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研究組長(zhǎng)介紹

  王鋒

  電話(huà)：63846590-776798
  郵箱：[email protected]

個(gè)人簡(jiǎn)歷

2001-2005 北京師范大學(xué) 學(xué)士

2005-2010 北京生命科學(xué)研究所  生物化學(xué)與分子生物學(xué) 博士

2010-2016 斯坦福大學(xué)醫(yī)學(xué)院 博士后

2016-至今 上海交通大學(xué)醫(yī)學(xué)院上海市免疫學(xué)研究所 研究員 課題組長(zhǎng)  

研究方向

主要研究T淋巴細(xì)胞的免疫識(shí)別，信號(hào)轉(zhuǎn)導(dǎo)和代謝調(diào)節(jié)機(jī)制，以及其在腫瘤、感染和自身免疫疾病中的作用。我們將應(yīng)用免疫學(xué)、分子細(xì)胞生物學(xué)、生物物理和生物化學(xué)等多種技術(shù)手段對(duì)以下三個(gè)方向進(jìn)行探索：（1）天然代謝產(chǎn)物調(diào)控T細(xì)胞識(shí)別和信號(hào)的分子機(jī)理和生理功能；（2）T細(xì)胞信號(hào)和免疫受體組庫(kù)在腫瘤和感染免疫中的作用；（3）T細(xì)胞免疫檢驗(yàn)點(diǎn)抑制劑引起的抗腫瘤和自身免疫反應(yīng)機(jī)制。

科研項(xiàng)目

論文與專(zhuān)著

1. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, DOI:https://doi.org/10.1073/pnas.1921223117.

2. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

3. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

4. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18:29. doi.org/10.1186/s12915-020-00765-9.

5. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.

6. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

7. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.

8. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

9. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

10. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

11. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

12. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

13. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

14. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

15. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.

     

     

專(zhuān)利與技術(shù)許可

2019101191437，微生物在治療和或預(yù)防免疫介導(dǎo)的腸道疾病中的應(yīng)用

2019105339382(PCT/CN2020/096054)，腫瘤新抗原多肽及其用途

2019111645949，調(diào)節(jié)T細(xì)胞所處微環(huán)境中CS的量以及應(yīng)用

2019111651371，突變型CD3及其應(yīng)用

榮譽(yù)與獎(jiǎng)勵(lì)

2018: 上海市青年拔尖人才

2018: 美國(guó)免疫學(xué)會(huì)-Early Career Faculty Travel Award

2017: 上海市浦江人才計(jì)劃

2017: 蒙民偉國(guó)際交流基金

2014: 中國(guó)科學(xué)院-Global Vision Lectures of the SKIPER College

2013: 美國(guó)免疫學(xué)會(huì)-Trainee Abstract Award

2012: 國(guó)際生物化學(xué)和分子生物學(xué)學(xué)會(huì)，歐洲生物化學(xué)學(xué)會(huì)－青年科學(xué)家獎(jiǎng)

2010: 戈登會(huì)議委員會(huì)-Carl Storm International Diversity Fellowship

2010: 北京師范大學(xué)優(yōu)秀博士畢業(yè)生

2009: 北京師范大學(xué)年度優(yōu)秀學(xué)術(shù)獎(jiǎng)

2008: 北京生命科學(xué)研究所－先正達(dá)獎(jiǎng)學(xué)金

團(tuán)隊(duì)介紹

羅凌杰-助理研究員

王為芳-技術(shù)員

王秦蘭-博士后

楊翠霞-博士后

梁文華-博士研究生

龐建峰-碩士研究生

王欣-碩士研究生