研究組長介紹
吳學鋒
電話：63846590-776684
郵箱：[email protected]
個人簡歷
1995-2002 南開大學學士(1999)/碩士(2002)
2002-2003 上海榮盛生物技術有限公司技術中心
2003-2008 美國賓夕法尼亞州州立大學(The Pennsylvania State University) 博士
2008-2009 M. D. Anderson Cancer Center 博士后
2010-2014 美國加州大學圣地亞哥分校(UCSD) 博士后/助理項目科學家
2014-2016 Ionis (former Isis) Pharmaceuticals Senior Scientist
2016.03-至今 上海交通大學醫(yī)學院上海市免疫學研究所 研究員
研究方向
炎癥在腫瘤發(fā)生發(fā)展和轉移等多個步驟中都起著至關重要的作用。本實驗室集中研究連接炎癥和腫瘤的細胞和分子機制。從以下三個方面開展研究：1.闡述腫瘤細胞來源的信號如何調控其微環(huán)境中的免疫細胞和免疫反應；2.樹突狀細胞和調節(jié)性T細胞抗腫瘤免疫的機制；3.探討調控腫瘤轉移的免疫調控機制。我們長期的目標是開發(fā)治療免疫疾病和癌癥的藥物和新策略。
科研項目
1. 31670910，國家自然科學基金面上項目，泛素綴合酶Ubc13在樹突狀細胞中的免疫調控功能及機制研究，2017/1-2020/12，項目負責人；
2. 海外高層次人才青年項目，2017/9-2022/12，項目負責人。
3.國家重點研發(fā)計劃干細胞及轉化研究重點專項，項目編號：2020YFA0112900, 2020.10-2024.12，骨干。
論文與專著
1.Yang XD, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020 Jan 15;39 (2):e102201. PMID:31762063
2. Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Mol Cell. 2019 Aug 22;75(4):823-834.e5. PMID: 31302001
3. Huang X, Zuo Y, Wang X, Wu X, Tan H, Fan Q, Dong B, Xue W, Chen GQ, Cheng J. SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function. Cancer Res. 2019 Aug 1;79(15):3891-3902. PMID: 31186231
4. Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 9(1):3157. (2018) PMID: 30089837
5. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz- Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 32(6):824-839.e8. (2017) PMID: 29153842
6.Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. .PI3Kγ is a molecular switch that controls immune suppression
.Nature,2016,539(7629):437-442.
7. Wu X, M Karin. Emerging roles of Lys63-linked polyubiquitylation in immune responses.Immunol Rev. ,2015,266(1):161-74.
8. Wu X, W Zhang, J Font-Burgada, T Palmer, AS Hamil, SK Biswas, M Poidinger, N Borcherding, Q Xie, LG Ellies, N Lytle, LW Wu, J Yang, SF Dowdy, T Reya, M Karin.Ubiqutin-conjugating Enzyme Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade.PNAS,2014,111(38): 13870-5.
9. Wu X#, Zhang M#and Sun S-C.Mutual regulation between deubiquitinase CYLD and Retroviral Oncoprotein Tax .Cell & Bioscience,2011,1(1):27.
10. Hu H#, Wu X#, Jin W, Chang M, Cheng X and Sun S-C.Noncanonical NF-κB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development .PNAS,2011,108(31):12827-32.
11. Wu X, M Yamamoto, S Akira, and S-C Sun.Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13 .PNAS,2009,106 (49): 20836-41.
12. Lee A#, Wu X#, H Cheng, X Zhou, X Cheng, and S-C Sun.CARMA1 regulation of Treg development involves modulation of IL-2 receptor signaling .J. Biol Chem. ,2010,285(21): 15696-703.
13. Zhang M#, Wu X#, AJ Lee, W Jin, M Chang, A Wright, T Imaizumi, and S-C Sun.Regulation of IKK-related kinases and antiviral responses by tumor suppressor CYLD . J Biol Chem.,2008,283(27): 8621-6.
14. Wu X, S-C Sun.Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating Tak1-IKK physical association .EMBO Rep.,2007,8(5): 510-5.
15. Inokuchi-Shimizu S, EJ Park, YS Roh, L Yang, B Zhang, J Song, S Liang, M Pimienta, K Taniguchi, X Wu, K Asahina, W Lagakos, MR Mackey, S Akira, MH Ellisman, DD Sears, JM Olefsky, M Karin, DA Brenner, E Seki.TAK1-Mediated Autophagy and Fatty Acid Oxidation Prevent Hepatosteatosis and Tumorigenesis .J Clin Invest.,2014,124(8):3566-78.
16. Charlaftis N, Suddason T, X Wu, M Karin and E Gallagher.The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines .EMBO J.,2014,33(21):2581-96.
17. Zhang H, H Hu, N Greeley, J Jin, A Matthews, E Ohashi, M Caetano, H Li, X Wu, P Mandel, J McMurray, SJ Moghaddam, S-C Sun, S. Watowich.STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13 .Nature Communications,2014,5:5798.
18. Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M.A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1 .Cancer Cell,2013,23(5):647-59.
19. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, Vandenberg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M.Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice .J Clin Invest.,2013,123(5):2231-43.
20. Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T.I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection .EMBO J.,2013,32(6):816-28.
21. Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion effector-like T cells .Nat Immunol.,2012,13: 481-490.
22. Zhang M, Lee AJ, Wu X, Sun SC.Regulation of antiviral innate immunity by deubiquitinase CYLD .Cell Mol Immunol.,2011,8(6):502-4.
23. Xu G, Y-C Lo, Q Li, G Napolitano, Wu X, X Jiang, Karin M and Wu H.Crystal structure of the inhibitor of κB kinase β (IKKβ).Nature,2011,472 (7343):325-30.
24. Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC.Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses .J Exp Med.,2007,204(6): 1475-85.
25. Jin W, Reiley WW, Lee AJ, Wright A, Wu X, Zhang M, Sun SC.Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells .J Biol Chem.,2007,282(21): 15884-93.
26. Babu G, Waterfield M, Chang M, Wu X, Sun SC.Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells.J Biol Chem.,2006,281(20): 14041-7.
27. Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun S.Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation .Biochim Biophys Acta.,2006,1763(2): 174-81.
28. Reiley W, M Zhang, Wu X, E Granger, and S-C Sun.Regulation of the deubiquitinating enzyme CYLD by IKKγ-dependent phosphorylation .Mol. Cell. Biol.,2005,25(10): 3886-95.
榮譽與獎勵
海外高層次人才青年項目
團隊介紹
吳學鋒課題組現(xiàn)有助理研究員1名，實驗技術員1名，在讀博士研究生生3名，在讀碩士研究生1名。
