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研究組長介紹

  王鋒

  電話：63846590-776798
  郵箱：[email protected]

個人簡歷

2001-2005 北京師范大學 學士

2005-2010 北京生命科學研究所  生物化學與分子生物學 博士

2010-2016 斯坦福大學醫(yī)學院 博士后

2016-至今 上海交通大學醫(yī)學院上海市免疫學研究所 研究員 課題組長  

研究方向

主要研究T淋巴細胞的免疫識別，信號轉導和代謝調節(jié)機制,，以及其在腫瘤,、感染和自身免疫疾病中的作用,。我們將應用免疫學、分子細胞生物學,、生物物理和生物化學等多種技術手段對以下三個方向進行探索：（1）天然代謝產(chǎn)物調控T細胞識別和信號的分子機理和生理功能,；（2）T細胞信號和免疫受體組庫在腫瘤和感染免疫中的作用；（3）T細胞免疫檢驗點抑制劑引起的抗腫瘤和自身免疫反應機制,。

科研項目

論文與專著

1. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, DOI:https://doi.org/10.1073/pnas.1921223117.

2. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

3. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

4. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18:29. doi.org/10.1186/s12915-020-00765-9.

5. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.

6. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

7. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.

8. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

9. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

10. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

11. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

12. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

13. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

14. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

15. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.

     

     

專利與技術許可

2019101191437,，微生物在治療和或預防免疫介導的腸道疾病中的應用

2019105339382(PCT/CN2020/096054)，腫瘤新抗原多肽及其用途

2019111645949,，調節(jié)T細胞所處微環(huán)境中CS的量以及應用

2019111651371,，突變型CD3及其應用

榮譽與獎勵

2018: 上海市青年拔尖人才

2018: 美國免疫學會-Early Career Faculty Travel Award

2017: 上海市浦江人才計劃

2017: 蒙民偉國際交流基金

2014: 中國科學院-Global Vision Lectures of the SKIPER College

2013: 美國免疫學會-Trainee Abstract Award

2012: 國際生物化學和分子生物學學會,，歐洲生物化學學會－青年科學家獎

2010: 戈登會議委員會-Carl Storm International Diversity Fellowship

2010: 北京師范大學優(yōu)秀博士畢業(yè)生

2009: 北京師范大學年度優(yōu)秀學術獎

2008: 北京生命科學研究所－先正達獎學金

團隊介紹

羅凌杰-助理研究員

王為芳-技術員

王秦蘭-博士后

楊翠霞-博士后

梁文華-博士研究生

龐建峰-碩士研究生

王欣-碩士研究生