研究組長(zhǎng)介紹
王瓊，上海交通大學(xué)醫(yī)學(xué)院研究員,，干細(xì)胞與再生醫(yī)學(xué)研究組組長(zhǎng),，博士生導(dǎo)師。2010年在美國羅切斯特大學(xué)獲得生物醫(yī)學(xué)遺傳學(xué)博士學(xué)位,。隨后在美國紀(jì)念斯隆-凱特琳癌癥中心進(jìn)行博士后研究,。2018年起在上海交通大學(xué)醫(yī)學(xué)院組織胚胎學(xué)和遺傳發(fā)育學(xué)系擔(dān)任課題組組長(zhǎng)。其實(shí)驗(yàn)室主要致力于干細(xì)胞的分化調(diào)控機(jī)制和臨床應(yīng)用的研究,，學(xué)術(shù)論文發(fā)表于Cell Stem Cell, Developmental Cell, Genes & Devlopment等雜志,。并先后獲得NYSTEM Postdoctoral Training Award，MSKCC Helena Johnson Hackley Society Scholar Prize等榮譽(yù)和國家自然科學(xué)基金面上項(xiàng)目的資助,。
研究方向與進(jìn)展
干細(xì)胞是一類具有自我復(fù)制和無限擴(kuò)增能力的多潛能細(xì)胞,。根據(jù)其產(chǎn)生的部位和分化能力，可分為胚胎干細(xì)胞和成體干細(xì)胞,。胚胎干細(xì)胞具有分化成多種類型的細(xì)胞和再生各種組織器官的功能,。而成體干細(xì)胞具有分化成來源器官的各種細(xì)胞類型的能力。闡明干細(xì)胞多能性和分化的調(diào)控信號(hào)通路是了解其生理功能和病理機(jī)制的前提條件,。本課題組主要使用基因組學(xué),、表觀遺傳學(xué)和計(jì)算生物學(xué)等方法，并結(jié)合干細(xì)胞,、類器官和動(dòng)物等多種模型研究干細(xì)胞在生理或病理情況下的分化調(diào)控機(jī)制,，最終促進(jìn)干細(xì)胞的臨床應(yīng)用。主要研究方向：1. 胚胎干細(xì)胞向中內(nèi)胚層分化的“開關(guān)”調(diào)控機(jī)制,。2. 中內(nèi)胚層成體干細(xì)胞的分化調(diào)控和臨床應(yīng)用,。
科研項(xiàng)目
1. 胚胎干細(xì)胞向中內(nèi)胚層分化的早期命運(yùn)決定機(jī)制國家 自然科學(xué)基金面上項(xiàng)目2021-01~2024-12 58萬元 課題負(fù)責(zé)人
2. 人胰腺前體細(xì)胞的類器官構(gòu)建與分化發(fā)育機(jī)制研究 上海市科委2020-07~2023-06 20萬元 課題負(fù)責(zé)人
3. TGFβ-SMAD信號(hào)通路對(duì)干細(xì)胞分化的調(diào)控機(jī)制國家自然科學(xué)基金面上項(xiàng)目2018-01~2021-12 63萬元 課題負(fù)責(zé)人
4. 上海交大新進(jìn)青年教師啟動(dòng)計(jì)劃 2018-07~2020-12 20萬元 課題負(fù)責(zé)人
5. 上海交通大學(xué)醫(yī)學(xué)院基金引進(jìn)人才啟動(dòng)基金2018-01~2023-08 200萬元 課題負(fù)責(zé)人
代表性論文、專著與專利
1. Wang, X., Wang P., Pan Y., Wang, Q.*, Yin M*. Effect and mechanism of phenotypic transformation of vascular smooth muscle cells regulated by TGF-β2 on the venous thrombus wall remodeling. Medical Journal of Chinese People’s Liberation Army. 2020; 45, 791-797. (* co-correspondence)
2. Su J., Morgani S.M., David C.J., Wang Q., Er E.E., Huang Y.H., Basnet H., Zou Y., Shu W., Soni R.K., Hendrickson R.C., Hadjantonakis A.K. & Massague J. TGF-beta orchestrates fibrogenic and developmental emts via the ras effector RREB1. Nature. 2020; 577, 566-571.
3. Aragón E.#, Wang Q.#, Zou Y.#, Morgani S., Ruiz L., Kaczmarska Z., Su J., Torner C., Tian L., Hu J., Shu W., Agrawal S., Gomes T., Márquez J., Hadjantonakis A., Macias M., and Massagué J. Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. Genes and Development. 2019; 33, 1506-1524 (# co-first author)
4. Li Q., Dixon G., Verma N., Rosen B., Gordillo M., Luo R., Xu C., Wang Q., Soh C., Xiang Q., Leonardo T., Evan T., Massague J., Garippa R., Huangfu D. Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nature Genetics. 2019; 51, 999–1010
5. Martin-Malpartida P., Batet M., Kaczmarska Z., Freier R., Gomes T., Aragón Eric, Zou Y., Wang Q., Xi Q., Ruiz L., Vea A., Márquez J., Massagué J. & Macias M. Structural Basis for Genome Wide Recognition of 5-bp GC Motifs by SMAD Transcription Factors. Nature Communications. 2017; 8(1): 2070-84
6. Wang Q., Zou Y., Nowotschin S., Kim S., Li Q. V., Soh C.-L., Su J., Zhang C., Shu W., Xi Q., Huangfu D., Hadjantonakis A.-K., and Massagué, J. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 2017; 20: 70-86 (with Preview)
7. Wang Q., Uhlirova M., and Bohmann D. Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis. Developmental Cell. 2010; 18: 157–164 (Cover article)
8. Gao F.H., Wang Q., Wu Y.L., Li X., Zhao K.W., Chen G.Q. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression. Biochemical and Biophysical Research Communications. 2007; 356: 505–511
9. Li X., Xu Y.B., Wang Q., Lu Y., Zheng Y., Wang Y.C., Lubbert M., Zhao K.W., Chen G.Q. Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: The role in AML1-ETO-induced growth arrest in leukemic cells. Journal of Cellular Physiology. 2006; 208(3): 594 – 01
10. Song M.G., Gao S.M., Du K.M., Xu M., Yu Y., Zhou Y.H., Wang Q., Chen Z., Zhu Y.S. and Chen G.Q. Nanomolar Level of NSC606985, a camptothecin analogue, induces leukemic cell apoptosis by protein kinase Cd-dependent mechanisms. BLOOD. 2005; 105(9): 3714-21
11. Chen G.Q., Wang Q., Yan H. and Chen Z. Arsenic trioxide and leukemia: from bedside to bench. (Chapter 11, p251-272) Natural Products: Drug Discovery and Therapeutic Medicine. 2005; Eds Humana Press Inc. 999, Totowa, NJ 0751
團(tuán)隊(duì)介紹
A young, fun and creative team with curiosity and passion to the unknown stem cell world!
