研究組長(zhǎng)介紹
路麗明,，女,，上海交通大學(xué)醫(yī)學(xué)院,，教授,，研究員,，博士生導(dǎo)師
基礎(chǔ)醫(yī)學(xué)院免疫學(xué)與微生物學(xué)系課題組長(zhǎng)（PI）
上海交通大學(xué)附屬胸科醫(yī)院實(shí)驗(yàn)中心創(chuàng)始主任
《現(xiàn)代免疫學(xué)》雜志執(zhí)行主編
聯(lián)系方式：021-63846590-776023
郵箱地址：[email protected]
郵編：200025
個(gè)人簡(jiǎn)歷
1998年7月畢業(yè)于廈門(mén)大學(xué),，獲學(xué)士學(xué)位,。2001年7月和2006年7月畢業(yè)于上海交通大學(xué)醫(yī)學(xué)院（原上海第二醫(yī)科大學(xué)）醫(yī)學(xué)免疫學(xué)專業(yè),，獲醫(yī)學(xué)碩士和醫(yī)學(xué)博士學(xué)位,。2013年至2014年英國(guó)劍橋大學(xué)高級(jí)訪問(wèn)學(xué)者。
擔(dān)任上海市免疫遺傳學(xué)會(huì)副主任委員,，上海市免疫學(xué)會(huì)常務(wù)理事,，中國(guó)免疫學(xué)會(huì)健康委員會(huì)常務(wù)委員，中華醫(yī)學(xué)生物免疫學(xué)會(huì)常務(wù)理事,，中國(guó)細(xì)胞治療質(zhì)控與研究專委會(huì)常務(wù)委員,，中華醫(yī)學(xué)會(huì)疫苗接種委員會(huì)常務(wù)委員，中國(guó)病理生理學(xué)會(huì)實(shí)驗(yàn)血液學(xué)專業(yè)委員會(huì)常務(wù)委員,，教育部學(xué)位中心全國(guó)博士論文評(píng)審專家,，國(guó)家自然科學(xué)基金委評(píng)審專家。
研究方向
研究方向?yàn)槊庖哒{(diào)節(jié),，開(kāi)展移植免疫耐受和腫瘤免疫治療獲益人群的篩選的研究,。取得一系列發(fā)現(xiàn)和成果。先后主持國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）子課題,，科技部863項(xiàng)目和國(guó)家自然科學(xué)基金,，上海市重點(diǎn)項(xiàng)目等15項(xiàng)。作為通訊作者和共同作者在本領(lǐng)域列期刊和國(guó)際專業(yè)期刊等發(fā)表論文100余篇,，SCI論文50篇,，引用近500次。申請(qǐng)或授權(quán)國(guó)家發(fā)明專利6項(xiàng),。
上海交通大學(xué)醫(yī)學(xué)院整合教程－機(jī)體防御與免疫主講老師,，熟練教授研究生、本科醫(yī)學(xué)免疫學(xué),、免疫學(xué)技術(shù)等課程,。《人體健康與免疫》科普叢書(shū)《嬰幼兒篇》副主編,、《常見(jiàn)問(wèn)題篇》,、參編國(guó)家新聞出版總署列為“十五”國(guó)家重點(diǎn)圖書(shū)出版規(guī)劃項(xiàng)目《組織工程學(xué)原理與實(shí)踐》,、《免疫學(xué)技術(shù)》、教育部研究生指定教材《免疫學(xué)原理》,、《醫(yī)學(xué)免疫學(xué)與檢驗(yàn)》英文版留學(xué)生教材《 Textbook of Immunology》,、 《腫瘤免疫學(xué)》、《醫(yī)學(xué)免疫學(xué)》等規(guī)劃教材,。入選上海市浦江人才計(jì)劃,、上海市曙光學(xué)者、上海市科技啟明星人才計(jì)劃,、上海市教委骨干教師出國(guó)高訪計(jì)劃,、上海市衛(wèi)生系統(tǒng)優(yōu)青、交大晨星學(xué)者,、醫(yī)學(xué)院新百人等人才計(jì)劃。
科研項(xiàng)目
(1) 國(guó)家973 重點(diǎn)基礎(chǔ)研究項(xiàng)目：?jiǎn)伪缎拖嗪弦浦玻ā氨本┓桨浮保┖筮m應(yīng)性免疫重建及調(diào)控機(jī)制（ 2017YFA0104600）,，主持
(2) 國(guó)家自然科學(xué)基金項(xiàng)目（ 82071856）: 中藥天花粉蛋白作為A群流腦疫苗免疫增效劑的應(yīng)用基礎(chǔ)研究,，主持
(3) 國(guó)家自然科學(xué)基金項(xiàng)目（81671579）: Tk衍生肽通過(guò)Treg細(xì)胞抑制同種異體肺移植慢性排斥的應(yīng)用基礎(chǔ)研究，主持
(4) 國(guó)家自然科學(xué)基金項(xiàng)目（ 31370904）: II類反式激活因子通過(guò)NLR信號(hào)調(diào)控Th2應(yīng)答的分子免疫學(xué)機(jī)制,，主持
(5) 國(guó)家自然科學(xué)基金青年項(xiàng)目（30700766）: 構(gòu)建CIITA突變體轉(zhuǎn)基因小鼠功能性剔除MHC及作用機(jī)制研究,，主持
(6) 國(guó)家自然科學(xué)基金面上項(xiàng)目（30972691）:天花粉蛋白衍生肽誘導(dǎo)的IL-9+IL-10+T細(xì)胞與Th9的免疫生物學(xué)特性比較研究，主持
(7) 上海市中醫(yī)藥局面上項(xiàng)目（2020JP009）：組蛋白去甲基化酶LSD1對(duì)天花粉蛋白誘導(dǎo)的CD8+Treg譜系維持的作用,，主持
(8) 上海市教委(16SG14)：中藥天花粉蛋白衍生肽通過(guò)Treg細(xì)胞延緩肺移植術(shù)后閉塞性細(xì)支氣管炎綜合癥的可行性研究,，主持
(9) 上海市科委基礎(chǔ)研究重點(diǎn)項(xiàng)目（11JC1410802）通過(guò)誘導(dǎo)調(diào)節(jié)性T細(xì)胞抑制肺移植慢性免疫排斥的應(yīng)用基礎(chǔ)研究，主持
(10) 上海市科委生藥研究重點(diǎn)項(xiàng)目（15401900500）：天花粉蛋白有效組分作為免疫調(diào)節(jié)細(xì)胞專一誘導(dǎo)劑的藥效學(xué)研究,，主持
(11) 上海市浦江人才計(jì)劃項(xiàng)目（15PJD021）生物活性多肽治療Th1細(xì)胞主宰疾病的藥效及作用機(jī)理研究,，主持
(12) 上海市科委產(chǎn)學(xué)研項(xiàng)目（14DZ1931003）自體免疫細(xì)胞治療肺癌的醫(yī)學(xué)轉(zhuǎn)化研究，主持
(13) 上海市衛(wèi)生系統(tǒng)新優(yōu)青人才培養(yǎng)計(jì)劃（2011XYQ015）IFN-gR+IL-10R+Tr1細(xì)胞的免疫生物學(xué)特性及應(yīng)用基礎(chǔ)研究,，主持
(14) 上海市教委資助項(xiàng)目（2685619）：mCIITA分子聯(lián)合B7-H1誘導(dǎo)產(chǎn)生的調(diào)節(jié)性T細(xì)胞的免疫生物學(xué)特性研究,，主持
(15) 上海市科委實(shí)驗(yàn)動(dòng)物項(xiàng)目（18140903800）肺癌雙人源化PDX模型的構(gòu)建與臨床患者藥物治療方案評(píng)估的探索，主持
(16) 國(guó)家973 重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（ 2020YFA010045）：人臍帶間充質(zhì)干細(xì)胞治療視神經(jīng)脊髓炎譜系疾病的臨床研究,，骨干成員
(17) 國(guó)家973重點(diǎn)基礎(chǔ)研究項(xiàng)目（ 2010CB945600）：組織干細(xì)胞的干性維持,、分化控制和免疫調(diào)節(jié)研究，骨干成員
(18) 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（ 30530690）： MHC和Th1/Th2分化相關(guān)基因轉(zhuǎn)錄激活調(diào)控的表觀遺傳學(xué)研究,，第一參與人
論文與專著
(1) Christopher D Nishimura, Marc C Pulanco, Wei Cui, Liming Lu*, Xingxing Zang PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies. Trends Mol Med.2020 Nov 13;S1471-4914(20)30266-5.
(2) Duo Zhang; Di Tang; Yu Heng; Xiao-Ke Zhu; Liang Zhou; Lei Tao; Li-Ming Lu* Prognostic Impact of Tumor-Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients. Laryngoscope. 2020 Oct 27. doi: 10.1002/lary.29196.
(3) Zhang Yu; Zhou Lin; Gu Xiang; Feng Xuan; Ding Ping; Xia Qiang; Li-Ming Lu* CXCL8high inflammatory B cells in the peripheral blood of patients with biliary atresia are involved in disease progression. Immunology & Cell Biology. 2020; 1–11
(4) Zhang, Na; Sun, Pan; Jin, Haizhen; Yang, Yuqin; Zhao, Qingya; Zhou, Lin; Guo, Lili; Yang, Xiaohua; Li-Ming Lu* Chidamide combined with paclitaxel effectively reverses the expression of histone deacetylase in lung cancer. Anti-Cancer Drugs. 2020 August; 31(7):702-708,
(5) Yi Xue , Di Tang , Sheng-Jie Li , Jian Zhou , Chi-Yao Hsueh , Dan-Dan Zhao , Yu Heng , Lei Tao, Li-Ming Lu* Link Between CIITA rs3087456 Polymorphism and the Risk of Laryngeal Squamous Cell Carcinoma in a Chinese Population. Pathol Res Pract. 2020 Jan;216(1):152793.
(6) Jian Zhou, Liang Zhou, Duo Zhang, Wei-Jing Tang, Di Tang, Xiao-Ling Shi, Yue Yang, Lin Zhou, Fei Liu, Yong Yu, Pentao Liu, Lei Tao, Li-Ming Lu*. BCL11A promotes the progression of laryngeal squamous cell carcinoma. Frontiers in Oncology. 2020 Mar 20;10:375. doi: 10.3389/fonc.2020.00375
(7) Gao, Xuefei; Nowak-Imialek, Monika; Chen, Xi; Chen, Dongsheng; Herrmann, Doris; Ruan, Degong; Chen, Andy Chun Hang; Eckersley-Maslin, Melanie A; Ahmad, Shakil; Lee, Yin Lau; Kobayashi, Toshihiro; Ryan, David; Zhong, Jixing; Zhu, Jiacheng; Wu, Jian; Lan, Guocheng; Petkov, Stoyan; Yang, Jian; Antunes, Liliana; Campos, Lia S; Fu, Beiyuan; Wang, Shengpeng; Yong, Yu; Wang, Xiaomin; Xue, Song-Guo; Ge, Liangpeng; Liu, Zuohua; Huang, Yong; Nie, Tao; Li, Peng; Wu, Donghai; Pei, Duanqing; Zhang, Yi; Lu, Liming; Yang, Fengtang; Kimber, Susan J; Reik, Wolf; Zou, Xiangang; Shang, Zhouchun; Lai, Liangxue; Surani, Azim; Tam, Patrick P L; Ahmed, Asif; Yeung, William Shu Biu; Teichmann, Sarah A; Niemann, Heiner; Liu, Pentao. Establishment of porcine and human expanded potential stem cells. Nature cell biology, 2019, 21(6): 687. Establishment of porcine and human expanded potential stem cells. Nature cell biology, 2019, 21(6): 687.
(8) Lin Ye, Yuqing Lou, Liming Lu* and Xiaohong Fan. Mesothelin-targeted second generation CAR-T cells inhibit growth of mesothelin-expressing tumors in vivo. Exp Ther Med. 2019 Jan;17(1):739-747.
(9) Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu* and Jun Liu*. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease. Journal of J Neuroinflammation. 2019;16(1):263.
(10) HeYu-Bin; GuoJiang-Hong; WangChong; Zhu Dan; Lu Li-Ming*. IL-33 promotes the progression of nonrheumatic aortic valve stenosis via inducing differential phenotypic transition in valvular interstitial cells. Journal of cardiology. 2019 Aug 12. [Epub ahead of print]
(11) Yi xue, Huai-Dong Du, Di Tang, Duo Zhang, Jian Zhou, Chang-Wen Zhai, Cun-Cun Yuan, Chi-Yao Hsueh, Sheng-Jie Li, Yu Heng, Lei Tao and Li-ming Lu*. Correlation Between the NLRP3 Inflammasome and the Prognosis of Patients With LSCC. FRONTIERS IN ONCOLOGY , 2019 , Jul 2;9:588
(12) Guo-wei Tu ,Min-jie Ju, Yi-jun zheng, Guang-wei Hao,Guo-guang Ma, Jun-yi Hou, Xue-peng Zhang, Zhe Luo, Li-ming Lu*. CXCL16/CXCR6 Is Involved in LPS-induced Acute Lung Injury via P38 Signaling. Cell Physiol Biochem. 2019; 00; 1-10
(13) Jun Lu, Hua Zhong, Tianqing Chu, Xueyan Zhang, Rong Li, Jiayuan Sun, Runbo Zhong, Yuqin Yang, Mohammad Shah Alam, Yuqing Lou, Jianlin Xu, Yanwei Zhang, Jun Wu, Xiaowei Li, Xiaodong Zhao, Kai Li, Liming Lu*, Baohui Han. Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for non-small cell lung cancer therapy. European Respiratory Journal . 2019 Mar 1;53(3). pii: 1801562. doi: 10.1183/13993003.01562-2018
(14) Weimin Fan, Yali Xu, Yue Liu , Zhengqing Zhang , Liming Lu* and Zhide Ding,，Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility. Frontiers in Physiology, 2018, 8:1117. doi: 10.3389/fphys.
(15) Xiaoyan Yu, Yimin Lao, Xiao-Lu Teng, Song Li, Yan Zhou, Feixiang Wang, Xinwei Guo, Siyu Deng, Yuzhou Chang, Xuefeng Wu, Zhiduo Liu, Lei Chen, Liming Lu, Jinke Cheng, Bin Li, Bing Su, Jin Jiang, Hua-Bing Li, Chuanxin Huang, Jing Yi & Qiang Zou . SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation[J]. Nature communications, 2018, 9(1): 3157. DOI: 10.1038/s41467-018-05676-6
(16) Xiaoyan Yu, XiaoLu Teng, Feixiang Wang, Yuhan Zheng, Guojun Qu, Yan Zhou, Zhilin Hu, Zhongqiu Wu, Yuzhou Chang, Lei Chen,HuaBing Li, Bing Su, Liming Lu*, Zhiduo Liu, ShaoCong Sun, and Qiang Zou. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J Exp Med . 2018 Sep 3;215(9):2463-2476. doi: 10.1084/jem.20180397
(17) Yue Wang, Qing Li, Lin Zhou, Xueping Ding, Li-ming Lu*. Peptede TK-PQ induces immunosuppression in skin allogeneic transplantation via increasing Foxp3+ Treg and impeding nuclear translocation of NF-κB. Molecular Immunology. 2018 Sep;101:597-607. doi: 10.1016/j.molimm.
(18) Xiao-yang Zhang, Lin Zhou, Zhen Guo, Ye Kong, Wei Zhang, Li-ming Lu*，Xin Li*, Regulatory T Cells may Play an Protection Role in Lung Injury after Operation in Rheumatic Heart Disease. Journal of Thoracic Disease, 2018 Jun;10(6):3196-3205. doi: 10.21037/jtd.2018.05.71
(19) ZongAn Chen*, Lin Zhou*, TaeHao Won, Zhen Gao, XiaoLi Wu and Li-ming Lu*,。Characterization of Memory T Lymphocytes in Keloid Disease. Br J Dermatol. 2018 Apr;178(4):940-950. doi: 10.1111/bjd.16173.
(20) Yang Jian,Ryan David J,Wang Wei, Jason Cheuk-Ho Tsang, Guocheng Lan, Hideki Masaki, Xuefei Gao, Liliana Antunes, Yong Yu, Zhexin Zhu, Juexuan Wang, Aleksandra A. Kolodziejczyk, Lia S. Campos, Cui Wang, Fengtang Yang, Zhen Zhong, Beiyuan Fu, Melanie A. Eckersley-Maslin, Michael Woods, Yosuke Tanaka, Xi Chen, Adam C. Wilkinson, James Bussell, Jacqui White, Ramiro Ramirez-Solis, Wolf Reik, Berthold Göttgens, Sarah A. Teichmann, Patrick P. L. Tam, Hiromitsu Nakauchi, Xiangang Zou, Liming Lu & Pentao Liu*. Establishment of mouse expanded potential stem cells.[J] .Nature, 2017, 550(7676): 393-397.
(21) Zhang D, Zhou J, Tang D, Lei Tao, Lu L*. Neutrophil infiltration mediated by CXCL5 accumulation in the laryngeal squamous cell carcinoma microenvironment: A mechanism by which tumour cells escape immune surveillance. Clinical Immunology, 2017, 175: 34-40.
(22) Tang Wei-Jing,Tao Lei, Li-ming Lu* et al. Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma.[J] .Oncol Lett, 2017, 14(1): 561-568.
(23) Zhou, J., Yang, Y., Zhang, D., Zhou, L., Tao, L., & Lu L*. Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma. PloS one, 2017 Feb 22;12(2):e0171116.
(24) Yu, Y, Tsang, C-H. J, Wang, C, Simon Clare, Juexuan Wang,Xi Chen, CordeliaBrandt, Leanne Kane, Lia S. Campos, Lu Lu*, Gabrielle T. Belz, Andrew N. J. McKenzie,Sarah A.Teichmann, Gordon Dougan& Pentao Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its developmental pathway. Nature. 2016 Sep; 539(7627)
(25) Li Z, Yang N, Zhou L, Lu L*, Chou KY. A peptide tetramer Tk-tPN induces tolerance of cardiac allografting by conversion of type 1 to type 2 immune responses via the Toll‐like receptor 2 signal‐promoted activation of the MCP1 gene. Immunology, 2016, 147(3): 355-366.
(26) Tang, D, W. J. Tang, X. L. Shi, W. P. Li, H. Zhou, Lu L*, L. Tao Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma. Acta Otolaryngol, 2016. 136, 806-11.
(27) Zhang, D, W. J. Tang, D. Tang, J. Zhou, L. Chou, L. Tao &Lu L* The ratio of CD4/CD8 T-cells in human papillomavirus-positive laryngeal squamous cell carcinoma accounts for improved outcome. Acta Otolaryngol, 2016.136, 826-33.
(28) Zhou, J, Y. Yang, D. Zhang, L. Zhou, F. Liu, L. Tao, Lu L* Association of the recurrence of vocal leukoplakia with MDM2-309 variants over a 2-year period: a prospective study. Acta Otolaryngol, 2016.136, 95-9.
(29) ZhouJ, D.Zhang, L. Zhou, Y. Yang, F. Liu, L. Tao, Lu L* Association of the recurrence and canceration rate of vocal leukoplakia with interleukin-10 promoter variants over a 2-year period. Acta Otolaryngol, 2016. 136, 1147-1153.
(30) Zhang D, Chen B, Zhou J, Zhou L, Li Q, Liu F, Chou KY, Tao L, Lu L*. Low concentration of Trichosanthin induces apoptosis and cell cycle arrest through JNK/MAPK activation. Molecular Medicine Report. 2015 Jan;11(1):349-56. doi: 10.3892/mmr
(31) Zhou J, Yang Y, Zhang D, Zhou L, Liu F, Tao L, Lu L*. Association of the recurrence of vocal leukoplakia with MDM2-309 variants over a 2-year period: a prospective study. Acta oto-laryngologica 2015:1-5.
(32) Yu Y, Wang C, Clare S, Wang J, Lee SC, Brandt C, Burke S1, Lu L*, He D, Jenkins NA, Copeland NG, Dougan G, Liu P.. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. The Journal of experimental medicine 2015; 212:865-74.
(33) Tsang JC, Yu Y, Burke S, Buettner F, Wang C, Kolodziejczyk , Teichmann SA, Lu L*, Liu P, Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells. Genome Biol. 2015 Sep 21;16(1):178. doi:10.1186/s13059-015-0739-5.
(34) Yang J, Wang W, Ooi J, Campos LS, Lu L*, Liu P Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells. Stem Cells. 2015 May 33(5):1390-404. doi: 10.1002/stem.1926
(35) Zhao AM, Xu HJ, Kang XM, Zhao AM, Lu. L* .New insights into myeloid-derived suppressor cells and their roles in feto-maternal immune cross-talk. J Reprod Immunol. 2015 Nov 10;113:35-41. doi: 10.1016/j.jri.2015.11.001.
(36) Xuefei Gao, Jason C.H. Tsang, Fortis Gaba, Donghai Wu, Lu L*, Pentao Liu Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. Nucleic Acids Research, 2014 doi: 10.1093/nar/gku836
(37) Tsang JC, Xuefei Gao, Lu. L*, Pentao Liu Cellular reprogramming by transcription factor engineering. Current Opinion in Genetics & Development 2014, 28:1–9
(38) Jian Zhou, Duo Zhang, Bin Chen, Qing Li, Lin Zhou, Fei Liu, Kuang-Yen Chou, Lei Tao, Lu L*. Association of interleukin 10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma ONCOLOGY LETTERS 2014,7: 1721-1727.
(39) F. Liu, X. Pan, L. Zhou, B. Chen, J. Shi, W. Gao and Lu. L*. Genetic polymorphism and plasma levels of interleukin-22 contribute to the development of nonsmall lung cancer. DNA and CellBiology. 2014 Oct;33(10):705-14. doi: 10.1089/dna.
(40) Zhou J, Liu F, Zhang D, Chen B, Li Q, Zhou L, Lu L*, Tao L. Significance of MDM2-309 polymorphisms and induced c orresponding plasma MDM2 levels in susceptibility to laryngeal squamous cell carcinoma DNA Cell Biol. 2014 Feb;33(2):88-94.
(41) Neng Yang, Zuoqing Li, Zhijun Jiao, Peng Gu, Yun Zhou, Lu.L*, Kuang-Yen Chou A Trichosanthin-derived peptide suppresses type 1 immune responses by TLR2-dependent activation of CD8+CD28?Tregs Clinic immunology (2013), 153, 277–287.
(42) Bin Chen, Duo Zhang, Jian Zhou, Qing Li, Lin Zhou, Shi-Min Li, Li Zhu, Kuang-Yen Chou, Liang Zhou, Lei Tao, Lu L*, High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma. ONCOLOGY REPORTS 2013 30: 1380-1390.
(43) Yang ZQ, Yang N, Zhou Y, Xin LJ, Lu L*, Chou KY. Mutated MHC class II transactivator upregulates IL-33-dependent differentiation of Th2 subset through Nod2 binding for NLR signaling initiation. Journal of Biological Chemistry, 2012 Mar 23;287(13) :9972-9981
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專利與技術(shù)許可
2007 Trichosanthin derived peptide and its application, Application Number: 200710173408.94.
2012 Screen of immunosuppressive effective epitope peptide of trichosanthin, Application Number: 201210390572.6.
2016 Application of Trichosanthin in enhancing vaccine specific antibodies, Application Number: 201610049358.2.
2017 PHPO Application for treating lung cancer, Application Number: 201710373254.1.
2020 Construction and application ofa Chinese lung adenocarcinoma cell line, Application Number: 201710426801.8.
團(tuán)隊(duì)介紹
本課題組成員目前有課題組長(zhǎng)路麗明，技術(shù)員丁旭蘋(píng),、侯亞菲,，博士二年級(jí)學(xué)生王雪,，碩士一年級(jí)學(xué)生吳謙，在路老師的帶領(lǐng)下潛心從事免疫調(diào)節(jié)方面的工作（腫瘤免疫,、移植免疫耐受誘導(dǎo)等）,， 組內(nèi)科研助理、學(xué)生等各成員間團(tuán)結(jié)協(xié)作,，密切交流,，營(yíng)造了和諧的科研氣氛。同時(shí)我們與仁濟(jì)醫(yī)院,、耳鼻喉醫(yī)院,、同仁醫(yī)院、胸科醫(yī)院等臨床教學(xué)醫(yī)院開(kāi)展長(zhǎng)期合作,，已聯(lián)合培養(yǎng)學(xué)生數(shù)名,。
