研究組長介紹
童雪梅,，上海交通大學(xué)基礎(chǔ)醫(yī)學(xué)院研究員,，細(xì)胞代謝研究組長,，博士生導(dǎo)師。
2006年畢業(yè)于美國約翰霍普金斯大學(xué)醫(yī)學(xué)院,，獲生物化學(xué)博士,。2006-2010年在美國賓夕法尼亞大學(xué)醫(yī)學(xué)院博士后期間開始細(xì)胞代謝領(lǐng)域研究。2010年起在上海交通大學(xué)基礎(chǔ)醫(yī)學(xué)院工作,，研究方向?yàn)槟[瘤,、脂肪肝和糖尿病等代謝性疾病的調(diào)控機(jī)制。在PNAS,、Genes & Development,、Cancer Research、Diabetes,、JBC等期刊發(fā)表SCI收錄通訊作者和第一作者論文多篇。國家優(yōu)青,、教育部 “新世紀(jì)優(yōu)秀人才支持計(jì)劃”,、上海高層次人才、上海市青年科技啟明星等獲得者,。擔(dān)任中國抗癌協(xié)會腫瘤代謝專委會青委會副主任委員,。
研究方向與進(jìn)展
本研究組致力于研究腫瘤、脂肪肝和糖尿病等代謝性疾病的調(diào)控機(jī)制,。研究進(jìn)展包括以下兩方面：
1）研究包括轉(zhuǎn)酮醇酶（TKT）在內(nèi)的磷酸戊糖途徑（PPP）代謝酶在腫瘤和代謝性疾病中的作用和機(jī)制,；
2）研究Mondo家族轉(zhuǎn)錄因子（MondoA和ChREBP）在腫瘤微環(huán)境代謝中的作用和機(jī)制。
科研項(xiàng)目
1. 童雪梅,，國家自然科學(xué)基金面上項(xiàng)目,，81972210，轉(zhuǎn)錄因子MondoA調(diào)控結(jié)直腸腫瘤微環(huán)境中調(diào)節(jié)性T細(xì)胞代謝和功能的機(jī)制研究,，2020.01-2023.12,，在研，主持,。
2. 童雪梅,，國家自然科學(xué)基金“糖脂代謝的時空網(wǎng)絡(luò)調(diào)控“重大研究計(jì)劃培育項(xiàng)目，92057117,，轉(zhuǎn)酮醇酶TKT調(diào)控NASH中糖脂代謝重塑和免疫細(xì)胞浸潤的機(jī)理研究,，2021.01-2023.12，在研，主持,。
3. 童雪梅,，國家重點(diǎn)研發(fā)計(jì)劃合成生物學(xué)重點(diǎn)專項(xiàng)，2019YFA0906100 設(shè)計(jì)構(gòu)建靶向?qū)嶓w瘤的新一代免疫細(xì)胞,，2019年12月-2024年12月,，在研，子課題骨干,。
4. 童雪梅,，上海市“科技創(chuàng)新行動計(jì)劃”基礎(chǔ)研究領(lǐng)域項(xiàng)目，19JC1410204,，基因突變導(dǎo)致的異常代謝調(diào)控結(jié)直腸癌發(fā)生發(fā)展的機(jī)制,，2019.11-2022.10，在研,，子課題負(fù)責(zé)人,。
5. 盧穎，國家自然科學(xué)基金青年項(xiàng)目,，82003012,，轉(zhuǎn)錄因子MondoA負(fù)調(diào)控腫瘤微環(huán)境CD8陽性T細(xì)胞功能的機(jī)制研究，2021.01-2023.12,，在研,，主持。
代表性論文,、專著與專利
1. Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L*, Tong X*. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis. Diabetes. 2020 Jul;69(7):1355-1367.
2. Li M, Zhang X, Lu Y, Meng S, Quan H, Hou P, Tong P, Chai D, Gao X, Zheng J*, Tong X*, Bai J*. The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines. Cell Death Dis. 2020 Jan 16;11(1):31. (*co-corresponding authors)
3. Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH*, Tong X*. Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides. Cancer Res. 2019 Jul 15;79(14):3689-3701.
4. Li Y, Yang D, Tian N, Zhang P, Zhu Y, Meng J, Feng M, Lu Y, Liu Q, Tong L, Hu L, Zhang L, Yang JY, Wu L*, Tong X*. The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation. J Biol Chem. 2019 Oct 4;294(40):14745-14756.
5. Sun Q, Wang W, Wu L, Cheng L, Tong X*, Xu X*. Unexpected ABCC6 mRNA splicing in a Chinese family with pseudoxanthoma elasticum. Acta Ophthalmol. 2019 May;97(3):e381-e389. (*co-corresponding authors)
6. Wang J, Tan M, Ge J, Zhang P, Zhong J, Tao L, Wang Q, Tong X*, Qiu J*. Lysosomal acid lipase promotes cholesterol ester metabolism and drives clear cell renal cell carcinoma progression. Cell Prolif. 2018 Aug;51(4):e12452. (*co-corresponding authors)
7. Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, Zhong J, Lin S, Tong X*, Su Q*. Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN. J Exp Clin Cancer Res. 2018 Mar 12;37(1):54. (*co-corresponding authors)
8. Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ET, Yang J, Yi J. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018 Mar 16;293(11):3965-3980.
9. Mao JY, Sun JT, Yang K, Shen WF, Lu L, Zhang RY, Tong X*, Liu Y*. Serum amyloid A enrichment impairs the anti-inflammatory ability of HDL from diabetic nephropathy patients. J Diabetes Complications. 2017 Oct;31(10):1538-1543. (*co-corresponding authors)
10. Meng J, Feng M, Dong W, Zhu Y, Li Y, Zhang P, Wu L, Li M, Lu Y, Chen H, Liu X, Lu Y, Sun H, Tong X*, Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose. Sci Rep. 2016 Mar 31;6:23944.
11. Wang J, Zhang P, Zhong J, Tan M, Ge J, Tao L, Li Y, Zhu Y, Wu L, Qiu J*, Tong X*, The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma. Oncotarget. 2016 Mar 25.
12. Zhang X, Li M, Sun K, Chen XJ, Meng J, Wu L, Zhang P, Tong X*, Jiang WW*. Decreased expression of GRIM-19 by DNA hypermethylation promotes aerobic glycolysis and cell proliferation in head and neck squamous cell carcinoma. Oncotarget. 2015 Jan 1;6(1):101-115.
13. Chen H, Wu L, Li Y, Meng J, Lin N, Yang D, Zhu Y, Li X, Li M, Xu Y, Wu Y, Tong X*, Su Q*. Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation. Mol Cell Endocrinol. 2014 Sep;395(1-2):69-78. (*co-corresponding authors)
14. Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X. Flightless I homolog negatively regulates ChREBP activity in cancer cells. Int J Biochem Cell Biol. 2013 Nov;45(11):2688-97.
15. Tang S, Huang G, Tong X, Xu L, Cai R, Li J, Zhou X, Song S, Huang C, Cheng J. Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism. PLoS One. 2013 May 14;8(5):e63965.
16. Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A. 2012 May 1;109(18): 6904-9.
17. Zhao F, Mancuso A, Bui TV, Tong X, Gruber JJ, Swider CR, Sanchez PV, Lum JJ, Sayed N, Melo JV, Perl AE, Carroll M, Tuttle SW, Thompson CB. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprogramming. Oncogene. 2010 May 20;29(20):2962-72.
18. Tong X, Zhao F, Mancuso A, Gruber JJ and Thompson CB. The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21660-5.
19. Tong X*, Zhao F*, Thompson CB*. The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Current Opinion in Genetics & Development. 2009 Feb;19(1):32-7. (*co-corresponding authors)
20. Larouche D, Tong X, Fradette J, Coulombe PA, Germain L. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile. FASEB J. 2008 May;22(5):1404-15.
21. Tong X, Coulombe PA. Keratin 17 modulates hair follicle cycling in a TNFa-dependent fashion. Genes & Development 2006 May;20(10):1353-64.
22. Coulombe PA, Tong X, Mazzalupo S, Wang Z, Wong P. Great promises yet to be fulfilled: defining keratin intermediate filament function in vivo. European Journal of Cell Biology 2004 Dec;83(11-12):735-46.
23. Tong X, Coulombe PA. A novel mouse type I intermediate filament gene, keratin 17n (K17n), exhibits preferred expression in nail tissue. Journal of Investigative Dermatology 2004 Apr;122(4):965-70.
24. Tong X, Coulombe PA. Mouse models of alopecia: identifying structural genes that are baldly needed. Trends in Molecular Medicine 2003 Feb;9(2):79-84.
25. McGowan KW*, Tong X*, Colucci-Guyon E, Langa F, Babinet C, Coulombe PA. Keratin 17 null mice exhibit age- and strain-dependent alopecia. Genes & Development 2002 Jun;16(11):1412-22. (*co-first authors)
團(tuán)隊(duì)介紹
童雪梅,，博士，研究員,，PI,，郵箱：[email protected]
張萍，副教授,，郵箱：[email protected]
吳麗芳,，助研，郵箱：[email protected]
朱曄敏,，高級實(shí)驗(yàn)師,，郵箱：[email protected]
李亞葵，高級實(shí)驗(yàn)師,，郵箱：[email protected]
盧穎,，博士后，郵箱：[email protected]
劉琪,，博士生,，郵箱：[email protected]
童靈鋒,，博士生，郵箱：[email protected]
胡蕾,，碩士生,，郵箱：[email protected]
季迎寧，碩士生,，郵箱：[email protected]
