrations derived by independent action model vs concentration addition model based on different species sensitivity distribution models. Ecotoxicology and Environmental Safety, 2021, 227, 112898.

18. Wang Z.J., Chen F., Xu Y.Q., Huang P., Liu S.S*. Protein model and function analysis in quorumsensing pathway of Vibrio qinghaiensis sp.-Q67. Biology-Basel, 2021, 10, 638.

19. Xu, Y.Q., Liu, S.S.*, Chen, F., Wang, Z.J. pH affects the hormesis profiles of personal care product components on luminescence of the bacteria Vibrio qinghaiensis sp. -Q67. Science of the Total Environment, 2020, 713, 136656.

20. Xu, Y.Q., Li, K., Wang, Z.J., Liu, S.S*. The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67. Environmental Sciences Europe, 2020, 32, 11.

21. Xu, Y.Q., Liu, S.S.*, Lu, B.Q., Wang, Z.J. Acute toxicity dataset for QSAR modeling and predicting missing data of six pesticides. Data in Brief, 2020, 29.

22. Huang, P., Li, K., Xu, Y.Q., Wang, Z.J., Liu, S.S*. Genetically modified Caenorhabditis elegans maylead to inaccurate toxicity evaluation of mixtures. Environmental Sciences Europe, 2020, 32(1), 63.

23. Lu, B.Q., Liu, S.S.*, Wang, Z.J., Xu, Y.Q. Conlecs: A novel procedure for deriving the concentration limits of chemicals outside the criteria of human drinking water using existing criteria and species sensitivity distribution based on quantitative structure-activity relationship prediction. Journal of Hazardous Materials, 2020, 384, 121380.

24. Wang, Z.J., Liu, S.S.*, Feng, L., Xu, Y.Q. BNNmix: A new approach for predicting the mixture toxicity of multiple components based on the back-propagation neural network. Science of the Total Environment, 2020, 738, 140317.

25. Wang, Y., Liu, S.S.*, Huang, P., Wang, Z.J., Xu, Y.Q. Assessing the combined toxicity of carbamate mixtures as well as organophosphorus mixtures to Caenorhabditis elegans using the locomotion behaviors as endpoints. Science of the Total Environment, 2020, 160, 143378.

26. Xu, Y.Q., Liu, S.S.*, Li, K., Wang, Z.J., Xiao, Q.F. Polyethylene glycol 400 significantly enhances the stimulation of 2-phenoxyethanol on Vibrio qinghaiensis sp.-Q67 bioluminescence. Ecotoxicology and Environmental Safety, 2019, 171, 240-246.

27. Xu, Y.Q., Liu, S.S.*, Wang, Z.J., Li, K., Qu, R. Commercial personal care product mixtures exhibit hormetic concentration-responses to Vibrio qinghaiensis sp.-Q67. Ecotoxicology and Environmental Safety, 2018, 162, 304-311.

28. Xu, Y.Q., Liu, S.S.*, Fan, Y., Li, K. Toxicological interaction of multi-component mixtures to Vibrio qinghaiensis sp.-Q67 induced by at least three components. Science of the Total Environment, 2018, 635, 432-442.

國家標(biāo)準(zhǔn)與軟件著作權(quán)

1. 乳粉中三種多溴二苯醚(PBDEs)成分分析標(biāo)準(zhǔn)物質(zhì),，國家標(biāo)準(zhǔn)物質(zhì)定級證書，證書號：國標(biāo)物證字第5127號,，編號：GBW（E）100928(低濃度),，2023年7月14日，第四完成人,。

2. 乳粉中三種多溴二苯醚(PBDEs)成分分析標(biāo)準(zhǔn)物質(zhì),，國家標(biāo)準(zhǔn)物質(zhì)定級證書,，證書號：國標(biāo)物證字第5127號，編號：GBW（E）100929(高濃度),，2023年7月14日,，第四完成人。

3. 單個(gè)/混合物毒性擬合,、預(yù)測與評估軟件[簡稱：FPAsmt]1.0. 計(jì)算機(jī)軟件著作權(quán)登記證書(證書號：軟著登字第9049442號,，登記號: 2022SR0095243，No. 10056721),，2022年01月14日,，第三完成人。

Biography

Yaqian Xu, Ph.D.

Assistant Professor, School of Global Health, Shanghai Jiao Tong University

Office: +86-021-63846590*776974

Email: [email protected]

Office Address: Rm 412, Building 1, 280 South Chongqing Road, Shanghai

Dr. Xu is an assistant professor in the School of Global Health at Shanghai Jiao Tong University in China. Her academic journey includes earning bachelor's and Ph.D. degrees from Shanghai Ocean University and Tongji University, respectively. She pursued postdoctoral research at the Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (RCEES, CAS) and the Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences (UCAS). Additionally, she was a visiting Ph.D. at the University of Copenhagen in Denmark. With over 28 peer-reviewed scientific articles in international journals such as Environmental Science & Technology and Environmental Research, her work has garnered over 260 citations and an H-index of 12. She has served as a member in multiple organizations, including the European Society of Environmental Toxicology and Chemistry (SETAC), the Chinese Society of Toxicology, and the Chinese Chemical Society. Presently, she is involved in research initiatives such as the Strategic Priority Research Program of the Chinese Academy of Sciences and the Open Fund of the Key Laboratory of Yangtze River Water Environment, Ministry of Education.

Employment and Education Background

2023.12~now, Assistant Professor, School of Global Health, Shanghai Jiao Tong University

2021.11~2023.11, Post-doctorate, State Key Laboratory of Environmental Chemistry and Ecotoxicology, RCEES, CAS and School of Environment, Hangzhou Institute for Advanced Study, UCAS

2019.09~2020.10, Guest Ph.D., Department of Plant and Environmental Sciences, University of Copenhagen

2015.09~2021.08, Ph.D., College of Environmental Science and Engineering, Tongji University

2011.09~2015.06, B.S., College of Fisheries and Life Science, Shanghai Ocean University

Research Interests and Expertise

Dr. Xu's research aims to evaluate the environmental health risks posed by pollutants to humans. It uses interdisciplinary research methods such as environmental chemistry and epidemiology to explore the links between pollutants and adverse health outcomes, with a particular focus on pollutants exhibiting the hormesis phenomenon. The goal is to provide scientific evidence to support pollutant regulation and promote sustainable population development.