研究組長介紹
曾凡一,，美國賓夕法尼亞大學醫(yī)學/理學雙博士,，研究員,，博導,。,，現任上海交通大學醫(yī)學院基礎醫(yī)學院,，組織胚胎學與遺傳發(fā)育學系PI,，上海交通大學特聘教授,、醫(yī)學院特聘教授,。
曾凡一教授主要從事醫(yī)學遺傳學和發(fā)育生物學，尤其是干細胞和哺乳動物胚胎工程等交叉領域的研究,，在國際著名期刊《Nature》,、《PNAS》等雜志發(fā)表SCI論文90 余篇,，研究成果多次入選“中國基礎研究十大新聞”以及“中國十大科技進展新聞”。近年來獲得國家自然科學獎二等獎,、教育部自然科學獎一等獎,、首屆第三世界女青年科學家獎、談家楨生命科學獎創(chuàng)新獎等獎項,。擔任國際干細胞組織（ISCF）秘書長及倫理委員會中國代表,、中國遺傳學會第十屆理事會常務理事以及人類與醫(yī)學遺傳專業(yè)委員會主任委員等職務。
研究方向與進展
醫(yī)學遺傳學和發(fā)育生物學,，尤其是干細胞和哺乳動物胚胎工程等交叉領域的研究
科研項目
國家重點研發(fā)計劃子課題“胚層形成過程細胞分子調控機制”
國家自然科學基金面上項目“克隆牛重編程的表觀遺傳機理研究 ”
代表性論文,、專著與專利
1. Shuo Tan, Yuan Chen, Yue Gao, Jiaping He, Xinbing Guo, Simin Zhang, Jingzhi Zhang*, Fanyi Zeng*. β-Galactosidase gene codon optimization results in post-transcriptional enhancement of expression. Gene, 748: 144676, 2020
2. Yudan Fang1, Yan Cheng1, Dan Lu1, Xiuli Gong, Guanheng Yang, Zhijuan Gong, Yiwen Zhu, Xiao Sang, Shuyue Fan, Jingzhi Zhang, Fanyi Zeng. Treatment of β654-thalassaemia by TALENs in a mouse model. Cell Proliferation, 51(6): e12491, 2018
3. Zhijuan Gong1, Qingwen Ma1, Xujun Wang1, Qin Cai, Xiuli Gong, Georgi Z. Genchev, Hui Lu* and Fanyi Zeng*. A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals. Genes, 9(8): 380, 2018
4. Jingzhi Zhang, Jingbin Yan, Fanyi Zeng. Recent Progress on Genetic Diagnosis and Therapy for β-Thalassemia in China and Around the World. Human Gene Therapy, 29(2): 197-203, 2018.2
5. Chuanliang Guo1, Yan Xue1, Guanheng Yang, Shang Yin, Wansheng Shi, Yan Cheng, Xiaoshuang Yan, Shuyue Fan, Huijun Zhang and Fanyi Zeng. Nanog RNA-binding proteins YBX1 and ILF3 affect pluripotency of embryonic stem cells. Cell Biology International, 40(8): 847-860, 2016
6. Xiaoshuang Yan, Yan Xue, Yiye Zhou, Yan Cheng, Shang Yin, Qingwen Ma, Fanyi Zeng. Activation of proHGF by St14 induces mouse embryonic stem cell differentiation. Protein&Cell, 7(8): 601-605, 2016
7. Jingbin Yan, Rong Zhang, Can Xiong, Cheng Hu, Yao Lv, Congrong Wang, Weiping Jia, Fanyi Zeng. Pyrosequencing Is an Accurate and Reliable Method for the analysis of Heteroplasmy of the A3243G Mutation in patients with Mitochondrial diabetes. The Journal of Molecular Diagnostics, 16(4): 431-439, 2014
8. Rosario Isasi*, Peter W. Andrews, Jay M. Baltz, Annelien L. Bredenoord, Paul Burton, Ing-Ming Chiu, Sara Chandros Hull, Ji-Won Jung, Andreas Kurtz, Geoffrey Lomax, Tenneille Ludwig, Michael McDonald, Clive Morris, Huck Hui Ng, Heather Rooke, Alka Sharma, Glyn N. Stacey, Clare Williams, Fanyi Zeng, and Bartha Maria Knoppers. Identifiability and Privacy in Pluripotent Stem Cell Research. Cell Stem Cell, 14(4): 427-430, 2014
9. Guanheng Yang, Wansheng Shi, Xingyin Hu, Jingzhi Zhang, Zhijuan Gong, Xinbing Guo, Zhaorui Ren, and Fanyi Zeng. Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia. Haematologica, 99(8): 1304-1311, 2014
10. Fanyi Zeng*, Shu-Zhen Huang, Zhi-Juan Gong, Mei-Jue Chen, Don A Baldwin, Wei Hu, Hui Qian, Jing-bin Yan, Juan Wang,Yan Ping Xiao, Yves Chalandon, Ashley Ringrose, Zhao-Rui Ren, Allen Eaves, Connie Eaves, Xiaoyan Jiang*. Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin–CD34+ cord blood cells. Cell Research, 23(6): 859-862, 2013
11. Z.-J. Gong, Y.-Y. Zhou, M. Xu, Q. Cai, H. Li, J.-B. Yan, J. Wang, H.-J. Zhang, S.-Y. Fan, Q. Yuan, S.-Z. Huang*, F. Zeng*. Aberrant expression of imprinted genes and their regulatory network in cloned cattle. Theriogenology, 78(4): 858-866, 2012
12. Linlin Wang, Yan Xue, Yihang Shen, Wei Li1, Yan Cheng, Xiaoshuang Yan, Wansheng Shi, Juan Wang, Zhijuan Gong, Guanheng Yang, Chuanliang Guo, Yiye Zhou, Xiang Wang, Qi Zhou, Fanyi Zeng. Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cells. Cell Research, 22(6): 1082-1085, 2012
13. Mai X. Luong*, Jonathan Auerbach, Jeremy M. Crook, Laurence Daheron, Derek Hei, Geoffrey Lomax, Jeanne F. Loring, Tenneille Ludwig, Thorsten M. Schlaeger, Kelly P. Smith, Glyn Stacey, Ren-He Xu, and Fanyi Zeng. A Call for Standardized Naming and Reporting of Human ESC and iPSC Lines. Cell Stem Cell, 8(4): 357-359, 2011
14. Zhong-hai Yan, Yi-ye Zhou, Jing Fu, Fei Jiao, Lei-wen Zhao, Peng-fei Guan, Shu-zhen Huang, Yi-tao Zeng, Fanyi Zeng. Donor-host mitochondrial compatibility improves efficiency of bovine somatic cell nuclear transfer. BMC Developmental Biology, 10: 31, 2010
15. Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Chang-long Guo, Qing-wen Ma, Liu Wang, Fanyi Zeng*, Qi Zhou*. iPS cells produce viable mice through tetraploid complementation. Nature, 461(7260): 86-90, 2009
團隊介紹
目前有1名副研究員薛燕，助理研究員周一葉,，實驗師馬姬,，博士生遲亞男，博士生樊莎莎
