科研項目 1. 國家自然科學(xué)基金,，腸道穩(wěn)態(tài)與損傷修復(fù)中基質(zhì)細(xì)胞的起源,、異質(zhì)性、可塑性及功能研究,，3201101152,，主持人，2020-2023,，198萬,。 2. 國家自然科學(xué)基金，新型間質(zhì)細(xì)胞亞群在腸道區(qū)域免疫中的功能及調(diào)控機制,，91942311,，主持人，2020-2022,，250萬,。 3. 上海市科委-國際科技合作項目，新型冠狀病毒蛋白介導(dǎo)肺炎的作用與細(xì)胞分子機制,，20410714000,，主持人，2020-2023,，45萬,。 4. 國家自然科學(xué)基金，固有淋巴細(xì)胞調(diào)控腸道免疫穩(wěn)態(tài)的分子機制及生理病理功能,，31930035,，主持人，2020-2024,，308萬,。 5. 國家自然科學(xué)基金，外周免疫失衡與炎癥性自身免疫病相關(guān)疾病發(fā)生發(fā)展的細(xì)胞分子機制,，81430033,，主持人，2015-2019,，320萬,。 6. 省部級項目，Sin1(mTORC2)在腫瘤發(fā)生中的作用及其分子機制,，16410723300,，主持人，2016-2019,，30萬,。 7. 國家自然科學(xué)基金,，MEKK2在固有免疫抗細(xì)菌感染中的調(diào)控機制，31470845,，主持人,，2015-2018，95萬,。
論文與專著 1.Ningbo Wu, Dongping Chen, Hongxiang Sun, Jianmei Tan, Yao Zhang, Tianyu Zhang , Yuheng Han1, Hongzhi Liu, Xinxing Ouyang, Xiao-Dong Yang, Xiaoyin Niu , Jie Zhong , Zhengting Wang, Bing Su.MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis[J]. ence China Life ences:1-15. 2.Yang XD, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020 Jan 15;39(2):e102201 3. M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,B Su.Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.Cell Mol Immunol,2019,doi: 10.1038/s41423-018-0185-x. 4. OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su..Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression ..J Immunol, 2018,201:908-915. 5. Xuemei Fan, Conghui Wang, Panlai Shi, Wen Gao, Jianmin Gu, Yan Geng, Wenlong Yang, Ningbo Wu, Yang Wang, Yanyan Xu, Xue Chen, Lin Zhang, Kemin Wang,Bing Su and Junling Liu.. Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.Blood Adv,2018,26;2(12):1439-1448. 6. Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B and Wu ZB.Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors .Nature Communications,2018, 9:4624. 7. Xu YY, Ouyang XX, Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B, and Liu JL.Sin1 regulates ischaemia-induced microthrombosis through integrin αIIbβ3-mediated outside-in signaling and hypoxia responses in platelets. . Arteriosclerosis, Thrombosis, and Vascular Biology.,2018,32. 8. X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, Bing Su..Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2. . J Mol Cell Biol,2018,11(2):93-106. 9. Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C Huang YH, Hamilton TA1,2, Su B and LiX..IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis. J Immunol,2017,199(11):3849-3857. 10. Tan R, Nakajima S, Wang Q, Sun H,Xue J, Wu J, Hellwig S, Zeng X, Yates NA7, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B, Lan L.Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.Mol Cell,2017 ,65(5):818-831. 11. Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B, Li Y .Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.Oncotarget,2016,7(9):10064-72. |
