研究組長介紹 >>>
肖澤宇,，上海交通大學(xué)醫(yī)學(xué)院教授，博導(dǎo),，課題組長,。國家高層次青年人才計劃獲得者。北京大學(xué)醫(yī)學(xué)部藥學(xué)院學(xué)士,；中國科學(xué)院化學(xué)所與美國佛羅里達(dá)大學(xué)聯(lián)合培養(yǎng)博士,；美國麻省理工學(xué)院與哈佛大學(xué)醫(yī)學(xué)院癌癥納米交叉研究中心Robert Langer實驗室博士后；2015年起在上海交通大學(xué)醫(yī)學(xué)院任現(xiàn)職至今。肖澤宇教授團隊長期致力于可視化藥物遞送領(lǐng)域的研究,，在Chem.Soc.Rev., Nature Comm. Angew.Chem., Nano Lett, ACS Nano等雜志發(fā)表論文40余篇,，總引用達(dá)4500多次，其中單篇引用>1000次1篇,、單篇引用>200次5篇,、單篇引用>100次7篇，3篇入選ESI高被引論文,。其中研發(fā)的1種可視化藥物載體已進入臨床試驗階段,。申請或授權(quán)國際專利2件、國內(nèi)專利1件,，參編英文專著3本,。研究成果多次被美國著名專業(yè)網(wǎng)絡(luò)雜志C&E News, Science Daily,等轉(zhuǎn)載報道。曾獲哈佛大學(xué)醫(yī)學(xué)院授予的哈佛大學(xué)生命科學(xué)領(lǐng)域杰出研究工作獎,，美國癌癥研究協(xié)會授予的青年女性學(xué)者獎等,。作為課題負(fù)責(zé)人主持科技部國家重點研發(fā)計劃課題1項、主持國家自然科學(xué)基金4項等,。
研究方向與進展 >>>
本團隊綜合運用化學(xué),、生物學(xué)、分子影像學(xué)等多學(xué)科交叉的技術(shù)和方法,，開發(fā)高靈敏度,、高選擇性、診治同步的“可視化藥物遞送體系”,，用于疾病診斷和治療的轉(zhuǎn)化醫(yī)學(xué)研究,。具體內(nèi)容為：
1.基于活體光學(xué)影像的可視化遞送體系用于術(shù)中診斷和清除殘余微小腫瘤、逆轉(zhuǎn)靶向藥物耐藥,；
2.基于核醫(yī)學(xué)影像的可視化遞送體系用于腫瘤早期診斷,、靶向用藥指導(dǎo)及療效評估；
3.口服裸眼可視化遞送體系用于結(jié)腸部位疾病的早期診斷及治療,。
科研項目 >>>
1.國家重點研發(fā)計劃子課題,，多模塊可編程納米藥物的活體動態(tài)可視化研究，2020.11 ～ 2025.10,，212萬元,，課題負(fù)責(zé)人；
2.上海交通大學(xué)醫(yī)學(xué)院附屬仁濟醫(yī)院基礎(chǔ)臨床協(xié)同研究中心合作項目,，分子影像與藥物遞送,，2018.11 ～ 2023.11，300萬元,，課題負(fù)責(zé)人,；
3.國家自然科學(xué)基金面上項目,，拉曼納米探針用于活性氧異常疾病的醫(yī)學(xué)分析研究，2019.01 ～ 2022.12,，64萬元,，課題負(fù)責(zé)人；
4.國家自然科學(xué)基金面上項目,，核酸識體納米藥物在組織臟器的三維精準(zhǔn)分布及靶向識別,，2017.01 ～ 2020.12，62萬元,，課題負(fù)責(zé)人,；
5.國家自然科學(xué)基金面上項目，DNA自主裝納米診療系統(tǒng)：構(gòu)建及術(shù)中成像介導(dǎo)下前列腺癌細(xì)胞清除的問題研究,，2015.01 ～ 2018.12,，73萬元，課題負(fù)責(zé)人,；
6.國家自然科學(xué)基金應(yīng)急管理項目,，SP-A核酸適體拉曼納米探針用于胎肺發(fā)育及異常的產(chǎn)前診斷研究，2018.01 ～ 2018.12,，20萬元,，課題負(fù)責(zé)人；
7.國家重點研發(fā)計劃,，新型冠狀病毒（2019-nCoV）核酸現(xiàn)場快速檢測設(shè)備及試劑的研發(fā),，2020.01 ～ 2020.04，100萬元,，學(xué)術(shù)骨干,；
8.上海交通大學(xué)醫(yī)工交叉研究基金重點項目，家庭簡易式新型冠狀病毒感染自查技術(shù)與試劑盒,，2020.02 ～ 2021.01,，100萬元，學(xué)術(shù)骨干.
代表性論文,、專著與專利 >>>
代表性論文：
1. Zhao N, Chen Y, Chen G, Xiao Z*(Corresponding Author). Artificial cells based on DNA nanotechnology. ACS Applied Bio Materials 2020,3,7,3928-3934.
2. Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, Li M, Song S, Fu W, Xiao Z*(Corresponding Author), Lu W* Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nat Commun. 2019,10(1):2206.
3. Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C, Zhang Y, Xu L, Chen H, Wan JB, Lu W, Xiao Z*(Corresponding Author). CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. Nano Lett. 2019,19(5):3344-3352.
4. Qiu Y, Lin M, Chen G, Fan C, Li M, Gu X, Cong S, Zhao Z, Fu L, Fang X*, Xiao Z*(Corresponding Author). Photodegradabl CuS SERS probes for intraoperative residual tumor detection, ablation and self-clearance. ACS Appl Mater Interfaces 2019, 11(26):23436-23444.
5. Zheng B, Xu J, Chen G, Zhang S, Xiao Z*(Corresponding Author), Lu W*. Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity. Adv. Func. Mater. 2019, 29(33):1901437.
6. Wu W, Xiao Z*(Corresponding Author). A deep learning “ticket” for single-molecule analysis of protein stoichiometry. Sci China Chem 2019. 62(10): 1269-1270.
7. Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W, Xiao Z*(Corresponding Author), Lu W*. High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy. ACS Nano 2019, 13,10242-10260.
8. Qiu Y, Zhang Y, Li M, Chen G, Fan C, Cui K, Wan J, Han A, Ye J*, Xiao Z*(Corresponding Author) Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags. ACS Nano 2018, 12(8):7974-7985.
9. Cui K, Fan C, Chen G, Qiu Y, Li M, Lin M, Wan JB, Cai C, Xiao Z*(Corresponding Author). para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo. Anal Chem. 2018, 90, 12137-12144.
10. Li M, Qiu Y, Fan C, Cui K, Zhang Y, Xiao Z*(Corresponding Author) Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures. Acta Pharm Sin B. 2018, 8(3):381-389.
11. Qi Q, Lu L, Li H, Yuan Z, Chen GX, Lin M, Ruan Z, Ye X*, Xiao Z* (Corresponding Author), Zhao Q* Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction. Int J Nanomedicine 2017, 12:4835-4848.
12. Zhang Y, Qiu Y, Lin L, Gu H, Xiao Z*(Corresponding Author), Ye J* Ultraphotostable Mesoporous Silica-Coated Gap-Enhanced Raman Tags (GERTs) for High-Speed Bioimaging. ACS Appl Mater Interfaces 2017, 9(4):3995-4005.
13. Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, Gu X, Xiao Z*(Corresponding Author) Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. Sci Bull 2016, 61(9):670-681.
14. Xiao Z*(Corresponding Author) CuS Nanoparticles: clinically-translational materials for photothermal therapy. Nanomedicine, 2014, 9(3),373-375.
15. Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW et al. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl 2014, 53(34):8975-8979.
16. Xiao Z, Levy-Nissenbaum E, Alex F, Luptak A, Teply B, Chan J, Shi J, Diggar E, Cheng J, Langer R, et al. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano 2012, 6 (1), 696-704.
17. Xiao Z, Ji C, Shi J, Pridgen E, Frieder J, Wu J, Farokhzad OC. DNA self-assembly of targeted near infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl 2012, 51(47):11853-11857.
18. Xiao Z, Farokhzad OC, Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities. ACS Nano 2012, 6(5), 3670-3676.
19. Kamaly N*, Xiao Z*(Co-First Author), Valencia PM, Radovic-Moreno AF, Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev 2012, 41(7), 2971-3010.
20. Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC. Progress in siRNA Delivery: A Multifunctional Approach by Polymeric Nanoparticles. Methods in Mol Biol 2010, 629, 53-67
21. hi J, Xiao Z, Votruba AR, Viols C, Farokhzad OC. Differently Charged Hollow Core/shell Lipid-polymer-lipid Hybrid Nanoparticles for Small Interfering RNA Delivery. Angew Chem Int Ed Engl 2011, 50, 7027-7031.
22. Shi J, Xiao Z, Kamaly N, Farokhzad OC. Self-assembled Targeted Nanoparticles: Evolution of Technologies and Bench to Bedside Translation. Acc Chem Res 2011, 44, 1123-34.
23. Liu Q, Chen B, Wang Q, Shi X, Xiao Z, Lin J, Fang X. Carbon Nanotubes as Molecular Tansporters for Walled Plant Cells. Nano Lett 2009, 9(3), 1007-1010.
24. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen Y. Single Molecule Imaging Reveals Transforming Growth Factor-β-induced Type II Receptor Dimerization. Proc Natl Acad Sci U S A 2009,106(37):15679-15683.
25. Xiao Z, Shangguan D, Cao ZC, Fang X, Tan W. Cell-specific Internalization Study of an Aptamer from Whole Cell Selection. Chemistry 2008, 14, 1769-1775.
26. Xiao Z, Zhang W, Yang Y, Xu L, Fang X. Single-molecule diffusion study of activated EGFR implicates its endocytic pathway. Biochem Biophys Res Commun 2008, 369, 730-734.
27. Xiao Z, Ma X, Jiang Y, Liao J, Yue J, Fang X. Single-Molecule Study of Lateral Mobility of Epidermal Growth Factor Receptor 2/HER2 on Activation. J Phys Chem B 2008, 112, 4140-4145.
28. Shangguan D, Meng L, Cao Z, Xiao Z, Fang X, Li Y, Cardona D, Witek RP, Liu C, Tan W. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells. Anal Chem 2008, 80(3), 721-728.
29. Yang R, Jin J, Chen Y, Shao N, Kang H, Xiao Z, Tang Z, Wu Y, Zhu Z, Tan W. Carbon. Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization. J.Am.Chem.Soc 2008, 130, 8351–8358.
專著（英文書章節(jié)）：
1. Qiu Y, Lu L, Hu D, Xiao Z*(Corresponding Author) Copper Sulfide nanoparticles: from synthesis to biomedical applications. Nano Based Drug Delivery, IAPC Publishing, 2015, 516-534, ISBN 978-953-56942-2-9
2. Guo L, Li Y, Xiao Z, Lu W. Photothermal Properties of Hollow Gold Nanostructures for Cancer Theranostics. Handbook of Nanomaterials Properties, Springer-Verlag Berlin Heidelberg 2014, ISBN 978-3-642-31107-9_50
3. Xiao Z, Frieder J, Teply B, Langer R, Farokhzad OC Aptamer conjugates: emerging delivery platforms for targeted cancer therapy. Drug Delivery in Oncology: From Basic Research to Cancer Therapy, Wiley-VCH, 2011, 1690 p., Hardcover, ISBN-13: 978-3-527-32823-9
專利
1. Shi J, Xiao Z, Vilos C, Votruba, A, Langer R, Farokhzad OC. Lipid-polymer hybrid particles. PCT/US2011/050334. （2017年1月24日已授權(quán) Patent NO: US9549901B2,；保護期至2034年1月12日）
2. Xiao Z, Lu L, Chen G, Lin M. Orally colon-targeted drug delivery systems. PCT/CN2016/106175
3. 肖澤宇,，藺淼,，崔凱. 活性氧響應(yīng)的聚合物、載體及其應(yīng)用 201811592907.6
團隊介紹 >>>
助理研究員：崔 凱,，崔彥娜
博士后：陳應(yīng)之
研究生：陳高賢（碩博生）,，趙 娜（碩博生），張永明（碩博生）,，劉涕澤（直博生）,，吳文偉（碩博生）,，李瑞珂（碩士生）
