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Research
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  • Name:Chuanxin Huang

  • Office Location:Room 1003, No.5 Bldg., West Area, 280 South Chongqing Rd,Shanghai 200025, China

  • Telephone:86-021-54610161

  • Email:[email protected]


Education


1992.09-1997.06 Fudan University B.S
2002.09-2007.05 Institute of Neuroscience, Chinese Academy of Sciences Ph.D



Career

2008.12-2014.10 Weill Cornell Medical College     Research Associate
1997.07-2002.08 Fudan University     Assistant teacher
2007.06-2008.11 Columbia University      Postdoctoral Fellow
2014.12-present Department of Immunology and Microbiology, Shanghai Jiaotong University School of Medicine     research professor and principal investigator

Research Interests

My research group is interested in the transcriptional control of B cell development, differentiation and malignant transformation. Currently, my research mainly focuses on the function and biochemical mechanisms of two disease-associated transcription factors BCL6 and BACH2. My lab is conducting two major research directions:  1) how BCL6 controls germinal center B cell development and the phenotype of B-cell lymphoma; and 2) the effect of BACH2 on B-cell development, lymphoma, leukemia and Inflammatory bowel disease.  The overall goal is to identify therapeutic targets in treatment of human lymphoma and autoimmune diseases as well as improve vaccination strategies


1.  Huang C, Melnick A.Mechanisms of action of BCL6 during germinal center B cell development.Science China Life sciences,2015,58(12): 1226-1232.   [Link]

2.  Huang C, Shi Y, Zhao Y.USP8 mutation in Cushings disease.Oncotarget ,2015,6(21): 18240-18241.   [Link]

3.  Ma ZY, Chen JH, Song ZJ, Huang C, Shi YY and Zhao Y.Recurrent gain-of-function USP8 mutations in Cushing’disease.Cell Res,2015,25(3):306-17.   [Link]

4.  Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A.The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers..Cell Reports,2014,8(5):1497-508.   [Link]

5.  Huang C, Geng H, Boss I, Wang L, Melnick AM.Cooperative transcriptional repression by BCL6 and BACH2 in germinal centre B-cell differentiation.Blood,2014,123(7):1012-20.   [Link]

6.  Huang C, Hatzi K, Melnick AM.Lineage-specific functions of Bcl6 in immunity and inflammation are mediated through distinct biochemical mechanisms.Nature Immunology ,2013,14(4): 380-8.   [Link]

7.  Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Carina Ng, Titz B, Hurtz C, Sadiyah F, Melnick AM, Müschen M.BACH2 mediates negative ion and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.Nature Medicine,2013,19(8):1014-22.   [Link]

8.  Sun Z, Huang C, He J, Lamb, Kristy L Kang X Shen WH Yin, Y.PTEN C-terminal deletion causes genomic instability and tumor development.Cell Reports,2014,6(5):844-54.   [Link]

9.  Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, GElemento O, Melnick A.A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters..Cell Reports,2013,15;4(3):578-88.   [Link]

10.  Cubedo E, Gentles AJ, Huang C, Natkunam, Y, Melnick A; Lossos IS.Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.Blood,2012,119(23): 5478-5491.   [Link]


               

Xuemin Jian

2015 visiting Ph.D. graduate student

E-mail:[email protected]


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Heng Zhang

2016 Ph.D

E-mail:[email protected]


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Hong Peng,Ph.D.

Research Fellow

E-mail:[email protected]


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fang Yang,M.S

Teaching Assistant

E-mail:[email protected]


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Chen Peng,Ph.D.

Lecturer

E-mail:[email protected]




Lab Location:Room 1001, No.5 Bldg., West Area, 280 South Chongqing Rd,Shanghai 200025, China

Tel:86-021-63846590x776724


                 

Copyright 2016. Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine.All Rights Reserved.