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Research


  • Name:Bing Su

    Office Location:280 South Chongqing Road, Room 1101, West #5 Building, Shanghai, China 200025

    Telephone:86-21-63846383

  • Email:[email protected]




Education

1984

Peking University

B.S.

1987

Yale University

M.Ph.

1991

Yale University

Ph.D.

Career

1991-1995

University of California at San Diego Postdoctoral Fellow

1995-2006

The University of Texas Health Science Center Assistant, Associate, and Full Professor,

2007-2014

Yale School of Medicine and Graduate School of Arts & Sciences Associate Professor (Tenure)

2015-present

Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale School of Medicine Adjunct Professor

2009-present

Xiangya Hospital, Central South University Guest Professor

2012-Present

Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine Director and Principal Investigator

2014-Present

Department of Immunology and Microbiology, Shanghai Jiaotong University School of Medicine Professor and Chair

2015-Present

Shanghai Jiaotong University KC Wong Endowed Chair Professor

2016-Present

Immune and Microbiota Related Diseases Research Center of Shanghai Institute of Immunology & Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Director

2018-Present

Shanghai Jiao Tong University School of Medicine-Yale University Immunometabolism Research Center (SYIRC) Director

Research Interests

The research in my laboratory focuses on the biology of signal transduction mediated by the intracellular protein kinase network such as the mitogen-activated protein kinase (MAPK) cascades and the mammalian target of rapamycine (mTOR) pathway in gut immune responses and blood vessel function/development. Our current studies have focused on the biological roles and regulatory mechanisms of these kinase pathways in intestinal mesenchymal stromal cells, macrophages, T and innate lymphocytes.

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1.Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B.(#).MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.Nature, 2021 Apr;592(7855):606-610.  [Link]

2.Qi, J, A Crinier, B Escaliere, Y Ye, Z Wang, T Zhang, L Batista, H Liu, L Hong, N Wu, M Zhang, L Chen, Y Liu, L Shen, E Narni-Mancinelli, E Vivier and B Su.(#). Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression.Cell Rep Med,,2021 2(8): 100353.  [Link]

3.Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Jiang C, Liang J, Li YM, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu SQ, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zuo Z, Bai F, Huang X, Zhou P, Jiang Q, Huang Z, Bei JX, Wei L, Bian XW, Liu X, Cheng T, Li X, Zhao P, Wang FS, Wang H, Su B (#), Zhang Z, Qu K, Wang X, Chen J, Jin R, Zhang Z.COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.Cell, 2021 Apr 1;184(7):1895-1913.e19.  [Link]

4.Yang XD, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B(#). PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J, 2020 Jan 15;39(2):e102201.  [Link]

5.Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B(#), Ginhoux F. Fate mapping via Ms4a3 expression history traces monocyte-derived cells. Cell, 2019 Sep 5;178(6):1509-1525.  [Link]

6.Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B(#), Liu J, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+T Cells. Cell Metabolism,, 2019 Aug 6;30(2):290-302.  [Link]

7.Ruan C, Ouyang X, Liu H, Li S, Jin J, Tang W, Xia Y, and Su B(#) . Sin1-mediated mTOR Signaling in Cell Growth, Metabolism and Immune Response. National Science Review,, 2019, Nov. 19; 6:1149-116.  [Link]

8.M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,B Su.(#).Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.Cell Mol Immunol,2019,doi: 10.1038/s41423-018-0185-x..  [Link]

9.OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su.(#).Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression ..J Immunol, 2018,201:908-915.  [Link]

10.Xuemei Fan, Conghui Wang, Panlai Shi, Wen Gao, Jianmin Gu, Yan Geng, Wenlong Yang, Ningbo Wu, Yang Wang, Yanyan Xu, Xue Chen, Lin Zhang, Kemin Wang,Bing Su(#) and Junling Liu.. Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.Blood Adv,2018,26;2(12):1439-1448.  [Link]

11.Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B(#) and Wu ZB.Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors .Nature Communications,2018, 9:4624.  [Link]

12.Xu YY, Ouyang XX, Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B(#), and Liu JL.Sin1 regulates ischaemia-induced microthrombosis through integrin αIIbβ3-mediated outside-in signaling and hypoxia responses in platelets. . Arteriosclerosis, Thrombosis, and Vascular Biology.,2018,32.(in press).  [Link]

13.X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, Bing Su.(#).Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2. . J Mol Cell Biol,2018,11(2):93-106.  [Link]

14.Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C Huang YH, Hamilton TA1,2, Su B (#)and  LiX..IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.. J Immunol,2017,199(11):3849-3857.  [Link]

15.Tan R, Nakajima S, Wang Q, Sun H,Xue J, Wu J, Hellwig S, Zeng X, Yates NA7, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B(#), Lan L.Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.Mol Cell,2017 ,65(5):818-831.  [Link]

16.Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B(#), Li Y .Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.Oncotarget,2016,7(9):10064-72..  [Link]

17.Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, Blenis J, Cantley LC, Toker A, Su B(#), Wei W.PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.Cancer Discov,2015,5(11):1194-209.  [Link]

18.Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. (#).Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun,2015,6:7937.  [Link]

19.Xing Chang, Fang Liu, Xiaofang Wang, and Su B. (#).MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation. Immunity,2011,34: 201-212,.  [Link]

20.Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang, Su B(#), and Estela Jacinto..The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J,2008,44.27(14):1932-43, .  [Link]

21.Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.(#).SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell,2006,127(1):125-37. .  [Link]

22.Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, and Su B.(#).Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3.Nature Immunology,2004,5:95-103.  [Link]

23.Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y, and Su B.(#).Essential role of MEKK3 in TNF-induced NF-kB activation.Nature Immunology,2001,2:624.  [Link]

24.Su B.(*), Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. .JNK mediates signal integration during costimulation of T lymphocytes..Cell  ,1994,77:727-736,.  [Link]




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Xiaodong Yang, Ph.D.

Professor

Email:[email protected]



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Ningbo Wu,Ph.D.

Associate Professor

E-mail:[email protected]



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Qijun Wang,Ph.D.

Associate Professor

E-mail:[email protected]



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Chun_Ruan,Ph.D.

Associate Professor

E-mail:[email protected]


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Xiaoli_Jiang,M.S.

Technician

E-mail:[email protected]



Dandan_Wu,M.S.

Technician

E-mail:[email protected]



12C7D

Shujing Lai,Ph.D.

Postdoctor

E-mail:[email protected]


Hongxiang Sun,Ph.D.

Postdoctor 

E-mail:[email protected]



Yao Chen, Ph.D.

Postdoctor

E-mail:[email protected]


Song Li, B.S.

Ph.D. Candidate (Class 2015)

E-mail:[email protected]



Jingsi Jin

Ph.D. Candidate (Class 2016)

E-mail:[email protected]


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Xiaoyun Zhao

Ph.D. Candidate (Class 2016)

E-mail:[email protected]


Jianmei_Tan

Ph.D Candidate (Class2017)

E-mail:[email protected]



Hongqian_Chen

Ph.D Candidate (Class2018)

E-mail:[email protected]



Liang_Li

Ph.D Candidate (Class2019)

E-mail:[email protected]



Xinyu_Wang

Ph.D Candidate (Class2019)

E-mail:[email protected]


Yao Zhang

M.D. Candidate (Dept.Gastroenterology, Ruijin Hospital)

E-mail:[email protected]


Wei Ma

M.D. Candidate (Dept. Oncology, Xiangya Hospital)

E-mail:[email protected]


Lang Zou, M.S.

Ph.D Candidate (co-mentored by Dr.Yinon Ben-Neriah)

E-mail:[email protected]


Xing Chen

Ph.D Candidate

E-mail:[email protected]


Zhenglan Duan

Ph.D Candidate

(Shanghai University of Traditional Chinese Medicine)

E-mail:[email protected]



Lab Location:Room 1111, No.5 Bldg., West Compus, 280 South Chongqing Rd.,Shanghai

Tel:86-021-63846590-776564



                 

Copyright 2016. Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine.All Rights Reserved.